AR078744A1 - Compuestos inhibidores de la prostaglandina e2 sintasa-1 microsomica (mpges-1), composiciones farmaceuticas que los contienen, y su uso como medicamentos para el tratamiento y/o prevencion de enfermedades inflama-torias y afecciones asociadas - Google Patents

Compuestos inhibidores de la prostaglandina e2 sintasa-1 microsomica (mpges-1), composiciones farmaceuticas que los contienen, y su uso como medicamentos para el tratamiento y/o prevencion de enfermedades inflama-torias y afecciones asociadas

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Publication number
AR078744A1
AR078744A1 ARP100103888A ARP100103888A AR078744A1 AR 078744 A1 AR078744 A1 AR 078744A1 AR P100103888 A ARP100103888 A AR P100103888A AR P100103888 A ARP100103888 A AR P100103888A AR 078744 A1 AR078744 A1 AR 078744A1
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AR
Argentina
Prior art keywords
alkyl
optionally substituted
groups
substituents
whose last
Prior art date
Application number
ARP100103888A
Other languages
English (en)
Inventor
Henri Doods
Roland Kuelzer
Roland Pfau
Henning Priepke
Dirk Stenkamp
Robert Roenn
Benjamin Pelcman
Original Assignee
Boehringer Ingelheim Int
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Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR078744A1 publication Critical patent/AR078744A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

Reivindicacion 1: Compuestos, caracterizados porque tienen la formula (1): en donde Z2, Z4, Z5 y Z6 representan respectivamente -C(Rz2)=, -C(Rz4)=, -C(Rz5)=, -C(Rz6)=; o Z2 y Z4 representan respectivamente -C(Rz2)= y -C(Rz4)=, y uno cualquiera o los dos de Z5 o Z6 representan -N=; Q3, Q4 y Q6 representa respectivamente -C(R3)=, -C(R4)= y -C(R6)=; R1 representa hidrogeno o alquilo C1-3 que está opcionalmente sustituido con uno o más átomos de fluor; R2 representa halo, CN, -N(Ry1)Ry2, -ORy10; alquilo C1-7, alquenilo C2-7, alquinilo C2-7, cicloalquil C3-8-alquil C0-2-, heterocicloalquil C3-8-alquil C0-2- [cuyos cinco ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de Ralquilo]; R3, R4 R6; representan independientemente hidrogeno, halo, -CN, -N(Ry1)Ry2, -ORy10; alquilo C1-7, alquenilo C2-7, alquinilo C2-7, cicloalquil C3-8-alquil C0-2-, heterocicloalquil C3-8-alquil C0-2- [cuyos cinco ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de Ralquilo]; o cualquier par adyacente de R2, R3 y R4 (esto es, R2 y R3 o R3 y R4) pueden estar unidos entre sí para formar, junto con los átomos de carbono esenciales del anillo que contiene Q3 al que están necesariamente unidos, un anillo adicional de 5 a 7 miembros, que contiene opcionalmente uno a tres heteroátomos, cuyo anillo puede contener una o dos insaturaciones adicionales y está opcionalmente sustituido con uno o más sustituyentes alquilo C1-3 y/o =O; cada Rz2, Rz4 y Rz5 representa independientemente hidrogeno, halo, -N(Ry1)Ry2, -ORy10, alquilo C1-7, alquenilo C2-7, alquinilo C2-7, cicloalquil C3-8-alquil C0-2-, heterocicloalquil C3-8-alquil C0-2- [cuyos cinco ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de Ralquilo); aril-alquil C0-2 o heteroaril-alquil C0-2 [cuyos dos ultimos grupos aromáticos están opcionalmente sustituidos con uno o más sustituyentes seleccionados de Rarilo]; RZ6 representa hidrogeno, halo, -N(Ry1)Ry2, -OH, -O-alquilo C1-6, -O-alquenilo C2-6, -O-alquinilo C3-6, -O-cicloalquilo C3-8, -O-heterocicloalquilo C4-8, alquilo C1-7, alquenilo C2-7, alquinilo C2-7, cicloalquilo C3-8, heterocicloalquilo C4-8 [cuyos diez ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados de fiuoro, -CN, =O, -N(Ry1)Ry2, -ORy10, -N(Ry3)-C(O)-Ry4, -N(Ry5)-S(O)2-Ry6, -C(O)ORy7, -C(O)N(Ry8)Ry9, -S(O)0-2-Ry11, -S(O)2O-Ry12, -S(O)2N(Ry13)Ry14, -C(O)Ry15, alquilo C1-7, alquenilo C2-7, alquinilo C2-7, cicloalquilo C3-6, heterocicloalquilo C4-6 (cuyos cinco ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados de Ralquilo), arilo y heteroarilo (cuyos dos ultimos grupos aromáticos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de Rarilo)]; o arilo o heteroarilo, O-arilo, O-heteroarilo, -N(Ry1)arilo, -N(Ry1)hetarilo (cuyos seis ultimos grupos aromáticos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de Rarilo); A representa heterocicloalquil C3-10-alquil C0-3, cicloalquil C3-10-alquil C0-3-, alquilo C1-12, alquenilo C3-12 o alquinilo C3-12, cuyos cinco ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados de R8; o aril-alquil C0-3- o heteroaril-alquil C0-3, cuyos dos ultimos grupos están opcionalmente sustituidos en el fragmento arilo con uno o más sustituyentes seleccionados de R9; Ra y Rb representan independientemente hidrogeno, alquilo C1-3 que está opcionalmente sustituido con uno o más átomos de fluor; o Ra y Rb junto con el átomo de carbono al que están unidos, pueden estar unidos entre sí para formar un anillo cicloalquileno de 3-6 miembros, en el que un grupo metileno puede estar oxidado hasta un grupo -C(=O)- y cuyo anillo está opcionalmente sustituido con uno o más sustituyentes alquilo C1-3 o átomos de fluor; W representa -C(=O)-, -S(=O)- o -S(=O)2-, M representa alquilo C1-9, alquenilo C2-9, alquinilo C2-9, cicloalquilo C3-10, heterocicloalquilo C3-10 y todos estos grupos están opcionalmente sustituidos con uno o más grupos seleccionados de fluoro, =O, -ORy10, -CN, -N(Ry1)Ry2, arilo, heteroarilo [cuyos dos ultimos grupos aromáticos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de Rarilo], alquilo C1-7, alquinilo C2-7, cicloalquil C3-7-alquiI C0-2, heterocicloalquil C3-7-alquil C0-2- [cuyos cuatro ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de RalquiIo]; o arilo, heteroarilo, cuyos dos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de halo, -ORy10, -CN, -N(Ry1)Ry2, arilo, heteroarilo, O-fenilo, O-bencilo [cuyos cuatro ultimos grupos aromáticos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de Rarilo], alquilo C1-7, alquinilo C2-7, cicloalquil C3-7-alquilo C0-2, heterocicloalquil C3-7-alquilo C0-2 [cuyos cuatro ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de RaIquiIo]; Ralquilo representa fluoro, -CN, =O, -N(Ry1)Ry2, -OH, -O-alquilo C1-3, alquilo C1-3 (cuyos dos ultimos grupos están opcionalmente sustituidos con uno o más átomos de fluor); Rarilo representa halo, CN, -N(Ry1)Ry2, OH, -O-alquilo C1-3, alquilo C1-3 (cuyos dos ultimos grupos están opcionalmente sustituidos con uno o más átomos de fluor); R7 representa hidrogeno o alquilo C1-3 que está opcionalmente sustituido con uno o más átomos de fluor; R8 representa fluoro, =O, -CN, -N(Ry1)Ry2, -N(Ry3)-C(O)-Ry4, -N(Ry5)-S(O)2-Ry6, -C(O)ORy7, -C(O)N(Ry8)Ry9, -ORy10, -S(O)0-2-Ry11, -S(O)2N(Ry13)Ry14 y -C(O)Ry15; alquilo C1-7, alquenilo C2-7, alquinilo C2-7, cicloalquil C3-6-alquil C0-2-, heterocicloalquil C3-6-alquil C0-2- [cuyos cinco ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados de Ralquilo]; o arilo o heteroarilo [cuyos dos ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente de halo, -CN, -ORy10, alquilo C1-7, alquenilo C2-7, alquinilo C2-7, cicloalquil C3-6-alquil C0-2, heterocicloalquil C3-6-alquil C0-2-, (cuyos cinco ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados independientemente entre fluoro y -ORy10)]; o dos sustituyentes R8 cualesquiera: cuando están unidos a átomos adyacentes del grupo no aromático o en el caso en que los sustituyentes R8 estén unidos al mismo átomo de carbono, pueden estar unidos entre sí para formar, junto con el átomo o átomos esenciales del grupo no aromático a los que estos sustituyentes R8 están necesariamente unidos, un anillo adicional de 3 a 8 miembros, que contiene opcionalmente uno o dos heteroátomos adicionales, y cuyo anillo adicional contiene opcionalmente una o dos insaturaciones y está opcionalmente sustituido con uno o más sustituyentes alquilo C1-3 y/o =O; R9 representa halo, -CN, -N(Ry1)Ry2, -N(Ry3)-C(O)-Ry4, -N(Ry5)-S(O)2-Ry6, -C(O)ORy7, -C(O)N(Ry8)Ry9, -ORy10, -S(O)0-2-Ry11, -S(O)2s-Ry12, -S(O)2N(Ry13)Ry14 y -C(O)Ry15; alquilo C1-7, alquenilo C2-7, alquinilo C2-7, cicloalquil C3-6-alquil C0-2-, heterocicloalquil C3-6-alquil C0-2- [cuyos cinco ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados de fluoro, =O, -CN, -N(Ry1)Ry2, -N(Ry3)-C(O)-Ry4, -C(O)ORy7, -C(O)N(Ry8)Ry9, -ORy10 y -C(O)Ry15]; o arilo o heteroarilo [cuyos dos ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados de halo, -CN, alquilo C1-7, alquenilo C2-7, alquinilo C2-7, cicloalquil C3-6-alquil C0-2-, heterocicloalquil C3-6-alquil C0-2- (cuyos cinco ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados entre fluoro y -ORy10), -O-alquilo C1-7, -O-alquenilo C2-7, -O-alquinilo C3-7, -O-alquil C0-2-cicloalquilo C3-6, -O-alquil C0-2-heterocicloalquilo C3-6 (cuyos cinco ultimos grupos están opcionalmente sustituidos con uno o más átomos de fluor)]; o dos sustituyentes R9 cualesquiera: cuando se unen a los átomos adyacentes del grupo arilo o hetarilo se pueden unir entre sí para formar, junto con los átomos esenciales del grupo arilo al que los sustituyentes R9 relevantes están necesariamente unidos, un anillo adicional de 5 a 8 miembros, que contiene opcionalmente uno o dos heteroátomos más, y cuyo anillo adicional contiene opcionalmente una o dos insaturaciones y está opcionalmente sustituido con uno o más sustituyentes alquilo C1-3 y/o =O; cada Ry4, Ry6, Ry11 y Ry15: representan independientemente alquilo C1-7, alquenilo C2-7, alquinilo C2-7, cicloalquilo C3-6, cuyos cuatro ultimos grupos están opcionalmente sustituidos con uno o más átomos de fluor; cada Ry1, Ry2, Ry3, Ry5, Ry7, Ry8, Ry9, Ry10, Ry12, Ry13 y Ry14: representan independientemente hidrogeno o alquilo C1-7, alquenilo C2-7, alquinilo C3-7, cicloalquilo C4-6, heterocicloalquilo C4-6, cuyos cinco ultimos grupos están opcionalmente sustituidos con uno o más sustituyentes seleccionados de fluoro, -alquilo C1-3 y -O-alquilo C1-3, cuyos dos ultimos grupos están opcionalmente sustituidos con uno o más átomos de fluor; o dos grupos cualesquiera, cuando se unen al mismo átomo de nitrogeno (esto es, Ry1 y Ry2), pueden, junto con dicho átomo de nitrogeno al que están necesariamente unidos, unirse entre sí para formar un anillo de 3 a 8 miembros, que contiene opcionalmente uno dos heteroátomos adicionales y cuyo anillo contiene opcionalmente una o dos insaturaciones y está opcionalmente sustituido con uno o más sustituyentes alquilo C1-3 y/o =O o con uno o más átomos de fluor, o una sal farmacéuticamente aceptable de los mismos.
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