AR068388A1 - Compuesto derivado de imidazol - fenil-oxo-1,4- diazaespiro arilo, su uso para preparar un medicamento, composicion farmaceutica y combinacion que lo comprenden - Google Patents

Compuesto derivado de imidazol - fenil-oxo-1,4- diazaespiro arilo, su uso para preparar un medicamento, composicion farmaceutica y combinacion que lo comprenden

Info

Publication number
AR068388A1
AR068388A1 ARP080103909A ARP080103909A AR068388A1 AR 068388 A1 AR068388 A1 AR 068388A1 AR P080103909 A ARP080103909 A AR P080103909A AR P080103909 A ARP080103909 A AR P080103909A AR 068388 A1 AR068388 A1 AR 068388A1
Authority
AR
Argentina
Prior art keywords
alkoxy
alkyl
haloalkoxy
haloalkyl
halo
Prior art date
Application number
ARP080103909A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0717728A external-priority patent/GB0717728D0/en
Priority claimed from GB0802586A external-priority patent/GB0802586D0/en
Priority claimed from GB0813501A external-priority patent/GB0813501D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AR068388A1 publication Critical patent/AR068388A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuesto de imidazol-fenil-oxo-1,4-diazaespiro arilo, que inhibe el transportador de glicina, de formula (1) o una sal del mismo donde: X es -CH2- u oxigeno; R1, R2, R3 y R4 se seleccionan independientemente entre hidrogeno, alquilo C1-4, alcoxi C1-4, ciano, halo, haloalquilo C1-4, haloalcoxi C1-4, alquiltio C1-4, cicloalquilo C3-6, cicloalquil C3-6-alquilo C1-4, cicloalquil C3-6-aIcoxi C1-4, alquilsulfonilo C1-4, alcoxi C1-4-alquilo C1-4 y CONRaRb, donde Ra y Rb se seleccionan independientemente entre hidrogeno y alquilo C1-4, o Ra y Rb, junto con el átomo de nitrogeno al que están unidos forman un anillo de 4 a 7 miembros; o R2 y R3 juntos forman un grupo seleccionado entre -O-CH2-O- y -O-CH2-CH2-O-; R5 se selecciona entre hidrogeno, cloro, fluor, alquilo C1-4 y CF3 uno de R6 y R7 se selecciona entre el grupo que consiste en: hidrogeno, alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4, halo, ciano, alcoxi C1-4-alcoxi C1-4 y alcoxi C1-4-alquilo; y el otro se selecciona entre el grupo que consiste en un anillo heteroarilo de 5 a 7 miembros, opcionalmente sustituido con alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4, halo o ciano; un anillo heterocíclico, bicíclico, de 9 a 10 miembros, opcionalmente sustituido con alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4, halo o ciano; y un anillo heterocíclico de 5 a 7 miembros, opcionalmente sustituido con alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4, halo o ciano; o R6 y R7 juntos forman un anillo heterocíclico de 5 a 7 miembros condensado con el anillo de fenilo o un anillo heteroarilo de 5 a 7 miembros condensado con el anillo de fenilo; donde el anillo heterocíclico o el anillo heteroarilo está opcionalmente sustituido con alquilo C1-4, alcoxi C1-4, haloalquilo C1-4, haloalcoxi C1-4, halo o ciano; R15 es hidrogeno o fluor; R8 se selecciona entre hidrogeno y metilo; y m se selecciona entre 0, 1 y 2. Su uso para preparar un medicamento util para tratar trastornos neurologicos y neuropsiquiátricos, en particular psicosis, demencia o trastorno de déficit de atencion. Formulaciones farmacéuticas que lo comprenden.
ARP080103909A 2007-09-11 2008-09-09 Compuesto derivado de imidazol - fenil-oxo-1,4- diazaespiro arilo, su uso para preparar un medicamento, composicion farmaceutica y combinacion que lo comprenden AR068388A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0717728A GB0717728D0 (en) 2007-09-11 2007-09-11 Compounds
GB0802586A GB0802586D0 (en) 2008-02-12 2008-02-12 Compounds
GB0813501A GB0813501D0 (en) 2008-07-23 2008-07-23 Pb62624p2

Publications (1)

Publication Number Publication Date
AR068388A1 true AR068388A1 (es) 2009-11-11

Family

ID=39877729

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080103909A AR068388A1 (es) 2007-09-11 2008-09-09 Compuesto derivado de imidazol - fenil-oxo-1,4- diazaespiro arilo, su uso para preparar un medicamento, composicion farmaceutica y combinacion que lo comprenden

Country Status (9)

Country Link
US (1) US20100317704A1 (es)
EP (1) EP2197852A1 (es)
JP (1) JP2010539128A (es)
AR (1) AR068388A1 (es)
CL (1) CL2008002674A1 (es)
PE (1) PE20091091A1 (es)
TW (1) TW200911234A (es)
UY (1) UY31332A1 (es)
WO (1) WO2009034061A1 (es)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009503006A (ja) * 2005-08-02 2009-01-29 グラクソ グループ リミテッド ＧｌｙＴ１トランスポーター阻害剤ならびに神経および神経精神障害の治療におけるその使用
EP1994010A1 (en) * 2006-03-16 2008-11-26 Glaxo Group Limited Compounds which inhibit the glycine transporter and uses thereof
US20090326027A1 (en) * 2006-03-16 2009-12-31 Steven Coulton N-Phenyl-2-0X0-1,4-Diazaspiro [4.5] Dec-3-EN-1-YL Acetamide Derivatives And Their Use As Glycine Transporter Inhibitors
JP2010517963A (ja) * 2007-02-01 2010-05-27 グラクソ グループ リミテッド 神経学的および神経精神病学的障害の治療におけるＧｌｙＴ１トランスポーター阻害薬としての８−オキサ−１，４−ジアザスピロ［４，５］デク−３−エン−１−イルおよび１，４，８−トリアザスピロ［４，５］デク−３−エン−１−イルアセトアミド誘導体
WO2008092872A1 (en) * 2007-02-01 2008-08-07 Glaxo Group Limited Glyt1 transporter inhibitors and uses thereof in treatment of neurological and neuropsychiatric disorders
JP2010517961A (ja) * 2007-02-01 2010-05-27 グラクソ グループ リミテッド ＧｌｙＴ１トランスポーター阻害薬および神経学的および神経精神病学的障害の治療におけるその使用

Also Published As

Publication number Publication date
US20100317704A1 (en) 2010-12-16
EP2197852A1 (en) 2010-06-23
JP2010539128A (ja) 2010-12-16
UY31332A1 (es) 2009-03-31
TW200911234A (en) 2009-03-16
WO2009034061A1 (en) 2009-03-19
PE20091091A1 (es) 2009-08-28
CL2008002674A1 (es) 2009-10-16

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