AR078137A1 - Metodo para la preparacion de neramexane - Google Patents
Metodo para la preparacion de neramexaneInfo
- Publication number
- AR078137A1 AR078137A1 ARP100102318A ARP100102318A AR078137A1 AR 078137 A1 AR078137 A1 AR 078137A1 AR P100102318 A ARP100102318 A AR P100102318A AR P100102318 A ARP100102318 A AR P100102318A AR 078137 A1 AR078137 A1 AR 078137A1
- Authority
- AR
- Argentina
- Prior art keywords
- pentamethylcyclohexane
- convert
- preparation
- tetramethylcyclohexanone
- chloroacetamido
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
- C07C211/35—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
- C07C209/62—Preparation of compounds containing amino groups bound to a carbon skeleton by cleaving carbon-to-nitrogen, sulfur-to-nitrogen, or phosphorus-to-nitrogen bonds, e.g. hydrolysis of amides, N-dealkylation of amines or quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
El método para la preparacion de 1-amino-1,3,3,5,5-pentametilciclohexano o una sal farmacéuticamente aceptable del mismo, que comprende al menos dos etapas seleccionadas de las siguientes etapas (i) a (iv): (i) convertir la isoforona a 3,3,5,5-tetrametilciclohexanona en presencia de cloruro de metilmagnesio; (ii) convertir 3,3,5,5-tetrametilciclohexanona a 1-hidroxi-1,3,3,5,5-pentametilciclohexano en presencia de cloruro de metilmagnesio; (iii) convertir 1-hidroxi-1,3,3,5,5-pentametilciclohexano a 1-cloroacetamido-1,3,3,5,5-pentametilciclohexano en presencia de cloroacetonitrilo en solucion ácida; (iv) convertir 1-cloroacetamido-1,3,3,5,5-pentametilciclohexano a 1-amino-1,3,3,5,5-pentametilciclohexano en presencia de tiourea en agua.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26977309P | 2009-06-29 | 2009-06-29 | |
EP09008461 | 2009-06-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR078137A1 true AR078137A1 (es) | 2011-10-19 |
Family
ID=41165435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100102318A AR078137A1 (es) | 2009-06-29 | 2010-06-29 | Metodo para la preparacion de neramexane |
Country Status (9)
Country | Link |
---|---|
US (1) | US20120116125A1 (es) |
EP (1) | EP2448908B1 (es) |
JP (1) | JP5749260B2 (es) |
AR (1) | AR078137A1 (es) |
BR (1) | BRPI1012674A2 (es) |
CA (1) | CA2765609A1 (es) |
ES (1) | ES2446365T3 (es) |
TW (1) | TW201107272A (es) |
WO (1) | WO2011000539A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5738854B2 (ja) * | 2009-06-29 | 2015-06-24 | メルツ・ファルマ・ゲーエムベーハー・ウント・コ・カーゲーアーアー | ネラメキサンの製造方法 |
CA2765610A1 (en) * | 2009-06-29 | 2011-01-06 | Merz Pharma Gmbh & Co. Kgaa | Method of preparing 3,3,5,5-tetramethylcyclohexanone |
JP5749259B2 (ja) | 2009-06-29 | 2015-07-15 | メルツ・ファルマ・ゲーエムベーハー・ウント・コ・カーゲーアーアー | 1−クロロアセトアミド−1,3,3,5,5−ペンタメチルシクロヘキサンを調製する方法 |
WO2014195004A1 (en) * | 2013-06-03 | 2014-12-11 | Merz Pharma Gmbh & Co. Kgaa | Neramexane salts |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4084009A (en) * | 1977-03-03 | 1978-04-11 | International Flavors & Fragrances Inc. | Flavoring with a hydroxy cyclohexenone derivative |
JP4260241B2 (ja) * | 1998-04-21 | 2009-04-30 | 第一三共株式会社 | イミダゾール誘導体の製造法 |
CA2568445C (en) * | 2004-06-17 | 2011-05-24 | Merz Pharma Gmbh & Co. Kgaa | Immediate release formulations of memantine oral dosage forms |
UA89964C2 (ru) * | 2004-09-08 | 2010-03-25 | Н.В. Органон | 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ |
FR2888849B1 (fr) * | 2005-07-19 | 2007-10-05 | Pierre Fabre Medicament Sa | Procede de preparation de la 4b-amino-4'-demethyl-4-desoxypodophyllotoxine |
US20070141148A1 (en) * | 2005-11-30 | 2007-06-21 | Merz Pharma Gmbh & Co. Kgaa | Neramexane MR matrix tablet |
EP1820792B1 (en) * | 2006-02-21 | 2012-01-18 | Hexal AG | Process for the preparation of adamantanamines |
JP2007308463A (ja) * | 2006-05-22 | 2007-11-29 | Mitsubishi Chemicals Corp | 2−メチル−2−アダマンチル(メタ)アクリレートの製造方法 |
JP2007308457A (ja) * | 2006-05-22 | 2007-11-29 | Mitsubishi Chemicals Corp | 2−メチル−2−アダマンタノールおよびそのマグネシウムクロリド塩の製造方法 |
JP2007308460A (ja) * | 2006-05-22 | 2007-11-29 | Mitsubishi Chemicals Corp | 2−メチル−2−アダマンタノールおよびそのマグネシウムクロリド塩の製造方法 |
JP2009131987A (ja) * | 2007-11-29 | 2009-06-18 | Jfe Galvanizing & Coating Co Ltd | プレコート鋼板 |
JP5738854B2 (ja) * | 2009-06-29 | 2015-06-24 | メルツ・ファルマ・ゲーエムベーハー・ウント・コ・カーゲーアーアー | ネラメキサンの製造方法 |
CA2765610A1 (en) * | 2009-06-29 | 2011-01-06 | Merz Pharma Gmbh & Co. Kgaa | Method of preparing 3,3,5,5-tetramethylcyclohexanone |
-
2010
- 2010-06-28 US US13/379,435 patent/US20120116125A1/en not_active Abandoned
- 2010-06-28 BR BRPI1012674A patent/BRPI1012674A2/pt not_active IP Right Cessation
- 2010-06-28 JP JP2012516586A patent/JP5749260B2/ja not_active Expired - Fee Related
- 2010-06-28 CA CA2765609A patent/CA2765609A1/en not_active Abandoned
- 2010-06-28 EP EP10734673.6A patent/EP2448908B1/en active Active
- 2010-06-28 ES ES10734673.6T patent/ES2446365T3/es active Active
- 2010-06-28 WO PCT/EP2010/003922 patent/WO2011000539A1/en active Application Filing
- 2010-06-29 AR ARP100102318A patent/AR078137A1/es unknown
- 2010-06-29 TW TW099121161A patent/TW201107272A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
JP2012531388A (ja) | 2012-12-10 |
CA2765609A1 (en) | 2011-01-06 |
ES2446365T3 (es) | 2014-03-07 |
WO2011000539A1 (en) | 2011-01-06 |
BRPI1012674A2 (pt) | 2016-04-05 |
EP2448908A1 (en) | 2012-05-09 |
EP2448908B1 (en) | 2013-09-18 |
JP5749260B2 (ja) | 2015-07-15 |
TW201107272A (en) | 2011-03-01 |
US20120116125A1 (en) | 2012-05-10 |
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Legal Events
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