AR089122A1 - Formulaciones orales para tratar la sobrecarga de metales - Google Patents

Formulaciones orales para tratar la sobrecarga de metales

Info

Publication number
AR089122A1
AR089122A1 ARP120104611A ARP120104611A AR089122A1 AR 089122 A1 AR089122 A1 AR 089122A1 AR P120104611 A ARP120104611 A AR P120104611A AR P120104611 A ARP120104611 A AR P120104611A AR 089122 A1 AR089122 A1 AR 089122A1
Authority
AR
Argentina
Prior art keywords
hydroxy
integer
hydrogen
independently selected
alkoxy
Prior art date
Application number
ARP120104611A
Other languages
English (en)
Original Assignee
Ferrokin Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48574916&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR089122(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferrokin Biosciences Inc filed Critical Ferrokin Biosciences Inc
Publication of AR089122A1 publication Critical patent/AR089122A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Formulaciones orales eficaces basadas en análogos de desazadesferritiocin-poliéter (DADFT-PE), sus sales y polimorfos, así como también su aplicación para el tratamiento de la sobrecarga de metal, en particular, la sobrecarga férrica, y enfermedades, trastornos y afecciones asociados. Reivindicación 1: Una formulación oral que comprende un compuesto de fórmula (1) en una cantidad eficaz para tratar la sobrecarga de metal y un excipiente farmacéuticamente aceptable, donde: R¹, R², R³, R⁴, y R⁵ se seleccionan independientemente entre hidrógeno, hidroxi, alquilo, arilalquilo, alcoxi, y CH₃O((CH₂)ₙ-O)ₘ-, cualquiera de los cuales puede estar opcionalmente sustituido; R⁶, R⁷, y R⁸ se seleccionan independientemente entre hidrógeno, halógeno, hidroxi, alquilo inferior, y alcoxi inferior; m es un número entero de 0 a 8; y n es un número entero de 0 a 8; o su sal o polimorfo. Reivindicación 38: Una forma de dosificación sólida que comprende un compuesto de fórmula (1) y un excipiente farmacéuticamente aceptable, donde la forma de dosificación sólida se caracteriza por una velocidad de disolución que da como resultado más del 50% del compuesto de fórmula (1) se disuelve en solución dentro de los 30 minutos en un ensayo de disolución conducido según un protocolo estándar de la USP, la Farmacopea Europea o la Farmacopea Británica; donde: R¹, R², R³, R⁴, y R⁵ se seleccionan independientemente entre hidrógeno, hidroxi, alquilo, arilalquilo, alcoxi, y CH₃O((CH₂)ₙ-O)ₘ-, cualquiera de los cuales puede estar opcionalmente sustituido; R⁶, R⁷, y R⁸ se seleccionan independientemente entre hidrógeno, halógeno, hidroxi, alquilo inferior, y alcoxi inferior; m es un número entero de 0 a 8; y n es un número entero de 0 a 8; o su sal o polimorfo.
ARP120104611A 2011-12-09 2012-12-07 Formulaciones orales para tratar la sobrecarga de metales AR089122A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161568890P 2011-12-09 2011-12-09
US201161568914P 2011-12-09 2011-12-09

Publications (1)

Publication Number Publication Date
AR089122A1 true AR089122A1 (es) 2014-07-30

Family

ID=48574916

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120104611A AR089122A1 (es) 2011-12-09 2012-12-07 Formulaciones orales para tratar la sobrecarga de metales

Country Status (9)

Country Link
US (1) US8993606B2 (es)
EP (1) EP2787994A4 (es)
JP (1) JP2015500294A (es)
AR (1) AR089122A1 (es)
AU (1) AU2012347595A1 (es)
BR (1) BR112014013985A2 (es)
CA (1) CA2857990A1 (es)
TW (1) TW201338777A (es)
WO (1) WO2013086312A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140343110A1 (en) 2011-12-16 2014-11-20 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
AU2014228308A1 (en) 2013-03-15 2015-08-27 Ferrokin Biosciences, Inc. Polymorph forms of desazadesferrithiocin analogs
EP3071201A4 (en) * 2013-11-22 2017-04-26 University of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
CA2984250A1 (en) 2015-04-27 2016-11-03 University Of Florida Research Foundation, Incorporated Metabolically programmed metal chelators and uses thereof
WO2018104130A1 (en) 2016-12-07 2018-06-14 Lumileds Holding B.V. Flash light emitter with remote communication function
AU2020316632A1 (en) * 2019-07-19 2022-02-24 Vifor (International) Ag Ferroportin-inhibitors for the use in the treatment of transfusion-dependent beta-thalassemia (TDT)
EP4281072A1 (en) 2021-01-20 2023-11-29 Vifor (International) Ag Ferroportin-inhibitors for the use in the treatment of myelodysplastic syndromes (mds)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1866296T3 (en) 2005-04-04 2017-02-13 Univ Florida DESFERRITHIOCINPOLYETHER-ANALOGS
US8067451B2 (en) * 2006-07-18 2011-11-29 Horizon Pharma Usa, Inc. Methods and medicaments for administration of ibuprofen
BRPI0809077A2 (pt) 2007-03-15 2014-09-09 Univ Florida Res Foudantion Inc Análogos de poliéter de desferritiocina
US8063227B2 (en) 2008-07-14 2011-11-22 Ferrokin Biosciences, Inc. Salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents
WO2011017054A2 (en) 2009-07-27 2011-02-10 Ferrokin Biosciences, Inc. Prodrugs of desazadesferrothiocin polyether analogues as metal chelation agents
AU2010290103B2 (en) 2009-08-25 2016-07-14 University Of Florida Research Foundation, Inc. Desferrithiocin polyether analogues and uses thereof
AU2011248158A1 (en) 2010-05-04 2012-12-20 Ferrokin Biosciences, Inc. Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents

Also Published As

Publication number Publication date
TW201338777A (zh) 2013-10-01
WO2013086312A1 (en) 2013-06-13
CA2857990A1 (en) 2013-06-13
JP2015500294A (ja) 2015-01-05
US20130225645A1 (en) 2013-08-29
EP2787994A1 (en) 2014-10-15
EP2787994A4 (en) 2015-08-26
BR112014013985A2 (pt) 2017-06-13
AU2012347595A1 (en) 2014-06-26
US8993606B2 (en) 2015-03-31

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