AR067877A1 - Compuestos de pirimidina - Google Patents
Compuestos de pirimidinaInfo
- Publication number
- AR067877A1 AR067877A1 ARP080103456A ARP080103456A AR067877A1 AR 067877 A1 AR067877 A1 AR 067877A1 AR P080103456 A ARP080103456 A AR P080103456A AR P080103456 A ARP080103456 A AR P080103456A AR 067877 A1 AR067877 A1 AR 067877A1
- Authority
- AR
- Argentina
- Prior art keywords
- co2r3
- coor3
- hal
- denotes
- nr3con
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Los compuestos son utiles, por ejemplo, en el tratamiento de trastornos autoinmunes, como, por ejemplo, la esclerosis multiple. Reivindicacion 1: Compuestos de acuerdo con la Formula (1) en donde: X es NRaRb,.SRb o Hal, Ra es H o A, Rb es A, A es alquilo lineal o ramificado que posee 1 a 12 átomos de carbono, en donde uno o más, con preferencia 1 a 7 átomos de H se pueden reemplazar por Hal, OR3, COOR3, CN o N(R3)2 y en donde uno o más, con preferencia 1 a 7 grupos CH2 no adyacentes se pueden reemplazar por O, NR3, S o SO2 y/o por grupos -CH=CH-, o denota cicloalquilo o cicloalquilalquileno que posee 3-7 átomos de C anulares; Hal es F, Cl, Br o I, W es C=O, C=S, SO2 o SO, Q es NR3, -O- o -S-, R es H, A, Ar, Het, Ar denota un anillo carbocíclico monocíclico o bicíclico, saturado, insaturado o aromático que posee 6 a 14 átomos de carbono, que puede estar no sustituido o monosustituido, disustituido o trisustituido por Hal, A, OR3, -[C(R3)2]n-OR3, N(R3)2, -[C(R3)2]n-N(R3)2, NO2, CN, COOR3, CF3, OCF3, CON(R3)2, NR3COA, NR3CON(R3)2, -[C(R3)2]n-, Het, -[C(R3)2]n-Ar, -[C(R3)2]n-cicloalkil, -[C(R3)2]n-, CON(R3)2, -[C(R3)2]n-COOR3, -[C(R3)2]-NR3-[C(R3)2]-CO2R3, -[C(R3)2]n-NR3-[C(R3)2]n-OR3, -SO2-[C(R3)2]n-CO2R3, -SO2- -N(R3)2-[C(R3)2]n-CO2R3, -[C(R3)2]-SO2-[C(R3)2]-CO2R3, -SO2-, [C(R3)2]n-OR3, -SO2-N(R3)2-[C(R3)2]n-OR3, -SO2-, [C(R3)2]n-OR3, -SO2-N(R3)2-[C(R3)2]n-OR3, -[C(R3)2]n-SO2-, [C(R3)2]n-OR3, NR3CON(R3)2, NR3SO2A, COR3, SO2N(R3)2, SO2N(R3)A, SOA, SONR3A, o SO2A, y/o -O[C(R3)2]n-COOR3, Het denota un anillo heterocíclico, nomocíclico o bicíclico, saturado, insaturado o aromático que posee 1 a 4 átomos de N, O y/o S que puede estar no sustituido o monosustituido, disustituido o trisustituido por Hal, A, OR3, -[C(R3)2]n-OR3, N(R3)2, -[C(R3)2)n-N(R3)2, NO2, CN, COOR3, CF3, OCF3, CON(R3)2, NR3COA, NR3CON(R3)2, -[C(R3)2]n-Het, -[C(R3)2]n-Ar, -[C(R3)2]n-cicloalkil, -[C(R3)2]n-CON(R3)2, -[C(R3)2]n-COOR3, -[C(R3)2]-NR3-[C(R3)2]n-CO2R3, -[C(R3)2]-NR3-[C(R3)2]n-OR3, -SO2-[C(R3)2]n-CO2R3, -SO2-, N(R3)2-[C(R3)2]n-CO2R3, -[C(R3)2]n-SO2-[C(R3)2]n-CO2R3, -SO2- [C(R3)2]n-OR3, -SO2-N(R3)2-[C(R3)2]n-OR3, -[C(R3)2]n-SO2-, [C(R3)2]n-OR3, NR3CON(R3)2, NR3SO2A, COR3, SO2N(R3)2, SO2N(R3)A, SOA, SONR3A, o SO2A, y/o -O[C(R3)2]-COOR3, R1 denota A o H, R2 denota H, A o HAL R3 es H o A n es 0, 1, 2, 3, 4, 5, 6, 7 o 8, y sus derivados, solvatos, tautomeros, sales y estereoisomeros farmacéuticamente aceptables, con inclusion de sus mezclas en todas las relaciones.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07113992 | 2007-08-08 | ||
US96486407P | 2007-08-15 | 2007-08-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR067877A1 true AR067877A1 (es) | 2009-10-28 |
Family
ID=38985492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080103456A AR067877A1 (es) | 2007-08-08 | 2008-08-07 | Compuestos de pirimidina |
Country Status (15)
Country | Link |
---|---|
US (2) | US8399448B2 (es) |
EP (1) | EP2183224B1 (es) |
JP (1) | JP5508265B2 (es) |
KR (1) | KR20100051849A (es) |
CN (1) | CN101790519B (es) |
AR (1) | AR067877A1 (es) |
AU (1) | AU2008285722B2 (es) |
BR (1) | BRPI0814975A2 (es) |
CA (1) | CA2696565C (es) |
EA (1) | EA201070238A1 (es) |
ES (1) | ES2445405T3 (es) |
IL (1) | IL203578A (es) |
MX (1) | MX2010001446A (es) |
WO (1) | WO2009019167A1 (es) |
ZA (1) | ZA201000585B (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2008302746B2 (en) * | 2007-09-20 | 2014-07-03 | Amgen Inc. | 1-(4-(benzylbenzamid0) -benzyl) azetidine-3-carboxylic acid derivatives and related compounds as SlP receptor modulators for the treatment of immune disorders |
MX354134B (es) | 2008-07-23 | 2018-02-14 | Arena Pharm Inc | Derivados de acido 1,2,3,4-tetrahidrociclopenta [b] indol-3-il) acetico sustituidos utiles en el tratamiento de enfermedades autoinmune e inflamatorias. |
CA2733671C (en) | 2008-08-27 | 2018-01-02 | Arena Pharmaceuticals, Inc. | Substituted tricyclic acid derivatives as s1p1 receptor agonists useful in the treatment of autoimmune and inflammatory disorders |
JP2013508385A (ja) | 2009-10-23 | 2013-03-07 | アラーガン インコーポレイテッド | 治療上有用な、受容体修飾薬としてのクマリン化合物 |
EP4148045A1 (en) | 2010-01-27 | 2023-03-15 | Arena Pharmaceuticals, Inc. | Intermediate compounds for the preparation of (r)-2-(7-(4-cyclopentyl-3- (trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b] indol-3-yl)acetic acid and salts thereof |
SG10201501575VA (en) | 2010-03-03 | 2015-04-29 | Arena Pharm Inc | Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof |
EP2547662A4 (en) * | 2010-03-17 | 2013-10-02 | Glaxo Group Ltd | PYRIMIDINE DERIVATIVES FOR USE AS AGONISTS OF SPHINGOSIN 1-PHOSPHATE 1 (S1P1) RECEPTORS |
SG194184A1 (en) * | 2011-04-14 | 2013-11-29 | Allergan Inc | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators |
EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
US20140235592A1 (en) * | 2013-02-21 | 2014-08-21 | Allergan, Inc. | Substituted 6-methoxy-4-amino-n-phenyl-2-naphtamides as sphingosine receptor modulators |
CN103408501B (zh) * | 2013-08-14 | 2016-03-09 | 合肥医工医药有限公司 | 苄基嘧啶衍生物、其制备方法及其医药用途 |
TWI667233B (zh) * | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
KR20160115933A (ko) * | 2014-01-10 | 2016-10-06 | 오리진 디스커버리 테크놀로지스 리미티드 | Irak4 억제제로서의 인다졸 화합물 |
SG10201811204RA (en) | 2014-01-13 | 2019-01-30 | Aurigene Discovery Tech Ltd | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
KR101499007B1 (ko) * | 2014-04-24 | 2015-03-05 | 고려대학교 산학협력단 | 염증성 질환의 예방 또는 치료용 약학 조성물 |
AU2016205361C1 (en) | 2015-01-06 | 2021-04-08 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the S1P1 receptor |
IL285890B (en) | 2015-06-22 | 2022-07-01 | Arena Pharm Inc | Slate-free crystal of the arginine salt of (Ar)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-4,3,2,1-tetrahydro-cyclopent[b]indole-3-yl ) acetic acid |
WO2018049214A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
US20180072741A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyrimidine compounds and uses thereof |
WO2018049191A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridone derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
CN115819417A (zh) | 2016-09-09 | 2023-03-21 | 因赛特公司 | 作为hpk1调节剂的吡唑并吡啶衍生物及其用于治疗癌症的用途 |
US20180228786A1 (en) | 2017-02-15 | 2018-08-16 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
US11478448B2 (en) | 2017-02-16 | 2022-10-25 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
US11534424B2 (en) | 2017-02-16 | 2022-12-27 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
KR102633530B1 (ko) | 2017-03-31 | 2024-02-02 | 오리진 온콜로지 리미티드 | 혈액 장애를 치료하기 위한 화합물 및 조성물 |
US10722495B2 (en) | 2017-09-08 | 2020-07-28 | Incyte Corporation | Cyanoindazole compounds and uses thereof |
WO2019089580A1 (en) | 2017-10-31 | 2019-05-09 | Curis, Inc. | Compounds and compositions for treating hematological disorders |
PL3755703T3 (pl) | 2018-02-20 | 2022-11-07 | Incyte Corporation | Pochodne n-(fenylo)-2-(fenylo)pirymidyno-4-karboksyamidu i związki pokrewne jako inhibitory hpk1 do leczenia nowotworu |
WO2019164847A1 (en) | 2018-02-20 | 2019-08-29 | Incyte Corporation | Indazole compounds and uses thereof |
US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
US11299473B2 (en) | 2018-04-13 | 2022-04-12 | Incyte Corporation | Benzimidazole and indole compounds and uses thereof |
US10899755B2 (en) | 2018-08-08 | 2021-01-26 | Incyte Corporation | Benzothiazole compounds and uses thereof |
US11555015B2 (en) | 2018-09-06 | 2023-01-17 | Arena Pharmaceuticals, Inc. | Compounds useful in the treatment of autoimmune and inflammatory disorders |
EP3856348B1 (en) | 2018-09-25 | 2024-01-03 | Incyte Corporation | Pyrazolo[4,3-d]pyrimidine compounds as alk2 and/or fgfr modulators |
AU2020326703A1 (en) | 2019-08-06 | 2022-02-17 | Incyte Corporation | Solid forms of an HPK1 inhibitor |
GB202213310D0 (en) * | 2022-09-12 | 2022-10-26 | Benevolentai Cambridge Ltd | New compounds and methods |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1115707T3 (da) * | 1998-09-25 | 2004-03-01 | Astrazeneca Ab | Benzamidderivater og deres anvendelse som cytokininhibitorer |
WO2002096903A2 (fr) * | 2001-05-28 | 2002-12-05 | Aventis Pharma S.A. | Derives chimiques et leur application comme agent antitelomerase |
WO2003105840A2 (en) | 2002-06-17 | 2003-12-24 | The Pennsylvania State Research Foundation | Sphingosine kinase inhibitors |
TW200524880A (en) | 2003-10-21 | 2005-08-01 | Sankyo Co | Pyrimidine compounds |
EP1694659B8 (en) | 2003-12-19 | 2008-10-08 | Schering Corporation | Thiadiazoles as cxc- and cc- chemokine receptor ligands |
US7919487B2 (en) | 2004-11-10 | 2011-04-05 | Synta Pharmaceuticals Corporation | Heteroaryl compounds |
AR067354A1 (es) * | 2007-06-29 | 2009-10-07 | Sunesis Pharmaceuticals Inc | Compuestos utiles como inhibidores de la raf quinasa |
-
2008
- 2008-07-29 US US12/671,996 patent/US8399448B2/en active Active
- 2008-07-29 CN CN2008801020927A patent/CN101790519B/zh not_active Expired - Fee Related
- 2008-07-29 EA EA201070238A patent/EA201070238A1/ru unknown
- 2008-07-29 KR KR1020107005173A patent/KR20100051849A/ko not_active Application Discontinuation
- 2008-07-29 EP EP08775369.5A patent/EP2183224B1/en active Active
- 2008-07-29 MX MX2010001446A patent/MX2010001446A/es not_active Application Discontinuation
- 2008-07-29 AU AU2008285722A patent/AU2008285722B2/en not_active Ceased
- 2008-07-29 JP JP2010519431A patent/JP5508265B2/ja not_active Expired - Fee Related
- 2008-07-29 BR BRPI0814975-5A2A patent/BRPI0814975A2/pt not_active IP Right Cessation
- 2008-07-29 ES ES08775369.5T patent/ES2445405T3/es active Active
- 2008-07-29 CA CA2696565A patent/CA2696565C/en not_active Expired - Fee Related
- 2008-07-29 WO PCT/EP2008/059933 patent/WO2009019167A1/en active Application Filing
- 2008-08-07 AR ARP080103456A patent/AR067877A1/es not_active Application Discontinuation
-
2010
- 2010-01-26 ZA ZA2010/00585A patent/ZA201000585B/en unknown
- 2010-01-28 IL IL203578A patent/IL203578A/en active IP Right Grant
-
2012
- 2012-12-12 US US13/711,893 patent/US9150519B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
WO2009019167A1 (en) | 2009-02-12 |
EA201070238A1 (ru) | 2010-08-30 |
ZA201000585B (en) | 2011-04-28 |
CN101790519A (zh) | 2010-07-28 |
US8399448B2 (en) | 2013-03-19 |
JP2010535734A (ja) | 2010-11-25 |
EP2183224A1 (en) | 2010-05-12 |
IL203578A (en) | 2014-02-27 |
CN101790519B (zh) | 2013-10-16 |
CA2696565A1 (en) | 2009-02-12 |
JP5508265B2 (ja) | 2014-05-28 |
ES2445405T3 (es) | 2014-03-03 |
MX2010001446A (es) | 2010-03-01 |
BRPI0814975A2 (pt) | 2015-02-03 |
KR20100051849A (ko) | 2010-05-18 |
EP2183224B1 (en) | 2013-11-06 |
AU2008285722B2 (en) | 2013-06-20 |
US9150519B2 (en) | 2015-10-06 |
AU2008285722A1 (en) | 2009-02-12 |
CA2696565C (en) | 2017-02-14 |
US20130109669A1 (en) | 2013-05-02 |
US20100210619A1 (en) | 2010-08-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR067877A1 (es) | Compuestos de pirimidina | |
AR068731A1 (es) | Compuestos de diaril 1,2,4-oxadiazol,composiciones farmaceuticas que los contienen, proceso de preparacion y uso de los mismos como agentes inmunosupresores en el tratamiento de enfermedades autoinmunes y/o inflamatorias cronicas. | |
AR076187A1 (es) | Derivados de oxadiazol, proceso de preparacion de los mismos y composicion farmaceutica que los contienen | |
AR076984A1 (es) | Derivados de pirazol oxadiazol | |
AR074700A1 (es) | Derivados heterociclicos fusionados con oxadiazola, composiciones farmaceuticas, procesos de preparacion y su uso en el tratamiento de esclerosis multiple y otras enfermedades | |
AR020851A2 (es) | Compuestos macrolidos, composiciones y su uso para la preparacion de medicamentos | |
AR067562A1 (es) | Compuestos heterociclicos inhibidores de kinasa | |
AR087196A1 (es) | Metodos plaguicidas que utilizan compuestos de 3-piridil tiazol sustituido y derivados para combatir las plagas de animales ii | |
UY26727A1 (es) | Derivados de tropano útiles en terapia | |
AR053569A1 (es) | Derivados de pirazol | |
AR037983A1 (es) | Derivados de pirido [2,1-a] isoquinolina | |
AR040546A1 (es) | Derivados de la 1-h- pirrolidin -2,4- diona espirociclicos, cis- alcoxisubstituidos | |
PE20060937A1 (es) | Derivados de sulfonilbencimidazol como agonistas del receptor cannabinoide 2 (cb2) | |
AR075635A1 (es) | N-alcoxiamidas de 6-(fenil sustituido)-4-aminopicolinatos y 2-(fenil sustituido)-6-amino-4-pirimidina carboxilatos, su uso como herbicidas selectivos para las cosechas y proceso de preparacion de dichos compuestos | |
AR071285A1 (es) | Pirido[3, 4-b]indoles, una composicion farmaceutica que los comprende y su uso en el tratamiento de trastornos neurologicos. | |
AR059428A1 (es) | Pirazoles para el tratamiento de enfermedades mediadas por la modulacion de los receptores de histamina h3 y una composicion farmaceutica que los comprende. | |
AR066972A1 (es) | Derivados azapeptidicos | |
AR081828A1 (es) | Compuestos de biguanida y su uso para el tratamiento del cancer | |
PE20080378A1 (es) | Derivados tiofeno-pirazolalcanamida con actividad sobre los receptores ampa | |
CO6150150A2 (es) | Derivados de 7-alquinil-1,8-naftiridonas su prepacion y su aplicacion en terapeutica | |
AR075394A1 (es) | Derivados del acido fenoxiacetico, composiciones farmaceuticas que los contienen, metodo de preparacion y uso de los mismos en el tratamiento de enfermedades inflamatorias,alergicas y neurodegenerativas. | |
AR053341A1 (es) | Derivados azol triciclicos su fabricacion y uso como agentes farmaceuticos | |
PE20050292A1 (es) | Derivados de acido alcanoico sustituidos con aril-cicloalquilo, procedimientos para su obtencion y su empleo como medicamentos | |
AR079997A1 (es) | Derivados de acido carboxilico de oxazolo[5,4-d]pirimidinas utiles en el tratamiento del sindrome del pie diabetico(dfs), composiciones farmaceuticas que los contienen y metodo de preparacion de los mismos. | |
AR071790A1 (es) | Derivados de n-(2-amino-fenil)-acrilamidas, utiles como agentes antitumorales. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |