AR060178A1 - Uso de estrobilurinas para el tratamiento de trastornos del metabolismo del hierro - Google Patents

Uso de estrobilurinas para el tratamiento de trastornos del metabolismo del hierro

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Publication number
AR060178A1
AR060178A1 ARP070101292A ARP070101292A AR060178A1 AR 060178 A1 AR060178 A1 AR 060178A1 AR P070101292 A ARP070101292 A AR P070101292A AR P070101292 A ARP070101292 A AR P070101292A AR 060178 A1 AR060178 A1 AR 060178A1
Authority
AR
Argentina
Prior art keywords
membered
alkylamino
radicals
substituted
alkyl
Prior art date
Application number
ARP070101292A
Other languages
English (en)
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38284013&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR060178(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Basf Ag filed Critical Basf Ag
Publication of AR060178A1 publication Critical patent/AR060178A1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pueden emplearse derivados de estrobilurina para el tratamiento y/o prevencion de trastornos del metabolismo del hierro en mamíferos. Reivindicacion 2: El uso de derivados de estrobilurina de acuerdo con la reivindicacion 1, caracterizado porque se emplea un derivado de estrobilurina de la formula (1) o una sal aceptable para uso farmacéutico, donde X es halogeno, alquilo C1-4 o trifluorometilo; m es 0 o 1; Q es C(=CH-CH3)-COOCH3, C(=CH-OCH3)-COOCH3, C(=N-OCH3)-CONHCH3, C(=N-OCH3)-COOCH3, N(- OCH3)-COOCH3 o un compuesto de formula (2); A es -O-B, -CH2O-B, -CH2S-B, -OCH2-B, -CH=CH-B, -CsC-B, -CH2O-, N=C(R1)-B, CH2O-N=C(R1)-C(R2)=N-OR3, o un compuesto de formula (3) o (4), donde B es fenilo, naftilo, un hetarilo de 5 o 6 miembros o un heterociclilo de 5 o 6 miembros, que comprende uno a tres átomos de N y/o un átomo de O o S o uno o dos átomos de O y/o S, donde los sistemas anulares no están sustituidos o están sustituidos con uno a tres radicales Ra; Ra es ciano, nitro, amino, aminocarbonilo, aminotiocarbonilo, halogeno, alquilo C1-6, haloalquilo C1-6, alquilcarbonilo C1-6, alquilsulfonilo C1-6, alquilsulfino C1-6, cicloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquiloxicarbonilo C1-6, alquiltio C1-6, alquilamino C1-6, di-alquilamino C1-6, alquilaminocarbonilo C1-6, di-alquilaminocarbonilo C1-6, alquilaminotiocarbonilo C1-6, di-alquilaminotiocarbonilo C1-6, alquenilo C2-6, alqueniloxi C2-6, fenilo, fenoxi, bencilo, benciloxi, heterociclilo de 5 o 6 miembros, heterocicliloxi de 5 o 6 miembros, hetarilo de 5 o 6 miembros, hetariloxi de 5 o 6 miembros, C(=NORa)-ORb, C(NORa)-Rb o OC(Ra)2-C(Rb)=NORb, donde a su vez los radicales cíclicos no están sustituidos o están sustituidos con uno a tres radicales Rb; Rb es ciano, nitro, halogeno, amino, aminocarbonilo, aminotiocarbonilo, alquilo C1-6, haloalquilo C1-6, alquilsulfonilo C1-6, alquilsulfinilo C1-6, cicloalquilo C3-6, alcoxi C1-6, haloalcoxi C1-6, alcoxicarbonilo C1-6, alquiltio C1-6, alquilamino C1- 6, di-alquilamino C1-6, alquilaminocarbonilo C1-6, di-alquilaminocarbonilo C1-6, alquilaminotiocarbonilo C1-6, di-alquilaminotiocarbonilo C1-6, alquenilo C2-6, alqueniloxi C2-6, cicloalquilo C3-6, cicloalquenilo C3-6, fenilo, fenoxi, feniltio, bencilo, benciloxi, hetarilo de 5 o 6 miembros, hetariloxi de 5 o 6 miembros o C(=NORa)-ORb; Ra, Rb son hidrogeno o alquilo C1-6; R1 es hidrogeno, ciano, alquilo C1-4, haloalquilo C1-4, cicloalquilo C3-6, alcoxi C1-4; R2 es fenilo, fenilcarbonilo, fenilsulfonilo, hetarilo de 5 o 6 miembros, hetarilcarbonilo de 5 o 6 miembros o hetarilsulfonilo de 5 o 6 miembros, donde los sistemas anulares no están sustituidos o están sustituidos con uno a tres radicales Ra, alquilo C1-10, cicloalquilo C3-6, alquenilo C2-10, alquinilo C2-10, alquilcarbonilo C1-10, alquenilcarbonilo C2-10, alquinilcarbonilo C3-10, alquilsulfonilo C1-10 o C(Ra)=NORb, donde los sistemas anulares no están sustituidos o están sustituidos con uno a tres radicales Rc; Rc es ciano, nitro, amino, aminocarbonilo, aminotiocarbonilo, halogeno, alquilo C1-6, haloalquilo C1-6, alquilsulfonilo C1-6, alquilsulfinilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alcoxicarbonilo C1-6, alquiltio C1-6, alquilamino C1-6, di-alquilamino C1-6, alquilaminocarbonilo C1-6, di-alquilaminocarbonilo C1-6, alquilaminotiocarbonilo C1-6, di-alquilaminotiocarbonilo C1-6, alquenilo C2-6, alqueniloxi C2-6, cicloalquilo C3-6, cicloalquiloxi C3-6, heterociclilo de 5 o 6 miembros, heterocicliloxi de 5 o 6 miembros, bencilo, benciloxi, fenilo, fenoxi, feniltio, hetarilo de 5 o 6 miembros, hetariloxi de 5 o 6 miembros y hetariltio, donde a su vez los radicales cíclicos pueden estar halogenados en forma parcial o completa o pueden portar uno a tres radicales Ra; y R3 es hidrogeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, donde los radicales hidrocarbonados de estos grupos no están sustituidos o están sustituidos con uno a tres radicales Rc.
ARP070101292A 2006-03-29 2007-03-28 Uso de estrobilurinas para el tratamiento de trastornos del metabolismo del hierro AR060178A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06111933 2006-03-29

Publications (1)

Publication Number Publication Date
AR060178A1 true AR060178A1 (es) 2008-05-28

Family

ID=38284013

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101292A AR060178A1 (es) 2006-03-29 2007-03-28 Uso de estrobilurinas para el tratamiento de trastornos del metabolismo del hierro

Country Status (16)

Country Link
US (1) US20100234366A1 (es)
EP (1) EP2001555A1 (es)
JP (1) JP2009531379A (es)
KR (1) KR20080111021A (es)
CN (1) CN101448550A (es)
AR (1) AR060178A1 (es)
AU (1) AU2007233829A1 (es)
BR (1) BRPI0710209A2 (es)
CA (1) CA2646209C (es)
CL (1) CL2007000836A1 (es)
EA (1) EA200801940A1 (es)
IL (1) IL194159A0 (es)
MX (1) MX2008012317A (es)
TW (1) TW200812592A (es)
WO (1) WO2007113170A1 (es)
ZA (1) ZA200809192B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101290745B1 (ko) 2010-06-03 2013-07-29 한국해양과학기술원 라말린을 함유하는 염증질환 또는 면역질환의 예방 또는 치료용 약학 조성물
US11433070B2 (en) 2019-06-28 2022-09-06 The Procter & Gamble Company Synergistic anti-inflammatory compositions
US11980612B2 (en) 2020-06-26 2024-05-14 The Procter & Gamble Company Synergistic anti-inflammatory compositions
US11701316B2 (en) 2020-12-18 2023-07-18 The Procter & Gamble Company Synergistic anti-inflammatory compositions

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Also Published As

Publication number Publication date
AU2007233829A1 (en) 2007-10-11
CN101448550A (zh) 2009-06-03
JP2009531379A (ja) 2009-09-03
ZA200809192B (en) 2010-01-27
EP2001555A1 (de) 2008-12-17
TW200812592A (en) 2008-03-16
CA2646209C (en) 2011-08-16
WO2007113170A1 (de) 2007-10-11
US20100234366A1 (en) 2010-09-16
MX2008012317A (es) 2008-10-10
EA200801940A1 (ru) 2009-04-28
CA2646209A1 (en) 2007-10-11
KR20080111021A (ko) 2008-12-22
BRPI0710209A2 (pt) 2011-05-24
IL194159A0 (en) 2011-08-01
CL2007000836A1 (es) 2008-05-23

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