AR077133A1 - Alcoxi-tienopirimidinas, composiciones farmaceuticas y uso de los mismos para el tratamiento de enfermedades inducidas por quinasas - Google Patents
Alcoxi-tienopirimidinas, composiciones farmaceuticas y uso de los mismos para el tratamiento de enfermedades inducidas por quinasasInfo
- Publication number
- AR077133A1 AR077133A1 ARP100102153A ARP100102153A AR077133A1 AR 077133 A1 AR077133 A1 AR 077133A1 AR P100102153 A ARP100102153 A AR P100102153A AR P100102153 A ARP100102153 A AR P100102153A AR 077133 A1 AR077133 A1 AR 077133A1
- Authority
- AR
- Argentina
- Prior art keywords
- alk
- denotes
- hal
- oalk
- mono
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Psychiatry (AREA)
- Dermatology (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los nuevos derivados de alcoxi-tienopirimidina de la formula (1) donde R1 denota un carboarilo mono- o bicíclico C6-10 o un heteroarilo mono- o bicíclico C2-9 y 1 a 4 átomos de N, O y/o S, cada uno de los cuales puede estar monosustituido con Hal, CN y/o A; R2 denota H, A, Cyc, -Alk-Cyc, Q o Het; Q denota alquilo no ramificado o ramificado C1-10, en el que al menos un átomo de H está reemplazado por al menos un sustituyente seleccionado del grupo de Hal, CN, NH2, NHA, NAA, -CO-NH2, -CO-NHA, -CO-NAA, OH, OA, -OAlk-OH, -OAlk-OA, -OAlk-NAA, -CHOH-Alk-OH, Het, -Oalk-Het, Ar, -OAlk-Ar, y/o en donde uno o dos grupos adyacentes CH2 están reemplazados, de modo independiente entre sí, por un grupo -CH=CH- y/o -C:::C-; A denota alquilo no ramificado o ramificado C1-10, en el que 1-7 átomos de H pueden estar reemplazados por Hal; Cyc denota cicloalquilo C3-7, en el que 1-4 átomos de H pueden estar reemplazados, de modo independiente entre sí, por A, Hal, OH, -Alk-OH y/u OA; Alk denota alquileno, alquenilo o alquinilo C1-6, en el que 1-4 átomos de H pueden estar reemplazados, de modo independiente entre sí, por Hal y/o CN; Het denota un heterociclo mono- o bicíclico saturado, insaturado o aromático C2-9 y 1 a 4 átomos de N, O y/o S, que puede estar mono-, di- o trisustituido con al menos un sustituyente seleccionado del grupo de Hal, A, OH, OA, -Alk-OH, -Alk-OA, -Alk-Het1, -Alk-NAA, SO2A, =O (oxígeno del carbonilo); Ar denota un carbociclo mono- o bicíclico saturado, insaturado o aromático C6-10, que puede estar mono-, di- o trisustituido con al menos un sustituyente seleccionado del grupo de Hal, A, OH, CA, -Alk-OH, -Alk-OA, -Alk-Het1, -Alk-NAA, -OAlk-Het1, SO2NH2, SO2NHA, SO2NAA; Het1 denota un heterociclo monocíclico saturado, insaturado o aromático C2-6 y 1 a 4 átomos de N, O y/o S; y Hal denota F, CI, Br o I; y/o sus sales fisiologicamente aceptables. Son inhibidores de la quinasa del receptor TGF-beta1 y se pueden emplear, entre otras cosas, para el tratamiento de tumores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09008130 | 2009-06-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR077133A1 true AR077133A1 (es) | 2011-08-03 |
Family
ID=42314846
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102153A AR077133A1 (es) | 2009-06-22 | 2010-06-18 | Alcoxi-tienopirimidinas, composiciones farmaceuticas y uso de los mismos para el tratamiento de enfermedades inducidas por quinasas |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20120101095A1 (es) |
| EP (1) | EP2445916A1 (es) |
| JP (1) | JP2012530731A (es) |
| AR (1) | AR077133A1 (es) |
| AU (1) | AU2010265164A1 (es) |
| CA (1) | CA2766193A1 (es) |
| IL (1) | IL217031A0 (es) |
| WO (1) | WO2010149257A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2813875T3 (es) | 2014-01-01 | 2021-03-25 | Medivation Tech Llc | Compuestos y procedimientos de uso |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE273441C (es) * | ||||
| DD273441A1 (de) * | 1988-06-27 | 1989-11-15 | Univ Dresden Tech | Verfahren zur herstellung von 2-alkoxy-5-amino-4-phenyl-thieno [2,3-d] pyrimidinen |
| TW200538120A (en) * | 2004-02-20 | 2005-12-01 | Kirin Brewery | Compound having TGF-beta inhibitory activity and pharmaceutical composition containing same |
| AU2007207536A1 (en) * | 2006-01-17 | 2007-07-26 | Signal Pharmaceuticals, Llc | Inhibitors of TNFalpha, PDE4 and B-RAF, compositions thereof and methods of use therewith |
| DE102008017853A1 (de) * | 2008-04-09 | 2009-10-15 | Merck Patent Gmbh | Thienopyrimidine |
-
2010
- 2010-05-27 JP JP2012516537A patent/JP2012530731A/ja active Pending
- 2010-05-27 CA CA2766193A patent/CA2766193A1/en not_active Abandoned
- 2010-05-27 WO PCT/EP2010/003232 patent/WO2010149257A1/en active Application Filing
- 2010-05-27 US US13/379,773 patent/US20120101095A1/en not_active Abandoned
- 2010-05-27 AU AU2010265164A patent/AU2010265164A1/en not_active Abandoned
- 2010-05-27 EP EP10723928A patent/EP2445916A1/en not_active Withdrawn
- 2010-06-18 AR ARP100102153A patent/AR077133A1/es unknown
-
2011
- 2011-12-15 IL IL217031A patent/IL217031A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL217031A0 (en) | 2012-02-29 |
| AU2010265164A1 (en) | 2012-02-09 |
| US20120101095A1 (en) | 2012-04-26 |
| WO2010149257A1 (en) | 2010-12-29 |
| JP2012530731A (ja) | 2012-12-06 |
| CA2766193A1 (en) | 2010-12-29 |
| EP2445916A1 (en) | 2012-05-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |