AR071548A1 - Amidas de acido 3-substituido-4-oxo-3, 4-dihidro-imidazo[5, 1-d]1, 2, 3, 5-tetracina-8-carboxilico, un metodo para su preparacion e intermediarios de su sintesis, una composicion farmaceutica que las comprende y su uso en la fabricacion de medicamentos para el tratamiento de diversos tipos de cancer - Google Patents
Amidas de acido 3-substituido-4-oxo-3, 4-dihidro-imidazo[5, 1-d]1, 2, 3, 5-tetracina-8-carboxilico, un metodo para su preparacion e intermediarios de su sintesis, una composicion farmaceutica que las comprende y su uso en la fabricacion de medicamentos para el tratamiento de diversos tipos de cancerInfo
- Publication number
- AR071548A1 AR071548A1 ARP080105534A ARP080105534A AR071548A1 AR 071548 A1 AR071548 A1 AR 071548A1 AR P080105534 A ARP080105534 A AR P080105534A AR P080105534 A ARP080105534 A AR P080105534A AR 071548 A1 AR071548 A1 AR 071548A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- compounds
- substituted
- dihydro
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 150000001408 amides Chemical class 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 11
- 125000004429 atom Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000012453 solvate Substances 0.000 abstract 3
- -1 para-methoxy-benzyl Chemical group 0.000 abstract 2
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1452007P | 2007-12-18 | 2007-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071548A1 true AR071548A1 (es) | 2010-06-30 |
Family
ID=40427129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105534A AR071548A1 (es) | 2007-12-18 | 2008-12-18 | Amidas de acido 3-substituido-4-oxo-3, 4-dihidro-imidazo[5, 1-d]1, 2, 3, 5-tetracina-8-carboxilico, un metodo para su preparacion e intermediarios de su sintesis, una composicion farmaceutica que las comprende y su uso en la fabricacion de medicamentos para el tratamiento de diversos tipos de cancer |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8450479B2 (https=) |
| EP (2) | EP2698370A3 (https=) |
| JP (1) | JP2011506588A (https=) |
| CN (1) | CN101945874A (https=) |
| AR (1) | AR071548A1 (https=) |
| AU (1) | AU2008337261A1 (https=) |
| CA (1) | CA2709749A1 (https=) |
| IL (1) | IL206453A0 (https=) |
| PE (1) | PE20091101A1 (https=) |
| TW (1) | TW200934782A (https=) |
| WO (1) | WO2009077741A2 (https=) |
| ZA (1) | ZA201004554B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20091101A1 (es) | 2007-12-18 | 2009-07-26 | Pharminox Ltd | AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO |
| CA2763766A1 (en) | 2009-06-23 | 2010-12-29 | Pharminox Limited | 3-substituted-8-substituted-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use |
| US20130012706A1 (en) * | 2010-03-01 | 2013-01-10 | Pharminox Limited | Methods and Intermediates for the Synthesis of 4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazines |
| WO2012085501A1 (en) | 2010-12-20 | 2012-06-28 | Pharminox Limited | 8 - sulfo - imidazotetrazin- 4 - one compounds and their use as anticancer drug |
| RU2545458C2 (ru) * | 2013-08-01 | 2015-03-27 | Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" | ПРОТИВОТУБЕРКУЛЕЗНОЕ ЛЕКАРСТВЕННОЕ СРЕДСТВО: КОМПОЗИЦИЯ ИМИДАЗО[1,2-b]ТЕТРАЗИНА С ПИРАЗИНАМИДОМ |
| CN108276415B (zh) * | 2018-02-08 | 2019-07-05 | 台州职业技术学院 | 一种烷氧化三唑并四嗪类化合物及其制备方法和应用 |
| EP3833342A4 (en) * | 2018-08-09 | 2022-07-13 | The Board of Trustees of the University of Illinois | IMIDAZOTETRAZINE COMPOUNDS |
| WO2020106560A1 (en) | 2018-11-20 | 2020-05-28 | Merck Sharp & Dohme Corp. | Substituted amino triazolopyrimidine and amino triazolopyrazine adenosine receptor antagonists, pharmaceutical compositions and their use |
| KR20210093964A (ko) | 2018-11-20 | 2021-07-28 | 머크 샤프 앤드 돔 코포레이션 | 치환된 아미노 트리아졸로피리미딘 및 아미노 트리아졸로피라진 아데노신 수용체 길항제, 제약 조성물 및 그의 용도 |
| TW202039496A (zh) | 2018-11-30 | 2020-11-01 | 美商默沙東藥廠 | 做為腺苷受體拮抗劑之9-經取代胺基三唑喹唑啉衍生物、醫藥組合物及其用途 |
| JP2022511778A (ja) | 2018-11-30 | 2022-02-01 | メルク・シャープ・アンド・ドーム・コーポレーション | アデノシン受容体拮抗薬としての７－、８－及び１０－置換されたアミノトリアゾロキナゾリン誘導体、医薬組成物及びそれらの使用 |
| GB201907813D0 (en) | 2019-05-31 | 2019-07-17 | Univ Nottingham | Therapeutic compounds |
| KR102571751B1 (ko) | 2020-03-24 | 2023-08-25 | 삼성에스디아이 주식회사 | 리튬 이차 전지의 전해질용 첨가제, 리튬 이차 전지용 전해질 및 이를 포함하는 리튬 이차 전지 |
| US20240294478A1 (en) * | 2021-06-18 | 2024-09-05 | Yale University | Anti-cancer compounds and methods of use |
| US20240400572A1 (en) * | 2021-09-23 | 2024-12-05 | Yale University | Compounds and methods for treating cancers that are mgmt deficient regardless of mmr status |
| WO2023150569A1 (en) * | 2022-02-01 | 2023-08-10 | The Board Of Trustees Of The University Of Illinois | Imidazotetrazine compounds and treatment of tmz-resistant cancers |
| KR20260047607A (ko) * | 2023-08-04 | 2026-04-08 | 모디파이 바이오사이언시즈, 인크. | 플루오로알콕시알킬렌-디히드로이미다조[5,1-d]테트라지논 화합물 및 관련 화합물 및 의학적 상태의 치료에서의 그의 용도 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260291A (en) * | 1981-08-24 | 1993-11-09 | Cancer Research Campaign Technology Limited | Tetrazine derivatives |
| OA07174A (fr) * | 1981-08-24 | 1984-04-30 | May & Baker Ltd | Nouvelles imidazotétrazionones, leur préparation et les médicaments qui les contiennent. |
| GB2125402B (en) | 1982-08-17 | 1985-11-13 | May & Baker Ltd | New tetrazine derivatives |
| US4504475A (en) | 1983-05-24 | 1985-03-12 | Warner Lambert Company | 3-(Haloethyl)-4-oxopyrazolo[5,1-D]-1,2,3,5-tetrazine-8-carboxamide compounds |
| GB9504361D0 (en) | 1995-03-04 | 1995-04-26 | Glaxo Spa | Heterocyclic compounds |
| CN101220033A (zh) | 2001-01-18 | 2008-07-16 | 先灵公司 | 替莫唑胺和类似物的合成 |
| CN1742723A (zh) | 2004-09-02 | 2006-03-08 | 天津倍方科技发展有限公司 | 含有替莫唑胺－8－羧酸酯的药物组合物以及该类化合物用于制备抗肿瘤药物的用途 |
| PE20091101A1 (es) | 2007-12-18 | 2009-07-26 | Pharminox Ltd | AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO |
| GB0807103D0 (en) | 2008-04-18 | 2008-05-21 | Univ Bradford The | Compounds |
| CA2763766A1 (en) | 2009-06-23 | 2010-12-29 | Pharminox Limited | 3-substituted-8-substituted-3h-imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use |
-
2008
- 2008-12-12 PE PE2008002071A patent/PE20091101A1/es not_active Application Discontinuation
- 2008-12-16 US US12/808,604 patent/US8450479B2/en not_active Expired - Fee Related
- 2008-12-16 AU AU2008337261A patent/AU2008337261A1/en not_active Abandoned
- 2008-12-16 JP JP2010538886A patent/JP2011506588A/ja active Pending
- 2008-12-16 EP EP20130175051 patent/EP2698370A3/en not_active Withdrawn
- 2008-12-16 EP EP08861839A patent/EP2229393A2/en not_active Withdrawn
- 2008-12-16 CA CA2709749A patent/CA2709749A1/en not_active Abandoned
- 2008-12-16 WO PCT/GB2008/004140 patent/WO2009077741A2/en not_active Ceased
- 2008-12-16 CN CN2008801269450A patent/CN101945874A/zh active Pending
- 2008-12-18 AR ARP080105534A patent/AR071548A1/es unknown
- 2008-12-18 TW TW097149411A patent/TW200934782A/zh unknown
-
2010
- 2010-06-17 IL IL206453A patent/IL206453A0/en unknown
- 2010-06-28 ZA ZA2010/04554A patent/ZA201004554B/en unknown
-
2013
- 2013-05-24 US US13/901,680 patent/US20130338104A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2709749A1 (en) | 2009-06-25 |
| EP2698370A3 (en) | 2014-07-16 |
| IL206453A0 (en) | 2010-12-30 |
| WO2009077741A2 (en) | 2009-06-25 |
| AU2008337261A1 (en) | 2009-06-25 |
| CN101945874A (zh) | 2011-01-12 |
| ZA201004554B (en) | 2011-09-28 |
| EP2229393A2 (en) | 2010-09-22 |
| EP2698370A2 (en) | 2014-02-19 |
| JP2011506588A (ja) | 2011-03-03 |
| US8450479B2 (en) | 2013-05-28 |
| WO2009077741A3 (en) | 2009-12-03 |
| PE20091101A1 (es) | 2009-07-26 |
| TW200934782A (en) | 2009-08-16 |
| US20100286088A1 (en) | 2010-11-11 |
| US20130338104A1 (en) | 2013-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |