AR070077A1 - Compuestos de n- fenil - imidazo (1,2-a) piridin -2- carboxamidas, su preparacion y su aplicacion en terapeutica - Google Patents
Compuestos de n- fenil - imidazo (1,2-a) piridin -2- carboxamidas, su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- AR070077A1 AR070077A1 ARP080105782A ARP080105782A AR070077A1 AR 070077 A1 AR070077 A1 AR 070077A1 AR P080105782 A ARP080105782 A AR P080105782A AR P080105782 A ARP080105782 A AR P080105782A AR 070077 A1 AR070077 A1 AR 070077A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- group
- atom
- alkoxy
- halogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Medicamento, composicion farmacéutica, compuestos intermedios 5-etilaminopiridin-2-amina, 5-(2-metoxietilamino)piridin-2-amina, utilizacion en terapéutica, en enfermedades neurodegenerativas, traumatismos cerebrales y epilepsia, enfermedades psiquiátricas, inflamatorias, osteoporosis, tumores malignos, esquizofrenia, depresion, dependencia a sustancias. Reivindicacion 1: Compuestos de formula (1) en la que: X representa un grupo fenilo eventualmente sustituido por uno o varios grupos elegidos independientemente unos de otros entre los átomos o grupos siguientes: halogeno, alcoxi C1-6, alquilo C1-6, NRaRb, pudiendo estar sustituidos eventualmente los grupos alquilo y alcoxi por uno o varios átomos de halogeno; R1 representa un átomo de hidrogeno, un átomo de halogeno, un grupo alcoxi C1-6, alquilo C1-6, amino, un grupo NRcRd, pudiendo estar sustituidos eventualmente los grupos alquilo y alcoxi por uno o varios átomos de halogeno, un grupo hidroxi, amino, o alcoxi C1-6; R2 representa uno de los grupo siguientes: un grupo NRcRd, -N=CH-NRaRb, nitro, hidroxiiminoalquilo, alcoxiiminoalquilo, alquil C1-6tio, alquil C1-6sulfinilo, alquil C1-6sulfonilo, -SO2-NR5R6, (alquil C1-6)3sililetinilo, R3 representa un átomo de hidrogeno, un grupo alquilo C1-6, alcoxi C1-6 o un átomo de halogeno; R4 representa un átomo de hidrogeno, un grupo alquilo C1-4, alcoxi C1-4 o un átomo de fluor; R5 y R6, iguales o diferentes, representan un átomo de H o un grupo alquilo C1-6; Ra y Rb representan, independientemente uno de otro, un átomo de H, un grupo alquilo C1-6 o forman con el átomo de N que los soporta un ciclo de 4 a 7 eslabones; Rc representa un átomo de H y Rd representa un átomo de H o un grupo alquilo C1-6, estando dicho alquilo eventualmente sustituido por un grupo alcoxi C1-6; en estado de base o de sal de adicion de ácido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800008A FR2925906B1 (fr) | 2008-01-02 | 2008-01-02 | COMPOSES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070077A1 true AR070077A1 (es) | 2010-03-10 |
Family
ID=39743816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105782A AR070077A1 (es) | 2008-01-02 | 2008-12-31 | Compuestos de n- fenil - imidazo (1,2-a) piridin -2- carboxamidas, su preparacion y su aplicacion en terapeutica |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20100317620A1 (es) |
| EP (1) | EP2225245B1 (es) |
| JP (1) | JP2011509251A (es) |
| KR (1) | KR20100103544A (es) |
| CN (1) | CN101910175A (es) |
| AR (1) | AR070077A1 (es) |
| AT (1) | ATE529426T1 (es) |
| AU (1) | AU2008353144A1 (es) |
| BR (1) | BRPI0821426A2 (es) |
| CA (1) | CA2710811A1 (es) |
| CL (1) | CL2008003931A1 (es) |
| CO (1) | CO6321242A2 (es) |
| EA (1) | EA201070819A1 (es) |
| FR (1) | FR2925906B1 (es) |
| IL (1) | IL206666A0 (es) |
| MA (1) | MA32036B1 (es) |
| TW (1) | TW200934778A (es) |
| UY (1) | UY31592A1 (es) |
| WO (1) | WO2009115651A2 (es) |
| ZA (1) | ZA201004520B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2925900B1 (fr) * | 2008-01-02 | 2011-03-04 | Sanofi Aventis | DERIVES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| US20150329540A1 (en) * | 2012-12-28 | 2015-11-19 | Shin Nippon Biomedical Laboratories, Ltd. | Oct3 activity inhibitor containing imidazopyridine derivative as active component, and oct3 detection agent |
| CN103350373B (zh) * | 2013-06-14 | 2017-10-17 | 肇庆市正海机械设备制造有限公司 | 一种磨刀机及磨刀方法 |
| AU2020226633A1 (en) * | 2019-02-19 | 2021-09-02 | Shangpharma Innovation Inc. | Nurr1 receptor modulators |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2638161B1 (fr) * | 1988-10-24 | 1991-01-11 | Centre Nat Rech Scient | Nouvelles benzoyl-2 imidazo (1,2-a) pyridines et leurs sels, leur procede de preparation, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant |
| WO2005030704A1 (en) * | 2003-09-24 | 2005-04-07 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US7544803B2 (en) * | 2004-01-23 | 2009-06-09 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| WO2005121126A1 (en) * | 2004-04-13 | 2005-12-22 | Icagen, Inc. | Polycyclic pyrazines as potassium ion channel modulators |
| FR2903108B1 (fr) * | 2006-07-03 | 2008-08-29 | Sanofi Aventis Sa | Utilisation de derives d'imidazo[1,2-a] pyridine-2-carboxamides en therapeutique. |
| FR2903107B1 (fr) * | 2006-07-03 | 2008-08-22 | Sanofi Aventis Sa | Derives d'imidazopyridine-2-carboxamides, leur preparation et leur application en therapeutique |
| FR2925900B1 (fr) * | 2008-01-02 | 2011-03-04 | Sanofi Aventis | DERIVES DE N-PHENYL-IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
-
2008
- 2008-01-02 FR FR0800008A patent/FR2925906B1/fr not_active Expired - Fee Related
- 2008-12-30 CL CL2008003931A patent/CL2008003931A1/es unknown
- 2008-12-30 UY UY31592A patent/UY31592A1/es not_active Application Discontinuation
- 2008-12-31 WO PCT/FR2008/001839 patent/WO2009115651A2/fr active Application Filing
- 2008-12-31 BR BRPI0821426-3A patent/BRPI0821426A2/pt not_active IP Right Cessation
- 2008-12-31 EA EA201070819A patent/EA201070819A1/ru unknown
- 2008-12-31 AT AT08873376T patent/ATE529426T1/de not_active IP Right Cessation
- 2008-12-31 EP EP08873376A patent/EP2225245B1/fr active Active
- 2008-12-31 AR ARP080105782A patent/AR070077A1/es unknown
- 2008-12-31 CA CA2710811A patent/CA2710811A1/fr not_active Abandoned
- 2008-12-31 CN CN2008801238397A patent/CN101910175A/zh active Pending
- 2008-12-31 AU AU2008353144A patent/AU2008353144A1/en not_active Abandoned
- 2008-12-31 JP JP2010541088A patent/JP2011509251A/ja not_active Withdrawn
- 2008-12-31 TW TW097151690A patent/TW200934778A/zh unknown
- 2008-12-31 KR KR1020107014643A patent/KR20100103544A/ko not_active Application Discontinuation
-
2010
- 2010-06-25 ZA ZA2010/04520A patent/ZA201004520B/en unknown
- 2010-06-28 IL IL206666A patent/IL206666A0/en unknown
- 2010-07-01 US US12/828,384 patent/US20100317620A1/en not_active Abandoned
- 2010-07-02 CO CO10080864A patent/CO6321242A2/es not_active Application Discontinuation
- 2010-07-27 MA MA33050A patent/MA32036B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011509251A (ja) | 2011-03-24 |
| EP2225245A2 (fr) | 2010-09-08 |
| CA2710811A1 (fr) | 2009-09-24 |
| ZA201004520B (en) | 2011-09-28 |
| TW200934778A (en) | 2009-08-16 |
| KR20100103544A (ko) | 2010-09-27 |
| CN101910175A (zh) | 2010-12-08 |
| CO6321242A2 (es) | 2011-09-20 |
| EP2225245B1 (fr) | 2011-10-19 |
| FR2925906B1 (fr) | 2010-08-20 |
| MA32036B1 (fr) | 2011-01-03 |
| EA201070819A1 (ru) | 2010-12-30 |
| ATE529426T1 (de) | 2011-11-15 |
| BRPI0821426A2 (pt) | 2015-06-16 |
| US20100317620A1 (en) | 2010-12-16 |
| WO2009115651A3 (fr) | 2010-02-25 |
| CL2008003931A1 (es) | 2010-01-22 |
| IL206666A0 (en) | 2010-12-30 |
| UY31592A1 (es) | 2009-08-03 |
| WO2009115651A2 (fr) | 2009-09-24 |
| FR2925906A1 (fr) | 2009-07-03 |
| AU2008353144A1 (en) | 2009-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |