AR081637A1 - Derivados del acido c-3-betulinico modificados inhibidores de la maduracion del vih, composiciones farmaceuticas que los contienen e intermediarios de sintesis - Google Patents

Derivados del acido c-3-betulinico modificados inhibidores de la maduracion del vih, composiciones farmaceuticas que los contienen e intermediarios de sintesis

Info

Publication number
AR081637A1
AR081637A1 ARP110101944A ARP110101944A AR081637A1 AR 081637 A1 AR081637 A1 AR 081637A1 AR P110101944 A ARP110101944 A AR P110101944A AR P110101944 A ARP110101944 A AR P110101944A AR 081637 A1 AR081637 A1 AR 081637A1
Authority
AR
Argentina
Prior art keywords
coor2
alkyl
compound
pharmaceutical compositions
group
Prior art date
Application number
ARP110101944A
Other languages
English (en)
Spanish (es)
Inventor
Alicia Regueiro-Ren
Jacob Swidorski
Zheng Liu
Sing Sit
Jie Yuen-Chen
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR081637A1 publication Critical patent/AR081637A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ARP110101944A 2010-06-04 2011-06-03 Derivados del acido c-3-betulinico modificados inhibidores de la maduracion del vih, composiciones farmaceuticas que los contienen e intermediarios de sintesis AR081637A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35133810P 2010-06-04 2010-06-04

Publications (1)

Publication Number Publication Date
AR081637A1 true AR081637A1 (es) 2012-10-10

Family

ID=44627236

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110101944A AR081637A1 (es) 2010-06-04 2011-06-03 Derivados del acido c-3-betulinico modificados inhibidores de la maduracion del vih, composiciones farmaceuticas que los contienen e intermediarios de sintesis

Country Status (12)

Country Link
US (1) US8754068B2 (enExample)
EP (1) EP2576585B8 (enExample)
JP (1) JP5752789B2 (enExample)
CN (1) CN103038245B (enExample)
AR (1) AR081637A1 (enExample)
BR (1) BR112012030818A2 (enExample)
CA (1) CA2801487C (enExample)
EA (1) EA022393B1 (enExample)
ES (1) ES2612452T3 (enExample)
MX (1) MX2012013703A (enExample)
TW (1) TW201201793A (enExample)
WO (1) WO2011153315A1 (enExample)

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US9295664B2 (en) 2011-06-06 2016-03-29 University Of Iowa Research Foundation Methods for lowering blood glucose
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US8906889B2 (en) * 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
WO2014105926A1 (en) 2012-12-31 2014-07-03 Hetero Research Foundation Novel betulinic acid proline derivatives as hiv inhibitors
JP6186010B2 (ja) * 2013-02-06 2017-08-23 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｈｉｖ成熟阻害活性を有するｃ−１９修飾トリテルペノイド類
KR20150121712A (ko) * 2013-02-25 2015-10-29 브리스톨-마이어스 스큅 컴퍼니 Hiv의 치료에 유용한 c-3 알킬 및 알케닐 개질된 베툴린산 유도체
MA39374A1 (fr) 2014-04-11 2018-06-29 Viiv Healthcare Uk No 4 Ltd Triterpénoïdes présentant une activité d'inhibition de la maturation du vih, substitués en 3ème position par un cycle non aromatique portant un substituant halogénoalkyle
WO2015195776A1 (en) 2014-06-19 2015-12-23 Bristol-Myers Squibb Company Betulinic acid derivatives with hiv maturation inhibitory activity
US20170129916A1 (en) 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
BR112017009850A2 (pt) * 2014-11-14 2018-01-16 Viiv Healthcare Uk No 5 Ltd composto, composição, e, uso de uma quantidade melhoradora de hiv de um composto
WO2016077572A1 (en) * 2014-11-14 2016-05-19 Bristol-Myers Squibb Company Extended betulinic acid analogs
RU2017118576A (ru) 2014-11-14 2018-12-14 ВАЙВ ХЕЛТКЕР ЮКей (N5) ЛИМИТЕД C-17-арил-замещённые аналоги бетулиновой кислоты
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
WO2016147099A2 (en) 2015-03-16 2016-09-22 Hetero Research Foundation C-3 novel triterpenone with c-28 amide derivatives as hiv inhibitors
KR20180028534A (ko) 2015-07-28 2018-03-16 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 Hiv 감염을 예방하거나 치료하기 위한 베투인 유도체
RU2018105352A (ru) 2015-07-28 2019-08-29 ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед Производные бетулина для предупреждения или лечения ВИЧ-инфекций
CN108368071A (zh) 2015-09-24 2018-08-03 葛兰素史克知识产权第二有限公司 具有hiv成熟抑制活性的化合物
CN108699103A (zh) 2016-01-20 2018-10-23 葛兰素史克知识产权第二有限公司 具有hiv成熟抑制活性的羽扇烷类的胺衍生物
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
EP3478661A1 (en) * 2016-06-30 2019-05-08 ViiV Healthcare UK (No.5) Limited Aza-substituted inhibitors of human immunodeficiency virus replication
EP3478703A1 (en) * 2016-06-30 2019-05-08 ViiV Healthcare UK (No.5) Limited Triterpenoid inhibitors of human immunodeficiency virus replication
US10493070B2 (en) 2016-06-30 2019-12-03 Viiv Healthcare Uk (No. 5) Limited Azadecalin derivatives as inhibitors of human immunodeficiency virus replication
WO2019207460A1 (en) 2018-04-24 2019-10-31 VIIV Healthcare UK (No.5) Limited Compounds with hiv maturation inhibitory activity
PL237998B1 (pl) 2018-05-28 2021-06-28 Narodowy Inst Lekow Fosfonowe pochodne kwasu 3-karboksyacylobetulinowego, sposób ich otrzymywania oraz ich zastosowanie

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US5869535A (en) 1995-03-21 1999-02-09 The Board Of Trustees Of The University Of Illinois Method and composition for selectively inhibiting melanoma
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Also Published As

Publication number Publication date
JP2013527242A (ja) 2013-06-27
EP2576585A1 (en) 2013-04-10
EA201270780A1 (ru) 2013-04-30
WO2011153315A1 (en) 2011-12-08
EA022393B1 (ru) 2015-12-30
CA2801487C (en) 2017-12-05
US20120142707A1 (en) 2012-06-07
US8754068B2 (en) 2014-06-17
JP5752789B2 (ja) 2015-07-22
TW201201793A (en) 2012-01-16
EP2576585B8 (en) 2016-12-21
ES2612452T3 (es) 2017-05-17
EP2576585B1 (en) 2016-10-12
MX2012013703A (es) 2012-12-17
CN103038245A (zh) 2013-04-10
BR112012030818A2 (pt) 2019-09-24
CA2801487A1 (en) 2011-12-08
CN103038245B (zh) 2015-03-25

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