AR075922A1 - Derivados anticancerosos, su preparacion y su aplicacion en terapeutica - Google Patents

Derivados anticancerosos, su preparacion y su aplicacion en terapeutica

Info

Publication number
AR075922A1
AR075922A1 ARP100100922A ARP100100922A AR075922A1 AR 075922 A1 AR075922 A1 AR 075922A1 AR P100100922 A ARP100100922 A AR P100100922A AR P100100922 A ARP100100922 A AR P100100922A AR 075922 A1 AR075922 A1 AR 075922A1
Authority
AR
Argentina
Prior art keywords
group
alkyl group
alkyl
hydrogen atom
represent
Prior art date
Application number
ARP100100922A
Other languages
English (en)
Inventor
Sandrine Hilairet
Samir Jegham
Claude Bernhart
Monsif Bouaboula
Jerome Arigon
Romain Combet
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR075922A1 publication Critical patent/AR075922A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente se refiere a derivados de nicotinamida que pueden ser utilizados como anticancerosos. Reivindicacion 1: Compuesto de la formula (1) en la que Z y Z' representan N o CH; W representa un grupo -alquilen C1-4-CH2CH2-; R1 representa un átomo de hidrogeno, un grupo alquilo C1-6, cicloalquilo C3-6, fenilo; R'1 representa un átomo de hidrogeno o un grupo alquilo C1-6; R2 representa un grupo cicloalquilo C3-6; un grupo alquilo C1-6, eventualmente sustituido con o uno o más grupos hidroxi o alcoxi C1-4 o un grupo NRaRb en el que Ra y Rb representan independientemente entre sí un átomo de hidrogeno o un grupo alquilo C1-6 o forman, junto con el átomo de nitrogeno al que están unidos, un grupo heterocicloalquilo C4-6, que incluye opcionalmente en el ciclo el grupo -S(O)q donde q= 0, 1 o 2 o el grupo -NH- o -N-alquilo-C1-4- y que está opcionalmente sustituido con uno o más sustituyentes, iguales o diferentes entre sí cuando hay varios, elegidos entre un grupo -OH; alcoxi C1-4 o alquilo C1-4; R3 representa al menos un sustituyente del nucleo de piridina, seleccionado entre un átomo de hidrogeno o de fluor, un grupo alquilo C1-4 o -NRcRd en el que Rc y Rd representan un átomo de hidrogeno o un grupo alquilo C1-4.
ARP100100922A 2009-03-24 2010-03-23 Derivados anticancerosos, su preparacion y su aplicacion en terapeutica AR075922A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0901367A FR2943675A1 (fr) 2009-03-24 2009-03-24 Composes anticancereux, leur preparation et leur application en therapeutique
FR0901589A FR2943671B1 (fr) 2009-03-24 2009-03-31 Composes anticancereux,leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR075922A1 true AR075922A1 (es) 2011-05-04

Family

ID=41137868

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100100922A AR075922A1 (es) 2009-03-24 2010-03-23 Derivados anticancerosos, su preparacion y su aplicacion en terapeutica

Country Status (8)

Country Link
US (1) US20120053209A1 (es)
EP (1) EP2411364A1 (es)
JP (1) JP2012521395A (es)
AR (1) AR075922A1 (es)
FR (2) FR2943675A1 (es)
TW (1) TW201038268A (es)
UY (1) UY32515A (es)
WO (1) WO2010109115A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20140011A1 (es) 2010-09-03 2014-01-31 Forma Tm Llc Compuestos y composiciones novedosos para la inhibicion de nampt
AU2011367222B2 (en) 2011-05-04 2017-04-13 Forma Tm, Llc Novel compounds and compositions for the inhibition of NAMPT

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19756261A1 (de) * 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
MY153569A (en) * 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
FR2921657A1 (fr) * 2007-09-28 2009-04-03 Sanofi Aventis Sa Derives de nicotinamide, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
TW201038268A (en) 2010-11-01
WO2010109115A1 (fr) 2010-09-30
EP2411364A1 (fr) 2012-02-01
FR2943671A1 (fr) 2010-10-01
UY32515A (es) 2010-10-29
JP2012521395A (ja) 2012-09-13
FR2943671B1 (fr) 2011-05-06
US20120053209A1 (en) 2012-03-01
WO2010109115A9 (fr) 2011-12-15
FR2943675A1 (fr) 2010-10-01

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