AR059371A1 - Terapia genica para la enfermedad de niemann-pick tipo a - Google Patents
Terapia genica para la enfermedad de niemann-pick tipo aInfo
- Publication number
- AR059371A1 AR059371A1 ARP070100528A ARP070100528A AR059371A1 AR 059371 A1 AR059371 A1 AR 059371A1 AR P070100528 A ARP070100528 A AR P070100528A AR P070100528 A ARP070100528 A AR P070100528A AR 059371 A1 AR059371 A1 AR 059371A1
- Authority
- AR
- Argentina
- Prior art keywords
- effective amount
- mammal
- niemann
- disease
- gene therapy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/007—Vectors comprising a special translation-regulating system cell or tissue specific
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La descripcion corresponde a métodos y composiciones para hacer tolerante el cerebro de un mamífero al polipéptido de esfingomielinasa ácida administrado exogenamente, suministrando primero una cantidad efectiva de un transgen que codifica el polipéptido al tejido hepático del mamífero y luego administrando una cantidad efectiva del transgen al sistema nervioso central (SNC) del mamífero. Reivindicacion 1: Un método que comprende las etapas de: a) administrar una cantidad efectiva de un vector viral que comprende un transgen que codifica un inmunogeno al tejido del hígado de un mamífero; y b) subsiguientemente administrar una cantidad efectiva de un segundo vector viral que comprende un transgen que codifica un inmunogeno al cerebro de dicho mamífero.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77162806P | 2006-02-08 | 2006-02-08 | |
US77236006P | 2006-02-09 | 2006-02-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR059371A1 true AR059371A1 (es) | 2008-03-26 |
Family
ID=38345806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP070100528A AR059371A1 (es) | 2006-02-08 | 2007-02-08 | Terapia genica para la enfermedad de niemann-pick tipo a |
Country Status (16)
Country | Link |
---|---|
US (3) | US20090117156A1 (es) |
EP (2) | EP1986661B1 (es) |
JP (2) | JP5706602B2 (es) |
AR (1) | AR059371A1 (es) |
BR (1) | BRPI0707590A2 (es) |
CY (1) | CY1121380T1 (es) |
DK (1) | DK1986661T3 (es) |
ES (1) | ES2700048T3 (es) |
HU (1) | HUE041928T2 (es) |
IL (2) | IL193165B (es) |
LT (1) | LT1986661T (es) |
MX (3) | MX360595B (es) |
PL (1) | PL1986661T3 (es) |
PT (1) | PT1986661T (es) |
SI (1) | SI1986661T1 (es) |
WO (1) | WO2007092563A2 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE525092T1 (de) | 2005-05-02 | 2011-10-15 | Genzyme Corp | Gentherapie für neurometabolische erkrankungen |
CN105770909A (zh) | 2005-05-02 | 2016-07-20 | 建新公司 | 脊髓失调症的基因治疗 |
ES2635726T3 (es) | 2007-06-06 | 2017-10-04 | Genzyme Corporation | Terapia génica para enfermedades de almacenamiento lisosómico |
US8734809B2 (en) | 2009-05-28 | 2014-05-27 | University Of Massachusetts | AAV's and uses thereof |
DK2826860T3 (en) * | 2010-04-23 | 2018-12-03 | Univ Massachusetts | CNS targeting AAV vectors and methods for their use |
US20130090374A1 (en) * | 2011-04-20 | 2013-04-11 | Miguel Sena-Esteves | Methods for the treatment of tay-sachs disease, sandhoff disease, and gm1-gangliosidosis |
CN115120746A (zh) * | 2013-05-15 | 2022-09-30 | 明尼苏达大学董事会 | 腺相关病毒介导的基因向中枢神经系统转移 |
CN107073051B (zh) | 2014-10-21 | 2021-08-24 | 马萨诸塞大学 | 重组aav变体及其用途 |
EP3270944B1 (en) * | 2015-03-17 | 2019-10-23 | Vrije Universiteit Brussel | Optimized liver-specific expression systems for fviii and fix |
GB201508025D0 (en) | 2015-05-11 | 2015-06-24 | Ucl Business Plc | Fabry disease gene therapy |
JP7171439B2 (ja) | 2016-04-15 | 2022-11-15 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | ムコ多糖症ii型を処置するための遺伝子療法 |
CA3038292A1 (en) | 2016-09-28 | 2018-04-05 | Cohbar, Inc. | Therapeutic mots-c related peptides |
US11578340B2 (en) | 2016-10-13 | 2023-02-14 | University Of Massachusetts | AAV capsid designs |
WO2018085688A1 (en) * | 2016-11-04 | 2018-05-11 | The Children's Hospital Of Philadelphia | Gene transfer compositions, methods and uses for treating neurodegenerative diseases |
WO2018156892A1 (en) | 2017-02-23 | 2018-08-30 | Adrx, Inc. | Peptide inhibitors of transcription factor aggregation |
US20230137562A1 (en) | 2017-06-07 | 2023-05-04 | Adrx, Inc. | Tau aggregation inhibitors |
WO2018237066A1 (en) * | 2017-06-20 | 2018-12-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | CODON OPTIMIZED HUMAN NPC1 GENES FOR THE TREATMENT OF C1-TYPE NIEMANN-PICK DISEASE AND ASSOCIATED STATES |
US11819539B2 (en) | 2017-09-22 | 2023-11-21 | The Trustees Of The University Of Pennsylvania | Gene therapy for treating Mucopolysaccharidosis type II |
JP7406677B2 (ja) | 2018-04-03 | 2023-12-28 | ギンコ バイオワークス インコーポレイテッド | 抗体を回避するウイルスベクター |
SG11202107761SA (en) | 2019-01-28 | 2021-08-30 | Cohbar Inc | Therapeutic peptides |
AU2020263573A1 (en) * | 2019-04-24 | 2021-10-28 | Oregon Health & Science University | Promoter sequence and related products and uses thereof |
CA3157700A1 (en) | 2019-10-17 | 2021-04-22 | Stridebio, Inc. | Adeno-associated viral vectors for treatment of niemann-pick disease type c |
WO2022006058A1 (en) * | 2020-06-30 | 2022-01-06 | Children's National Medical Center | Use of recombinant human acid sphingomyelinase to improve skeletal myofiber repair |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
US3939350A (en) | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4277437A (en) | 1978-04-05 | 1981-07-07 | Syva Company | Kit for carrying out chemically induced fluorescence immunoassay |
US4366241A (en) | 1980-08-07 | 1982-12-28 | Syva Company | Concentrating zone method in heterogeneous immunoassays |
DE3424893A1 (de) | 1984-07-06 | 1986-02-06 | Agfa-Gevaert Ag, 5090 Leverkusen | Photographisches silberhalogenidaufzeichnungsmaterial |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
US5773278A (en) | 1991-05-03 | 1998-06-30 | Mount Sinai Medical Center | Acid sphingomyelinase gene |
US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
US6114114A (en) | 1992-07-17 | 2000-09-05 | Incyte Pharmaceuticals, Inc. | Comparative gene transcript analysis |
JP3532566B2 (ja) | 1993-06-24 | 2004-05-31 | エル. グラハム,フランク | 遺伝子治療のためのアデノウイルスベクター |
ATE437232T1 (de) | 1993-10-25 | 2009-08-15 | Canji Inc | Rekombinanter adenoviren-vektor und verfahren zur verwendung |
DE69433592T2 (de) | 1993-11-09 | 2005-02-10 | Targeted Genetics Corp., Seattle | Die erzielung hoher titer des rekombinanten aav-vektors |
US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
US7252989B1 (en) | 1994-04-04 | 2007-08-07 | Board Of Regents, The University Of Texas System | Adenovirus supervector system |
CA2187626C (en) | 1994-04-13 | 2009-11-03 | Michael G. Kaplitt | Aav-mediated delivery of dna to cells of the nervous system |
US5795716A (en) | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
JP2002522509A (ja) | 1997-10-29 | 2002-07-23 | ジェンザイム・コーポレイション | リソソーム貯蔵疾患治療組成物および方法 |
US6544785B1 (en) | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
ES2284545T3 (es) | 1999-11-16 | 2007-11-16 | Genzyme Corporation | Vectores y transgenes con elementos reguladores para la administracion de genes del higado. |
WO2001036603A2 (en) * | 1999-11-17 | 2001-05-25 | Avigen, Inc. | Recombinant adeno-associated virus virions for the treatment of lysosomal disorders |
CA2400634A1 (en) * | 2000-02-17 | 2001-08-23 | Chester Li | Genetic modification of the lung as a portal for gene delivery |
US20040204379A1 (en) * | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
EP1578199A2 (en) * | 2002-06-14 | 2005-09-28 | Yeda Research And Development Company, Ltd. | Antigen-presenting cells for neuroprotection and nerve regeneration |
US7220577B2 (en) * | 2002-08-28 | 2007-05-22 | University Of Florida Research Foundation, Inc. | Modified AAV |
US20040258666A1 (en) * | 2003-05-01 | 2004-12-23 | Passini Marco A. | Gene therapy for neurometabolic disorders |
-
2007
- 2007-02-08 ES ES07763560T patent/ES2700048T3/es active Active
- 2007-02-08 JP JP2008554342A patent/JP5706602B2/ja active Active
- 2007-02-08 PL PL07763560T patent/PL1986661T3/pl unknown
- 2007-02-08 WO PCT/US2007/003388 patent/WO2007092563A2/en active Application Filing
- 2007-02-08 PT PT07763560T patent/PT1986661T/pt unknown
- 2007-02-08 EP EP07763560.5A patent/EP1986661B1/en active Active
- 2007-02-08 EP EP18190420.2A patent/EP3456331B1/en active Active
- 2007-02-08 HU HUE07763560A patent/HUE041928T2/hu unknown
- 2007-02-08 BR BRPI0707590-1A patent/BRPI0707590A2/pt not_active IP Right Cessation
- 2007-02-08 AR ARP070100528A patent/AR059371A1/es not_active Application Discontinuation
- 2007-02-08 LT LTEP07763560.5T patent/LT1986661T/lt unknown
- 2007-02-08 MX MX2014005624A patent/MX360595B/es unknown
- 2007-02-08 DK DK07763560.5T patent/DK1986661T3/da active
- 2007-02-08 SI SI200732075T patent/SI1986661T1/sl unknown
-
2008
- 2008-07-31 IL IL193165A patent/IL193165B/en not_active IP Right Cessation
- 2008-08-07 US US12/187,844 patent/US20090117156A1/en not_active Abandoned
- 2008-08-07 MX MX2018013684A patent/MX2018013684A/es unknown
- 2008-08-07 MX MX2018008355A patent/MX2018008355A/es unknown
-
2013
- 2013-04-25 JP JP2013092907A patent/JP5881641B2/ja active Active
-
2018
- 2018-04-09 IL IL258587A patent/IL258587A/en unknown
- 2018-11-28 CY CY20181101265T patent/CY1121380T1/el unknown
-
2019
- 2019-08-19 US US16/544,735 patent/US20200080066A1/en not_active Abandoned
-
2023
- 2023-03-08 US US18/119,201 patent/US20230287366A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
MX360595B (es) | 2018-11-09 |
JP5706602B2 (ja) | 2015-04-22 |
DK1986661T3 (da) | 2019-01-02 |
IL258587A (en) | 2018-06-28 |
EP1986661B1 (en) | 2018-08-29 |
EP1986661A2 (en) | 2008-11-05 |
US20200080066A1 (en) | 2020-03-12 |
LT1986661T (lt) | 2018-12-10 |
MX2018008355A (es) | 2021-06-15 |
BRPI0707590A2 (pt) | 2011-05-10 |
IL193165B (en) | 2018-04-30 |
US20230287366A1 (en) | 2023-09-14 |
MX2018013684A (es) | 2021-06-15 |
JP5881641B2 (ja) | 2016-03-09 |
SI1986661T1 (sl) | 2018-12-31 |
HUE041928T2 (hu) | 2019-06-28 |
US20090117156A1 (en) | 2009-05-07 |
JP2009526067A (ja) | 2009-07-16 |
PT1986661T (pt) | 2018-12-05 |
EP3456331B1 (en) | 2021-05-26 |
WO2007092563A3 (en) | 2007-11-22 |
JP2013166777A (ja) | 2013-08-29 |
WO2007092563A2 (en) | 2007-08-16 |
EP3456331A1 (en) | 2019-03-20 |
PL1986661T3 (pl) | 2019-02-28 |
CY1121380T1 (el) | 2020-05-29 |
EP1986661A4 (en) | 2012-04-25 |
ES2700048T3 (es) | 2019-02-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AR059371A1 (es) | Terapia genica para la enfermedad de niemann-pick tipo a | |
Zhu et al. | Rabies control and treatment: from prophylaxis to strategies with curative potential | |
JP2020128427A (ja) | 補助的免疫抑制処置を行わないmapc療法 | |
ECSP088262A (es) | Proteínas de fusión de albúmina | |
JP2017500061A5 (es) | ||
BR112015004696A2 (pt) | polipeptídeos quiméricos tendo especificidade de ligação alvejada | |
ECSP12011787A (es) | Polipéptidos para unión al "receptor para productos finales de glicosilación avanzada" así como composiciones y métodos que implican a los mismos | |
BR112015020885A2 (pt) | polipeptídeos de ligação hiperglicosilados | |
BR112015012152A2 (pt) | Proteína de fusão terapêutica direcionada que compreende uma enzima lisossomal, ácido nucleico, composição farmacêutica, método para produzir a dita proteína e usos da proteína para tratar uma doença de armazenamento lisossomal e mucopolissacaridose tipo iiib | |
GT200500254A (es) | Proceso para la concentracion de anticuerpos y productos terapeùticos relacionados. | |
WO2012099851A3 (en) | Prenatal enzyme replacement therapy | |
BRPI0507026A (pt) | proteìnas de fusão de albumina | |
AR038596A1 (es) | Sistemas de expresion de virus parainfluenza recombinantes y vacunas que comprenden antigenos heterologos derivados de metapneumovirus | |
AR076800A1 (es) | Metodo para producir una preparacion de inmunoglobulina con un alto rendimiento | |
EA201000211A1 (ru) | Способ модулирования рецептора gpr119, сопряженного с g-белком, и используемые при этом соединения | |
WO2007146038A3 (en) | Albumin fusion proteins | |
SI2540309T1 (en) | Tissue protective peptides and their uses | |
BR112014001875A2 (pt) | sistema e método personalizáveis para anestesiar membrana timpânica | |
UA110323C2 (en) | Derivative of serum amyloid p and their receipt and application | |
CR20120415A (es) | Polipéptidos agonistas que se enlazan a dr5 | |
AR061894A1 (es) | Vacunas para malaria | |
GT200800307A (es) | 18-metil-19-nor-androst-4-en-17,17-espiroeteres (18-metil-19-nor-20-espirox-4-en-3-onas), asi como preparaciones farmaceuticas que los contienen | |
EA201391200A1 (ru) | Способы и композиции для вакцинации от staphylococcus aureus | |
JP2013510169A5 (es) | ||
BR112014012460A2 (pt) | proteínas recombinantes e seus usos terapêuticos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |