AR086780A1 - Metodo para producir particulas finas de cristales de anhidrido de aripiprazol b - Google Patents

Metodo para producir particulas finas de cristales de anhidrido de aripiprazol b

Info

Publication number
AR086780A1
AR086780A1 ARP120102315A ARP120102315A AR086780A1 AR 086780 A1 AR086780 A1 AR 086780A1 AR P120102315 A ARP120102315 A AR P120102315A AR P120102315 A ARP120102315 A AR P120102315A AR 086780 A1 AR086780 A1 AR 086780A1
Authority
AR
Argentina
Prior art keywords
crystals
aripiprazole
producing fine
lower alcohol
aripiprazol
Prior art date
Application number
ARP120102315A
Other languages
English (en)
Inventor
Bando Takuji
Yano Katsuhiko
Fukana Makoto
Aoki Satoshi
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR086780A1 publication Critical patent/AR086780A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

La presente se refiere a un método para producir partículas finas de cristales de anhídrido de aripiprazol B. El método para producir partículas finas de cristales de anhídrido de aripiprazol B comprende las etapas de: (1) calentar y disolver aripiprazol crudo en un alcohol inferior, y posteriormente enfriar la mezcla resultante para precipitar los cristales para obtener cristales de solvato de alcohol inferior de aripiprazol; (2) someter los cristales de solvato de alcohol inferior de aripiprazol a molienda húmeda en forma de suspensión que contiene el alcohol inferior; y (3) someter la dispersión de los cristales molidos en húmedo a separación sólido-líquido para obtener los cristales, y calentar los cristales.
ARP120102315A 2011-06-29 2012-06-28 Metodo para producir particulas finas de cristales de anhidrido de aripiprazol b AR086780A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161502417P 2011-06-29 2011-06-29

Publications (1)

Publication Number Publication Date
AR086780A1 true AR086780A1 (es) 2014-01-22

Family

ID=46690661

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP120102315A AR086780A1 (es) 2011-06-29 2012-06-28 Metodo para producir particulas finas de cristales de anhidrido de aripiprazol b

Country Status (15)

Country Link
US (1) US9278934B2 (es)
EP (1) EP2726461A1 (es)
JP (1) JP2014518197A (es)
KR (1) KR20140037236A (es)
CN (1) CN103619819A (es)
AR (1) AR086780A1 (es)
AU (1) AU2012276562A1 (es)
BR (1) BR112013033349A2 (es)
CA (1) CA2840574A1 (es)
CO (1) CO6862158A2 (es)
EA (1) EA022343B1 (es)
MX (1) MX2013015213A (es)
TW (1) TW201309651A (es)
WO (1) WO2013002420A1 (es)
ZA (1) ZA201309246B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20200109A1 (ar) 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
CN105246461B (zh) * 2013-04-30 2018-03-30 大塚制药株式会社 包含阿立哌唑的口服固体制剂以及用于产生包含阿立哌唑的口服固体制剂的方法
JOP20200296A1 (ar) * 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
JP6023770B2 (ja) * 2014-10-01 2016-11-09 株式会社パーマケム・アジア アリピプラゾール無水物ｂ形結晶の製造方法
WO2016181406A1 (en) * 2015-05-08 2016-11-17 Davuluri Ramamohan Rao Improved process for the preparation of aripiprazole with reduced particle size
KR102128883B1 (ko) * 2019-10-02 2020-07-01 (주)삼화바이오팜 고순도 아리피프라졸의 신규 결정형 및 이의 제조방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54130587A (en) 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
US5006528A (en) 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
AR033485A1 (es) * 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
EP1812397A1 (en) * 2004-11-18 2007-08-01 Synthon B.V. Process of making crystalline aripiprazole
WO2006053780A1 (en) * 2004-11-18 2006-05-26 Synthon B.V. Crystalline aripiprazole solvates
CN102060763B (zh) * 2010-12-27 2012-11-14 齐鲁制药有限公司 微粉型阿立哌唑晶型ⅰ或ⅱ的制备方法

Also Published As

Publication number Publication date
MX2013015213A (es) 2014-02-20
TW201309651A (zh) 2013-03-01
EA201490181A1 (ru) 2014-04-30
BR112013033349A2 (pt) 2016-09-06
CN103619819A (zh) 2014-03-05
NZ620429A (en) 2015-08-28
AU2012276562A1 (en) 2014-01-16
JP2014518197A (ja) 2014-07-28
US20140228567A1 (en) 2014-08-14
CA2840574A1 (en) 2013-01-03
WO2013002420A1 (en) 2013-01-03
ZA201309246B (en) 2015-04-29
US9278934B2 (en) 2016-03-08
EP2726461A1 (en) 2014-05-07
EA022343B1 (ru) 2015-12-30
KR20140037236A (ko) 2014-03-26
CO6862158A2 (es) 2014-02-10

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