AR081405A1 - Proceso para la preparacion de aminas olefinicas sustituidas con arilo o heteroarilo e intermediarios de las mismas - Google Patents
Proceso para la preparacion de aminas olefinicas sustituidas con arilo o heteroarilo e intermediarios de las mismasInfo
- Publication number
- AR081405A1 AR081405A1 ARP110101739A ARP110101739A AR081405A1 AR 081405 A1 AR081405 A1 AR 081405A1 AR P110101739 A ARP110101739 A AR P110101739A AR P110101739 A ARP110101739 A AR P110101739A AR 081405 A1 AR081405 A1 AR 081405A1
- Authority
- AR
- Argentina
- Prior art keywords
- penten
- methyl
- amine
- preparation
- mol equivalent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01D—COMPOUNDS OF ALKALI METALS, i.e. LITHIUM, SODIUM, POTASSIUM, RUBIDIUM, CAESIUM, OR FRANCIUM
- C01D15/00—Lithium compounds
- C01D15/06—Sulfates; Sulfites
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D9/00—Crystallisation
- B01D9/02—Crystallisation from solutions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/20—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
- C07C211/21—Monoamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/04—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups from amines with formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
Abstract
Un proceso mejorado para la preparacion de aminas olefínicas sustituidas con arilo tales como (2S)-(4E)-N-metil-5-[3-(5-isopropoxipiridin)il]-4-penten-2-amina y (2S)-(4E)-N-metil-5-[3-(5-metoxipiridin)il]-4-penten-2-amina y a compuestos intermediarios utilizados en dicho proceso. Reivindicacinn 1: Un proceso para la preparacion de 4-penten-2-ol que comprende: agregar cloruro de vinilmagnesio a una mezcla de cloruro de cobre(l) y cloruro de litio, seguido por la adicion de oxido de propileno en un solvente adecuado. Reivindicacinn 4: Un proceso para la preparacion de N-(terc-butoxicarbonil)-N-metil-4-penten-2-amina que comprende: un proceso de acuerdo con la reivindicacion 3, seguido por: la adicion de 4-penten-2-ol a una solucion de 1,0 mol equivalente (en relacion con el oxido de propileno) de cloruro de p-toluenosulfonilo en tetrahidrofurano, la adicion del p-toluenosulfonato de 4-penten-2-ilo en solucion de tetrahidrofurano, a metilamina acuosa al 40%, la combinacion de la solucion resultante de N-metil-4-penten-2-amina con una mezcla de dicarbonato de di-terc-butilo en metil terc-butil éter, y la adicion de N,N-dimetiletanodiamina a la mezcla de reaccion de N-metil-4-penten-2-amina a N-(terc-butoxicarbonil)-N-metil-4-penten-2-amina. Reivindicacinn 5: Un proceso para la preparacion del ácido N-metil-4-penten-2-amina di- benzoil-L-(-)-tartárico que comprende: agregar una solucion de ácido (L)-(-)-benzoil-tartárico (0,5 mol equivalente en relacion con N-metil-4-penten-2-amina) a una solucion de N-metil-4-penten-2-amina en un solvente orgánico. Reivindicacinn 6: Un proceso para la preparacion de aminas olefínicas sustituidas con arilo tales como (2S)-(4E)-N-metil-5-[3-(5-isopropoxipiridin)il]-4-penten-2-amina que comprende: a) mezclar (2S)-N-(terc-butoxicarbonil)-N-metil-4-penten-2-amina (1 mol equivalente) y 5-bromo-3-alcoxipiridina (1,1 mol equivalente) con una fuente de paladio (0,01 mol equivalente), un ligando de fosfina (0,24 mol equivalente) y una base (1,5 mol equivalente) en un solvente orgánico adecuado en una atmosfera de nitrogeno; b) agregar agua y calendar la mezcla hasta 90°C durante 15 a 25 horas o hasta que se haya logrado el nivel apropiado de conversion; c) enfriar la mezcla y agregar agua y un ácido, seguido de la agitacion a 0-70 °C durante 3 a 8 horas; d) separar el solvente orgánico y la fase acuosa ácida seguido del lavado de la fase acuosa con un solvente orgánico; e) ajustar el pH en la fase acuosa mediante la adicion de una base, y f) extraer el producto en la fase orgánica seguido por la separacion de la fase orgánica; y opcionalmente g) tratar la fase orgánica con un material de barrido de metales o carbon. Reivindicacinn 12: El compuesto de sal del ácido N-metil-4-penten-2-amina hemi-di-benzoil-L-(-)-tartárico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34650410P | 2010-05-20 | 2010-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR081405A1 true AR081405A1 (es) | 2012-08-29 |
Family
ID=44991920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110101739A AR081405A1 (es) | 2010-05-20 | 2011-05-20 | Proceso para la preparacion de aminas olefinicas sustituidas con arilo o heteroarilo e intermediarios de las mismas |
Country Status (15)
Country | Link |
---|---|
US (1) | US8703802B2 (es) |
EP (1) | EP2574188A4 (es) |
JP (1) | JP2013528601A (es) |
KR (1) | KR20130081221A (es) |
CN (1) | CN103180277A (es) |
AR (1) | AR081405A1 (es) |
AU (1) | AU2011256866B2 (es) |
BR (1) | BR112012029326A2 (es) |
CA (1) | CA2799650A1 (es) |
IL (1) | IL222940A0 (es) |
MX (1) | MX2012013193A (es) |
RU (1) | RU2012150449A (es) |
SG (1) | SG185497A1 (es) |
TW (1) | TW201213287A (es) |
WO (1) | WO2011146009A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108715573A (zh) * | 2018-08-02 | 2018-10-30 | 江西力田维康科技有限公司 | 一种3-丁烯-1-醇的制备方法 |
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-
2011
- 2011-05-19 BR BR112012029326A patent/BR112012029326A2/pt not_active IP Right Cessation
- 2011-05-19 RU RU2012150449/04A patent/RU2012150449A/ru not_active Application Discontinuation
- 2011-05-19 CA CA2799650A patent/CA2799650A1/en not_active Abandoned
- 2011-05-19 US US13/697,807 patent/US8703802B2/en not_active Expired - Fee Related
- 2011-05-19 JP JP2013511128A patent/JP2013528601A/ja active Pending
- 2011-05-19 SG SG2012082632A patent/SG185497A1/en unknown
- 2011-05-19 CN CN2011800363048A patent/CN103180277A/zh active Pending
- 2011-05-19 AU AU2011256866A patent/AU2011256866B2/en not_active Ceased
- 2011-05-19 KR KR1020127030245A patent/KR20130081221A/ko not_active Application Discontinuation
- 2011-05-19 EP EP11783835.9A patent/EP2574188A4/en not_active Withdrawn
- 2011-05-19 MX MX2012013193A patent/MX2012013193A/es not_active Application Discontinuation
- 2011-05-19 WO PCT/SE2011/050630 patent/WO2011146009A1/en active Application Filing
- 2011-05-20 TW TW100117840A patent/TW201213287A/zh unknown
- 2011-05-20 AR ARP110101739A patent/AR081405A1/es not_active Application Discontinuation
-
2012
- 2012-11-08 IL IL222940A patent/IL222940A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2011256866A1 (en) | 2012-12-20 |
CA2799650A1 (en) | 2011-11-24 |
MX2012013193A (es) | 2012-12-17 |
KR20130081221A (ko) | 2013-07-16 |
IL222940A0 (en) | 2012-12-31 |
BR112012029326A2 (pt) | 2017-08-08 |
US20130225827A1 (en) | 2013-08-29 |
TW201213287A (en) | 2012-04-01 |
RU2012150449A (ru) | 2014-06-27 |
CN103180277A (zh) | 2013-06-26 |
EP2574188A4 (en) | 2015-09-02 |
SG185497A1 (en) | 2012-12-28 |
JP2013528601A (ja) | 2013-07-11 |
AU2011256866B2 (en) | 2014-05-22 |
US8703802B2 (en) | 2014-04-22 |
EP2574188A1 (en) | 2013-04-03 |
WO2011146009A8 (en) | 2012-01-19 |
WO2011146009A1 (en) | 2011-11-24 |
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