AR076020A1 - Anticuerpos contra la proteina tweak humana y usos de los mismos - Google Patents

Anticuerpos contra la proteina tweak humana y usos de los mismos

Info

Publication number
AR076020A1
AR076020A1 ARP100101066A ARP100101066A AR076020A1 AR 076020 A1 AR076020 A1 AR 076020A1 AR P100101066 A ARP100101066 A AR P100101066A AR P100101066 A ARP100101066 A AR P100101066A AR 076020 A1 AR076020 A1 AR 076020A1
Authority
AR
Argentina
Prior art keywords
antibody
tweak protein
same
antibodies against
against human
Prior art date
Application number
ARP100101066A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR076020A1 publication Critical patent/AR076020A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Un anticuerpo que se une a la proteína TWEAK, caracterizado por una union a la proteína TWEAK que se caracteriza porque comprende como dominio variable de cadena pesada una CDR3H seleccionada de entre el grupo que consiste en las secuencias SEC ID N° 8, 16 o 24. Composicion farmacéutica que comprende dicho anticuerpo, ácido nucleico que codifica el anticuerpo, vectores que comprenden los ácidos nucleicos, células huéspedes que incluyen vectores, y método para produccion de dicho anticuerpo son objetos proporcionados en la presente. Los anticuerpos descritos son utiles para el tratamiento de pacientes que sufren cáncer, especialmente cáncer de colon, pulmon o páncreas.
ARP100101066A 2009-04-02 2010-03-31 Anticuerpos contra la proteina tweak humana y usos de los mismos AR076020A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09004905 2009-04-02

Publications (1)

Publication Number Publication Date
AR076020A1 true AR076020A1 (es) 2011-05-11

Family

ID=40673340

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100101066A AR076020A1 (es) 2009-04-02 2010-03-31 Anticuerpos contra la proteina tweak humana y usos de los mismos

Country Status (23)

Country Link
US (3) US8093006B2 (es)
EP (2) EP2414398A2 (es)
JP (1) JP5596777B2 (es)
KR (1) KR101344611B1 (es)
CN (1) CN102369219A (es)
AR (1) AR076020A1 (es)
AU (1) AU2010233997A1 (es)
BR (1) BRPI1014867A2 (es)
CA (1) CA2756245A1 (es)
CL (1) CL2011002452A1 (es)
CO (1) CO6362025A2 (es)
CR (1) CR20110462A (es)
EC (1) ECSP11011362A (es)
IL (1) IL214355A0 (es)
MA (1) MA33097B1 (es)
MX (1) MX2011010117A (es)
NZ (1) NZ594347A (es)
PE (1) PE20120577A1 (es)
RU (1) RU2011143903A (es)
SG (2) SG175005A1 (es)
TW (1) TWI423815B (es)
UA (1) UA105520C2 (es)
WO (1) WO2010115555A2 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8093006B2 (en) * 2009-04-02 2012-01-10 Hoffmann-La Roche Inc. Antibodies against human tweak and uses thereof
US9526846B2 (en) 2009-08-19 2016-12-27 Safety Syringes, Inc. Patient-contact activated needle stick safety device
WO2011097500A2 (en) 2010-02-04 2011-08-11 University Of Louisville Research Foundation, Inc. The tweak/fn14 system regulates skeletal muscle atrophy and regeneration
CA2809632A1 (en) 2010-10-05 2012-04-12 Monika Baehner Antibodies against human tweak and uses thereof
WO2012122513A2 (en) 2011-03-10 2012-09-13 Omeros Corporation Generation of anti-fn14 monoclonal antibodies by ex-vivo accelerated antibody evolution
WO2013150043A1 (en) 2012-04-05 2013-10-10 F. Hoffmann-La Roche Ag Bispecific antibodies against human tweak and human il17 and uses thereof
JP2016000003A (ja) * 2013-04-19 2016-01-07 アステラス製薬株式会社 新規抗ヒトｔｗｅａｋ抗体
CN103399151A (zh) * 2013-06-24 2013-11-20 上海交通大学医学院附属瑞金医院 Cxcl8细胞因子检测试剂在制备甲状腺乳头状癌的诊断试剂中的应用
IL282650B1 (en) * 2018-10-31 2024-05-01 Astellas Pharma Inc Anti-human FN14 antibody

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3883899T3 (de) 1987-03-18 1999-04-22 Sb2 Inc Geänderte antikörper.
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US7129061B1 (en) 1996-08-07 2006-10-31 Biogen Idec Ma Inc. Tumor necrosis factor related ligand
EP1591530B8 (en) 1996-08-07 2015-04-22 Biogen Idec MA Inc. A tumor necrosis factor related ligand
WO1998035061A2 (en) 1997-02-12 1998-08-13 Abbott Laboratories Member of the tnf family useful for treatment and diagnosis of disease
EP1724282B1 (en) 1997-05-21 2013-05-15 Merck Patent GmbH Method for the production of non-immunogenic proteins
CA2305713A1 (en) 1997-10-10 1999-04-22 Genentech, Inc. Apo-3 ligand
BR0007556A (pt) 1999-01-15 2001-10-23 Biogen Inc Antagonistas de tweak e de receptor de tweak e uso dos mesmos para tratar distúrbios imunológicos
JP2003521836A (ja) 1999-03-04 2003-07-15 ビジョン−サイエンシズ・インコーポレイテッド 個別に制御可能な電子シャッター回路を備えた画像センサユニットセル
GB9922069D0 (en) 1999-09-17 1999-11-17 Technolog Ltd Water distribution pressure control method and apparatus
AU1226301A (en) 1999-10-22 2001-05-08 University Of Pittsburgh Stem cell engraftment-enhancing cellular proteins and their uses
WO2001030429A1 (en) 1999-10-22 2001-05-03 Scimed Life Systems, Inc. Guided injection device
WO2001045730A2 (en) 1999-12-20 2001-06-28 Immunex Corporation Tweak receptor
EP1363657A2 (en) 2000-05-08 2003-11-26 Biogen, Inc. Method for promoting neovascularization using a tweak agonist and an angiogenic factor
US7208151B2 (en) 2001-09-12 2007-04-24 Biogen Idec Ma Inc. Tweak receptor agonists as anti-angiogenic agents
WO2003086311A2 (en) 2002-04-09 2003-10-23 Biogen, Inc. Methods for treating tweak-related conditions
CA2587018A1 (en) 2004-11-08 2006-05-18 University Of Maryland, Baltimore Tweak as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death
US7939490B2 (en) 2004-12-13 2011-05-10 University Of Maryland, Baltimore TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death
WO2006088890A2 (en) 2005-02-17 2006-08-24 Biogen Idec Ma Inc. Treating stroke
DK2529619T3 (en) 2005-02-17 2016-01-11 Biogen Ma Inc Treatment of neurological disorders
CN102225200A (zh) 2005-03-07 2011-10-26 健泰科生物技术公司 用于调控tweak和fn14活性的方法和组合物
EP1885388B1 (en) 2005-05-10 2013-09-11 Biogen Idec MA Inc. Treating and evaluating inflammatory disorders
WO2006130429A2 (en) * 2005-05-27 2006-12-07 Biogen Idec Ma Inc. Treatment of cancer
DK1888113T3 (da) 2005-05-27 2014-09-01 Biogen Idec Inc Tweak-bindende antistoffer
US8093006B2 (en) * 2009-04-02 2012-01-10 Hoffmann-La Roche Inc. Antibodies against human tweak and uses thereof

Also Published As

Publication number Publication date
WO2010115555A2 (en) 2010-10-14
PE20120577A1 (es) 2012-05-23
AU2010233997A1 (en) 2011-08-18
TW201039847A (en) 2010-11-16
KR20110122868A (ko) 2011-11-11
CR20110462A (es) 2011-09-21
CL2011002452A1 (es) 2012-03-23
SG175005A1 (en) 2011-11-28
MX2011010117A (es) 2011-10-14
EP2597104A1 (en) 2013-05-29
US20100255008A1 (en) 2010-10-07
US8852887B2 (en) 2014-10-07
US20120207750A1 (en) 2012-08-16
US8883976B2 (en) 2014-11-11
CA2756245A1 (en) 2010-10-14
CN102369219A (zh) 2012-03-07
EP2414398A2 (en) 2012-02-08
UA105520C2 (uk) 2014-05-26
MA33097B1 (fr) 2012-03-01
CO6362025A2 (es) 2012-01-20
TWI423815B (zh) 2014-01-21
WO2010115555A3 (en) 2011-01-06
SG10201404107SA (en) 2014-10-30
JP2012521771A (ja) 2012-09-20
JP5596777B2 (ja) 2014-09-24
BRPI1014867A2 (pt) 2016-04-12
US8093006B2 (en) 2012-01-10
ECSP11011362A (es) 2011-10-31
IL214355A0 (en) 2011-09-27
NZ594347A (en) 2012-09-28
RU2011143903A (ru) 2013-05-10
KR101344611B1 (ko) 2013-12-30
US20120083015A1 (en) 2012-04-05

Similar Documents

Publication Publication Date Title
AR076020A1 (es) Anticuerpos contra la proteina tweak humana y usos de los mismos
EA201591131A1 (ru) Днк-конструкции антитела и способ их применения
AR106752A1 (es) Proteínas de unión a pd1 / ctla4
EA201590986A1 (ru) Антитела к ceacam5 и их применения
AR102698A1 (es) Anticuerpos contra cd73 y sus usos
AR090047A1 (es) Dominio variable dual de inmunoglobulinas y sus usos
UY31862A (es) Inmunoglobulina con dominio variable dual y usos de la misma
AR124676A2 (es) Formulación farmacéutica que comprende una droga biofarmacéutica
CY1117922T1 (el) Her2/neu-eiδika αντισωματα και μεθοδοι χρησης αυτων
AR074756A1 (es) Anticuerpos contra la angiopoyetina-2 humana
UY31861A (es) Inmunoglobulina con dominio variable dual y usos de la misma
EA201492149A8 (ru) St2-антигенсвязывающие белки
CR20110631A (es) Inmunoglobulina con dominio variable dual y usos de la misma
CY1115572T1 (el) Αντι cxcr4 αντισωματα και χρηση αυτων για τη θεραπεια καρκινου
CO6680687A2 (es) Inmunoglobinas con dominio variable dual capaces de unirse a il 1 beta e il-17, composiciones farmaceúticas y conjugados de proteína de unión de las mismas
AR088514A1 (es) Inmunoligantes biespecificos dirigidos contra tnf
CO6351751A2 (es) Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
CY1119410T1 (el) Βελτιστοποιημενα μονοκλωνικα αντισωματα εναντι του αναστολεα της οδου του ιστικου παραγοντα (tfpi)
CR20120154A (es) Inmunoglobulinas con dominio variable dual y usos de las mismas
UY33826A (es) Proteínas de unión con dominios trivariables y sus usos
AR085955A1 (es) Proteinas de union al antigeno
AR073072A1 (es) Anticuerpos humanos para el ligando del activador del receptor de nf-kb (rankl) humano
AR063829A1 (es) Moleculas de enlace de lingo y uso farmaceutico de las mismas
DOP2014000083A (es) Inmunoenlazadores dirigidos contra el tnf
AR080794A1 (es) Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2

Legal Events

Date Code Title Description
FB Suspension of granting procedure