AR070542A1 - Composicion farmaceutica oral microencapsulada que comprende la combinacion de una sal de ketorolaco y vitaminas del complejo b - Google Patents

Composicion farmaceutica oral microencapsulada que comprende la combinacion de una sal de ketorolaco y vitaminas del complejo b

Info

Publication number
AR070542A1
AR070542A1 ARP090100696A ARP090100696A AR070542A1 AR 070542 A1 AR070542 A1 AR 070542A1 AR P090100696 A ARP090100696 A AR P090100696A AR P090100696 A ARP090100696 A AR P090100696A AR 070542 A1 AR070542 A1 AR 070542A1
Authority
AR
Argentina
Prior art keywords
pharmaceutical composition
pharmaceutically acceptable
compartment
vitamins
complex
Prior art date
Application number
ARP090100696A
Other languages
English (en)
Inventor
Lopez Enrique Raul Garcia-Salgado
Paniagua M Angelica Arzola
Hernandez Gustavo Barranco
Aguilar Juan Aurelio Senosiain
Original Assignee
Senosiain S A De C V Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senosiain S A De C V Lab filed Critical Senosiain S A De C V Lab
Publication of AR070542A1 publication Critical patent/AR070542A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente se refiere a una composicion farmacéutica oral solida que comprende la combinacion de ketorolaco y complejo B, compuesto entre otros de tiamina, piridoxina y cianocobalamina (vitaminas B1, B6 y B12, respectivamente) y/o sus sales farmacéuticamente aceptables, adicionalmente, vehículos y/o excipientes farmacéuticamente aceptables; el proceso de fabricacion de la composicion y el uso de dicha composicion con actividad terapéutica sinérgica, indicada para el tratamiento de dolor de moderado a severo o neuralgias de diversas localizacion. Reivindicacion 1: Una composicion farmacéutica para administracion oral de comprimidos en tabletas caracterizada porque comprende: un primer compartimiento que comprende cantidades terapéuticamente efectivas de ketorolaco, vitamina B1, vitamina B12, o sus sales farmacéuticamente aceptables, vehiculo de compresibilidad, aglutinante diluente, antiestático, lubricante, plastificante y desintegrante; un segundo compartimiento que comprende una cubierta o capa aislante formada de un polímero de recubrimiento; y un tercer compartimiento que comprende piridoxina o sus sales farmacéuticamente aceptables, y polímero ligante aglutinante. Reivindicacion 2: La composicion farmacéutica de conformidad con la reivindicacion 1 caracterizada porque comprende adicionalmente una cubierta final formada por un polímero de recubrimiento y acabado.
ARP090100696A 2008-03-07 2009-02-27 Composicion farmaceutica oral microencapsulada que comprende la combinacion de una sal de ketorolaco y vitaminas del complejo b AR070542A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MX2008003230A MX2008003230A (es) 2008-03-07 2008-03-07 Composicion famaceutica oral que comprende la combinacion de una sal de ketorolaco y vitaminas del complejo b.

Publications (1)

Publication Number Publication Date
AR070542A1 true AR070542A1 (es) 2010-04-14

Family

ID=41055594

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090100696A AR070542A1 (es) 2008-03-07 2009-02-27 Composicion farmaceutica oral microencapsulada que comprende la combinacion de una sal de ketorolaco y vitaminas del complejo b

Country Status (15)

Country Link
US (1) US20110059171A1 (es)
EP (1) EP2255803B1 (es)
AR (1) AR070542A1 (es)
BR (1) BRPI0908988A2 (es)
CA (1) CA2717900C (es)
CO (1) CO6290082A1 (es)
CR (1) CR11668A (es)
DO (1) DOP2010000265A (es)
EC (1) ECSP10010442A (es)
ES (1) ES2526359T3 (es)
HN (1) HN2010001775A (es)
MX (1) MX2008003230A (es)
PE (1) PE20091592A1 (es)
PL (1) PL2255803T3 (es)
WO (1) WO2009109836A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2619344C1 (ru) * 2016-03-01 2017-05-15 Петр Александрович Попов Способ лечения невралгии
TR201702630A2 (tr) 2017-02-22 2018-09-21 Montero Gida Sanayi Ve Ticaret Anonim Sirketi Alfa li̇poi̇k asi̇t ve suda çözünür vi̇tami̇nler i̇çeren oral farmasöti̇k bi̇leşi̇mler
EP3366291A1 (en) * 2017-02-22 2018-08-29 Montero Gida Sanayi Ve Ticaret A.S. Solid oral pharmaceutical compositions comprising alpha lipoic acid and water-soluble vitamins
US20230414545A1 (en) 2020-12-04 2023-12-28 Laboratorios Silanes S.A. De C.V. Fixed combination medicine for the control and management of neuropathic pain

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR4492M (es) * 1965-07-07 1966-10-10
US4579846A (en) * 1984-10-11 1986-04-01 Pfizer Inc. Antiinflammatory compositions and methods
US5382591A (en) * 1992-12-17 1995-01-17 Sepracor Inc. Antipyretic and analgesic methods using optically pure R-ketorolac
US6051587A (en) * 1998-04-16 2000-04-18 Medicure, Inc. Treatment of iatrogenic and age-related hypertension and pharmaceutical compositions useful therein
US6352721B1 (en) * 2000-01-14 2002-03-05 Osmotica Corp. Combined diffusion/osmotic pumping drug delivery system
US7670612B2 (en) * 2002-04-10 2010-03-02 Innercap Technologies, Inc. Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
US9668972B2 (en) * 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
MXPA02010828A (es) * 2002-11-04 2004-07-16 Leopoldo Espinosa Abdala Composicion farmaceutica en capsulas que comprende un antiinflamatorio no esteroideo y un analgesico opiaceo para el manejo del dolor.
US7335384B2 (en) * 2006-03-17 2008-02-26 4K Nutripharma International Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith
DOP2007000055A (es) * 2006-04-10 2007-10-31 Senosiain S A De C V Lab Composición farmaceutica que comprende un analgésico y vitaminas

Also Published As

Publication number Publication date
CO6290082A1 (es) 2011-06-20
DOP2010000265A (es) 2010-09-30
PE20091592A1 (es) 2009-11-11
CA2717900C (en) 2016-05-10
CR11668A (es) 2010-11-30
CA2717900A1 (en) 2009-09-11
HN2010001775A (es) 2013-01-15
BRPI0908988A2 (pt) 2020-08-04
PL2255803T4 (pl) 2015-05-29
WO2009109836A1 (es) 2009-09-11
PL2255803T3 (pl) 2015-05-29
US20110059171A1 (en) 2011-03-10
EP2255803A4 (en) 2011-06-29
ECSP10010442A (es) 2010-10-30
EP2255803B1 (en) 2014-09-17
MX2008003230A (es) 2009-09-07
EP2255803A1 (en) 2010-12-01
ES2526359T3 (es) 2015-01-09

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