AR075922A1 - Derivados anticancerosos, su preparacion y su aplicacion en terapeutica - Google Patents
Derivados anticancerosos, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR075922A1 AR075922A1 ARP100100922A ARP100100922A AR075922A1 AR 075922 A1 AR075922 A1 AR 075922A1 AR P100100922 A ARP100100922 A AR P100100922A AR P100100922 A ARP100100922 A AR P100100922A AR 075922 A1 AR075922 A1 AR 075922A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl group
- alkyl
- hydrogen atom
- represent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se refiere a derivados de nicotinamida que pueden ser utilizados como anticancerosos. Reivindicacion 1: Compuesto de la formula (1) en la que Z y Z' representan N o CH; W representa un grupo -alquilen C1-4-CH2CH2-; R1 representa un átomo de hidrogeno, un grupo alquilo C1-6, cicloalquilo C3-6, fenilo; R'1 representa un átomo de hidrogeno o un grupo alquilo C1-6; R2 representa un grupo cicloalquilo C3-6; un grupo alquilo C1-6, eventualmente sustituido con o uno o más grupos hidroxi o alcoxi C1-4 o un grupo NRaRb en el que Ra y Rb representan independientemente entre sí un átomo de hidrogeno o un grupo alquilo C1-6 o forman, junto con el átomo de nitrogeno al que están unidos, un grupo heterocicloalquilo C4-6, que incluye opcionalmente en el ciclo el grupo -S(O)q donde q= 0, 1 o 2 o el grupo -NH- o -N-alquilo-C1-4- y que está opcionalmente sustituido con uno o más sustituyentes, iguales o diferentes entre sí cuando hay varios, elegidos entre un grupo -OH; alcoxi C1-4 o alquilo C1-4; R3 representa al menos un sustituyente del nucleo de piridina, seleccionado entre un átomo de hidrogeno o de fluor, un grupo alquilo C1-4 o -NRcRd en el que Rc y Rd representan un átomo de hidrogeno o un grupo alquilo C1-4.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0901367A FR2943675A1 (fr) | 2009-03-24 | 2009-03-24 | Composes anticancereux, leur preparation et leur application en therapeutique |
FR0901589A FR2943671B1 (fr) | 2009-03-24 | 2009-03-31 | Composes anticancereux,leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
AR075922A1 true AR075922A1 (es) | 2011-05-04 |
Family
ID=41137868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100100922A AR075922A1 (es) | 2009-03-24 | 2010-03-23 | Derivados anticancerosos, su preparacion y su aplicacion en terapeutica |
Country Status (8)
Country | Link |
---|---|
US (1) | US20120053209A1 (es) |
EP (1) | EP2411364A1 (es) |
JP (1) | JP2012521395A (es) |
AR (1) | AR075922A1 (es) |
FR (2) | FR2943675A1 (es) |
TW (1) | TW201038268A (es) |
UY (1) | UY32515A (es) |
WO (1) | WO2010109115A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112013004773B1 (pt) | 2010-09-03 | 2022-05-31 | Forma Tm, Llc | Compostos, seus usos, e composições para a inibição de nampt |
JP5978293B2 (ja) | 2011-05-04 | 2016-08-24 | フォーマ ティーエム, エルエルシー. | Namptを阻害するための新規な化合物および組成物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19756261A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide |
MY153569A (en) * | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
FR2921657A1 (fr) * | 2007-09-28 | 2009-04-03 | Sanofi Aventis Sa | Derives de nicotinamide, leur preparation et leur application en therapeutique |
-
2009
- 2009-03-24 FR FR0901367A patent/FR2943675A1/fr active Pending
- 2009-03-31 FR FR0901589A patent/FR2943671B1/fr not_active Expired - Fee Related
-
2010
- 2010-03-18 WO PCT/FR2010/050489 patent/WO2010109115A1/fr active Application Filing
- 2010-03-18 JP JP2012501346A patent/JP2012521395A/ja not_active Withdrawn
- 2010-03-18 US US13/258,921 patent/US20120053209A1/en not_active Abandoned
- 2010-03-18 EP EP10715954A patent/EP2411364A1/fr not_active Withdrawn
- 2010-03-23 TW TW099108542A patent/TW201038268A/zh unknown
- 2010-03-23 AR ARP100100922A patent/AR075922A1/es unknown
- 2010-03-24 UY UY0001032515A patent/UY32515A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2010109115A1 (fr) | 2010-09-30 |
EP2411364A1 (fr) | 2012-02-01 |
FR2943671A1 (fr) | 2010-10-01 |
TW201038268A (en) | 2010-11-01 |
FR2943675A1 (fr) | 2010-10-01 |
JP2012521395A (ja) | 2012-09-13 |
UY32515A (es) | 2010-10-29 |
WO2010109115A9 (fr) | 2011-12-15 |
FR2943671B1 (fr) | 2011-05-06 |
US20120053209A1 (en) | 2012-03-01 |
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