AR078351A1 - Inhibidores de la hsl para el tratamiento de la diabetes - Google Patents
Inhibidores de la hsl para el tratamiento de la diabetesInfo
- Publication number
- AR078351A1 AR078351A1 ARP100103302A ARP100103302A AR078351A1 AR 078351 A1 AR078351 A1 AR 078351A1 AR P100103302 A ARP100103302 A AR P100103302A AR P100103302 A ARP100103302 A AR P100103302A AR 078351 A1 AR078351 A1 AR 078351A1
- Authority
- AR
- Argentina
- Prior art keywords
- piperidine
- phenyl
- methoxy
- benzenesulfonyl
- carboxylic acid
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- -1 dimethylpropyl Chemical group 0.000 abstract 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
- 239000002253 acid Substances 0.000 abstract 6
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000005085 alkoxycarbonylalkoxy group Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- 239000000460 chlorine Substances 0.000 abstract 2
- XCSWWTGQHOOLAE-UHFFFAOYSA-N 1-(4-methoxyphenyl)sulfonylpiperidine-4-carboxylic acid Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1CCC(C(O)=O)CC1 XCSWWTGQHOOLAE-UHFFFAOYSA-N 0.000 abstract 1
- OITAPMITMVNZID-UHFFFAOYSA-N 1-(4-methylphenyl)sulfonyl-n-[4-(trifluoromethoxy)phenyl]piperidine-4-carboxamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1CCC(C(=O)NC=2C=CC(OC(F)(F)F)=CC=2)CC1 OITAPMITMVNZID-UHFFFAOYSA-N 0.000 abstract 1
- RXAREPVTLZJDST-UHFFFAOYSA-N 1-(benzenesulfonyl)-n-(4-propan-2-ylphenyl)piperidine-4-carboxamide Chemical compound C1=CC(C(C)C)=CC=C1NC(=O)C1CCN(S(=O)(=O)C=2C=CC=CC=2)CC1 RXAREPVTLZJDST-UHFFFAOYSA-N 0.000 abstract 1
- ROBBWMKVNMSDPF-UHFFFAOYSA-N 1-(benzenesulfonyl)piperidine-4-carboxylic acid Chemical compound C1CC(C(=O)O)CCN1S(=O)(=O)C1=CC=CC=C1 ROBBWMKVNMSDPF-UHFFFAOYSA-N 0.000 abstract 1
- AQMPGQRWKICRSA-UHFFFAOYSA-N 1-benzoyl-n-(4-propan-2-ylphenyl)piperidine-4-carboxamide Chemical compound C1=CC(C(C)C)=CC=C1NC(=O)C1CCN(C(=O)C=2C=CC=CC=2)CC1 AQMPGQRWKICRSA-UHFFFAOYSA-N 0.000 abstract 1
- 125000003541 2-chlorobenzoyl group Chemical group ClC1=C(C(=O)*)C=CC=C1 0.000 abstract 1
- 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 abstract 1
- 125000000590 4-methylphenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 abstract 1
- PHAUGUKWOKDXFM-UHFFFAOYSA-N O=C(C(CC1)CCN1S(C1=CC=CC=C1)(=O)=O)NCC1(CCCC1)C1=CC=CC=C1 Chemical compound O=C(C(CC1)CCN1S(C1=CC=CC=C1)(=O)=O)NCC1(CCCC1)C1=CC=CC=C1 PHAUGUKWOKDXFM-UHFFFAOYSA-N 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000005111 carboxyalkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 abstract 1
- 125000004994 halo alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000003253 isopropoxy group Chemical group [H]C([H])([H])C([H])(O*)C([H])([H])[H] 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- YZMXSQBZSOSZBV-UHFFFAOYSA-N n-[2-[4-(difluoromethoxy)phenyl]ethyl]-1-(4-methylphenyl)sulfonylpiperidine-4-carboxamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1CCC(C(=O)NCCC=2C=CC(OC(F)F)=CC=2)CC1 YZMXSQBZSOSZBV-UHFFFAOYSA-N 0.000 abstract 1
- LRTFPLFDLJYEKT-UHFFFAOYSA-N para-isopropylaniline Chemical compound CC(C)C1=CC=C(N)C=C1 LRTFPLFDLJYEKT-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09170071 | 2009-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR078351A1 true AR078351A1 (es) | 2011-11-02 |
Family
ID=42983383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100103302A AR078351A1 (es) | 2009-09-11 | 2010-09-09 | Inhibidores de la hsl para el tratamiento de la diabetes |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8258158B2 (enExample) |
| EP (1) | EP2475644B1 (enExample) |
| JP (1) | JP5642793B2 (enExample) |
| KR (1) | KR101369551B1 (enExample) |
| CN (1) | CN102498099B (enExample) |
| AR (1) | AR078351A1 (enExample) |
| AU (1) | AU2010294326A1 (enExample) |
| BR (1) | BR112012005140A2 (enExample) |
| CA (1) | CA2771452A1 (enExample) |
| ES (1) | ES2445166T3 (enExample) |
| IL (1) | IL217966A0 (enExample) |
| IN (1) | IN2012DN01232A (enExample) |
| MX (1) | MX2012002597A (enExample) |
| SG (1) | SG179031A1 (enExample) |
| TW (1) | TW201114744A (enExample) |
| WO (1) | WO2011029808A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2600739C2 (ru) | 2011-03-18 | 2016-10-27 | Байер Интеллектчуал Проперти Гмбх | N-(3-карбамоилфенил)-1н-пиразол-5-карбоксамидные производные и их применение для борьбы с животными-вредителями |
| EP2892888B1 (en) | 2012-09-10 | 2018-04-18 | Boehringer Ingelheim International GmbH | N-cyclopropyl-n-piperidinyl-amides, pharmaceutical compositions containing them, and uses thereof |
| CN110325527B (zh) * | 2016-12-09 | 2022-08-09 | 勃林格殷格翰国际有限公司 | 作为细胞外柠檬酸盐摄取的抑制剂的磺酰胺 |
| GB2560713A (en) * | 2017-03-20 | 2018-09-26 | Eternygen Gmbh | Inhibitor of citrate transporter |
| CN110003176B (zh) * | 2019-05-28 | 2021-12-21 | 沈阳药科大学 | 含有酰胺的苯并咪唑类化合物及其应用 |
| CN110003177B (zh) * | 2019-05-28 | 2021-11-19 | 沈阳药科大学 | 含有脲基的苯并咪唑类化合物及应用 |
| GB201918410D0 (en) | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of alpha1-antitrypsin deficiency |
| WO2022130352A1 (en) * | 2020-12-19 | 2022-06-23 | Cadila Healthcare Limited | Novel compounds suitable for the treatment of dyslipidemia |
| GB202108523D0 (en) | 2021-06-15 | 2021-07-28 | Z Factor Ltd | Compositions and their use for the treatment of alpha1-antitrypsin deficiency |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3779339B2 (ja) | 1994-03-04 | 2006-05-24 | 三井化学株式会社 | 含フッ素カルボン酸エステル化合物、液晶材料、液晶組成物および液晶素子 |
| WO1999065867A1 (en) * | 1998-06-17 | 1999-12-23 | Du Pont Pharmaceuticals Company | Cyclic hydroxamic acids as metalloproteinase inhibitors |
| AR037352A1 (es) | 2001-11-14 | 2004-11-03 | Schering Corp | Compuestos ligandos de los receptores de los cannabinoides, una composicion farmaceutica , y el uso de dichos compuestos para la manufactura de medicamentos |
| EP1866285A1 (en) * | 2005-03-03 | 2007-12-19 | F. Hoffmann-Roche AG | 1-sulfonyl-piperdine-3-carboxylic acid amide derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase for the treatment of type ii diabetes mellitus |
| US8003662B2 (en) * | 2006-01-30 | 2011-08-23 | Array Biopharma, Inc. | Heterobicyclic thiophene compounds and methods of use |
| WO2007144394A2 (en) * | 2006-06-16 | 2007-12-21 | High Point Pharmaceuticals, Llc. | Pharmaceutical use of substituted piperidine carboxamides |
| EP1958631A1 (en) | 2007-02-14 | 2008-08-20 | AEterna Zentaris GmbH | Novel triazole derivatives as ligands of G-protein coupled receptors |
| US8324250B2 (en) * | 2009-03-19 | 2012-12-04 | Hoffmann-La Roche Inc. | Piperidine derivatives as NK3 receptor antagonists |
| US8329904B2 (en) * | 2009-05-12 | 2012-12-11 | Hoffmann-La Roche Inc. | Azacyclic derivatives |
| US8399676B2 (en) * | 2009-07-30 | 2013-03-19 | Hoffman-La Roche Inc. | Piperidine derivatives |
-
2010
- 2010-09-03 US US12/875,446 patent/US8258158B2/en not_active Expired - Fee Related
- 2010-09-07 KR KR1020127009254A patent/KR101369551B1/ko not_active Expired - Fee Related
- 2010-09-07 WO PCT/EP2010/063078 patent/WO2011029808A1/en not_active Ceased
- 2010-09-07 SG SG2012016085A patent/SG179031A1/en unknown
- 2010-09-07 IN IN1232DEN2012 patent/IN2012DN01232A/en unknown
- 2010-09-07 AU AU2010294326A patent/AU2010294326A1/en not_active Abandoned
- 2010-09-07 CA CA2771452A patent/CA2771452A1/en not_active Abandoned
- 2010-09-07 JP JP2012528339A patent/JP5642793B2/ja not_active Expired - Fee Related
- 2010-09-07 EP EP10751931.6A patent/EP2475644B1/en not_active Not-in-force
- 2010-09-07 CN CN201080039803.8A patent/CN102498099B/zh not_active Expired - Fee Related
- 2010-09-07 ES ES10751931.6T patent/ES2445166T3/es active Active
- 2010-09-07 MX MX2012002597A patent/MX2012002597A/es active IP Right Grant
- 2010-09-07 BR BR112012005140A patent/BR112012005140A2/pt not_active Application Discontinuation
- 2010-09-08 TW TW099130350A patent/TW201114744A/zh unknown
- 2010-09-09 AR ARP100103302A patent/AR078351A1/es unknown
-
2012
- 2012-02-06 IL IL217966A patent/IL217966A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8258158B2 (en) | 2012-09-04 |
| BR112012005140A2 (pt) | 2016-05-03 |
| EP2475644B1 (en) | 2014-01-08 |
| IN2012DN01232A (enExample) | 2015-05-15 |
| WO2011029808A1 (en) | 2011-03-17 |
| US20110065707A1 (en) | 2011-03-17 |
| EP2475644A1 (en) | 2012-07-18 |
| ES2445166T3 (es) | 2014-02-28 |
| IL217966A0 (en) | 2012-03-29 |
| TW201114744A (en) | 2011-05-01 |
| CN102498099A (zh) | 2012-06-13 |
| CN102498099B (zh) | 2014-10-29 |
| HK1169993A1 (en) | 2013-02-15 |
| KR20120059617A (ko) | 2012-06-08 |
| JP5642793B2 (ja) | 2014-12-17 |
| KR101369551B1 (ko) | 2014-03-04 |
| JP2013504533A (ja) | 2013-02-07 |
| MX2012002597A (es) | 2012-04-02 |
| SG179031A1 (en) | 2012-04-27 |
| CA2771452A1 (en) | 2011-03-17 |
| AU2010294326A1 (en) | 2012-03-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |