AR066909A1 - Compuestos inhibidores de transcriptasa inversa, composicion farmaceutica y uso en hiv - Google Patents
Compuestos inhibidores de transcriptasa inversa, composicion farmaceutica y uso en hivInfo
- Publication number
- AR066909A1 AR066909A1 ARP080102424A ARP080102424A AR066909A1 AR 066909 A1 AR066909 A1 AR 066909A1 AR P080102424 A ARP080102424 A AR P080102424A AR P080102424 A ARP080102424 A AR P080102424A AR 066909 A1 AR066909 A1 AR 066909A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkoxy
- alkyl
- optionally substituted
- cycloalkyl
- heterocycle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Reivindicacion 1: Un compuesto de la formula (1), en donde m es 1, 2, 3 o 4; n es 1, 2, 3 o 4; cada R1 es independientemente halogeno, -CN alquilo C1-5, alquenilo C2-5, alquinilo C2-6, cicloalquilo C3-7, hidroxilo, alcoxilo C1-8, -C(O)OR5, -C(O)N(R5)2, -OR5, -R3CN, o -N(R5)2; cada R2 es independientemente halogeno, -CN, alquilo C1-5, alquenilo C2-5, alquinilo C2-6, cicloalquilo C3-7, hidroxilo, alcoxilo C1-8, -C(O)OR5, -C(O)N(R5)2, -OR5, -R3CN o -N(R5)2; A es arilo C5-12 o heterociclo C5-12; Q es hidrogeno o alquilo C1-4, Y es -C(O)-, -S(O)2-, o -S(O)-; Z es arilo C4-12, heterociclo C3-14, R3Het, o R3Ar, cada uno opcionalmente sustituido con uno o más de alquilo C1-8, cicloalquilo C3-7, alcoxilo C1-8, halogeno, oxo, hidroxilo, -CN, -NO2, -N(R5)C(O)R5, -N(R5)2, -OR5, -C3-12 Het, -C(O)N(R5)2, C4-12 Ar, -SR5, -S(O)2N(R5)2, -OR3HetC(O)R5, -OCF3, -S(O)2R5, -OR3R5, -N(R5)C(O)R3OR5 -N(R5)C(O)R3N(R5)2, -N(R5)C(O)R3R5, -OR3N(R5)2, -R3Het, -R3N(R5)2, -R3N(R5)C(O)R5, -OR3SR5, -C(O)R5, -C(R5)3, -R3C(O)OR5, -R3C(O)N(R5)2, o -N(R5)S(O)2R5; o Z está enlazado con Q para formar un heterociclo C4-14 junto con el átomo de nitrogeno y el grupo Y con el que están unidos, y están opcionalmente sustituidos con -C(O)OR5 o alcoxilo C1-6; cada R5 es independientemente hidrogeno, alquilo C1-8, cicloalquilo C3-7, oxo, heterociclo C3-12, arilo C4-12, o alcoxilo C1-8, cada uno opcionalmente sustituido con hidroxilo, alcoxilo C1-4, o cicloalquilo C3-7; R3 es alquenileno C2-6 o alquileno C1-4, cada uno opcionalmente sustituido con hidroxilo o alcoxilo C1-8; Het es heterociclo C3-12 y está opcionalmente sustituido con uno o más de alquilo C1-6, -C(O)N(R5)2, -R3S(O)2R5, o halogeno; y Ar es arilo C4-12 y está opcionalmente sustituido con uno o más de alquilo C1-6 o halogeno; o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94226607P | 2007-06-06 | 2007-06-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR066909A1 true AR066909A1 (es) | 2009-09-23 |
Family
ID=40130130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080102424A AR066909A1 (es) | 2007-06-06 | 2008-06-06 | Compuestos inhibidores de transcriptasa inversa, composicion farmaceutica y uso en hiv |
Country Status (25)
Country | Link |
---|---|
US (1) | US8304419B2 (es) |
EP (1) | EP2166856A4 (es) |
JP (1) | JP2010529965A (es) |
KR (1) | KR20100039301A (es) |
CN (1) | CN101790313A (es) |
AR (1) | AR066909A1 (es) |
AU (1) | AU2008261977A1 (es) |
BR (1) | BRPI0812738A2 (es) |
CA (1) | CA2694871A1 (es) |
CL (1) | CL2008001631A1 (es) |
CO (1) | CO6251246A2 (es) |
CR (1) | CR11196A (es) |
DO (1) | DOP2009000266A (es) |
EA (1) | EA017141B1 (es) |
IL (1) | IL202217A0 (es) |
MA (1) | MA31500B1 (es) |
MX (1) | MX2009013349A (es) |
NZ (1) | NZ581409A (es) |
PE (1) | PE20090330A1 (es) |
SG (1) | SG182162A1 (es) |
TW (1) | TW200901969A (es) |
UA (1) | UA98784C2 (es) |
UY (1) | UY31132A1 (es) |
WO (1) | WO2008154271A1 (es) |
ZA (1) | ZA200908604B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2076492A4 (en) * | 2006-10-06 | 2010-12-22 | Merck Sharp & Dohme | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS |
CN102264737A (zh) * | 2008-12-23 | 2011-11-30 | 雅培制药有限公司 | 抗病毒化合物 |
JP2012513410A (ja) | 2008-12-23 | 2012-06-14 | アボット・ラボラトリーズ | 抗ウイルス化合物 |
CN102459165B (zh) | 2009-04-15 | 2015-09-02 | Abbvie公司 | 抗病毒化合物 |
WO2011017030A2 (en) * | 2009-08-06 | 2011-02-10 | Neuraltus Pharmaceuticals, Inc. | Treatment of macrophage-related disorders |
JP5851998B2 (ja) * | 2009-10-27 | 2016-02-03 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 殺虫剤および殺ダニ剤としてのハロアルキル置換アミド |
EP2496578A4 (en) | 2009-11-05 | 2013-08-21 | Univ Notre Dame Du Lac | IMIDAZO [1,2-A] PYRIDINE COMPOUNDS, THEIR SYNTHESIS AND METHODS OF USE THEREOF |
NZ602311A (en) * | 2010-03-18 | 2014-08-29 | Pasteur Institut Korea | Anti-infective compounds |
JP2013526581A (ja) * | 2010-05-21 | 2013-06-24 | ギリアード サイエンシーズ, インコーポレイテッド | ヘテロ環式フラビウイルス科ウイルス阻害剤 |
US8987307B2 (en) | 2011-03-03 | 2015-03-24 | Hoffmann-La Roche Inc. | 3-amino-pyridines as GPBAR1 agonists |
EP2511263A1 (en) | 2011-04-14 | 2012-10-17 | Phenex Pharmaceuticals AG | Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORgamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases |
KR20150000884A (ko) | 2012-04-04 | 2015-01-05 | 에프. 호프만-라 로슈 아게 | Gpbar1 조절제로서 1,2-피리다진, 1,6-피리다진 또는 피리미딘-벤즈아미드 유도체 |
EP2963013A4 (en) | 2013-02-27 | 2016-09-14 | Shionogi & Co | INDOLE AND AZAINDOLE DERIVATIVES HAVING AMPK ACTIVATION ACTIVITY EACH |
JO3603B1 (ar) * | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
KR20180022826A (ko) | 2015-07-02 | 2018-03-06 | 얀센 사이언시즈 아일랜드 유씨 | 항균 화합물 |
KR20180053386A (ko) | 2015-09-17 | 2018-05-21 | 마빈 제이. 밀러 | 마이코박테리아 감염에 대해 유용한 벤질 아민-함유 헤테로사이클릭 화합물 및 조성물 |
KR20190017948A (ko) | 2016-06-16 | 2019-02-20 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 항균제로서의 헤테로고리 화합물 |
WO2018073828A1 (en) | 2016-10-20 | 2018-04-26 | B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Dna primase and gyrase inhibitors |
CN110831630A (zh) | 2017-03-01 | 2020-02-21 | 爱尔兰詹森科学公司 | 组合疗法 |
CN109748927A (zh) * | 2017-11-03 | 2019-05-14 | 上海交通大学医学院附属瑞金医院 | 杂芳基酰胺类化合物、其制备方法、药用组合物及其应用 |
WO2019168164A1 (ja) * | 2018-03-02 | 2019-09-06 | 国立大学法人大阪大学 | タンパク質及び/又はペプチド修飾用分子 |
US11370758B2 (en) * | 2018-03-23 | 2022-06-28 | Cmg Pharmaceutical Co., Ltd. | IDO-TDO dual inhibitor and related methods of use |
CN111954532A (zh) * | 2018-04-13 | 2020-11-17 | 上海交通大学医学院附属瑞金医院 | 杂芳基酰胺类化合物的抗肿瘤多药耐药性、治疗癌症的用途和蛋白质-药物分子复合物 |
JP2022513310A (ja) | 2018-10-02 | 2022-02-07 | ディスク・メディスン,インコーポレイテッド | マトリプターゼ2阻害剤及びその使用 |
US10959987B2 (en) | 2019-04-15 | 2021-03-30 | King Abdulaziz University | Imidazole-based compounds as hepatitis C virus inhibitors |
KR102051783B1 (ko) * | 2019-09-02 | 2019-12-03 | 부산대학교 산학협력단 | 3,10-이치환 벤조풀벤 유도체의 신규 합성방법 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9716446D0 (en) * | 1997-08-05 | 1997-10-08 | Agrevo Uk Ltd | Fungicides |
JP2000256323A (ja) * | 1999-01-08 | 2000-09-19 | Japan Tobacco Inc | 2−オキソキノリン化合物及びその医薬用途 |
DE10161765A1 (de) * | 2001-12-15 | 2003-07-03 | Bayer Cropscience Gmbh | Substituierte Phenylderivate |
AU2004220225B2 (en) * | 2003-03-14 | 2010-06-17 | Ono Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic derivatives and drugs containing the same as the active ingredient |
NZ544980A (en) * | 2003-09-11 | 2009-02-28 | Tibotec Pharm Ltd | Entry inhibitors of the HIV virus |
WO2005026114A1 (en) * | 2003-09-17 | 2005-03-24 | Pfizer Inc. | Hiv protease inhibitors, compositions containing the same and their pharmaceutical uses |
US20070082907A1 (en) * | 2003-11-25 | 2007-04-12 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
CA2563180C (en) * | 2004-04-23 | 2013-08-06 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
US7166738B2 (en) * | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
US20060004197A1 (en) * | 2004-07-02 | 2006-01-05 | Thomas Thrash | Sulfonamide-based compounds as protein tyrosine kinase inhibitors |
US20060025480A1 (en) * | 2004-08-02 | 2006-02-02 | Boehringer Ingelheim International Gmbh | Benzoic acid derivatives as non nucleoside reverse transcriptase inhibitors |
AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
US7606430B2 (en) * | 2005-08-30 | 2009-10-20 | Asml Netherlands B.V. | Lithographic apparatus and device manufacturing method utilizing a multiple dictionary compression method for FPD |
EP2155692B1 (en) * | 2007-05-30 | 2015-06-17 | F. Hoffmann-La Roche AG | Non-nucleoside reverse transcriptase inhibitors |
-
2008
- 2008-06-04 CL CL2008001631A patent/CL2008001631A1/es unknown
- 2008-06-04 TW TW097120769A patent/TW200901969A/zh unknown
- 2008-06-05 BR BRPI0812738-7A2A patent/BRPI0812738A2/pt not_active IP Right Cessation
- 2008-06-05 SG SG2012041091A patent/SG182162A1/en unknown
- 2008-06-05 MX MX2009013349A patent/MX2009013349A/es not_active Application Discontinuation
- 2008-06-05 PE PE2008000971A patent/PE20090330A1/es not_active Application Discontinuation
- 2008-06-05 NZ NZ581409A patent/NZ581409A/en not_active IP Right Cessation
- 2008-06-05 EA EA200901490A patent/EA017141B1/ru not_active IP Right Cessation
- 2008-06-05 AU AU2008261977A patent/AU2008261977A1/en not_active Abandoned
- 2008-06-05 JP JP2010511315A patent/JP2010529965A/ja active Pending
- 2008-06-05 UA UAA200911848A patent/UA98784C2/ru unknown
- 2008-06-05 KR KR1020097027635A patent/KR20100039301A/ko not_active Application Discontinuation
- 2008-06-05 US US12/667,581 patent/US8304419B2/en not_active Expired - Fee Related
- 2008-06-05 CN CN200880102121A patent/CN101790313A/zh active Pending
- 2008-06-05 EP EP08756713A patent/EP2166856A4/en not_active Withdrawn
- 2008-06-05 CA CA2694871A patent/CA2694871A1/en not_active Abandoned
- 2008-06-05 WO PCT/US2008/065865 patent/WO2008154271A1/en active Application Filing
- 2008-06-06 AR ARP080102424A patent/AR066909A1/es not_active Application Discontinuation
- 2008-06-06 UY UY31132A patent/UY31132A1/es not_active Application Discontinuation
-
2009
- 2009-11-18 IL IL202217A patent/IL202217A0/en unknown
- 2009-11-27 DO DO2009000266A patent/DOP2009000266A/es unknown
- 2009-12-03 ZA ZA2009/08604A patent/ZA200908604B/en unknown
- 2009-12-09 CO CO09140797A patent/CO6251246A2/es active IP Right Grant
-
2010
- 2010-01-04 MA MA32473A patent/MA31500B1/fr unknown
- 2010-01-06 CR CR11196A patent/CR11196A/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
TW200901969A (en) | 2009-01-16 |
US20100216746A1 (en) | 2010-08-26 |
CL2008001631A1 (es) | 2009-01-02 |
CA2694871A1 (en) | 2008-12-18 |
CO6251246A2 (es) | 2011-02-21 |
BRPI0812738A2 (pt) | 2014-09-30 |
KR20100039301A (ko) | 2010-04-15 |
EA200901490A1 (ru) | 2010-06-30 |
SG182162A1 (en) | 2012-07-30 |
UY31132A1 (es) | 2009-03-31 |
EP2166856A1 (en) | 2010-03-31 |
CR11196A (es) | 2010-03-08 |
WO2008154271A1 (en) | 2008-12-18 |
MX2009013349A (es) | 2010-01-20 |
MA31500B1 (fr) | 2010-07-01 |
IL202217A0 (en) | 2010-06-16 |
US8304419B2 (en) | 2012-11-06 |
CN101790313A (zh) | 2010-07-28 |
EA017141B1 (ru) | 2012-10-30 |
NZ581409A (en) | 2012-03-30 |
JP2010529965A (ja) | 2010-09-02 |
UA98784C2 (ru) | 2012-06-25 |
PE20090330A1 (es) | 2009-04-30 |
AU2008261977A1 (en) | 2008-12-18 |
EP2166856A4 (en) | 2012-05-30 |
DOP2009000266A (es) | 2010-02-15 |
ZA200908604B (en) | 2011-02-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR066909A1 (es) | Compuestos inhibidores de transcriptasa inversa, composicion farmaceutica y uso en hiv | |
AR063240A1 (es) | Derivados de n-aril pirazol,composiciones farmaceuticas que los contienen y usos para el tratamiento de la diabetes tipo2,y enfermedades relacionadas. | |
PE20180227A1 (es) | Benzamidas sustituidas con 1,3-tiazol-2-ilo | |
AR105836A1 (es) | Compuestos y composiciones útiles para tratar trastornos relacionados con ntrk | |
AR101106A1 (es) | Inhibidores de tirosina quinasa de bruton | |
PE20090641A1 (es) | Amidas heterociclicas | |
AR072249A1 (es) | Inhibidores de amida hidrolasa de acido graso. usos. metodos. | |
AR043367A2 (es) | Derivados de benzofenona, composiciones farmaceuticas y procesos de preparacion. | |
AR074336A1 (es) | Compuestos de arilo con sustituyentes heterociclicos y su uso | |
ES2569539T3 (es) | Derivados de piperidin-4-il azetidina como inhibidores de JAK1 | |
ES2616477T3 (es) | Heterociclaminas como inhibidores de pi3k | |
AR049711A1 (es) | Compuestos heterociclicos condensados como inhibidores de la aldosterona sintasa; composiciones farmaceuticas que los contienen y su uso en la preparacion de un medicamento para el tratamiento o prevencion de enfermedades relacionadas con el hiperaldosterismo y por una liberacion excesiva de cortiso | |
AR061101A1 (es) | Compuesto de fenil-triazolil- metoxi- arilo, su uso para la manufactura de un medicamento y composicion farmaceutica que lo comprende | |
AR049126A1 (es) | Derivados de 5, 6, 7, 8 - tetrahidroimidazo[1,5a]piridina con actividad inhibitoria de la aldosterona sintasa, composiciones farmaceuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento del hiperaldosterismo y del sindrome de cushing. | |
AR071857A1 (es) | Derivados de indazol sustituidos con fenilo y benzodioxinilo, una composicion farmaceutica que los comprende y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por el receptor de glucocorticoides. | |
AR076775A1 (es) | Inhibidores de la replicacion del virus de la inmunodeficiencia humana | |
AR055344A1 (es) | Derivados de 1-oxoindano y 1-oxo-2,3-dihidroisoindol como inhibidores de p38, composiciones farmaceuticas que los contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mediadas por la cinasa p38 | |
AR058362A1 (es) | Derivados de isoquinolina - aminopirazol su obtencion y su utilizacion como agentes farmaceuticos | |
PE20090042A1 (es) | Analogos de ciclopamina | |
AR092505A2 (es) | Compuestos antivirales | |
AR035174A1 (es) | Compuesto derivado de beta-aminoacido, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para tratar o prevenir trastornos inflamatorios y enfermedades mediadas por mmp, tnf y agrecansa y combinaciones de los mismos | |
AR064010A1 (es) | Inhibidores de la actividad de la akt | |
AR062510A1 (es) | Derivados de piridona con actividad antagonista de mch y medicamentos que comprenden estos compuestos | |
PE20081448A1 (es) | Inhibidores de transcriptasa inversa no nucleosidicos | |
AR078733A1 (es) | Compuestos heterociclicos fusionados como moduladores del receptor de orexina |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |