AR059848A1 - 2-amino-4-fenildihidroquinolinas sustituidas, medicamentos que las contienen y su uso para prevenir o tratar insuficiencias renales, respiratorias o trastornos del sistema nervioso central. - Google Patents

2-amino-4-fenildihidroquinolinas sustituidas, medicamentos que las contienen y su uso para prevenir o tratar insuficiencias renales, respiratorias o trastornos del sistema nervioso central.

Info

Publication number
AR059848A1
AR059848A1 ARP070101052A ARP070101052A AR059848A1 AR 059848 A1 AR059848 A1 AR 059848A1 AR P070101052 A ARP070101052 A AR P070101052A AR P070101052 A ARP070101052 A AR P070101052A AR 059848 A1 AR059848 A1 AR 059848A1
Authority
AR
Argentina
Prior art keywords
carbon atoms
alkyl
hydrogen
independently
replaced
Prior art date
Application number
ARP070101052A
Other languages
English (en)
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of AR059848A1 publication Critical patent/AR059848A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)

Abstract

Reivindicacion 1: Compuestos de la formula 1 en la cual: R1, R2, R3 y R4 independientemente unos de otros son hidrogeno, F, CI, Br, I, CN, NO2, CF3, CH3-SO2, alquilo que tiene 1, 2, 3, o 4 átomos de carbono, NH2, NH-CH3 o N(CH3)2; R5 y R6 independientemente el uno del otro son hidrogeno, alquilo que tiene 1, 2, 3, 4, 5 o 6 átomos de carbono, CF3-CH2-, cicloalquilo que tiene 3, 4, 5 o 6 átomos de carbono o ciclopropil-CH2-, o R5 y R6 forman junto con el átomo de nitrogeno al que se unen un anillo de 4, 5, 6, 7, 8, 9 o 10 átomos en el que uno o dos grupos CH2 pueden estar reemplazados independientemente uno del otro por NR12, azufre, oxigeno, C(O) o SO2, R12 es hidrogeno, alquilo que tiene 1, 2, 3 o 4 átomos de carbono o cicloalquilo que tiene 3, 4, 5 o 6 átomos de carbono; R7 es hidrogeno o alquilo que tiene 1, 2, 3 o 4 átomos de carbono; R8 y R9 independientemente el uno del otro son hidrogeno, F, CI, Br, OH, alquilo que tiene 1, 2, 3 o 4 átomos de carbono, CH3O, CF3 o CH3SO2; R10 y R11 independientemente el uno del otro son R13-(CmH2m)-Bn, donde m cero, 1, 2, 3 o 4; n cero o 1; B -CO-, -CONR14- o -SO2-;R14 es hidrogeno o alquilo que tiene 1, 2, 3, 4, 5 o 6 átomos de carbono; R13 es hidrogeno, alquilo que tiene 1, 2, 3 o 4 átomos de carbono, cicloalquilo que tiene 3, 4, 5 o 6 átomos de carbono, 1-pirrolidinilo, 1-piperidinilo, 1-(4-metilpiperazinilo), 1-morfolinilo, -COOR15, OR16, NR17R18 o fenilo que tiene, independientemente uno del otro, 1 o 2 sustituyentes seleccionados entre el grupo de cloro, fluor, metilo y metoxi; R15, R16, R17 y R18 independientemente unos de otros son hidrogeno o alquilo que tiene 1, 2, 3, 4, 5 o 6 átomos de carbono; o R10 y R11 forman junto con el átomo de nitrogeno al que se unen un anillo de 4, 5, 6, 7, 8, 9 o 10 átomos en el que uno, dos o tres grupos CH2 pueden estar reemplazados independientemente unos de otros por NR19, azufre, oxígeno, C(O) o SO2; R19 es hidrogeno, alquilo que tiene 1, 2, 3 o 4 átomos de carbono o cicloalquilo que tiene 3, 4, 5 o 6 átomos de carbono; y las sales farmacéuticamente aceptables y trifluoroacetatos de los mismos.
ARP070101052A 2006-03-18 2007-03-15 2-amino-4-fenildihidroquinolinas sustituidas, medicamentos que las contienen y su uso para prevenir o tratar insuficiencias renales, respiratorias o trastornos del sistema nervioso central. AR059848A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102006012545A DE102006012545A1 (de) 2006-03-18 2006-03-18 Substituierte 2-Amino-4-phenyl-dihydrochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
AR059848A1 true AR059848A1 (es) 2008-04-30

Family

ID=38161982

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101052A AR059848A1 (es) 2006-03-18 2007-03-15 2-amino-4-fenildihidroquinolinas sustituidas, medicamentos que las contienen y su uso para prevenir o tratar insuficiencias renales, respiratorias o trastornos del sistema nervioso central.

Country Status (17)

Country Link
US (1) US8106204B2 (es)
EP (1) EP1999112B1 (es)
JP (1) JP2009530324A (es)
KR (1) KR20080105090A (es)
CN (1) CN101395137A (es)
AR (1) AR059848A1 (es)
AU (1) AU2007229095A1 (es)
BR (1) BRPI0708816A2 (es)
CA (1) CA2646204A1 (es)
DE (1) DE102006012545A1 (es)
ES (1) ES2543345T3 (es)
MX (1) MX2008011589A (es)
NO (1) NO20084401L (es)
PL (1) PL1999112T3 (es)
TW (1) TW200800903A (es)
UY (1) UY30218A1 (es)
WO (1) WO2007107246A2 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120088737A2 (en) * 2009-10-02 2012-04-12 Ajinomoto Co., Inc Novel acyl guanidine derivatives
LT3173408T (lt) 2014-07-25 2018-12-27 Taisho Pharmaceutical Co., Ltd. Fenilo tetrahidroizochinolino junginys, turintis heteroarilo pakaitų

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3538101A (en) * 1967-05-15 1970-11-03 Ciba Geigy Corp 4 phenol dihydroquinolines
UA71592C2 (uk) * 1998-12-23 2004-12-15 Янссен Фармацевтика Н.В. Похідні 1,2-анельованого хіноліну, спосіб їх одержання (варіанти), фармацевтична композиція, що їх містить, проміжна сполука та спосіб її одержання
US6706699B2 (en) * 2001-06-21 2004-03-16 Ariad Pharmaceuticals, Inc. Quinolines and uses thereof
DK1453810T3 (da) * 2001-12-05 2009-07-20 Sanofi Aventis Deutschland Substituerede 4-phenyltetrahydroisoquinoliner, fremgangsmåde til deres fremstilling, deres anvendelse som medikament indeholdende samme

Also Published As

Publication number Publication date
JP2009530324A (ja) 2009-08-27
UY30218A1 (es) 2007-10-31
CA2646204A1 (en) 2007-09-27
WO2007107246A3 (de) 2008-06-05
KR20080105090A (ko) 2008-12-03
PL1999112T3 (pl) 2015-10-30
US20090118329A1 (en) 2009-05-07
CN101395137A (zh) 2009-03-25
NO20084401L (no) 2008-12-11
DE102006012545A1 (de) 2007-09-27
WO2007107246A2 (de) 2007-09-27
AU2007229095A1 (en) 2007-09-27
EP1999112B1 (de) 2015-04-22
TW200800903A (en) 2008-01-01
MX2008011589A (es) 2008-09-22
BRPI0708816A2 (pt) 2011-06-14
EP1999112A2 (de) 2008-12-10
US8106204B2 (en) 2012-01-31
ES2543345T3 (es) 2015-08-18

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