AR069004A1 - Compuestos de 2,3-dihidro-benzofurano sus usos para la preparacion de medicamentos y sus usos para el tratamiento de alteraciones melatoninergicas, y composiciones farmaceuticas que los comprende - Google Patents
Compuestos de 2,3-dihidro-benzofurano sus usos para la preparacion de medicamentos y sus usos para el tratamiento de alteraciones melatoninergicas, y composiciones farmaceuticas que los comprendeInfo
- Publication number
- AR069004A1 AR069004A1 ARP080104618A ARP080104618A AR069004A1 AR 069004 A1 AR069004 A1 AR 069004A1 AR P080104618 A ARP080104618 A AR P080104618A AR P080104618 A ARP080104618 A AR P080104618A AR 069004 A1 AR069004 A1 AR 069004A1
- Authority
- AR
- Argentina
- Prior art keywords
- benzofuran
- dihydro
- ethyl
- methoxy
- alterations
- Prior art date
Links
- 230000004075 alteration Effects 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 230000001193 melatoninergic effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 3
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract 2
- 206010022437 insomnia Diseases 0.000 abstract 2
- 230000007170 pathology Effects 0.000 abstract 2
- AQLMOMUIYTZJOY-UHFFFAOYSA-N 1-[2-(5-methoxy-2,3-dihydro-1-benzofuran-3-yl)ethyl]cyclopropane-1-carboxamide Chemical compound C12=CC(OC)=CC=C2OCC1CCC1(C(N)=O)CC1 AQLMOMUIYTZJOY-UHFFFAOYSA-N 0.000 abstract 1
- ZNVNMIZVRXAQCQ-UHFFFAOYSA-N 1-ethyl-3-[2-(5-methoxy-2,3-dihydro-1-benzofuran-3-yl)ethyl]urea Chemical compound C1=C(OC)C=C2C(CCNC(=O)NCC)COC2=C1 ZNVNMIZVRXAQCQ-UHFFFAOYSA-N 0.000 abstract 1
- HBEDSQVIWPRPAY-UHFFFAOYSA-N 2,3-dihydrobenzofuran Chemical class C1=CC=C2OCCC2=C1 HBEDSQVIWPRPAY-UHFFFAOYSA-N 0.000 abstract 1
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000019888 Circadian rhythm sleep disease Diseases 0.000 abstract 1
- 208000001456 Jet Lag Syndrome Diseases 0.000 abstract 1
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010033664 Panic attack Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 206010039966 Senile dementia Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000036528 appetite Effects 0.000 abstract 1
- 235000019789 appetite Nutrition 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 210000002249 digestive system Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 206010015037 epilepsy Diseases 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 208000033915 jet lag type circadian rhythm sleep disease Diseases 0.000 abstract 1
- 230000006984 memory degeneration Effects 0.000 abstract 1
- 208000023060 memory loss Diseases 0.000 abstract 1
- ZLLDMTLCXLGMSU-UHFFFAOYSA-N methyl n-[2-(5-methoxy-2,3-dihydro-1-benzofuran-3-yl)ethyl]carbamate Chemical compound C1=C(OC)C=C2C(CCNC(=O)OC)COC2=C1 ZLLDMTLCXLGMSU-UHFFFAOYSA-N 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- OULJWKNKFAPDOQ-UHFFFAOYSA-N n-[2-(5-methoxy-2,3-dihydro-1-benzofuran-3-yl)ethyl]acetamide Chemical compound COC1=CC=C2OCC(CCNC(C)=O)C2=C1 OULJWKNKFAPDOQ-UHFFFAOYSA-N 0.000 abstract 1
- UQIPDPLDZRBYKJ-UHFFFAOYSA-N n-[2-(5-methoxy-2,3-dihydro-1-benzofuran-3-yl)ethyl]butanamide Chemical compound C1=C(OC)C=C2C(CCNC(=O)CCC)COC2=C1 UQIPDPLDZRBYKJ-UHFFFAOYSA-N 0.000 abstract 1
- QUOXGHGAIKTNTI-UHFFFAOYSA-N n-[2-(5-methoxy-2,3-dihydro-1-benzofuran-3-yl)ethyl]propanamide Chemical compound C1=C(OC)C=C2C(CCNC(=O)CC)COC2=C1 QUOXGHGAIKTNTI-UHFFFAOYSA-N 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 208000019906 panic disease Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 208000012672 seasonal affective disease Diseases 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 230000035882 stress Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
Abstract
Compuestos de 2,3-dihidro-benzofurano que se seleccionan del grupo consistente en: 1) N-[2-(5-metoxi-2,3-dihidro-benzofuran-3-il)-etil]-acetamida; 2) N-[2-(5-metoxi-2,3-dihidro-benzofuran-3-il)-etil]-propionamida; 3) N-[2-(5-metoxi-2,3-dihidro-benzofuran-3-il)-etiI]-butiramida; 4) [2-(5-metoxi-2,3-dihidro-benzofuran-3-il)-etil]-ciclopropancarboxamida; 5) 1-etil-3-[2-(5-metoxi-2,3-dihidro-benzofuran-3-il)-etil]-urea; y 6) [2-(5-metoxi-2,3-dihidro-benzofuran-3-il)-etil]-carbamato de metilo; y sus sales e hidratos farmacéuticamente aceptables. Sus usos para la preparación de un medicamento y para el tratamiento o la prevención de las alteraciones melatoninérgicas, seleccionadas del grupo de: la depresión, el stress, las alteraciones del sueño, la ansiedad, los trastornos afectivos estacionales, la patología cardiovascular, la patología del sistema digestivo, el insomnio o la fatiga debidos al jet lag, la esquizofrenia, los ataques de pánico, la melancolía, las alteraciones del apetito, la obesidad, el insomnio, las enfermedades psicóticas, la epilepsia, la diabetes, la enfermedad de Parkinson, la demencia senil, las alteraciones asociadas con el envejecimiento normal o patológico, la migraña, la pérdida de memoria, la enfermedad de Alzheimer y las alteraciones de la circulación cerebral.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200702799A ES2331275B1 (es) | 2007-10-25 | 2007-10-25 | Compuestos de 2,3-dihidro-benzofurano. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069004A1 true AR069004A1 (es) | 2009-12-23 |
Family
ID=40325834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080104618A AR069004A1 (es) | 2007-10-25 | 2008-10-23 | Compuestos de 2,3-dihidro-benzofurano sus usos para la preparacion de medicamentos y sus usos para el tratamiento de alteraciones melatoninergicas, y composiciones farmaceuticas que los comprende |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20120059053A1 (es) |
| EP (1) | EP2205579A1 (es) |
| JP (1) | JP2011500765A (es) |
| KR (1) | KR20100072044A (es) |
| CN (1) | CN101868450A (es) |
| AR (1) | AR069004A1 (es) |
| AU (1) | AU2008316476A1 (es) |
| BR (1) | BRPI0818848A2 (es) |
| CA (1) | CA2703461A1 (es) |
| CL (1) | CL2008003140A1 (es) |
| ES (1) | ES2331275B1 (es) |
| MX (1) | MX2010004422A (es) |
| RU (1) | RU2010120846A (es) |
| TW (1) | TW200920349A (es) |
| UY (1) | UY31424A1 (es) |
| WO (1) | WO2009053444A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180006522A (ko) | 2016-07-07 | 2018-01-18 | 삼성디스플레이 주식회사 | 액정 조성물 및 이를 포함하는 액정 표시 장치 |
| CN116253704A (zh) * | 2021-12-10 | 2023-06-13 | 中国科学院昆明植物研究所 | Paeoveitol D衍生物及其药物组合物和其制备方法与其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996008466A1 (en) * | 1994-09-12 | 1996-03-21 | Takeda Chemical Industries, Ltd. | Benzocycloalkene compounds, their production and use |
| FR2772766B1 (fr) * | 1997-12-24 | 2000-06-30 | Adir | Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6569894B1 (en) * | 2001-10-04 | 2003-05-27 | Bristol-Myers Squibb Company | Arylalkylbenzofuran derivatives as melatonergic agents |
| US20050137247A1 (en) * | 2003-12-22 | 2005-06-23 | The Brigham And Women's Hospital, Inc. | Methods and compositions for treatment of hypertension |
-
2007
- 2007-10-25 ES ES200702799A patent/ES2331275B1/es not_active Withdrawn - After Issue
-
2008
- 2008-10-23 CN CN200880113104A patent/CN101868450A/zh active Pending
- 2008-10-23 EP EP08842657A patent/EP2205579A1/en not_active Withdrawn
- 2008-10-23 RU RU2010120846/04A patent/RU2010120846A/ru not_active Application Discontinuation
- 2008-10-23 BR BRPI0818848 patent/BRPI0818848A2/pt not_active IP Right Cessation
- 2008-10-23 WO PCT/EP2008/064393 patent/WO2009053444A1/en active Application Filing
- 2008-10-23 MX MX2010004422A patent/MX2010004422A/es active IP Right Grant
- 2008-10-23 AR ARP080104618A patent/AR069004A1/es not_active Application Discontinuation
- 2008-10-23 AU AU2008316476A patent/AU2008316476A1/en not_active Abandoned
- 2008-10-23 JP JP2010530465A patent/JP2011500765A/ja not_active Abandoned
- 2008-10-23 KR KR1020107008775A patent/KR20100072044A/ko not_active Application Discontinuation
- 2008-10-23 CA CA2703461A patent/CA2703461A1/en not_active Abandoned
- 2008-10-23 US US12/739,600 patent/US20120059053A1/en not_active Abandoned
- 2008-10-24 CL CL2008003140A patent/CL2008003140A1/es unknown
- 2008-10-24 TW TW097140811A patent/TW200920349A/zh unknown
- 2008-10-24 UY UY31424A patent/UY31424A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200920349A (en) | 2009-05-16 |
| AU2008316476A1 (en) | 2009-04-30 |
| JP2011500765A (ja) | 2011-01-06 |
| MX2010004422A (es) | 2010-05-05 |
| CA2703461A1 (en) | 2009-04-30 |
| ES2331275B1 (es) | 2010-10-21 |
| WO2009053444A1 (en) | 2009-04-30 |
| US20120059053A1 (en) | 2012-03-08 |
| BRPI0818848A2 (pt) | 2015-04-14 |
| KR20100072044A (ko) | 2010-06-29 |
| CL2008003140A1 (es) | 2009-03-06 |
| RU2010120846A (ru) | 2011-11-27 |
| EP2205579A1 (en) | 2010-07-14 |
| UY31424A1 (es) | 2009-04-30 |
| ES2331275A1 (es) | 2009-12-28 |
| CN101868450A (zh) | 2010-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |