BR112014013985A2 - formulações orais para tratamento de sobrecarga de metal - Google Patents
formulações orais para tratamento de sobrecarga de metalInfo
- Publication number
- BR112014013985A2 BR112014013985A2 BR112014013985A BR112014013985A BR112014013985A2 BR 112014013985 A2 BR112014013985 A2 BR 112014013985A2 BR 112014013985 A BR112014013985 A BR 112014013985A BR 112014013985 A BR112014013985 A BR 112014013985A BR 112014013985 A2 BR112014013985 A2 BR 112014013985A2
- Authority
- BR
- Brazil
- Prior art keywords
- oral formulations
- metal
- treatment
- metal overload
- overload treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
resumo formulações orais para tratamento de sobrecarga de metal a presente invenção fornece, entre outras coisas, formulações orais eficazes baseadas em análogos do poliéter de desazadesferritiocina (dadft-pe), sais e polimorfos do mesmo, bem como sua aplicação para o tratamento da sobrecarga de metal, em particular, sobrecarga de ferro e doenças, distúrbios e condições associadas.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161568914P | 2011-12-09 | 2011-12-09 | |
US201161568890P | 2011-12-09 | 2011-12-09 | |
PCT/US2012/068432 WO2013086312A1 (en) | 2011-12-09 | 2012-12-07 | Oral formulations for treating metal overload |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014013985A2 true BR112014013985A2 (pt) | 2017-06-13 |
Family
ID=48574916
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014013985A BR112014013985A2 (pt) | 2011-12-09 | 2012-12-07 | formulações orais para tratamento de sobrecarga de metal |
Country Status (9)
Country | Link |
---|---|
US (1) | US8993606B2 (pt) |
EP (1) | EP2787994A4 (pt) |
JP (1) | JP2015500294A (pt) |
AR (1) | AR089122A1 (pt) |
AU (1) | AU2012347595A1 (pt) |
BR (1) | BR112014013985A2 (pt) |
CA (1) | CA2857990A1 (pt) |
TW (1) | TW201338777A (pt) |
WO (1) | WO2013086312A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2012352025B2 (en) | 2011-12-16 | 2018-01-18 | University Of Florida Research Foundation, Inc. | Uses of 4'-desferrithiocin analogs |
EP2970162A1 (en) | 2013-03-15 | 2016-01-20 | Ferrokin Biosciences, Inc. | Polymorph forms of desazadesferrithiocin analogs |
EP3071201A4 (en) * | 2013-11-22 | 2017-04-26 | University of Florida Research Foundation, Inc. | Desferrithiocin analogs and uses thereof |
KR20170140306A (ko) | 2015-04-27 | 2017-12-20 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 대사적으로 프로그램화된 금속 킬레이트화제 및 그의 용도 |
WO2018104130A1 (en) | 2016-12-07 | 2018-06-14 | Lumileds Holding B.V. | Flash light emitter with remote communication function |
BR112022001062A2 (pt) * | 2019-07-19 | 2022-03-15 | Vifor Int Ag | Inibidores de ferroportina para o uso no tratamento de beta-talassemia dependente de transfusão (tdt) |
MX2023008515A (es) | 2021-01-20 | 2023-07-27 | Vifor Int Ag | Inhibidores de ferroportina para su uso en el tratamiento de sindromes mielodisplasicos (smd). |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0610644B8 (pt) | 2005-04-04 | 2021-05-25 | Univ Florida | composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável. |
US8067451B2 (en) * | 2006-07-18 | 2011-11-29 | Horizon Pharma Usa, Inc. | Methods and medicaments for administration of ibuprofen |
NZ579994A (en) | 2007-03-15 | 2011-09-30 | Univ Florida | Desferrithiocin polyether analogues useful in the treatment of pathological conditions responsive to chelation or sequestration of trivalent metal |
NZ590302A (en) * | 2008-07-14 | 2013-02-22 | Ferrokin Biosciences Inc | Novel salts and polymorphs of desazadesferrithiocin polyether analogues as metal chelation agents |
CN102648189A (zh) | 2009-07-27 | 2012-08-22 | 费罗金生物科学股份有限公司 | 作为金属螯合剂的脱氮杂去铁硫辛聚醚类似物的前药 |
JP5925679B2 (ja) | 2009-08-25 | 2016-05-25 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション,インコーポレイティド | デスフェリチオシンポリエーテル類似体およびその使用 |
AU2011248158A1 (en) | 2010-05-04 | 2012-12-20 | Ferrokin Biosciences, Inc. | Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents |
-
2012
- 2012-12-07 CA CA2857990A patent/CA2857990A1/en not_active Abandoned
- 2012-12-07 WO PCT/US2012/068432 patent/WO2013086312A1/en active Application Filing
- 2012-12-07 JP JP2014546115A patent/JP2015500294A/ja active Pending
- 2012-12-07 US US13/708,087 patent/US8993606B2/en not_active Expired - Fee Related
- 2012-12-07 BR BR112014013985A patent/BR112014013985A2/pt not_active IP Right Cessation
- 2012-12-07 AU AU2012347595A patent/AU2012347595A1/en not_active Abandoned
- 2012-12-07 EP EP12856135.4A patent/EP2787994A4/en not_active Withdrawn
- 2012-12-07 AR ARP120104611A patent/AR089122A1/es not_active Application Discontinuation
- 2012-12-07 TW TW101146269A patent/TW201338777A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP2787994A4 (en) | 2015-08-26 |
US20130225645A1 (en) | 2013-08-29 |
WO2013086312A1 (en) | 2013-06-13 |
TW201338777A (zh) | 2013-10-01 |
AR089122A1 (es) | 2014-07-30 |
JP2015500294A (ja) | 2015-01-05 |
EP2787994A1 (en) | 2014-10-15 |
CA2857990A1 (en) | 2013-06-13 |
AU2012347595A1 (en) | 2014-06-26 |
US8993606B2 (en) | 2015-03-31 |
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Legal Events
Date | Code | Title | Description |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2494 DE 23-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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B350 | Update of information on the portal [chapter 15.35 patent gazette] |