PE20100154A1 - Pregn-4-en-21,17-carbolactonas sustituidas en el anillo c, asi como preparados farmaceuticos que las contienen - Google Patents
Pregn-4-en-21,17-carbolactonas sustituidas en el anillo c, asi como preparados farmaceuticos que las contienenInfo
- Publication number
- PE20100154A1 PE20100154A1 PE2009000762A PE2009000762A PE20100154A1 PE 20100154 A1 PE20100154 A1 PE 20100154A1 PE 2009000762 A PE2009000762 A PE 2009000762A PE 2009000762 A PE2009000762 A PE 2009000762A PE 20100154 A1 PE20100154 A1 PE 20100154A1
- Authority
- PE
- Peru
- Prior art keywords
- beta
- pregn
- carbolactones
- substituted
- contain
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
- C07J53/008—3 membered carbocyclic rings in position 15/16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/28—Antiandrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/34—Gestagens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE PREGN-4-EN-21,17-CARBOLACTONAS DE FORMULA (I), DONDE R6,7 ES METILENO EN POSICION ALFA O BETA; R9 ES H; R11 ES Br, Cl, F; R9 Y R11 JUNTOS FORMAN UN ENLACE. SON COMPUESTOS SELECCIONADOS 6(BETA),7(BETA);15(BETA),16(BETA)-DIMETILEN-3-OXO-17-PREGNA-4,9(11)-DIEN-21,17(BETA)-CARBOLACTONA; 11(BETA)-CLORO-6(BETA),7(BETA);15(BETA),16(BETA)-DIMETILEN-3-OXO-17-PREGN-4-EN-21,17(BETA)-CARBOLACTONA. TAMBIEN SE REFIERE A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGENTES UTLES PARA EL TRATAMIENTO DE TRASTORNOS PREMENSTRUALES TALES COMO CEFALEAS, HUMOR DEPRESIVO, RETENCION DE AGUA, MASTODINIA, ENTRE OTROS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102008026793A DE102008026793A1 (de) | 2008-06-02 | 2008-06-02 | C-Ring-substituierte Pregn-4-en-21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20100154A1 true PE20100154A1 (es) | 2010-03-20 |
Family
ID=41061273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000762A PE20100154A1 (es) | 2008-06-02 | 2009-06-02 | Pregn-4-en-21,17-carbolactonas sustituidas en el anillo c, asi como preparados farmaceuticos que las contienen |
Country Status (29)
Country | Link |
---|---|
US (1) | US20110130371A1 (es) |
EP (1) | EP2297177B1 (es) |
JP (1) | JP2012528075A (es) |
KR (1) | KR20110020240A (es) |
CN (1) | CN102046646B (es) |
AR (1) | AR071984A1 (es) |
AU (1) | AU2009254266A1 (es) |
BR (1) | BRPI0913401A2 (es) |
CA (1) | CA2726855A1 (es) |
CL (1) | CL2009001342A1 (es) |
CO (1) | CO6321132A2 (es) |
CR (1) | CR11821A (es) |
DE (1) | DE102008026793A1 (es) |
DO (1) | DOP2010000372A (es) |
EA (1) | EA017570B1 (es) |
EC (1) | ECSP10010652A (es) |
ES (1) | ES2389237T3 (es) |
HK (1) | HK1156954A1 (es) |
HN (1) | HN2010002548A (es) |
IL (1) | IL209371A0 (es) |
MA (1) | MA32321B1 (es) |
MX (1) | MX2010013233A (es) |
NZ (1) | NZ589593A (es) |
PE (1) | PE20100154A1 (es) |
SV (1) | SV2010003748A (es) |
TW (1) | TW201000106A (es) |
UY (1) | UY31859A (es) |
WO (1) | WO2009146811A1 (es) |
ZA (1) | ZA201009097B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012004248A1 (de) | 2010-07-08 | 2012-01-12 | Bayer Pharma Aktiengesellschaft | MIKROBIOLOGISCHES VERFAHREN ZUR HERSTELLUNG VON 11α-HYDROXY-DROSPIRENON |
WO2012059594A1 (en) | 2010-11-04 | 2012-05-10 | Bayer Pharma Aktiengesellschaft | Mineralcorticoid receptor antagonists for the treatment of corticoid-induced obesity |
CN102876582B (zh) * | 2011-07-15 | 2015-01-07 | 复旦大学 | 金龟子绿僵菌突变株及其在甾体化合物羟化反应中的应用 |
WO2015055789A1 (en) * | 2013-10-17 | 2015-04-23 | Bayer Pharma Aktiengesellschaft | INTRAVAGINAL USE OF 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, INTRAVAGINAL RINGS COMPRISING 18-METHYL-15ß,16ß-METHYLENE-19-NOR-20-SPIROX-4-EN-3-ONES, AND USE THEREOF IN CONTRACEPTION |
CN105779553B (zh) * | 2014-12-15 | 2020-10-27 | 天津金耀集团有限公司 | 新月弯孢霉和节杆菌联合发酵制备11β-羟基-1,4-二烯-3,20-二酮甾体化合物 |
CN105779555B (zh) * | 2014-12-15 | 2021-02-02 | 天津金耀集团有限公司 | 犁头霉和节杆菌联合发酵制备11β-羟基-1,4-二烯-3,20-二酮甾体化合物 |
CN104862323B (zh) * | 2015-06-02 | 2018-01-16 | 中国农业科学院生物技术研究所 | 修饰苯二酚类化合物的羟化酶基因 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3092628A (en) * | 1959-05-29 | 1963-06-04 | Merck & Co Inc | Aldosterone antagonists |
US3095412A (en) * | 1961-12-19 | 1963-06-25 | Searle & Co | 9alpha, 11alpha-epoxy and 11beta-chloro-9alpha-hydroxy 17alpha-(2-carboxyethyl)-17beta-hydroxyandrost-4-en-3-one gamma-lactones and delta1 and delta6 analogs |
DE1183500B (de) | 1962-10-12 | 1964-12-17 | Schering Ag | Verfahren zur Herstellung von alpha, beta-Methylenketonen der Steroidreihe |
US3539558A (en) * | 1968-08-09 | 1970-11-10 | Searle & Co | 3 - oxygenated 3 - (9alpha,11beta - dichloro-17beta- hydroxyandrosten - 17alpha-yl)propionic acid gamma-lactones and congeners |
DE2453823C2 (de) * | 1974-11-11 | 1984-08-09 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11β,17α-Dihydroxy-15α,16α-methylen-1,4-pregnadien-3,20-dion |
DE2922500A1 (de) | 1979-05-31 | 1980-12-04 | Schering Ag | 6 beta .7 beta |
FI77669C (fi) * | 1983-04-13 | 1989-04-10 | Ciba Geigy Ag | 20-spiroxaner och analoger, som innehaoller en oeppen ring e, foerfarande foer deras framstaellning samt dessa innehaollande farmaceutiska preparat. |
HUP0402466A2 (en) * | 2004-11-30 | 2006-07-28 | Richter Gedeon Vegyeszet | Industrial process for preparing 17-hydroxy-6-betha, 7-betha, 15-betha, 16-betha-bis-methylene-3-oxo-17-alpha-pregn-4-ene-21-carboxylic acid gamma lacton and the main, intermediates of the process |
DE102004063864A1 (de) | 2004-12-30 | 2006-07-13 | Schering Ag | 18-Methyl-19-nor-17-pregn-4-en21,17-carbolactone, sowie diese enthaltende pharmazeutische Präparate |
ATE403668T1 (de) * | 2005-07-21 | 2008-08-15 | Bayer Schering Pharma Ag | Verfahren zur herstellung von 3-oxo-pregn-4-en-21,17-carbolactonen durch die metallfreie oxidation von 17-(3-hydroxypropyl)-3,17- dihydroxyandrostanen |
WO2007025780A2 (en) * | 2005-09-02 | 2007-03-08 | Recordati Ireland Limited | Aldosterone receptor antagonists |
DE102006030416A1 (de) | 2006-06-29 | 2008-01-03 | Bayer Schering Pharma Ag | 18-Methyl-19-nor-androst-4-en-17,17-spiroether (18-Methyl-19-nor-20-spirox-4-en-3-one) sowie diese enthaltende pharmazeutische Präparate |
ITMI20061802A1 (it) * | 2006-09-22 | 2008-03-23 | Antibioticos Spa | Epossidazione di 17-oxo-15,16-metilen steroidi con ilidi di solfossonio |
-
2008
- 2008-06-02 DE DE102008026793A patent/DE102008026793A1/de not_active Withdrawn
-
2009
- 2009-05-26 KR KR1020107026986A patent/KR20110020240A/ko not_active Application Discontinuation
- 2009-05-26 WO PCT/EP2009/003716 patent/WO2009146811A1/de active Application Filing
- 2009-05-26 CN CN2009801206066A patent/CN102046646B/zh not_active Expired - Fee Related
- 2009-05-26 BR BRPI0913401A patent/BRPI0913401A2/pt not_active IP Right Cessation
- 2009-05-26 MX MX2010013233A patent/MX2010013233A/es active IP Right Grant
- 2009-05-26 ES ES09757194T patent/ES2389237T3/es active Active
- 2009-05-26 JP JP2011512002A patent/JP2012528075A/ja active Pending
- 2009-05-26 US US12/995,475 patent/US20110130371A1/en not_active Abandoned
- 2009-05-26 NZ NZ589593A patent/NZ589593A/en not_active IP Right Cessation
- 2009-05-26 AU AU2009254266A patent/AU2009254266A1/en not_active Abandoned
- 2009-05-26 CA CA2726855A patent/CA2726855A1/en not_active Abandoned
- 2009-05-26 EP EP09757194A patent/EP2297177B1/de active Active
- 2009-05-26 EA EA201001861A patent/EA017570B1/ru not_active IP Right Cessation
- 2009-06-02 PE PE2009000762A patent/PE20100154A1/es not_active Application Discontinuation
- 2009-06-02 AR ARP090101974A patent/AR071984A1/es unknown
- 2009-06-02 CL CL2009001342A patent/CL2009001342A1/es unknown
- 2009-06-02 TW TW098118251A patent/TW201000106A/zh unknown
- 2009-06-02 UY UY0001031859A patent/UY31859A/es not_active Application Discontinuation
-
2010
- 2010-11-17 IL IL209371A patent/IL209371A0/en unknown
- 2010-11-30 MA MA33376A patent/MA32321B1/fr unknown
- 2010-12-02 CO CO10152259A patent/CO6321132A2/es active IP Right Grant
- 2010-12-02 DO DO2010000372A patent/DOP2010000372A/es unknown
- 2010-12-02 HN HN2010002548A patent/HN2010002548A/es unknown
- 2010-12-02 EC EC2010010652A patent/ECSP10010652A/es unknown
- 2010-12-02 SV SV2010003748A patent/SV2010003748A/es unknown
- 2010-12-03 CR CR11821A patent/CR11821A/es not_active Application Discontinuation
- 2010-12-17 ZA ZA2010/09097A patent/ZA201009097B/en unknown
-
2011
- 2011-10-24 HK HK11111415.1A patent/HK1156954A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1156954A1 (es) | 2012-06-22 |
AR071984A1 (es) | 2010-07-28 |
CL2009001342A1 (es) | 2010-05-28 |
HN2010002548A (es) | 2012-08-27 |
MA32321B1 (fr) | 2011-05-02 |
CA2726855A1 (en) | 2009-12-10 |
CR11821A (es) | 2011-02-04 |
US20110130371A1 (en) | 2011-06-02 |
CN102046646B (zh) | 2013-03-27 |
EA017570B1 (ru) | 2013-01-30 |
TW201000106A (en) | 2010-01-01 |
SV2010003748A (es) | 2011-04-06 |
CN102046646A (zh) | 2011-05-04 |
EP2297177A1 (de) | 2011-03-23 |
CO6321132A2 (es) | 2011-09-20 |
AU2009254266A1 (en) | 2009-12-10 |
UY31859A (es) | 2010-01-05 |
MX2010013233A (es) | 2010-12-21 |
DE102008026793A1 (de) | 2009-12-03 |
JP2012528075A (ja) | 2012-11-12 |
WO2009146811A1 (de) | 2009-12-10 |
IL209371A0 (en) | 2011-01-31 |
BRPI0913401A2 (pt) | 2015-11-24 |
KR20110020240A (ko) | 2011-03-02 |
ECSP10010652A (es) | 2011-01-31 |
EA201001861A1 (ru) | 2011-08-30 |
ZA201009097B (en) | 2012-05-01 |
NZ589593A (en) | 2012-04-27 |
ES2389237T3 (es) | 2012-10-24 |
EP2297177B1 (de) | 2012-06-20 |
DOP2010000372A (es) | 2010-12-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration | ||
FD | Application declared void or lapsed |