AR060904A1 - Derivados de 3,4-dihidro-2h-benzo [1,4] oxazina y tiazina como inhibidores de cetp - Google Patents
Derivados de 3,4-dihidro-2h-benzo [1,4] oxazina y tiazina como inhibidores de cetpInfo
- Publication number
- AR060904A1 AR060904A1 ARP070102055A ARP070102055A AR060904A1 AR 060904 A1 AR060904 A1 AR 060904A1 AR P070102055 A ARP070102055 A AR P070102055A AR P070102055 A ARP070102055 A AR P070102055A AR 060904 A1 AR060904 A1 AR 060904A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- optionally substituted
- halogenated
- alkoxy
- independently selected
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Composiciones farmacéuticas que los contienen y usos para prevenir o tratar enfermedades coronarias, y como agentes anticolesterolémicos y antilipidémicos. Reivindicacion 1: Un compuesto de formula (1) en el cual: L es un enlace covalente u O; X es O, o S; Q es arilo C6-10 o heteroarilo de 5 a 6 miembros, n es de 0 a 3; m es de 0 a 3; R1 es alquilo C1-10, alquenilo C2-10, alquinilo C2-10, cicloalquilo C3-10, heteroarilo de 5 o 6 miembros, donde cada uno de los alquilo C1-10, alquenilo C2-10, alquinilo C2-10, cicloalquilo C3-10, heteroarilo de 5 o 6 miembros puede estar sustituido en forma opcional; o R1 es fenilo sustituido en forma opcional con 1 o 2 miembros seleccionados de Ra y Rb, donde Ra y Rb se seleccionan en forma independiente del grupo que consiste en alquilo C1-4 sustituido en forma opcional, alquilo C1-4 halogenado, alquenilo C2-4 sustituido en forma opcional, alquinilo C2-4 sustituido en forma opcional, alcoxi C1-4 sustituido en forma opcional, alcoxi C1-4 halogenado, alquiltio C1-4 sustituido en forma opcional, halo, ciano e hidroxi, o Ra y Rb junto con los átomos de carbono del anillo fenilo a los cuales están unidos forman un heterociclilo de 5 o 6 miembros sustituido en forma opcional fusionado al anillo fenilo; cada R2 se selecciona en forma independiente de halo, hidroxi, ciano, alcoxi C1-4, alcoxi C1-4 halogenado, alquilo C1-4, alquilo C1-4 halogenado, alquenilo C2-4, alquinilo C2-4 y -C(O)H; cada R3 se selecciona en forma independiente de alquilo C1-4, alquilo C1-4 halogenado, alquenilo C2-4, alquinilo C2-4, alcoxi C1-4, halo, ciano e hidroxi; R4 es alquilo C1-10 sustituido en forma opcional con 1-3 miembros seleccionados en forma independiente de halo, oxo, hidroxi, alquilo C1-4 halogenado, alcoxi C1-4, cicloalquilo C3-8, CN, ter-butildimetilsililoxi, heterociclilo sustituido en forma opcional y -NRcRd, donde Rc y Rd se seleccionan en forma independiente de H, alquilo C1-3 sustituido en forma opcional, -C(O)alquilo C1-3, - C(O)O-alquilo C1-3, y -SO2alquilo C1-3, o R4 es alquilo C1-6 sustituido con heteroarilo o fenilo sustituido con 1 a 3 miembros seleccionados en forma independiente de halo, hidroxi, alquilo C1-3, alquilo halogenado C1-3, alcoxi C1-4, y alcoxi C1-4 halogenado, y sus enantiomeros, diastereomeros, tautomeros, solvatos o sales aceptables desde el punto de vista farmacéutico.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79960406P | 2006-05-11 | 2006-05-11 | |
| US87114806P | 2006-12-21 | 2006-12-21 | |
| US11/746,776 US7749995B2 (en) | 2006-05-11 | 2007-05-10 | 3,4-dihydro-2h-benzo[1,4]oxazine and thiazine derivatives as CETP inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060904A1 true AR060904A1 (es) | 2008-07-23 |
Family
ID=38694691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070102055A AR060904A1 (es) | 2006-05-11 | 2007-05-11 | Derivados de 3,4-dihidro-2h-benzo [1,4] oxazina y tiazina como inhibidores de cetp |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7749995B2 (es) |
| EP (1) | EP2023934A2 (es) |
| JP (1) | JP2009536954A (es) |
| AR (1) | AR060904A1 (es) |
| CA (1) | CA2651817A1 (es) |
| PE (1) | PE20080701A1 (es) |
| TW (1) | TW200808752A (es) |
| WO (1) | WO2007134149A2 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| WO2009097995A1 (de) * | 2008-02-07 | 2009-08-13 | Sanofi-Aventis | Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| WO2012120052A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2014034871A1 (ja) * | 2012-08-30 | 2014-03-06 | 株式会社 三和化学研究所 | 脂質異常症の予防又は治療薬 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61227506A (ja) | 1985-04-01 | 1986-10-09 | Nippon Tokushu Noyaku Seizo Kk | カルバモイルイミダゾ−ル類、その中間体、それらの製法並びに除草剤又は農園芸用殺菌剤 |
| CZ283619B6 (cs) * | 1991-09-12 | 1998-05-13 | Smithkline Beecham P.L.C | Použití derivátů kyseliny benzoové pro výrobu farmaceutických prostředků, deriváty kyseliny benzoo vé, způsob jejich výroby a farmaceutické prostředky s jejich obsahem |
| CA2116863A1 (en) * | 1992-07-03 | 1994-01-20 | Sumio Yokota | Condensed heterocyclic derivatives and herbicides |
| KR100232341B1 (ko) | 1994-10-13 | 2000-07-01 | 디. 제이. 우드 | 류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물 |
| WO1996015099A1 (en) | 1994-11-09 | 1996-05-23 | Novo Nordisk A/S | Heterocyclic compounds, their preparation and use |
| EP0801060A1 (en) | 1996-04-09 | 1997-10-15 | Pfizer Inc. | Heterocyclic Beta-3 Adrenergenic Agonists |
| DE19638484A1 (de) * | 1996-09-20 | 1998-03-26 | Basf Ag | Hetaroylderivate |
| DE19638486A1 (de) | 1996-09-20 | 1998-03-26 | Basf Ag | Hetaroylderivate |
| NZ509007A (en) | 1998-06-09 | 2002-11-26 | Basf Ag | The synergistic nature of a combination of a 3 heterocyclyl-substituted benzoyl derivative herbicide, a nitrogenous fertiliser and an adjuvant |
| CA2341542A1 (en) | 1999-06-24 | 2000-12-28 | Toray Industries, Inc. | .alpha.1b-adrenergic receptor antagonists |
| GB9919411D0 (en) | 1999-08-18 | 1999-10-20 | Zeneca Ltd | Chemical compounds |
| US6451830B1 (en) * | 1999-09-23 | 2002-09-17 | G.D. Searle & Co. | Use of substituted N,N-disubstituted non-fused heterocyclo amino compounds for inhibiting cholesteryl ester transfer protein activity |
| AU2001236606A1 (en) * | 2000-02-01 | 2001-08-14 | Cor Therapeutics, Inc. | 3,4-dihydro-2h-benzo(1,4)oxazine inhibitors of factor xa |
| CN101307046B (zh) * | 2000-10-30 | 2012-08-15 | 詹森药业有限公司 | 三肽酶抑制剂 |
| JP4350946B2 (ja) * | 2000-10-31 | 2009-10-28 | メルク エンド カムパニー インコーポレーテッド | 糖尿病及び脂質異常症の治療のためのベンゾピランカルボン酸誘導体 |
| ITMI20012060A1 (it) | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | Nuovi eterocilcli n-acilati |
| IL161431A0 (en) * | 2001-10-16 | 2004-09-27 | Reddys Lab Ltd Dr | beta-PHENYL-alpha-OXYSUBSTITUTED PROPIONIC ACID DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| US7015219B2 (en) * | 2001-12-19 | 2006-03-21 | Bristol-Myers Squibb Company | 3-aryl-hydroxybenzoxazines and 3, 4-dihydro-3-aryl-hydroxybenzoxazines as selective estrogen receptor beta modulators |
| GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| WO2004072041A1 (en) | 2003-02-12 | 2004-08-26 | Care X S.A. | Tetrahydroquinolines as agonists of liver- x receptors |
| WO2004072042A2 (en) | 2003-02-12 | 2004-08-26 | Carex S.A. | Quinoline derivative and their use for modulation of lxr activity |
| WO2005096688A1 (en) | 2004-04-02 | 2005-10-13 | Original Solutions Inc. | System and method for defect detection and process improvement for printed circuit board assemblies |
| WO2005099688A2 (en) * | 2004-04-07 | 2005-10-27 | Takeda Pharmaceutical Company Limited | Cyclic compounds |
-
2007
- 2007-05-10 JP JP2009510170A patent/JP2009536954A/ja not_active Withdrawn
- 2007-05-10 EP EP07783559A patent/EP2023934A2/en not_active Withdrawn
- 2007-05-10 CA CA002651817A patent/CA2651817A1/en not_active Abandoned
- 2007-05-10 US US11/746,776 patent/US7749995B2/en not_active Expired - Fee Related
- 2007-05-10 WO PCT/US2007/068636 patent/WO2007134149A2/en active Application Filing
- 2007-05-11 AR ARP070102055A patent/AR060904A1/es unknown
- 2007-05-11 PE PE2007000570A patent/PE20080701A1/es not_active Application Discontinuation
- 2007-05-11 TW TW096116730A patent/TW200808752A/zh unknown
-
2010
- 2010-05-18 US US12/782,280 patent/US8012963B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2023934A2 (en) | 2009-02-18 |
| PE20080701A1 (es) | 2008-06-13 |
| US20100227857A1 (en) | 2010-09-09 |
| JP2009536954A (ja) | 2009-10-22 |
| US7749995B2 (en) | 2010-07-06 |
| US8012963B2 (en) | 2011-09-06 |
| CA2651817A1 (en) | 2007-11-22 |
| WO2007134149A3 (en) | 2008-01-10 |
| US20070265252A1 (en) | 2007-11-15 |
| TW200808752A (en) | 2008-02-16 |
| WO2007134149A2 (en) | 2007-11-22 |
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Legal Events
| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |