AR061744A1 - Metodo para identificar proteinas mediadoras de respuesta a colapsina - Google Patents

Metodo para identificar proteinas mediadoras de respuesta a colapsina

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Publication number
AR061744A1
AR061744A1 ARP070102916A ARP070102916A AR061744A1 AR 061744 A1 AR061744 A1 AR 061744A1 AR P070102916 A ARP070102916 A AR P070102916A AR P070102916 A ARP070102916 A AR P070102916A AR 061744 A1 AR061744 A1 AR 061744A1
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AR
Argentina
Prior art keywords
alkyl
aryl
heterocyclic
group
crmp
Prior art date
Application number
ARP070102916A
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English (en)
Inventor
Bettina Beyreuther
Thomas Stohr
Joachim Freitag
Original Assignee
Sanol Arznei Schwarz Gmbh
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Priority claimed from EP06013655A external-priority patent/EP1873527A1/en
Priority claimed from EP06021470A external-priority patent/EP1920780A1/en
Priority claimed from EP06024241A external-priority patent/EP1925314A1/en
Application filed by Sanol Arznei Schwarz Gmbh filed Critical Sanol Arznei Schwarz Gmbh
Publication of AR061744A1 publication Critical patent/AR061744A1/es

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    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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Abstract

Reivindicacion 1: Un método para identificar un modulador de CRMP adecuado para la prevencion, alivio y/o tratamiento de una enfermedad asociada con CRMP, caracterizado porque comprende los pasos de: (a) seleccionar una sustancia; b) poner en contacto la sustancia seleccionada en el paso (a) con CRMP, y c) determinar si la CRMP interactua con la sustancia, en donde la sustancia que interactua con CRMP es un modulador de CRMP. Reivindicacion 37: Un complejo caracterizado porque comprende CRMP y un compuesto formula general (1) en donde R es hidrogeno, alquilo, alquenilo, alquinilo, arilo, aril alquilo heterocíclico, heterocíclico alquilo, alquilo heterocíclico, cicloalquilo o cicloalquil alquilo, y R está insustituido o está sustituido con al menos un grupo aceptor de electrones, y/o al menos un grupo donante de electrones; R1 es hidrogeno o alquilo, alquenilo, alquinilo, aril alquilo, arilo, heterocíclico alquilo, alquilo heterocíclico, heterocíclico, cicloalquilo, cicloalquil alquilo, cada uno insustituido o sustituido con al menos un grupo donante de electrones y/o al menos un grupo aceptor de electrones; R2 y R3 son independientemente hidrogeno, alquilo, alquenilo, alquinilo, alcoxi, alcoxialquilo, aril alquilo, arilo, halo, heterocíclico, heterocíclico alquilo, alquilo heterocíclico, cicloalquilo, cicloalquil alquilo, o Z-Y en donde R2 y R3 pueden estar insustituidos o sustituidos con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; Z es O, S, S(O)a, NR4, NR'6, PR4 o un enlace químico; Y es hidrogeno, alquilo, arilo, aril alquilo, alquenilo, alquinilo, halo, heterocíclico, heterocíclico alquilo, alquil heterocíclico e Y puede estar insustituido o sustituido con al menos un grupo donante de electrones y/o al menos un grupo aceptor de electrones, con la condicion de que, cuando Y es halo, Z es un enlace químico, o ZY conjuntamente son NR4NR5R7, NR4OR5, ONR4R7, OPR4R5, PR4OR5, SNR4R7, NR4SR7, SPR4R5, PR4SR7, NR4PR5R6, PR4NR5R7, N+R5R6R7, NR4C(=O)R5, SC(=O)R5, NR4C(=O)OR5, SC(=O)OR5 o NR4NR5-C(=O)OR6; R'6 es hidrogeno, alquilo, alquenilo o alquinilo y que puede estar insustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; R4, R5 y R6 son independientemente hidrogeno, alquilo, arilo, aril alquilo, alquenilo, o alquinilo, en donde R4, R5 y R6 pueden estar independientemente insustituidos o sustituidos con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; R7 es R6 o COOR8 o COR8, en donde R7 puede estar insustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; R8 es hidrogeno o alquilo, o aril alquilo, y el grupo arilo o alquilo puede estar insustituido o sustituido con al menos un grupo aceptor de electrones y/o al menos un grupo donante de electrones; y n es 1-4; o una sal farmacéuticamente aceptable o metabolito del mismo, en donde el compuesto, sal farmacéuticamente aceptable del mismo o metabolito del mismo, exhibe afinidad con CRMP distinguida por un KD inferior a aproximadamente 5 mM.
ARP070102916A 2006-06-30 2007-06-29 Metodo para identificar proteinas mediadoras de respuesta a colapsina AR061744A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP06013655A EP1873527A1 (en) 2006-06-30 2006-06-30 Method for identifying CRMP modulators
EP06021469 2006-10-12
EP06021470A EP1920780A1 (en) 2006-10-12 2006-10-12 Peptide compounds for the treatment of hyperexcitability disorders
EP06024241A EP1925314A1 (en) 2006-11-22 2006-11-22 Pharmaceutical composition with synergistic anticonvulsant effect

Publications (1)

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AR061744A1 true AR061744A1 (es) 2008-09-17

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Family Applications (2)

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ARP070102915A AR061743A1 (es) 2006-06-30 2007-06-29 Compuestos peptidicos para el tratamiento de trastornos de hiperexcitabilidad y trastornos asociados con disfuncion del canal de hierro
ARP070102916A AR061744A1 (es) 2006-06-30 2007-06-29 Metodo para identificar proteinas mediadoras de respuesta a colapsina

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ARP070102915A AR061743A1 (es) 2006-06-30 2007-06-29 Compuestos peptidicos para el tratamiento de trastornos de hiperexcitabilidad y trastornos asociados con disfuncion del canal de hierro

Country Status (14)

Country Link
US (3) US9308183B2 (es)
EP (3) EP2038659A2 (es)
JP (1) JP2009541397A (es)
KR (1) KR20090030329A (es)
CN (2) CN101466390B (es)
AR (2) AR061743A1 (es)
AU (1) AU2007263936A1 (es)
BR (1) BRPI0713994A2 (es)
CA (1) CA2654652C (es)
EA (1) EA200900098A1 (es)
ES (1) ES2569333T3 (es)
MX (1) MX2009000249A (es)
TW (2) TW200819744A (es)
WO (2) WO2008000512A2 (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60100055T2 (de) * 2001-03-21 2003-07-24 Sanol Arznei Schwarz Gmbh Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen
US20100256179A1 (en) * 2004-03-26 2010-10-07 Ucb Pharma Gmbh Combination therapy for pain in painful diabetic neuropathy
CA2562937A1 (en) * 2004-04-16 2005-10-27 Schwarz Pharma Ag Use of peptidic compounds for the prophylaxis and treatment of chronic headache
EP1604655A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
AU2005276634B2 (en) * 2004-08-27 2011-03-24 Ucb Pharma Gmbh Use of peptide compounds for treating bone cancer pain, chemotherapy-and nucleoside-induced pain
EP1642889A1 (en) * 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
EP1754476A1 (en) * 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia
US20070043120A1 (en) * 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
EA027836B1 (ru) 2006-06-15 2017-09-29 ЮСиБи ФАРМА ГМБХ Фармацевтическая комбинация для профилактики, облегчения и/или лечения приступов эпилепсии и ее применение
EP1873527A1 (en) * 2006-06-30 2008-01-02 Schwarz Pharma Ag Method for identifying CRMP modulators
CN101466390B (zh) 2006-06-15 2014-03-12 优时比制药有限公司 用于治疗难治性癫痫持续状态的肽类化合物
US20100260716A1 (en) * 2007-10-23 2010-10-14 Ucb Pharma Gmbh Compounds for treating demyelination conditions
US8829033B2 (en) 2009-09-23 2014-09-09 The University Of North Carolina At Chapel Hill N-benzylamide substituted derivatives of 2-(acylamido)acetic acid and 2-(acylamido)propionic acids: potent neurological agents
CN102051408B (zh) * 2009-11-04 2012-07-04 高新 用于前列腺癌转移早期诊断的试剂盒
CA2817654A1 (en) 2010-12-02 2012-06-07 Ucb Pharma Gmbh Once daily formulation of lacosamide
EP2468261A1 (en) 2010-12-02 2012-06-27 UCB Pharma GmbH Formulation of lacosamide
US8779355B2 (en) 2011-12-28 2014-07-15 Quest Diagnostics Investments, Inc. Methods for detecting lacosamide by mass spectrometry
KR101361546B1 (ko) * 2012-07-09 2014-02-13 전남대학교산학협력단 유전성 골격근 이온통로병 원인 예측방법을 수행하기 위한 컴퓨터 프로그램이 수록된 컴퓨터로 읽을 수 있는 기록매체 및 이를 실행시키는 장치
WO2014139539A1 (en) * 2013-03-15 2014-09-18 Syddansk Universitet Inhibitor of dpysl3/crmp4 for treatment of bone loss
CA3008048C (en) * 2015-12-11 2023-11-14 Aarhus Universitet Rufinamide for use in the treatment of myotonia
BR112018012870A2 (pt) 2015-12-30 2018-12-04 Adamas Pharmaceuticals Inc métodos e composições para o tratamento de transtornos relacionados à crise
WO2017210489A1 (en) 2016-06-01 2017-12-07 M3 Biotechnology, Inc. Compounds
CN106551900A (zh) * 2016-12-05 2017-04-05 北京万全德众医药生物技术有限公司 一种拉科酰胺口服溶液及其制备工艺
WO2018187288A1 (en) * 2017-04-04 2018-10-11 The Trustees Of Columbia University In The City Of New York Compounds and methods for inhibiting cdk5 alleviate cardiac phenotypes in timothy syndrome and related conditions
US11278634B1 (en) 2021-02-12 2022-03-22 Extrovis Ag Stable parenteral composition of lacosamide
BR112023025925A2 (pt) * 2021-06-11 2024-02-27 Lupin Atlantis Holdings Sa Composições de liberação prolongada de mexiletina para administração oral
US11806405B1 (en) 2021-07-19 2023-11-07 Zeno Management, Inc. Immunoconjugates and methods

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319338A1 (fr) * 1975-08-01 1977-02-25 Synthelabo Nouveaux derives de a- phenyl benzylideniques des acides amines, leur preparation et les medicaments qui en contiennent
US4736866A (en) 1984-06-22 1988-04-12 President And Fellows Of Harvard College Transgenic non-human mammals
US5378729A (en) 1985-02-15 1995-01-03 Research Corporation Technologies, Inc. Amino acid derivative anticonvulsant
US5585358A (en) 1993-07-06 1996-12-17 Yissum Research Development Corporation Of The Hebrew University Of Jerusalem Derivatives of valproic acid amides and 2-valproenoic acid amides, method of making and use thereof as anticonvulsant agents
US5780589A (en) * 1994-11-30 1998-07-14 The United States Of America As Represented By The Department Of Health And Human Services Ultraselective opioidmimetic peptides and pharmacological and therapeutic uses thereof
EP0840612A1 (en) 1995-07-24 1998-05-13 Trustees Of Boston University Inhibition of nmda receptor activity by pregnenolone sulfate derivatives
US5773475A (en) 1997-03-17 1998-06-30 Research Corporation Technologies, Inc. Anticonvulsant enantiomeric amino acid derivatives
US6277825B1 (en) 1996-07-22 2001-08-21 University Of Utah Research Foundation Use of conantokins for treating pain
US6589994B1 (en) 1996-08-30 2003-07-08 Nps Pharmaceuticals, Inc. Treating a variety of pathological conditions, including spasticity and convulsions, by effecting a modulation of CNS activity with isovaleramide, isovaleric acid, or a related compound
US6048899A (en) * 1997-03-17 2000-04-11 Research Corporation Tech., Inc. Anticonvulsant enantiomeric amino acid derivatives
WO2002002620A2 (en) * 2000-06-29 2002-01-10 Mayo Foundation For Medical Education And Research Crmp-5 (collapsin response-mediator protein) encoding nucleic acid, polypeptide and uses thereof
CA2418455A1 (en) 2000-08-17 2002-02-21 Teva Pharmaceutical Industries, Ltd. Valproic acid derivatives for the treatment of pain
ATE357227T1 (de) 2000-08-25 2007-04-15 Res Corp Technologies Inc Verwendung von aminosäurehältigen antikonvulsiva zur behandlung von schmerz
US20020119944A1 (en) * 2000-11-09 2002-08-29 Michelle Aguera Use of Ulip-and/or Ulip2 in the treatment of myelin disorders
AU2002224847A1 (en) 2000-11-21 2002-06-03 U C B, S.A. N-alkylated gaba compounds, processes for their preparation and their use as medicaments
DK1243262T3 (da) 2001-03-20 2006-10-02 Sanol Arznei Schwarz Gmbh Hidtil ukendt anvendelse af en peptidklasse af forbindelser til behandling af ikke-neuropatiske, inflammatoriske smerter
DE60100055T2 (de) 2001-03-21 2003-07-24 Sanol Arznei Schwarz Gmbh Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen
ZA200204907B (en) * 2001-06-26 2003-03-03 Univ Nat Taiwan Collapsin Response Mediator Protein-1.
JP4499414B2 (ja) 2001-09-07 2010-07-07 アンスティテュ ナシオナル ドゥ ラ サントゥ エ ドゥ ラ ルシェルシェ メディカル（イーエヌエスエーエールエム） 免疫系に関する疾病を治療するためのｃｒｍｐファミリーのタンパク質の使用
US7687080B2 (en) 2002-11-25 2010-03-30 Taraxos Inc. Treatment of neuropathy
CA2514574A1 (en) 2003-01-30 2004-08-12 Dynogen Pharmaceuticals, Inc. Use of sodium channel modulators for treating gastrointestinal tract disorders
US20040209960A1 (en) 2003-01-30 2004-10-21 Dynogen Pharmaceuticals, Inc. Methods of treating lower urinary tract disorders using sodium channell modulators
WO2005051413A2 (en) * 2003-11-26 2005-06-09 Novartis Ag Disease associated genes
JP4664924B2 (ja) 2003-12-02 2011-04-06 ウーツェーベー ファルマ ゲーエムベーハー 中枢神経因性疼痛の治療のためのペプチド化合物の新規使用
EP1537862A1 (en) 2003-12-02 2005-06-08 Schwarz Pharma Ag Novel use of peptide compounds for treating central neuropathic pain
US20060009384A1 (en) 2003-12-05 2006-01-12 David Rudd Novel use of peptide compounds for treating status epilepticus or related conditions
EP1541138A1 (en) * 2003-12-05 2005-06-15 Schwarz Pharma Ag Novel use of peptide compounds for treating status epilepticus or related conditions
US20100256179A1 (en) 2004-03-26 2010-10-07 Ucb Pharma Gmbh Combination therapy for pain in painful diabetic neuropathy
US20070042969A1 (en) 2004-03-26 2007-02-22 Srz Properties, Inc. Combination therapy for pain in painful diabetic neuropathy
EP1579858A1 (en) 2004-03-26 2005-09-28 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in painful diabetic neuropathy
CA2562937A1 (en) 2004-04-16 2005-10-27 Schwarz Pharma Ag Use of peptidic compounds for the prophylaxis and treatment of chronic headache
EP1604654A1 (en) * 2004-05-18 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating dyskinesia
EP1604656A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS)
EP1604655A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
US7427601B2 (en) 2004-06-24 2008-09-23 Schwarz Pharma Ag Method for treating tremor
AU2005276634B2 (en) * 2004-08-27 2011-03-24 Ucb Pharma Gmbh Use of peptide compounds for treating bone cancer pain, chemotherapy-and nucleoside-induced pain
EP1642889A1 (en) 2004-10-02 2006-04-05 Schwarz Pharma Ag Improved synthesis scheme for lacosamide
US20060252749A1 (en) 2005-01-28 2006-11-09 Srz Properties, Inc. Lacosamide for add-on therapy of psychosis
CA2595330A1 (en) * 2005-01-28 2006-08-03 Schwarz Pharma Ag Spm 927 for add-on therapy of schizophrenia
US20070043120A1 (en) 2005-08-18 2007-02-22 Bettina Beyreuther Therapeutic combination for painful medical conditions
EP1754476A1 (en) 2005-08-18 2007-02-21 Schwarz Pharma Ag Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia
US20070048372A1 (en) 2005-08-18 2007-03-01 Srz Properties, Inc. Method for treating non-inflammatory osteoarthritic pain
EP1873527A1 (en) 2006-06-30 2008-01-02 Schwarz Pharma Ag Method for identifying CRMP modulators
CN101466390B (zh) 2006-06-15 2014-03-12 优时比制药有限公司 用于治疗难治性癫痫持续状态的肽类化合物
EA027836B1 (ru) 2006-06-15 2017-09-29 ЮСиБи ФАРМА ГМБХ Фармацевтическая комбинация для профилактики, облегчения и/или лечения приступов эпилепсии и ее применение
US20100260716A1 (en) 2007-10-23 2010-10-14 Ucb Pharma Gmbh Compounds for treating demyelination conditions
KR101755548B1 (ko) * 2008-11-07 2017-07-07 유씨비 파르마 게엠베하 아미노산 유도체의 제조 방법
EP2621893A1 (en) * 2010-10-01 2013-08-07 UCB Pharma GmbH Process for the preparation of amino acid derivatives
EP2487152A1 (en) * 2010-11-17 2012-08-15 UCB Pharma GmbH Process for the preparation of Lacosamide including resolution of O-methyl-DL-serine
EP2468261A1 (en) 2010-12-02 2012-06-27 UCB Pharma GmbH Formulation of lacosamide
CA2817654A1 (en) 2010-12-02 2012-06-07 Ucb Pharma Gmbh Once daily formulation of lacosamide

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