AR077433A1 - 4, 5-dihidro-1h-benzo[g]indazol como activador de fshr - Google Patents

4, 5-dihidro-1h-benzo[g]indazol como activador de fshr

Info

Publication number
AR077433A1
AR077433A1 ARP100102744A ARP100102744A AR077433A1 AR 077433 A1 AR077433 A1 AR 077433A1 AR P100102744 A ARP100102744 A AR P100102744A AR P100102744 A ARP100102744 A AR P100102744A AR 077433 A1 AR077433 A1 AR 077433A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
heteroaryl
4alkyl
alkoxy
Prior art date
Application number
ARP100102744A
Other languages
English (en)
Inventor
Cornelis Marius Timmers
Hubert Jan Jozef Loozen
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Publication of AR077433A1 publication Critical patent/AR077433A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pregnancy & Childbirth (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Los compuestos pueden ser usados para el tratamiento de la infertilidad. Reivindicacion 1: Un compuesto de dihidrobenzoindazol de acuerdo con la formula (1) o una sal farmacéuticamente aceptable de él, caracterizado porque R1 es fenilo, opcionalmente sustituido por halogeno, nitro, alquilo C1-6, alquenilo C2-6, alcoxi C1-6, heteroarilo C2-5, cicloalquilo C3-6; o R1 es heteroarilo C2-5, opcionalmente fundido con un grupo benzo y opcionalmente sustituido en el grupo heteroarilo o benzo por halogeno o alquilo C1-4; o R1 es heterocicloalquilo C2-5 o heterocicloalquenilo C2-5, ambos opcionalmente sustituidos por uno o más fluoros, grupos alquilo C1-2 o grupos alcoxi C1-3; R2 es alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alcoxi C1-6 o alquilsulfonamino C1-4, todos los grupos alquilo opcionalmente sustituidos por uno o más hidroxilo o fluoros; o R2 es heteroarilo C2-5, R5-carbonilamino o R5-aminocarbonilo; R3 alcoxi C1-6 o hidroxilo; R4 es (di)[alquil C1-6]amino; o R4 es pirrolidin-1-ilo, opcionalmente sustituido por uno o más grupos alquilo; o R4 es diazacicloheptilo, opcionalmente sustituido por alquilcarbonilo C1-6 o cicloalquilcarbonilo C3-6; o R4 es como en formulas (2) o (3); R5 es heteroarilo C2-5 o alquilo C1-6 ambos opcionalmente sustituidos por uno o más grupos hidroxilo o halogenos; o R5 es heterocicloalquil C2-5-alquilo C1-4, el grupo heterocicloalquilo opcionalmente sustituido por alquilo C1-4 o (di)[alquil C1-4]amino-alquilo C1-4; y R6 es alquilo C1-6.
ARP100102744A 2009-07-31 2010-07-29 4, 5-dihidro-1h-benzo[g]indazol como activador de fshr AR077433A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09166930 2009-07-31

Publications (1)

Publication Number Publication Date
AR077433A1 true AR077433A1 (es) 2011-08-24

Family

ID=40951652

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102744A AR077433A1 (es) 2009-07-31 2010-07-29 4, 5-dihidro-1h-benzo[g]indazol como activador de fshr

Country Status (8)

Country Link
EP (1) EP2459551B1 (es)
JP (1) JP5698744B2 (es)
AR (1) AR077433A1 (es)
AU (1) AU2010277601B2 (es)
CA (1) CA2768904A1 (es)
ES (1) ES2497165T3 (es)
TW (1) TW201116515A (es)
WO (1) WO2011012674A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102318498B1 (ko) * 2013-06-24 2021-10-27 메르크 파텐트 게엠베하 Fshr의 조절인자로서의 피라졸 화합물 및 이의 용도
WO2024077006A1 (en) * 2022-10-05 2024-04-11 Radionetics Oncology, Inc. Follicle-stimulating hormone receptor (fshr) targeted therapeutics and uses thereof

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1382773A (en) 1972-04-07 1975-02-05 Searle & Co Esters and amides of 4,5-dihydrobenz-g-indazole-3-carboxylic acids and related compounds
US3940418A (en) 1972-04-07 1976-02-24 G. D. Searle & Co. Esters and amides of 4,5-dihydrobenz[g]indazole-3-carboxylic acids and related compounds
PT1102763E (pt) 1998-08-07 2005-01-31 Applied Research Systems Mimeticos fsh para o tratamento da infertilidade
FR2800375B1 (fr) 1999-11-03 2004-07-23 Sanofi Synthelabo Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant
AU2001278006A1 (en) 2000-07-27 2002-02-13 Smithkline Beecham Corporation Agonists of follicle stimulating hormone activity
CN1261099C (zh) 2001-07-02 2006-06-28 阿克佐诺贝尔公司 四氢喹啉衍生物
AR037090A1 (es) 2001-09-19 2004-10-20 Pharmacia Corp Compuestos pirazolilo sustituidos para el tratamiento de inflamaciones
JP4713152B2 (ja) 2002-09-20 2011-06-29 メルク セローノ ソシエテ アノニム ピペラジン誘導体及び使用方法
US20080004263A1 (en) 2004-03-04 2008-01-03 Santora Vincent J Ligands of Follicle Stimulating Hormone Receptor and Methods of Use Thereof
UA92007C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодности
PL1879866T3 (pl) 2005-05-04 2011-07-29 N V Organon Pochodne dihydropirydynowe
UA92009C2 (ru) 2005-05-04 2010-09-27 Н.В. Органон Производные 4-фенил-5-оксо-1,4,5,6,7,8-гексагидрохинолина для лечения бесплодия
UA92008C2 (en) 2005-05-04 2010-09-27 Н.В. Органон 4-PHENYL-5-OXO-l,4,5,6,7,8-HEXAHYDROQUINOLINE DERIVATIVES AS MEDICAMENTS FOR THE TREATMENT OF INFERTILITY
JP2009506127A (ja) 2005-08-31 2009-02-12 バイエル・ヘルスケア・エルエルシー 糖尿病の処置に有用なアニリノピラゾール誘導体

Also Published As

Publication number Publication date
JP2013500948A (ja) 2013-01-10
EP2459551A1 (en) 2012-06-06
EP2459551B1 (en) 2014-07-02
AU2010277601B2 (en) 2014-08-21
WO2011012674A1 (en) 2011-02-03
CA2768904A1 (en) 2011-02-03
ES2497165T3 (es) 2014-09-22
TW201116515A (en) 2011-05-16
AU2010277601A1 (en) 2012-01-12
JP5698744B2 (ja) 2015-04-08

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