AR065373A1 - Proteinas de fusion de inmunoglobulina y metodos de elaboracion - Google Patents
Proteinas de fusion de inmunoglobulina y metodos de elaboracionInfo
- Publication number
- AR065373A1 AR065373A1 ARP080100659A ARP080100659A AR065373A1 AR 065373 A1 AR065373 A1 AR 065373A1 AR P080100659 A ARP080100659 A AR P080100659A AR P080100659 A ARP080100659 A AR P080100659A AR 065373 A1 AR065373 A1 AR 065373A1
- Authority
- AR
- Argentina
- Prior art keywords
- immunoglobulin
- protein
- polypeptide
- immunoglobulin polypeptide
- fusion proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Plant Pathology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se revelan proteínas de fusion de inmunoglobulina y métodos de elaboracion de dichas proteínas.La proteína de fusion puede incluir un polipéptido no inmunoglobulina unido a un polipéptido inmunoglobulina, el polipéptido, no inmunoglobulina puedaincluir una region. que reemplaza a una region bisagra Fc de inmunoglobulina, pero que permite el ensamble correcto de las cadenas de inmunoglobulina tambien un acido nucleico que codifica dicha proteina un receptor que comprende el acido nucleicoasi como una celula que expresa la proteina. Reivindicacion 1: Una proteína de fusion que comprende: (a) un polipéptido inmunogiobulina del cual se ha extraído la region bisagra; y (b) un polipéptido no inmunoglobulina que comprende una porcionininterrumpida de una proteína supergénica de inmunoglobulina, en donde la porcion ininterrumpida de la proteína supergénica de inmunoglobulina está compuésta de un primer dominio de polipéptido no inmunoglobulina directamente unido al extremo N-terminal de un primer conector entre dominios, y en donde el polipéptido inmunoglobulina está unido de manera operable al extremo C-terminal del primer conector entre dominios.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90154007P | 2007-02-15 | 2007-02-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR065373A1 true AR065373A1 (es) | 2009-06-03 |
Family
ID=39690682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080100659A AR065373A1 (es) | 2007-02-15 | 2008-02-15 | Proteinas de fusion de inmunoglobulina y metodos de elaboracion |
Country Status (6)
Country | Link |
---|---|
US (2) | US20080199467A1 (es) |
AR (1) | AR065373A1 (es) |
CL (1) | CL2008000460A1 (es) |
TW (1) | TW200848071A (es) |
UY (1) | UY30925A1 (es) |
WO (1) | WO2008100470A2 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3192872A1 (en) | 2003-08-26 | 2017-07-19 | The Regents of the University of Colorado, a body corporate | Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections |
EP1776459A1 (en) * | 2004-08-03 | 2007-04-25 | Transtech Pharma, Inc. | Rage fusion proteins and methods of use |
NZ552128A (en) * | 2004-08-03 | 2009-09-25 | Transtech Pharma Inc | Rage fusion proteins without Fc hinge region and methods of use |
CA2634908C (en) * | 2005-12-23 | 2015-05-19 | Gcoder Systems Ab | Positioning pattern |
US20090004190A1 (en) * | 2006-02-09 | 2009-01-01 | Mjalli Adnan M M | Rage Fusion Proteins And Methods Of Use |
US7981424B2 (en) | 2006-05-05 | 2011-07-19 | Transtech Pharma, Inc. | RAGE fusion proteins, formulations, and methods of use thereof |
US20080199467A1 (en) * | 2007-02-15 | 2008-08-21 | Mjalli Adnan M M | Immunoglobulin fusion proteins and methods of making |
ES2564634T3 (es) | 2007-06-14 | 2016-03-28 | Galactica Pharmaceuticals, Inc. | Proteínas de fusión de RAGE |
EP2250196B1 (en) | 2008-01-31 | 2012-12-26 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Engineered constant domain molecule of an antibody |
EP2421892A1 (en) | 2009-04-20 | 2012-02-29 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
JP6216921B2 (ja) | 2011-06-24 | 2017-11-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | アルファ−1抗トリプシン融合分子のための組成物、方法および使用 |
EP2802653A4 (en) | 2012-01-10 | 2015-09-02 | Univ Colorado Regents | ALPHA-1 ANTITRYPSIN FUSION MOLECULE COMPOSITIONS, METHODS AND USES THEREOF |
EP3442554A4 (en) * | 2016-04-14 | 2019-12-04 | Iconic Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATING DISEASES RELATED TO NEOVASCULARIZATION |
EP3483180A1 (en) * | 2017-11-14 | 2019-05-15 | Affilogic | Multi specific molecules |
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US5656261A (en) * | 1995-01-18 | 1997-08-12 | The Picower Institute For Medical Research | Preventing and reversing advanced glycosylation endproducts |
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US7258857B2 (en) * | 1996-11-22 | 2007-08-21 | The Trustees Of Columbia University In The City Of New York | Rage-related methods for treating inflammation |
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US7981424B2 (en) * | 2006-05-05 | 2011-07-19 | Transtech Pharma, Inc. | RAGE fusion proteins, formulations, and methods of use thereof |
US20080199467A1 (en) * | 2007-02-15 | 2008-08-21 | Mjalli Adnan M M | Immunoglobulin fusion proteins and methods of making |
-
2008
- 2008-02-11 US US12/069,499 patent/US20080199467A1/en not_active Abandoned
- 2008-02-11 WO PCT/US2008/001786 patent/WO2008100470A2/en active Application Filing
- 2008-02-13 CL CL200800460A patent/CL2008000460A1/es unknown
- 2008-02-15 UY UY30925A patent/UY30925A1/es not_active Application Discontinuation
- 2008-02-15 TW TW097105462A patent/TW200848071A/zh unknown
- 2008-02-15 AR ARP080100659A patent/AR065373A1/es unknown
-
2010
- 2010-10-06 US US12/899,073 patent/US20110110945A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20080199467A1 (en) | 2008-08-21 |
WO2008100470A3 (en) | 2008-12-24 |
TW200848071A (en) | 2008-12-16 |
UY30925A1 (es) | 2008-09-30 |
CL2008000460A1 (es) | 2008-08-22 |
US20110110945A1 (en) | 2011-05-12 |
WO2008100470A2 (en) | 2008-08-21 |
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