AR079263A1 - Metodos y composiciones para incrementar la titulacion de vectores del adenovirus porcino 3 recombinante - Google Patents

Metodos y composiciones para incrementar la titulacion de vectores del adenovirus porcino 3 recombinante

Info

Publication number
AR079263A1
AR079263A1 ARP100104482A ARP100104482A AR079263A1 AR 079263 A1 AR079263 A1 AR 079263A1 AR P100104482 A ARP100104482 A AR P100104482A AR P100104482 A ARP100104482 A AR P100104482A AR 079263 A1 AR079263 A1 AR 079263A1
Authority
AR
Argentina
Prior art keywords
padv
recombinant
methods
increase
vector
Prior art date
Application number
ARP100104482A
Other languages
English (en)
Inventor
Michael Sheppard
Original Assignee
Vectogen Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vectogen Pty Ltd filed Critical Vectogen Pty Ltd
Publication of AR079263A1 publication Critical patent/AR079263A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10351—Methods of production or purification of viral material
    • C12N2710/10352—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Métodos para incrementar la titulacion del PAdV-3 recombinante producido en células huésped porcinas. Los métodos comprenden incrementar la eficiencia de la encapsidacion del PAdV-3. Composiciones relacionadas. Vectores optimizados del PAdV-3 recombinante en los que se ha optimizado la senal de encapsidacion. En particular, la optimizacion comprende incrementar la cantidad de elementos encapsidados en el genoma del virus PAdV-3. Reivindicacion 1: Un vector de un adenovirus porcino recombinante 3 (PAdV-3), caracterizado porque dicho vector comprende secuencias de la ITR del adenovirus 3 porcino, y al menos una secuencia de nucleotidos heterologa, en donde dicho genoma de PAdV-3 contiene una senal de empaquetamiento modificada que comprende al menos tres elementos de empaquetamiento TTTG/C entre la repeticion terminal invertida 5' y la region de transcripcion temprana E1A.
ARP100104482A 2009-12-04 2010-12-03 Metodos y composiciones para incrementar la titulacion de vectores del adenovirus porcino 3 recombinante AR079263A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26654109P 2009-12-04 2009-12-04

Publications (1)

Publication Number Publication Date
AR079263A1 true AR079263A1 (es) 2012-01-04

Family

ID=44082256

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104482A AR079263A1 (es) 2009-12-04 2010-12-03 Metodos y composiciones para incrementar la titulacion de vectores del adenovirus porcino 3 recombinante

Country Status (4)

Country Link
US (1) US20110135688A1 (es)
AR (1) AR079263A1 (es)
TW (1) TW201137123A (es)
WO (1) WO2011066615A1 (es)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO856097A0 (en) * 1997-08-14 1997-09-04 Commonwealth Scientific And Industrial Research Organisation Vector
US6492343B1 (en) * 1998-04-15 2002-12-10 University Of Saskatchewan Porcine adenovirus type 3 genome
US7569217B2 (en) * 2001-09-24 2009-08-04 University Of Saskatchewan Porcine adenovirus E1 and E4 regions
US7687615B2 (en) * 2002-07-19 2010-03-30 University Of Saskatchewan PAV regions for encapsidation and E1 transcriptional control

Also Published As

Publication number Publication date
WO2011066615A1 (en) 2011-06-09
TW201137123A (en) 2011-11-01
US20110135688A1 (en) 2011-06-09

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