AR063371A1 - Derivados de benzacepin-2 (1h) -ona - Google Patents
Derivados de benzacepin-2 (1h) -onaInfo
- Publication number
- AR063371A1 AR063371A1 ARP070104703A ARP070104703A AR063371A1 AR 063371 A1 AR063371 A1 AR 063371A1 AR P070104703 A ARP070104703 A AR P070104703A AR P070104703 A ARP070104703 A AR P070104703A AR 063371 A1 AR063371 A1 AR 063371A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- crarb
- crcrd
- ch2ph
- benzacepin
- Prior art date
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 5
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003674 animal food additive Substances 0.000 abstract 1
- 102000014974 beta2-adrenergic receptor activity proteins Human genes 0.000 abstract 1
- 108040006828 beta2-adrenergic receptor activity proteins Proteins 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 244000144972 livestock Species 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Derivados de benzacepin-2-(1H)-ona y sales farmacéuticamente aceptables de los mismos son agonistas del adrenoceptor beta-2. Son utiles como aditivos de pienso para animales de ganado. Reivindicacion 1: Un compuesto de formula (1) o un profármaco farmacéuticamente aceptable del mismo, o una sal farmacéutica o veterinariamente aceptable de dicho compuesto o profármaco, en la que A es CH2, CH-alquilo C1-3 o C-(alquilo C1-3)2; y B es un enlace covalente, -CRARB-, -CRARB-CRCRD-, -CRARB-CRCRD- CRERF-, -CRARB-O, -OCRARB-, -O-CRARB-CRCRD-, -CRARB-O-CRCRD-, o -CRARB-CRCRD-O-; o -A-B- es -CRA=CRB-; RA, RB, RC, RD, RE y RF se seleccionan cada uno independientemente de H o alquilo C1-3; R1 y R2 son cada uno independientemente H o alquilo C1-3, o R1 y R2 junto con el átomo de carbono al que están unidos forman un anillo carbocíclico saturado de 3 a 6 miembros; y Het es un grupo heteroarilo monocíclico de 5 o 6 miembros o bicíclico de 9 o 10 miembros que puede estar opcionalmente sustituido con hasta 3 grupos independientemente seleccionados de halo, -CN, alquilo C1-4, -CH2Ph, -OH, -O- alquilo C1-4, -O-CH2-cicloalquilo C3-6, -O-CH2Ph, -NH2, -NH-alquilo C1-4, -N(alquilo C1-4)2, -CONH2, -CONH-alquilo C1-4, -CON-(alquilo C1-4)2, -CO2H y - CO2-alquilo C1-4.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86286806P | 2006-10-25 | 2006-10-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063371A1 true AR063371A1 (es) | 2009-01-21 |
Family
ID=38922427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104703A AR063371A1 (es) | 2006-10-25 | 2007-10-24 | Derivados de benzacepin-2 (1h) -ona |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20080103130A1 (es) |
| AR (1) | AR063371A1 (es) |
| CL (1) | CL2007003083A1 (es) |
| TW (1) | TW200824688A (es) |
| UY (1) | UY30664A1 (es) |
| WO (1) | WO2008050207A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101150634B1 (ko) * | 2007-02-01 | 2012-07-04 | 인터벳 인터내셔널 비.브이. | 6-아미노-7-히드록시-4,5,6,7-테트라히드로-이미다조［4,5,1-ｊｋ］［1］-벤즈아제핀-2［1ｈ］-온 및 질파테롤의 에난시오선택적 합성 |
| KR101240147B1 (ko) * | 2007-03-31 | 2013-03-08 | 인터벳 인터내셔널 비.브이. | 질파테롤 및 이의 염의 제조 방법 |
| TW201033217A (en) | 2008-12-17 | 2010-09-16 | Intervet Int Bv | Process for making a crystalline zilpaterol salt |
| WO2010140835A2 (ko) * | 2009-06-01 | 2010-12-09 | 연세대학교 산학협력단 | 신규한 피리돈 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 암 치료용 약학 조성물 |
| EP2628734A4 (en) * | 2010-10-15 | 2014-04-23 | Federalnoe G Bydzhetnoe Uchrezhdenie Nauki Inst Fiziol Aktivnikh Veschestv Rossiiskoi Akademii Nauk | DERIVATIVES OF 5-AMINO - [1,2,4] THIADIAZOLE |
| CA2856711A1 (en) | 2011-11-25 | 2013-05-30 | Bayer Intellectual Property Gmbh | Novel heterocyclic alkanol-derivatives |
| CN102603650A (zh) * | 2012-02-21 | 2012-07-25 | 玛耀生物医药（上海）有限公司 | 2，3-二氢-2-氧-1h-苯并咪唑-1-丁酸的制备方法 |
| RU2662815C2 (ru) * | 2012-03-23 | 2018-07-31 | Новартис Аг | Химический способ получения спироиндолонов и их промежуточных соединений |
| AU2013363731B2 (en) * | 2012-12-18 | 2018-04-19 | Intervet International B.V. | An improved process for making zilpaterol |
| CN104418808A (zh) * | 2013-09-11 | 2015-03-18 | 中美华世通生物医药科技（武汉）有限公司 | 一种适于工业化生产的中间体Buzolic acid的制备方法 |
| CN103554113B (zh) * | 2013-09-25 | 2016-04-27 | 湖北美天生物科技有限公司 | 一种盐酸齐帕特罗的合成方法 |
| PT3157912T (pt) | 2014-06-19 | 2019-06-04 | Boehringer Ingelheim Animal Health Usa Inc | Composições parasiticidas compreendendo derivados de indole, seus métodos e suas utilizações |
| US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| WO2018200323A1 (en) | 2017-04-23 | 2018-11-01 | Washington University | Small molecule regulators of mitochondrial fusion and methods of use thereof |
| WO2019094830A1 (en) * | 2017-11-10 | 2019-05-16 | Washington University | Mitofusin modulation agents and methods of use thereof |
| CN115925698A (zh) * | 2022-10-28 | 2023-04-07 | 中新科农(山东)生态农业有限公司 | 一种咪唑并[4,5-g]喹啉-2-酮类化合物及其作为杀虫剂的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2534257A1 (fr) * | 1982-10-12 | 1984-04-13 | Roussel Uclaf | Nouveaux derives de la 6-amino 7-hydroxy 4,5,6,7-tetrahydro-imidazo/4,5,1-j-k/ /1/ benzazepin-2(1h)-one, leurs sels, application a titre de medicaments, compositions les renfermant et un intermediaire |
| US4690951A (en) * | 1983-01-31 | 1987-09-01 | Eli Lilly And Company | Growth promotion |
| US4734437A (en) * | 1983-01-31 | 1988-03-29 | Eli Lilly And Company | Growth promotion |
| US5643967A (en) * | 1983-01-31 | 1997-07-01 | Eli Lilly And Company | Growth promotion |
| US4992473A (en) * | 1983-01-31 | 1991-02-12 | Eli Lilly And Company | Growth promotion |
| US4849453A (en) * | 1983-01-31 | 1989-07-18 | Eli Lilly And Company | Growth promotion |
| US5147869A (en) * | 1986-12-11 | 1992-09-15 | Roussel Uclaf | Zootechnical compositions |
| IE60964B1 (en) * | 1986-12-11 | 1994-09-07 | Roussel Uclaf | Zootechnical compositions containing a beta-adrenergic |
| US6841563B1 (en) * | 1999-11-15 | 2005-01-11 | Eli Lilly And Company | Aryloxy propanolamines for improving livestock production |
-
2007
- 2007-10-16 WO PCT/IB2007/003153 patent/WO2008050207A1/en active Application Filing
- 2007-10-24 TW TW096139891A patent/TW200824688A/zh unknown
- 2007-10-24 US US11/877,861 patent/US20080103130A1/en not_active Abandoned
- 2007-10-24 AR ARP070104703A patent/AR063371A1/es not_active Application Discontinuation
- 2007-10-25 CL CL200703083A patent/CL2007003083A1/es unknown
- 2007-10-29 UY UY30664A patent/UY30664A1/es not_active Application Discontinuation
-
2008
- 2008-04-11 US US12/101,317 patent/US20080267942A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080267942A1 (en) | 2008-10-30 |
| UY30664A1 (es) | 2008-05-31 |
| US20080103130A1 (en) | 2008-05-01 |
| WO2008050207A1 (en) | 2008-05-02 |
| CL2007003083A1 (es) | 2008-04-25 |
| TW200824688A (en) | 2008-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |