AR087993A1 - Procesos e intermediarios para la preparacion de un inhibidor macrociclico de la proteasa del hcv - Google Patents
Procesos e intermediarios para la preparacion de un inhibidor macrociclico de la proteasa del hcvInfo
- Publication number
- AR087993A1 AR087993A1 ARP120103498A AR087993A1 AR 087993 A1 AR087993 A1 AR 087993A1 AR P120103498 A ARP120103498 A AR P120103498A AR 087993 A1 AR087993 A1 AR 087993A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- acid
- cinconidine
- preparation
- organic solvent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/18—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicación 1: Un proceso para la preparación de una sal de cinconidina de la fórmula (4) que comprende los siguientes pasos: (a) someter al ácido 4-oxo-1,2-ciclopentandicarboxílico de fórmula (5) a reducción en un ambiente acuoso, para producir así una solución acuosa del ácido 4-hidroxi-1,2-ciclopentandicarboxílico racémico de fórmula (6); (b) agregar un solvente orgánico (por ej. un solvente orgánico miscible con agua) a la solución acuosa obtenida en (a); (c) someter al hidroxiácido racémico de fórmula (6) a ciclación a fin de obtener una solución acuosa de solventes orgánicos del correspondiente ácido racémico de lactona de fórmula (2); (d) agregar cinconidina a la solución acuosa de solvente orgánico obtenida en (c) para obtener la sal de cinconidina de fórmula (3) del ácido de lactona; (e) dejar que la sal de cinconidina cristalice para obtener la sal de cinconidina cristalina enantioméricamente purificada del ácido de lactona de fórmula (4).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11182375 | 2011-09-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR087993A1 true AR087993A1 (es) | 2014-04-30 |
Family
ID=46924427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP120103498 AR087993A1 (es) | 2011-09-22 | 2012-09-21 | Procesos e intermediarios para la preparacion de un inhibidor macrociclico de la proteasa del hcv |
Country Status (16)
Country | Link |
---|---|
US (1) | US9227965B2 (es) |
EP (1) | EP2758386A1 (es) |
JP (1) | JP6235473B2 (es) |
KR (1) | KR20140063726A (es) |
CN (2) | CN107011339A (es) |
AR (1) | AR087993A1 (es) |
AU (1) | AU2012311461B2 (es) |
BR (1) | BR112014006984A2 (es) |
CA (1) | CA2845720A1 (es) |
CL (1) | CL2014000687A1 (es) |
EA (1) | EA201490675A1 (es) |
HK (1) | HK1199449A1 (es) |
IL (1) | IL231024A (es) |
MX (1) | MX356686B (es) |
TW (1) | TWI565704B (es) |
WO (1) | WO2013041655A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA41812A (fr) | 2015-03-27 | 2018-01-30 | Janssen Pharmaceuticals Inc | Procédés et intermédiaires pour la préparation d'un inhibiteur de protéase macrocyclique du vhc |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ548740A (en) | 2004-01-30 | 2010-06-25 | Medivir Ab | HCV NS-3 Serine protease inhibitors |
PE20070211A1 (es) | 2005-07-29 | 2007-05-12 | Medivir Ab | Compuestos macrociclicos como inhibidores del virus de hepatitis c |
DE602008001251D1 (de) | 2007-02-01 | 2010-06-24 | Tibotec Pharm Ltd | Verfahren und zwischenprodukte zur herstellung eines makrozyklischen proteasehemmers von hcv |
US8426360B2 (en) * | 2007-11-13 | 2013-04-23 | Enanta Pharmaceuticals, Inc. | Carbocyclic oxime hepatitis C virus serine protease inhibitors |
RU2016120007A (ru) | 2008-12-23 | 2018-11-13 | Орто-Макнейл-Янссен Фармасьютикалз, Инк | Способы и промежуточные соединения для получения макроциклического ингибитора протеазы вируса гепатита c |
IN2012DN02693A (es) * | 2009-09-28 | 2015-09-04 | Intermune Inc | |
US9586893B2 (en) * | 2010-03-16 | 2017-03-07 | Janssen Pharmaceuticals | Processes and intermediates for preparing a macrocyclic protease inhibitor of HCV |
-
2012
- 2012-09-21 AR ARP120103498 patent/AR087993A1/es unknown
- 2012-09-21 AU AU2012311461A patent/AU2012311461B2/en not_active Ceased
- 2012-09-21 TW TW101134606A patent/TWI565704B/zh not_active IP Right Cessation
- 2012-09-21 CN CN201610933386.0A patent/CN107011339A/zh active Pending
- 2012-09-21 WO PCT/EP2012/068593 patent/WO2013041655A1/en active Application Filing
- 2012-09-21 CN CN201280046217.5A patent/CN103906739B/zh not_active Expired - Fee Related
- 2012-09-21 EA EA201490675A patent/EA201490675A1/ru unknown
- 2012-09-21 CA CA 2845720 patent/CA2845720A1/en active Pending
- 2012-09-21 BR BR112014006984A patent/BR112014006984A2/pt not_active IP Right Cessation
- 2012-09-21 MX MX2014003509A patent/MX356686B/es active IP Right Grant
- 2012-09-21 KR KR20147007588A patent/KR20140063726A/ko not_active Application Discontinuation
- 2012-09-21 US US14/345,980 patent/US9227965B2/en not_active Expired - Fee Related
- 2012-09-21 EP EP12762583.8A patent/EP2758386A1/en not_active Withdrawn
- 2012-09-21 JP JP2014531241A patent/JP6235473B2/ja not_active Expired - Fee Related
-
2014
- 2014-02-18 IL IL231024A patent/IL231024A/en active IP Right Grant
- 2014-03-20 CL CL2014000687A patent/CL2014000687A1/es unknown
- 2014-12-31 HK HK14113084.4A patent/HK1199449A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20140228574A1 (en) | 2014-08-14 |
EA201490675A1 (ru) | 2014-08-29 |
AU2012311461A1 (en) | 2014-03-06 |
TWI565704B (zh) | 2017-01-11 |
HK1199449A1 (en) | 2015-07-03 |
IL231024A (en) | 2017-09-28 |
WO2013041655A1 (en) | 2013-03-28 |
EP2758386A1 (en) | 2014-07-30 |
IL231024A0 (en) | 2014-03-31 |
MX2014003509A (es) | 2014-07-22 |
JP2014528943A (ja) | 2014-10-30 |
CN107011339A (zh) | 2017-08-04 |
TW201329074A (zh) | 2013-07-16 |
BR112014006984A2 (pt) | 2017-04-04 |
CN103906739B (zh) | 2016-12-28 |
AU2012311461B2 (en) | 2017-07-06 |
MX356686B (es) | 2018-06-07 |
CL2014000687A1 (es) | 2014-08-01 |
JP6235473B2 (ja) | 2017-11-22 |
KR20140063726A (ko) | 2014-05-27 |
US9227965B2 (en) | 2016-01-05 |
CA2845720A1 (en) | 2013-03-28 |
CN103906739A (zh) | 2014-07-02 |
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Legal Events
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FB | Suspension of granting procedure |