AR059972A1 - Administracion intranasal o inhalacional de virosomas - Google Patents

Administracion intranasal o inhalacional de virosomas

Info

Publication number
AR059972A1
AR059972A1 ARP070101114A ARP070101114A AR059972A1 AR 059972 A1 AR059972 A1 AR 059972A1 AR P070101114 A ARP070101114 A AR P070101114A AR P070101114 A ARP070101114 A AR P070101114A AR 059972 A1 AR059972 A1 AR 059972A1
Authority
AR
Argentina
Prior art keywords
intranasal
influenza
composition
inhalational administration
virosomes
Prior art date
Application number
ARP070101114A
Other languages
English (en)
Inventor
Rheineck Leyssius Dorine H Van
Pieter J Schoen
Jozef J P Nauta
Alexander J Kersten
Lisya Gerez
Original Assignee
Solvay Pharm Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Bv filed Critical Solvay Pharm Bv
Publication of AR059972A1 publication Critical patent/AR059972A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Composicion de virosomas de influenza que comprenden envolturas reconstituidas de dicho virus, donde las envolturas virales están totalmente derivadas de partículas virales de influenza, donde no se agrega lípido de una fuente externa a los virosomas reconstituidos, donde los virosomas comprenden los antígenos de influenza hemoaglutinina y/o neuroaminidasa o derivados de los mismos, donde no se agrega adyuvante y/o estimulante inmune a la composicion y donde la composicion es para administracion intranasal o inhalacional, composicion que está caracterizada porque una sola administracion intranasal o inhalacional a un ser humano es suficiente para la induccion de una respuesta inmune sistémica y/o una respuesta inmune local y/o una respuesta de linfocitos citotoxicos contra dichos antígenos de influenza, respuesta sistémica que está en concordancia con los criterios CHMP (Comité para productos medicinales ara uso humano) para una vacuna de influenza y donde la dosis de hemoaglutinina por cepa viral por administracion intranasal o inhalacional es menor de o igual a 30 ?g. La invencion también provee el uso de virosomas de influenza reconstituidos para la fabricacion de dicha composicion y formulaciones de vacuna preparadas para dicho uso. Dispositivo para administracion intranasal o inhalacional.
ARP070101114A 2006-03-22 2007-03-20 Administracion intranasal o inhalacional de virosomas AR059972A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78446206P 2006-03-22 2006-03-22
EP06111534 2006-03-22

Publications (1)

Publication Number Publication Date
AR059972A1 true AR059972A1 (es) 2008-05-14

Family

ID=38038698

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101114A AR059972A1 (es) 2006-03-22 2007-03-20 Administracion intranasal o inhalacional de virosomas

Country Status (21)

Country Link
EP (2) EP2158921B1 (es)
JP (1) JP5285595B2 (es)
KR (1) KR20090016659A (es)
AR (1) AR059972A1 (es)
AT (2) ATE451931T1 (es)
AU (1) AU2007228736B2 (es)
BR (1) BRPI0709864A2 (es)
CA (1) CA2646895A1 (es)
DE (1) DE602007003815D1 (es)
DK (2) DK2158921T3 (es)
EA (1) EA014532B1 (es)
ES (2) ES2338382T3 (es)
HR (2) HRP20100144T1 (es)
IL (1) IL193840A (es)
MY (1) MY142996A (es)
NO (1) NO20084452L (es)
PL (2) PL2158921T3 (es)
PT (2) PT1996229E (es)
SA (1) SA07280116B1 (es)
SI (2) SI2158921T1 (es)
WO (1) WO2007107585A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2318044B1 (en) * 2008-08-01 2015-12-02 Gamma Vaccines Pty Limited Influenza vaccines
CA2826234A1 (en) * 2010-11-02 2012-05-10 Hector Manuel Zepeda Lopez Novel vaccines against the a/h1n1 pandemic flu virus
US11523988B2 (en) 2018-11-29 2022-12-13 Catalent U.K. Swindon Zydis Limited Oral dispersible vaccine comprising virosomes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9018690D0 (en) * 1990-08-24 1990-10-10 Wellcome Found Vaccines
EP1447080A1 (en) * 2003-02-13 2004-08-18 Bestewil Holding B.V. Method for producing virosome-like particles
TWI329130B (en) * 2003-06-19 2010-08-21 Bestewil Holding Bv Functionally reconstituted viral membranes containing adjuvant

Also Published As

Publication number Publication date
EP1996229B1 (en) 2009-12-16
BRPI0709864A2 (pt) 2011-07-26
AU2007228736B2 (en) 2011-12-15
ES2375436T8 (es) 2012-03-15
DK1996229T3 (da) 2010-05-03
PL1996229T3 (pl) 2010-05-31
JP5285595B2 (ja) 2013-09-11
SA07280116B1 (ar) 2010-10-19
KR20090016659A (ko) 2009-02-17
EA200870361A1 (ru) 2009-02-27
CA2646895A1 (en) 2007-09-27
EP2158921B1 (en) 2012-01-04
ES2375436T3 (es) 2012-02-29
PL2158921T3 (pl) 2012-06-29
JP2009530351A (ja) 2009-08-27
HRP20120013T1 (hr) 2012-01-31
ES2338382T3 (es) 2010-05-06
EA014532B1 (ru) 2010-12-30
WO2007107585A1 (en) 2007-09-27
ATE539766T1 (de) 2012-01-15
HRP20100144T1 (hr) 2010-04-30
AU2007228736A1 (en) 2007-09-27
NO20084452L (no) 2008-10-22
MY142996A (en) 2011-02-14
SI1996229T1 (sl) 2010-04-30
ATE451931T1 (de) 2010-01-15
IL193840A (en) 2011-10-31
EP1996229A1 (en) 2008-12-03
IL193840A0 (en) 2011-08-01
DE602007003815D1 (en) 2010-01-28
PT2158921E (pt) 2012-03-27
SI2158921T1 (sl) 2012-03-30
DK2158921T3 (da) 2012-05-07
PT1996229E (pt) 2010-03-16
EP2158921A1 (en) 2010-03-03

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