AR071790A1 - Derivados de n-(2-amino-fenil)-acrilamidas, utiles como agentes antitumorales. - Google Patents

Derivados de n-(2-amino-fenil)-acrilamidas, utiles como agentes antitumorales.

Info

Publication number
AR071790A1
AR071790A1 ARP090101736A ARP090101736A AR071790A1 AR 071790 A1 AR071790 A1 AR 071790A1 AR P090101736 A ARP090101736 A AR P090101736A AR P090101736 A ARP090101736 A AR P090101736A AR 071790 A1 AR071790 A1 AR 071790A1
Authority
AR
Argentina
Prior art keywords
alkyl
cycloalkyl
compounds
lower alkyl
unsubstituted
Prior art date
Application number
ARP090101736A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR071790A1 publication Critical patent/AR071790A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procesos para la obtencion de dichos compuestos as¡ como a los medicamentos que contienen dichos compuestos. Los compuestos de esta solicitud poseen actividad anti-proliferante e inductora de la diferenciacion y por ello son utiles para el tratamiento de enfermedades tales como el c ncer en seres humanos y en animales. Reivindicacion 1: Compuestos de la formula (1) en la que R1 es hidrogeno; alquilo inferior; cicloalquilo; heterociclilo; arilo o heteroarilo; y todos los grupos recien mencionados pueden estar sin sustituir o sustituidos una o varias veces por halogeno; alquilo inferior, que est  sin sustituir o sustituido una o varias veces por halogeno; alcoxi inferior; cicloalquilo; ciano; -NRaRb; -OCF3; o -S(O)2-alquilo inferior; en los que Ra/Rb con independencia entre s¡ son alquilo inferior o cicloalquilo, o junto con el  tomo de nitrogeno al que est n unidos pueden formar un heterociclilo de 4-6 eslabones; R2, R3, R4 se eligen con independencia entre hidrogeno; halogeno; alquilo interior, que est  sin sustituir o sustituido una vez por hidroxi; alcoxi inferior; hidroxi; heterociclilo; un grupo de formula (2), o -NRR', en el que R/R' con independencia entre s¡ son hidrogeno; alquilo inferior sustituido por hidroxi; -C(O)-alquilo inferior; o el mismo alquilo inferior u otro diferente; y n es el numero 0, 1 o 2; o R2 y R3 junto con los  tomos de carbono a los que est n unidos pueden formar un cicloalquilo de 4-6 eslabones, en el que uno de los  tomos de carbono puede haberse reemplazado por nitrogeno, ox¡geno o azufre; y sus sales farmaceuticamente activas, mezclas racemicas, enantiomeros, isomeros opticos o formas tautomeras.
ARP090101736A 2008-05-16 2009-05-14 Derivados de n-(2-amino-fenil)-acrilamidas, utiles como agentes antitumorales. AR071790A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP08156365 2008-05-16

Publications (1)

Publication Number Publication Date
AR071790A1 true AR071790A1 (es) 2010-07-14

Family

ID=40756614

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP090101736A AR071790A1 (es) 2008-05-16 2009-05-14 Derivados de n-(2-amino-fenil)-acrilamidas, utiles como agentes antitumorales.

Country Status (15)

Country Link
US (1) US7999000B2 (es)
EP (1) EP2280940A1 (es)
JP (1) JP2011519966A (es)
KR (1) KR20100132553A (es)
CN (1) CN102026969A (es)
AR (1) AR071790A1 (es)
AU (1) AU2009248231A1 (es)
BR (1) BRPI0912399A2 (es)
CA (1) CA2724003A1 (es)
CL (1) CL2009001150A1 (es)
IL (1) IL208873A0 (es)
MX (1) MX2010012297A (es)
PE (1) PE20100139A1 (es)
TW (1) TW200951110A (es)
WO (1) WO2009138338A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8202866B2 (en) * 2008-09-17 2012-06-19 Hoffmann-La Roche Inc. Ortho-aminoanilides for the treatment of cancer
JP2012518612A (ja) * 2009-02-23 2012-08-16 エフ．ホフマン−ラ ロシュ アーゲー ガンの治療のための新規なオルトアミノアミド類
US9212132B2 (en) 2011-12-05 2015-12-15 Ricoh Company Ltd. (Meth)acrylic acid ester, activation energy ray curing composition, and inkjet recording ink
EP2975031A4 (en) 2013-03-14 2017-04-19 Takeda Pharmaceutical Company Limited Heterocyclic compound
US10053468B2 (en) 2013-07-03 2018-08-21 Takeda Pharmaceutical Company Limited Heterocyclic compound
WO2015002230A1 (ja) 2013-07-03 2015-01-08 武田薬品工業株式会社 アミド化合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1033046B (it) 1970-10-31 1979-07-10 Finotto Martino Procedimento di fabbricazione di benzimidazoli sostituiti
DE2201062A1 (de) 1972-01-11 1973-07-26 Bayer Ag N-alkoxycarbonyl- bzw. n-alkylthiocarbonyl-2-(2'-thienyl)-benzimidazole, ein verfahren zu ihrer herstellung und ihre verwendung als fungizide
ATE514674T1 (de) * 1999-11-23 2011-07-15 Methylgene Inc Inhibitoren für histone-deacetylase
AU2002327627B2 (en) * 2001-09-14 2006-09-14 Methylgene Inc. Inhibitors of histone deacetylase
US7253204B2 (en) * 2004-03-26 2007-08-07 Methylgene Inc. Inhibitors of histone deacetylase
WO2006115845A1 (en) * 2005-04-20 2006-11-02 Merck & Co., Inc. Benzothiophene derivatives
CA2635210A1 (en) 2006-01-12 2007-08-02 Merck & Co., Inc. Hydroxyalkylarylamide derivatives
WO2007100657A2 (en) * 2006-02-28 2007-09-07 Merck & Co., Inc. Inhibitors of histone deacetylase
EP2238103A1 (en) * 2008-01-29 2010-10-13 F. Hoffmann-La Roche AG Novel n-(2-amino-phenyl)-amide derivatives

Also Published As

Publication number Publication date
MX2010012297A (es) 2010-12-06
CN102026969A (zh) 2011-04-20
EP2280940A1 (en) 2011-02-09
TW200951110A (en) 2009-12-16
AU2009248231A1 (en) 2009-11-19
CA2724003A1 (en) 2009-11-19
US20090286848A1 (en) 2009-11-19
KR20100132553A (ko) 2010-12-17
JP2011519966A (ja) 2011-07-14
CL2009001150A1 (es) 2010-06-11
WO2009138338A1 (en) 2009-11-19
IL208873A0 (en) 2011-01-31
US7999000B2 (en) 2011-08-16
BRPI0912399A2 (pt) 2016-01-12
PE20100139A1 (es) 2010-03-05

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