AR069002A1 - Compuestos de fenilpirrolidina, sus usos para la preparacion de medicamentos y sus usos para el tratamiento de alteraciones melatoninergicas, y composiciones farmaceuticas que los comprende - Google Patents
Compuestos de fenilpirrolidina, sus usos para la preparacion de medicamentos y sus usos para el tratamiento de alteraciones melatoninergicas, y composiciones farmaceuticas que los comprendeInfo
- Publication number
- AR069002A1 AR069002A1 ARP080104616A ARP080104616A AR069002A1 AR 069002 A1 AR069002 A1 AR 069002A1 AR P080104616 A ARP080104616 A AR P080104616A AR P080104616 A ARP080104616 A AR P080104616A AR 069002 A1 AR069002 A1 AR 069002A1
- Authority
- AR
- Argentina
- Prior art keywords
- phenyl
- pyrrolidin
- methoxy
- disorders
- butyramide
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 230000001193 melatoninergic effect Effects 0.000 title abstract 2
- -1 PHENYL PIRROLIDINE COMPOUNDS Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract 2
- 230000004075 alteration Effects 0.000 abstract 2
- 206010022437 insomnia Diseases 0.000 abstract 2
- 230000007170 pathology Effects 0.000 abstract 2
- BOQSRQYKGXIQIA-IAXJKZSUSA-N (2s)-2-[1-(3-methoxyphenyl)pyrrolidin-3-yl]butanamide Chemical compound C1C([C@H](CC)C(N)=O)CCN1C1=CC=CC(OC)=C1 BOQSRQYKGXIQIA-IAXJKZSUSA-N 0.000 abstract 1
- RDVWEXSYTNNSLM-NSHDSACASA-N 1-ethyl-3-[(3s)-1-(3-methoxyphenyl)pyrrolidin-3-yl]urea Chemical compound C1[C@@H](NC(=O)NCC)CCN1C1=CC=CC(OC)=C1 RDVWEXSYTNNSLM-NSHDSACASA-N 0.000 abstract 1
- VDQQJMHXZCMNMU-UHFFFAOYSA-N 1-phenylpyrrolidine Chemical class C1CCCN1C1=CC=CC=C1 VDQQJMHXZCMNMU-UHFFFAOYSA-N 0.000 abstract 1
- ZYCJOIXTTRTPPP-VIFPVBQESA-N 2,2,2-trifluoro-n-[(3s)-1-(3-methoxyphenyl)pyrrolidin-3-yl]acetamide Chemical compound COC1=CC=CC(N2C[C@H](CC2)NC(=O)C(F)(F)F)=C1 ZYCJOIXTTRTPPP-VIFPVBQESA-N 0.000 abstract 1
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000027559 Appetite disease Diseases 0.000 abstract 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 abstract 1
- 208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033664 Panic attack Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 210000002249 digestive system Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 abstract 1
- 230000006984 memory degeneration Effects 0.000 abstract 1
- 208000023060 memory loss Diseases 0.000 abstract 1
- CFJDFLKIXFRYLR-JTQLQIEISA-N methyl n-[(3s)-1-(3-methoxyphenyl)pyrrolidin-3-yl]carbamate Chemical compound C1[C@@H](NC(=O)OC)CCN1C1=CC=CC(OC)=C1 CFJDFLKIXFRYLR-JTQLQIEISA-N 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- UJYFWBHTOBRJNK-LBPRGKRZSA-N n-[(3s)-1-(3-methoxyphenyl)pyrrolidin-3-yl]-2,2-dimethylpropanamide Chemical compound COC1=CC=CC(N2C[C@H](CC2)NC(=O)C(C)(C)C)=C1 UJYFWBHTOBRJNK-LBPRGKRZSA-N 0.000 abstract 1
- KUOOFEYJCRNFOO-LBPRGKRZSA-N n-[(3s)-1-(3-methoxyphenyl)pyrrolidin-3-yl]-2-methylpropanamide Chemical compound COC1=CC=CC(N2C[C@H](CC2)NC(=O)C(C)C)=C1 KUOOFEYJCRNFOO-LBPRGKRZSA-N 0.000 abstract 1
- KNVMZTZPDNRYEJ-ZDUSSCGKSA-N n-[(3s)-1-(3-methoxyphenyl)pyrrolidin-3-yl]-3-methylbutanamide Chemical compound COC1=CC=CC(N2C[C@H](CC2)NC(=O)CC(C)C)=C1 KNVMZTZPDNRYEJ-ZDUSSCGKSA-N 0.000 abstract 1
- BDYQJTXTXBSBMC-LBPRGKRZSA-N n-[(3s)-1-(3-methoxyphenyl)pyrrolidin-3-yl]butanamide Chemical compound C1[C@@H](NC(=O)CCC)CCN1C1=CC=CC(OC)=C1 BDYQJTXTXBSBMC-LBPRGKRZSA-N 0.000 abstract 1
- HUNZQHPOZLXJNI-NSHDSACASA-N n-[(3s)-1-(3-methoxyphenyl)pyrrolidin-3-yl]propanamide Chemical compound C1[C@@H](NC(=O)CC)CCN1C1=CC=CC(OC)=C1 HUNZQHPOZLXJNI-NSHDSACASA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229940080818 propionamide Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000012672 seasonal affective disease Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 230000035882 stress Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200702800A ES2331276B1 (es) | 2007-10-25 | 2007-10-25 | Compuestos de fenilpirrolidina. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069002A1 true AR069002A1 (es) | 2009-12-23 |
Family
ID=40291255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080104616A AR069002A1 (es) | 2007-10-25 | 2008-10-23 | Compuestos de fenilpirrolidina, sus usos para la preparacion de medicamentos y sus usos para el tratamiento de alteraciones melatoninergicas, y composiciones farmaceuticas que los comprende |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20120184594A1 (enExample) |
| EP (1) | EP2203422B1 (enExample) |
| JP (1) | JP2011500764A (enExample) |
| KR (1) | KR20100072287A (enExample) |
| CN (1) | CN101878198A (enExample) |
| AR (1) | AR069002A1 (enExample) |
| AT (1) | ATE513809T1 (enExample) |
| AU (1) | AU2008316473A1 (enExample) |
| BR (1) | BRPI0817660A2 (enExample) |
| CA (1) | CA2703458A1 (enExample) |
| CL (1) | CL2008003141A1 (enExample) |
| DK (1) | DK2203422T3 (enExample) |
| ES (2) | ES2331276B1 (enExample) |
| MX (1) | MX2010004469A (enExample) |
| PL (1) | PL2203422T3 (enExample) |
| PT (1) | PT2203422E (enExample) |
| RU (1) | RU2010120845A (enExample) |
| SI (1) | SI2203422T1 (enExample) |
| TW (1) | TW200920353A (enExample) |
| UY (1) | UY31425A1 (enExample) |
| WO (1) | WO2009053441A1 (enExample) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5753709A (en) * | 1995-06-07 | 1998-05-19 | Bristol-Myers Squibb Company | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics |
| DE60007745T2 (de) * | 1999-06-30 | 2005-03-10 | Bristol-Myers Squibb Co. | Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffe |
-
2007
- 2007-10-25 ES ES200702800A patent/ES2331276B1/es not_active Withdrawn - After Issue
-
2008
- 2008-10-23 DK DK08842890.9T patent/DK2203422T3/da active
- 2008-10-23 AT AT08842890T patent/ATE513809T1/de active
- 2008-10-23 AR ARP080104616A patent/AR069002A1/es not_active Application Discontinuation
- 2008-10-23 BR BRPI0817660A patent/BRPI0817660A2/pt not_active IP Right Cessation
- 2008-10-23 SI SI200830368T patent/SI2203422T1/sl unknown
- 2008-10-23 EP EP08842890A patent/EP2203422B1/en not_active Not-in-force
- 2008-10-23 JP JP2010530463A patent/JP2011500764A/ja not_active Abandoned
- 2008-10-23 CN CN2008801131031A patent/CN101878198A/zh active Pending
- 2008-10-23 PL PL08842890T patent/PL2203422T3/pl unknown
- 2008-10-23 WO PCT/EP2008/064390 patent/WO2009053441A1/en not_active Ceased
- 2008-10-23 AU AU2008316473A patent/AU2008316473A1/en not_active Abandoned
- 2008-10-23 MX MX2010004469A patent/MX2010004469A/es active IP Right Grant
- 2008-10-23 US US12/739,708 patent/US20120184594A1/en not_active Abandoned
- 2008-10-23 PT PT08842890T patent/PT2203422E/pt unknown
- 2008-10-23 CA CA2703458A patent/CA2703458A1/en not_active Abandoned
- 2008-10-23 KR KR1020107008900A patent/KR20100072287A/ko not_active Withdrawn
- 2008-10-23 RU RU2010120845/04A patent/RU2010120845A/ru not_active Application Discontinuation
- 2008-10-23 ES ES08842890T patent/ES2368697T3/es active Active
- 2008-10-24 UY UY31425A patent/UY31425A1/es unknown
- 2008-10-24 TW TW097140810A patent/TW200920353A/zh unknown
- 2008-10-24 CL CL2008003141A patent/CL2008003141A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE513809T1 (de) | 2011-07-15 |
| EP2203422A1 (en) | 2010-07-07 |
| WO2009053441A1 (en) | 2009-04-30 |
| BRPI0817660A2 (pt) | 2015-09-29 |
| ES2331276A1 (es) | 2009-12-28 |
| PT2203422E (pt) | 2011-09-26 |
| CA2703458A1 (en) | 2009-04-30 |
| ES2368697T3 (es) | 2011-11-21 |
| ES2331276B1 (es) | 2010-10-21 |
| TW200920353A (en) | 2009-05-16 |
| UY31425A1 (es) | 2009-04-30 |
| SI2203422T1 (sl) | 2011-10-28 |
| CN101878198A (zh) | 2010-11-03 |
| PL2203422T3 (pl) | 2011-11-30 |
| AU2008316473A1 (en) | 2009-04-30 |
| US20120184594A1 (en) | 2012-07-19 |
| CL2008003141A1 (es) | 2009-03-06 |
| KR20100072287A (ko) | 2010-06-30 |
| JP2011500764A (ja) | 2011-01-06 |
| RU2010120845A (ru) | 2011-11-27 |
| MX2010004469A (es) | 2010-07-06 |
| EP2203422B1 (en) | 2011-06-22 |
| DK2203422T3 (da) | 2011-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |