AR063559A1 - Compuesto de tetrahidrociclopenta [b] indol, su uso para la manufactura de un medicamento y composicion farmaceutica que lo comprende - Google Patents

Compuesto de tetrahidrociclopenta [b] indol, su uso para la manufactura de un medicamento y composicion farmaceutica que lo comprende

Info

Publication number
AR063559A1
AR063559A1 ARP070104913A ARP070104913A AR063559A1 AR 063559 A1 AR063559 A1 AR 063559A1 AR P070104913 A ARP070104913 A AR P070104913A AR P070104913 A ARP070104913 A AR P070104913A AR 063559 A1 AR063559 A1 AR 063559A1
Authority
AR
Argentina
Prior art keywords
alkyl
manufacture
nrarb
cyclopropyl
reduction
Prior art date
Application number
ARP070104913A
Other languages
English (en)
Spanish (es)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR063559A1 publication Critical patent/AR063559A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/58[b]- or [c]-condensed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/58[b]- or [c]-condensed
    • C07D209/70[b]- or [c]-condensed containing carbocyclic rings other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
ARP070104913A 2006-11-20 2007-11-05 Compuesto de tetrahidrociclopenta [b] indol, su uso para la manufactura de un medicamento y composicion farmaceutica que lo comprende AR063559A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86648406P 2006-11-20 2006-11-20

Publications (1)

Publication Number Publication Date
AR063559A1 true AR063559A1 (es) 2009-02-04

Family

ID=39415431

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070104913A AR063559A1 (es) 2006-11-20 2007-11-05 Compuesto de tetrahidrociclopenta [b] indol, su uso para la manufactura de un medicamento y composicion farmaceutica que lo comprende

Country Status (36)

Country Link
US (1) US7968587B2 (cg-RX-API-DMAC7.html)
EP (1) EP2094658B1 (cg-RX-API-DMAC7.html)
JP (1) JP5399259B2 (cg-RX-API-DMAC7.html)
KR (1) KR101121471B1 (cg-RX-API-DMAC7.html)
CN (1) CN101541749B (cg-RX-API-DMAC7.html)
AR (1) AR063559A1 (cg-RX-API-DMAC7.html)
AT (1) ATE538091T1 (cg-RX-API-DMAC7.html)
AU (1) AU2007324046B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0719092B8 (cg-RX-API-DMAC7.html)
CA (1) CA2670340C (cg-RX-API-DMAC7.html)
CL (1) CL2007003182A1 (cg-RX-API-DMAC7.html)
CO (1) CO6190513A2 (cg-RX-API-DMAC7.html)
CR (1) CR10802A (cg-RX-API-DMAC7.html)
CY (1) CY1112284T1 (cg-RX-API-DMAC7.html)
DK (1) DK2094658T3 (cg-RX-API-DMAC7.html)
EA (1) EA015627B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP099350A (cg-RX-API-DMAC7.html)
ES (1) ES2376048T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20120032T1 (cg-RX-API-DMAC7.html)
IL (1) IL198410A (cg-RX-API-DMAC7.html)
JO (1) JO2800B1 (cg-RX-API-DMAC7.html)
MA (1) MA31072B1 (cg-RX-API-DMAC7.html)
MX (1) MX2009005251A (cg-RX-API-DMAC7.html)
MY (1) MY154547A (cg-RX-API-DMAC7.html)
NO (1) NO342531B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ576296A (cg-RX-API-DMAC7.html)
PE (1) PE20081161A1 (cg-RX-API-DMAC7.html)
PL (1) PL2094658T3 (cg-RX-API-DMAC7.html)
PT (1) PT2094658E (cg-RX-API-DMAC7.html)
RS (1) RS52191B (cg-RX-API-DMAC7.html)
SI (1) SI2094658T1 (cg-RX-API-DMAC7.html)
TN (1) TN2009000189A1 (cg-RX-API-DMAC7.html)
TW (1) TWI398438B (cg-RX-API-DMAC7.html)
UA (1) UA98777C2 (cg-RX-API-DMAC7.html)
WO (1) WO2008063867A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA200903096B (cg-RX-API-DMAC7.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2488990T3 (es) 2008-02-22 2014-09-01 Radius Health, Inc. Moduladores selectivos del receptor de andrógenos
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
SI2297100T1 (sl) * 2008-05-16 2013-02-28 Eli Lilly & Company Tetrahidrociklopenta(b)indoli kot modulatorji androgenskega receptorja
AR078862A1 (es) 2009-11-13 2011-12-07 Lilly Co Eli Ester isopropilico del acido ((s)-7-ciano-4-((2r,3s)-3-hidroxitetrahidrofuran-2-ilmetil)-1,2,3,4-tetrahidro-ciclopenta(b)indol-2-il)carbamico, composiciones farmaceuticas que lo comprenden y su uso en terapia
AU2011212813B2 (en) 2010-02-04 2014-10-23 Radius Health, Inc. Selective androgen receptor modulators
DK2568806T3 (en) 2010-05-12 2016-08-15 Radius Health Inc therapy Programs
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
WO2012047617A1 (en) 2010-09-28 2012-04-12 Radius Health, Inc. Selective androgen receptor modulators
US20140113824A1 (en) 2011-05-10 2014-04-24 Bayer Intellectual Property Gmbh Bicyclic (thio)carbonylamidines
CN103265479B (zh) * 2013-06-14 2017-12-08 南开大学 一种6‑氯甲基烟酸叔丁酯的合成方法
PL3122426T3 (pl) 2014-03-28 2023-05-15 Duke University Leczenie raka sutka z zastosowaniem selektywnych modulatorów receptora estrogenowego
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
JOP20180072A1 (ar) * 2014-09-11 2019-01-30 Lilly Co Eli علاج الأعراض المرتبطة بالعلاج بالحرمان من الأندروجين
HRP20220619T1 (hr) 2016-06-22 2023-02-03 Ellipses Pharma Ltd Postupci za liječenje ar+ raka dojke
US20180185347A1 (en) 2016-11-16 2018-07-05 Transition Therapeutics (Ireland 2) Limited Tetrahydrocyclopenta[b]indole compounds and phosphodiesterase inhibitors for the treatment of the signs and symptoms of bhp
EP3565542B1 (en) 2017-01-05 2024-04-10 Radius Pharmaceuticals, Inc. Polymorphic forms of rad1901-2hcl
SG11202013177WA (en) 2018-07-04 2021-01-28 Radius Pharmaceuticals Inc Polymorphic forms of rad 1901-2hcl
MA54946A (fr) 2019-02-12 2021-12-22 Radius Pharmaceuticals Inc Procédés et composés
AU2021213297A1 (en) * 2020-01-27 2022-08-18 Eirgen Pharma Ltd. Tetrahydrocyclopenta[b]indole compounds for the treatment of renal disease
US11986461B1 (en) * 2023-08-24 2024-05-21 King Faisal University 3-(1-(3-(dimethylamino)propyl)-4,5-diphenyl-1H-imidazol-2-yl)pyridin-2-ol as an antitumor and antimicrobial compound

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US4988820A (en) 1986-02-21 1991-01-29 Bayer Aktiengesellschaft Cycloalkano(1,2-B) indole-sulponamides
GB8924392D0 (en) 1989-10-30 1989-12-20 Bayer Ag Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) 1990-04-10 1990-06-06 Bayer Ag Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
DE4027278A1 (de) 1990-08-29 1992-03-05 Bayer Ag Heterocyclisch substituierte indolsulfonamide
DE4131346A1 (de) 1991-09-20 1993-03-25 Bayer Ag Indolsulfonamid substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
AU7558900A (en) * 1999-10-14 2001-04-23 Kaken Pharmaceutical Co., Ltd. Tetrahydroquinoline derivatives
EP1423366A1 (en) 2001-08-09 2004-06-02 Eli Lilly And Company Cyclopenta b ! indole derivatives as spla2 inhibitors
DE10164564B4 (de) 2001-12-14 2007-05-16 Zentaris Gmbh Tetrahydrocarbazolderivate als Liganden für G-Protein gekoppelte Rezeptoren (GPCR)
JP4484108B2 (ja) 2002-05-16 2010-06-16 塩野義製薬株式会社 Pgd2受容体拮抗作用を有する化合物
US20060074124A1 (en) 2003-09-12 2006-04-06 Andrew Napper Methods of treating a disorder
US20050245540A1 (en) * 2003-12-09 2005-11-03 Fujisawa Pharmaceutical Co., Ltd. New methods
US7019022B2 (en) 2003-12-15 2006-03-28 Merck Frosst Canada & Co. Substituted tetrahydrocarbazole and cyclopentanoindole derivatives
BRPI0507657A (pt) * 2004-03-03 2007-07-10 Lilly Co Eli composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, método para tratar um distúrbio, e, uso de um composto ou um sal farmaceuticamente aceitável do mesmo
US20090170923A1 (en) * 2004-11-22 2009-07-02 Kristjan Gudmundsson Hcv inhibitors
EP1817025A2 (en) 2004-11-23 2007-08-15 PTC Therapeutics, Inc. Tetrahydrocarbazoles as active agents for inhibiting vegf production by translational control
US7297704B2 (en) 2005-02-17 2007-11-20 Wyeth Cycloalkyfused indole, benzothiophene, benzofuran and idene derivatives
ES2339480T3 (es) 2005-06-24 2010-05-20 Eli Lilly And Company Derivados de tetrahidrocarbazol utiles como moduladores del receptor de androgenos (sarm).
US20090022694A1 (en) 2005-10-18 2009-01-22 Distefano Peter Sirt1 inhibition
WO2008019825A1 (en) 2006-08-14 2008-02-21 Santhera Pharmaceuticals (Schweiz) Ag Use of tricyclic indole derivatives for the treatment of muscular diseases
SI2297100T1 (sl) 2008-05-16 2013-02-28 Eli Lilly & Company Tetrahidrociklopenta(b)indoli kot modulatorji androgenskega receptorja

Also Published As

Publication number Publication date
BRPI0719092B8 (pt) 2021-05-25
RS52191B (sr) 2012-10-31
PE20081161A1 (es) 2008-08-15
TN2009000189A1 (en) 2010-10-18
TW200827347A (en) 2008-07-01
US20100069404A1 (en) 2010-03-18
CA2670340A1 (en) 2008-05-29
CR10802A (es) 2009-07-13
MY154547A (en) 2015-06-30
DK2094658T3 (da) 2012-02-13
TWI398438B (zh) 2013-06-11
AU2007324046A1 (en) 2008-05-29
ATE538091T1 (de) 2012-01-15
KR101121471B1 (ko) 2012-02-28
AU2007324046B2 (en) 2012-04-05
PT2094658E (pt) 2012-02-22
CY1112284T1 (el) 2015-12-09
MX2009005251A (es) 2009-08-19
EA015627B1 (ru) 2011-10-31
SI2094658T1 (sl) 2012-04-30
NO20092103L (no) 2009-05-28
NZ576296A (en) 2011-11-25
WO2008063867A3 (en) 2008-07-31
JP2010510231A (ja) 2010-04-02
BRPI0719092B1 (pt) 2020-08-18
BRPI0719092A2 (pt) 2013-12-03
IL198410A0 (en) 2010-02-17
US7968587B2 (en) 2011-06-28
EA200970500A1 (ru) 2009-10-30
MA31072B1 (fr) 2010-01-04
HK1134089A1 (en) 2010-04-16
NO342531B1 (no) 2018-06-11
UA98777C2 (en) 2012-06-25
EP2094658B1 (en) 2011-12-21
PL2094658T3 (pl) 2012-05-31
ZA200903096B (en) 2010-07-28
CN101541749B (zh) 2013-03-27
CL2007003182A1 (es) 2008-06-27
ECSP099350A (es) 2009-06-30
EP2094658A2 (en) 2009-09-02
IL198410A (en) 2013-09-30
CA2670340C (en) 2014-05-20
ES2376048T3 (es) 2012-03-08
WO2008063867A2 (en) 2008-05-29
KR20090082229A (ko) 2009-07-29
CN101541749A (zh) 2009-09-23
HRP20120032T1 (hr) 2012-02-29
JO2800B1 (en) 2014-03-15
JP5399259B2 (ja) 2014-01-29
CO6190513A2 (es) 2010-08-19

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