AR063153A1 - Anticuerpo monoclonal para prevenir/tratar el cancer - Google Patents
Anticuerpo monoclonal para prevenir/tratar el cancerInfo
- Publication number
- AR063153A1 AR063153A1 ARP070104425A ARP070104425A AR063153A1 AR 063153 A1 AR063153 A1 AR 063153A1 AR P070104425 A ARP070104425 A AR P070104425A AR P070104425 A ARP070104425 A AR P070104425A AR 063153 A1 AR063153 A1 AR 063153A1
- Authority
- AR
- Argentina
- Prior art keywords
- nectin
- prevent
- monoclonal antibody
- treat cancer
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- Pregnancy & Childbirth (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Microbiology (AREA)
- Gynecology & Obstetrics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Un anticuerpo monoclonal humano contra una proteína que comprende la misma o sustancialmente la misma secuencia de aminoácidos que la secuencia de aminoácidos representada por la SEC ID N°:1 o SEC ID N°: 3, su péptido parcial o una sal del mismo, es util como agente para prevenir/tratar el cáncer. Un inductor de apoptosis de células cancerosas, un inhibidor del crecimiento de células cancerosas, un agente citotoxico contra células cancerosas a través de un mecanismo de defensa del huésped mediado por la region FC de un anticuerpo y demás. Reivindicacion 9: El anticuerpo de acuerdo con la reivindicacion 1, caracterizado porque tiene actividad inhibitoria de la union trans de nectina-2/nectina-3 o nectina-2/nectina-2. Reivindicacion 15: Una célula de hibridoma, caracterizado porque es capaz de producir el anticuerpo de acuerdo con la reivindicacion 1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2006/320429 WO2007043635A1 (ja) | 2005-10-07 | 2006-10-06 | 癌の予防・治療剤 |
CL200700974A CL2007000974A1 (es) | 2005-10-07 | 2007-04-05 | Anticuerpo monoclonal anti-nectina 2; composicion farmaceutica que lo comprende; y su uso para tratar o prevenir el cancer. |
JP2007100876 | 2007-04-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR063153A1 true AR063153A1 (es) | 2008-12-30 |
Family
ID=44083820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070104425A AR063153A1 (es) | 2006-10-06 | 2007-10-09 | Anticuerpo monoclonal para prevenir/tratar el cancer |
Country Status (21)
Country | Link |
---|---|
US (1) | US20100008928A1 (es) |
EP (1) | EP2067791A4 (es) |
JP (1) | JPWO2008044754A1 (es) |
KR (1) | KR20090078339A (es) |
CN (1) | CN101541834A (es) |
AR (1) | AR063153A1 (es) |
AU (1) | AU2007307536A1 (es) |
BR (1) | BRPI0717024A2 (es) |
CA (1) | CA2666249A1 (es) |
CL (1) | CL2007002879A1 (es) |
CO (1) | CO6190538A2 (es) |
EC (1) | ECSP099276A (es) |
IL (1) | IL197389A0 (es) |
MA (1) | MA30816B1 (es) |
MX (1) | MX2009003126A (es) |
NO (1) | NO20091783L (es) |
PE (1) | PE20081456A1 (es) |
RU (1) | RU2009117237A (es) |
TN (1) | TN2009000090A1 (es) |
TW (1) | TW200823235A (es) |
WO (1) | WO2008044754A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK2658970T3 (en) | 2010-12-31 | 2017-01-16 | Bioatla Llc | Express humanization of antibodies |
US9175074B2 (en) * | 2011-08-04 | 2015-11-03 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prophylaxis of cancer |
US20140056890A1 (en) * | 2012-06-06 | 2014-02-27 | Oncomed Pharmaceuticals, Inc. | Binding Agents That Modulate the Hippo Pathway and Uses Thereof |
WO2014069681A1 (ko) * | 2012-10-29 | 2014-05-08 | 인제대학교 산학협력단 | 암 표적 항체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
WO2014069682A1 (ko) * | 2012-10-29 | 2014-05-08 | 인제대학교 산학협력단 | 암 표적 항체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
SG11201706583PA (en) | 2015-02-19 | 2017-09-28 | Compugen Ltd | Anti-pvrig antibodies and methods of use |
EP3978929A1 (en) | 2015-02-19 | 2022-04-06 | Compugen Ltd. | Pvrig polypeptides and methods of treatment |
JO3620B1 (ar) * | 2015-08-05 | 2020-08-27 | Amgen Res Munich Gmbh | مثبطات نقطة فحص مناعية للاستخدام في علاج سرطانات محمولة عبر الدم |
PL3347379T3 (pl) | 2016-08-17 | 2020-05-18 | Compugen Ltd. | Przeciwciała anty-tigit, przeciwciała anty-pvrig i ich połączenia |
RU2765410C2 (ru) | 2016-11-30 | 2022-01-28 | Онкомед Фармасьютикалс, Инк. | Способы лечения рака, включающие связывающие tigit агенты |
CA3064331A1 (en) | 2017-06-01 | 2018-12-06 | Compugen Ltd. | Triple combination antibody therapies |
EP3823673A4 (en) | 2018-07-20 | 2022-05-11 | Surface Oncology, Inc. | ANTI-CD112R COMPOSITIONS AND METHODS |
CA3207893A1 (en) | 2021-01-15 | 2022-07-21 | Seagen Inc. | Immunomodulatory antibody-drug conjugates |
EP4288109A1 (en) | 2021-02-03 | 2023-12-13 | Seagen Inc. | Immunostimulatory compounds and conjugates |
WO2023161943A1 (en) * | 2022-02-28 | 2023-08-31 | Nectin Therapeutics Ltd. | Humanized antibodies against nectin-2 and drug conjugates thereof |
WO2023215740A1 (en) | 2022-05-06 | 2023-11-09 | Seagen Inc. | Immunomodulatory antibody-drug conjugates |
WO2024030577A1 (en) | 2022-08-03 | 2024-02-08 | Seagen Inc. | Immunostimulatory anti-pd-l1-drug conjugates |
EP4321522A1 (en) | 2022-08-12 | 2024-02-14 | Seagen Inc. | Cytotoxic compounds and conjugates thereof |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
CA2089661C (en) | 1990-08-29 | 2007-04-03 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
AU4228699A (en) | 1998-06-03 | 1999-12-20 | Northwestern University | Cellular proteins which mediate herpesvirus entry |
US20030129685A1 (en) * | 1998-10-28 | 2003-07-10 | Jian Ni | 12 human secreted proteins |
DE19852800C1 (de) | 1998-11-16 | 2000-04-13 | Univ Albert Ludwigs Freiburg | Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist |
US20030022279A1 (en) * | 1999-06-14 | 2003-01-30 | Fraser Christopher C. | Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses |
WO2002000677A1 (en) | 2000-06-07 | 2002-01-03 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
WO2002028902A2 (en) | 2000-10-05 | 2002-04-11 | Immunex Corporation | Nectin polypeptides, polynucleotides, methods of making and use thereof |
JP2005505257A (ja) | 2001-06-05 | 2005-02-24 | エクセリクシス・インコーポレイテッド | p53経路のモディファイヤーとしてのIGsおよび使用方法 |
US20030003581A1 (en) | 2001-06-06 | 2003-01-02 | Economides Aris N. | Method for targeting transcriptionally active loci |
WO2003020743A1 (en) | 2001-09-05 | 2003-03-13 | Regeneron Pharmaceuticals, Inc. | Methods of expressing transgenes |
JP2005536190A (ja) * | 2002-04-16 | 2005-12-02 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
JP2006516089A (ja) | 2002-10-02 | 2006-06-22 | ジェネンテック・インコーポレーテッド | 腫瘍の診断と治療のための組成物と方法 |
EP2070546A1 (en) * | 2004-04-09 | 2009-06-17 | Takeda Pharmaceutical Company Limited | Preventives/remedies for cancer |
-
2007
- 2007-10-04 BR BRPI0717024-6A2A patent/BRPI0717024A2/pt not_active IP Right Cessation
- 2007-10-04 CN CNA2007800371476A patent/CN101541834A/zh active Pending
- 2007-10-04 CA CA002666249A patent/CA2666249A1/en not_active Abandoned
- 2007-10-04 RU RU2009117237/10A patent/RU2009117237A/ru not_active Application Discontinuation
- 2007-10-04 PE PE2007001348A patent/PE20081456A1/es not_active Application Discontinuation
- 2007-10-04 EP EP07829644A patent/EP2067791A4/en not_active Withdrawn
- 2007-10-04 US US12/444,382 patent/US20100008928A1/en not_active Abandoned
- 2007-10-04 JP JP2008538759A patent/JPWO2008044754A1/ja not_active Withdrawn
- 2007-10-04 KR KR1020097009036A patent/KR20090078339A/ko not_active Application Discontinuation
- 2007-10-04 MX MX2009003126A patent/MX2009003126A/es not_active Application Discontinuation
- 2007-10-04 WO PCT/JP2007/069908 patent/WO2008044754A1/ja active Application Filing
- 2007-10-04 AU AU2007307536A patent/AU2007307536A1/en not_active Abandoned
- 2007-10-05 TW TW096137411A patent/TW200823235A/zh unknown
- 2007-10-05 CL CL200702879A patent/CL2007002879A1/es unknown
- 2007-10-09 AR ARP070104425A patent/AR063153A1/es unknown
-
2009
- 2009-03-03 IL IL197389A patent/IL197389A0/en unknown
- 2009-03-16 TN TN2009000090A patent/TN2009000090A1/fr unknown
- 2009-04-23 EC EC2009009276A patent/ECSP099276A/es unknown
- 2009-04-27 MA MA31823A patent/MA30816B1/fr unknown
- 2009-05-04 CO CO09044621A patent/CO6190538A2/es not_active Application Discontinuation
- 2009-05-05 NO NO20091783A patent/NO20091783L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2008044754A1 (fr) | 2008-04-17 |
AU2007307536A1 (en) | 2008-04-17 |
BRPI0717024A2 (pt) | 2014-03-11 |
CO6190538A2 (es) | 2010-08-19 |
MX2009003126A (es) | 2009-04-06 |
EP2067791A4 (en) | 2009-11-25 |
PE20081456A1 (es) | 2008-11-27 |
MA30816B1 (fr) | 2009-10-01 |
IL197389A0 (en) | 2011-08-01 |
TW200823235A (en) | 2008-06-01 |
NO20091783L (no) | 2009-07-01 |
AU2007307536A2 (en) | 2009-04-30 |
TN2009000090A1 (en) | 2010-08-19 |
JPWO2008044754A1 (ja) | 2010-02-18 |
EP2067791A1 (en) | 2009-06-10 |
US20100008928A1 (en) | 2010-01-14 |
CA2666249A1 (en) | 2008-04-17 |
CN101541834A (zh) | 2009-09-23 |
KR20090078339A (ko) | 2009-07-17 |
CL2007002879A1 (es) | 2008-06-27 |
ECSP099276A (es) | 2009-06-30 |
RU2009117237A (ru) | 2010-11-20 |
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Legal Events
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