AR058082A1 - Formulacion en aerosol para la inhalacion de beta- agonistas - Google Patents
Formulacion en aerosol para la inhalacion de beta- agonistasInfo
- Publication number
- AR058082A1 AR058082A1 ARP060104405A ARP060104405A AR058082A1 AR 058082 A1 AR058082 A1 AR 058082A1 AR P060104405 A ARP060104405 A AR P060104405A AR P060104405 A ARP060104405 A AR P060104405A AR 058082 A1 AR058082 A1 AR 058082A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- salts
- enantiomers
- halogen
- possibly
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Dispersion Chemistry (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Reivindicacion 1: Formulacion farmacologica que contiene como principio activo uno o varios compuestos de la formula general (1) en los que R1 es H, alquilo C1-4, O-alquilo C1-4 o halogeno; R2 es H, alquilo C1-4, O-alquilo C1-4 o halogeno; R3 es H, alquilo C1-4, O-alquilo C1-4, halogeno, OH, -O-alquilen C1-4-COOH u O-alquilen C1-4-COO-alquilo C1-4; X- es un anion de carga negativa simple, con preferencia un anion de carga negativa simple seleccionado el grupo compuesto por cloruro, bromuro, yoduro sulfato, fosfato, metansulfonato, nitrato, maleato, acetato, benzoato, citrato, salicilato, trifluoroacetato, fumarato, tartrato, oxalato, succinato, benzoato y p-toluensulfonato; eventualmente en forma de sus tautomeros, enantiomeros, mezclas de los enantiomeros, racematos, solvatos o hidratos; otro principio activo 2 seleccionado del grupo compuesto por sales de tiotropio, sales de oxitropio, sales de flutropio, sales de ipratropio, sales de glucopirronio y sales de trospio, eventualmente en forma de sus tautomeros, enantiomeros, mezclas de los enantiomeros, racematos, solvatos o hidratos; al menos un ácido farmacologicamente tolerable, eventualmente otros coadyuvantes y/o formadores de complejos farmacologicamente tolerables, y como disolvente agua, etanol o una mezcla de agua y etanol.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05109376 | 2005-10-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR058082A1 true AR058082A1 (es) | 2008-01-23 |
Family
ID=35241312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060104405A AR058082A1 (es) | 2005-10-10 | 2006-10-06 | Formulacion en aerosol para la inhalacion de beta- agonistas |
Country Status (31)
Country | Link |
---|---|
US (3) | US20070088030A1 (es) |
EP (1) | EP1940349B1 (es) |
JP (1) | JP2009511542A (es) |
KR (1) | KR20080059290A (es) |
CN (1) | CN101282712A (es) |
AR (1) | AR058082A1 (es) |
AU (1) | AU2006301330B9 (es) |
BR (1) | BRPI0617278A2 (es) |
CA (1) | CA2624786C (es) |
CY (1) | CY1120199T1 (es) |
DK (1) | DK1940349T3 (es) |
EA (1) | EA200800927A1 (es) |
EC (1) | ECSP088294A (es) |
ES (1) | ES2668364T3 (es) |
HR (1) | HRP20180713T1 (es) |
HU (1) | HUE039186T2 (es) |
IL (1) | IL190682A (es) |
LT (1) | LT1940349T (es) |
MY (1) | MY163503A (es) |
NO (1) | NO343363B1 (es) |
NZ (1) | NZ567545A (es) |
PE (1) | PE20070708A1 (es) |
PL (1) | PL1940349T3 (es) |
PT (1) | PT1940349T (es) |
RS (1) | RS57085B1 (es) |
SI (1) | SI1940349T1 (es) |
TW (1) | TWI389692B (es) |
UA (1) | UA99250C2 (es) |
UY (1) | UY29844A1 (es) |
WO (1) | WO2007042468A2 (es) |
ZA (1) | ZA200801390B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7056916B2 (en) * | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
US20050272726A1 (en) * | 2004-04-22 | 2005-12-08 | Boehringer Ingelheim International Gmbh | Novel medicaments for the treatment of respiratory diseases |
US20050255050A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Powder formulations for inhalation, comprising enantiomerically pure beta agonists |
US7220742B2 (en) * | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
US20050256115A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Aerosol formulation for the inhalation of beta-agonists |
MX2008001976A (es) * | 2005-08-15 | 2008-03-25 | Boehringer Ingelheim Int | Procedimiento para la preparacion de betamimeticos. |
WO2010057927A1 (en) * | 2008-11-21 | 2010-05-27 | Boehringer Ingelheim International Gmbh | Aerosol formulation for the inhalation of beta agonists |
EP2358350A1 (en) * | 2008-11-21 | 2011-08-24 | Boehringer Ingelheim International GmbH | Aerosol formulation for the inhalation of beta agonists |
GB201200525D0 (en) | 2011-12-19 | 2012-02-29 | Teva Branded Pharmaceutical Prod R & D Inc | An inhalable medicament |
WO2014016548A2 (en) | 2012-07-27 | 2014-01-30 | Cipla Limited | Pharmaceutical composition |
EP2906218B1 (en) | 2012-10-09 | 2016-12-14 | Boehringer Ingelheim International GmbH | Beta-2-adrenoceptor agonist for the treatment of cough |
US20140235627A1 (en) * | 2012-12-21 | 2014-08-21 | Boehringer Ingelheim International Gmbh | ß2-ADRENOCEPTOR AGONIST FOR IMPROVEMENT OF EXERCISE TOLERANCE |
US10034866B2 (en) | 2014-06-19 | 2018-07-31 | Teva Branded Pharmaceutical Products R&D, Inc. | Inhalable medicament comprising tiotropium |
BR112017020039A2 (pt) * | 2015-05-18 | 2018-06-05 | Glenmark Specialty S.A. | composição farmacêutica, kit, método, processo para preparar uma composição e solução farmacêutica |
CN110062625A (zh) | 2016-12-12 | 2019-07-26 | 勃林格殷格翰国际有限公司 | 尼达尼布通过与奥达特罗共给予用于治疗间质性肺病的方法 |
CN115397417A (zh) * | 2020-04-16 | 2022-11-25 | 广州谷森制药有限公司 | 含有噻托溴铵和奥达特罗的可吸入溶液制剂 |
CN114259481A (zh) * | 2021-11-26 | 2022-04-01 | 南京华盖制药有限公司 | 一种奥达特罗复方吸入溶液 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3134590A1 (de) * | 1981-09-01 | 1983-03-10 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue benzo-heterocyclen |
DE3931041C2 (de) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
KR100312357B1 (ko) * | 1992-12-09 | 2002-04-24 | 데이비드 이. 프랭크하우저 | 안정화된약제의에어로졸용액제제 |
EE200200602A (et) * | 2000-04-27 | 2004-04-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pikatoimelised beetamimeetikumid, meetod nende valmistamiseks ja nende kasutamine ravimitena |
DE10216036A1 (de) | 2002-04-11 | 2003-10-23 | Boehringer Ingelheim Pharma | Aerosolformulierung für die Inhalation enthaltend ein Tiotropiumsalz |
DE10253282A1 (de) | 2002-11-15 | 2004-05-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittel zur Behandlung von chronisch obstruktiver Lungenerkrankung |
US7056916B2 (en) * | 2002-11-15 | 2006-06-06 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments for the treatment of chronic obstructive pulmonary disease |
US7244728B2 (en) * | 2004-03-17 | 2007-07-17 | Boehringer Ingelheim International Gmbh | Long acting betamimetics for the treatment of respiratory diseases |
KR101287460B1 (ko) | 2004-04-22 | 2013-07-23 | 베링거 인겔하임 인터내셔날 게엠베하 | 벤즈옥사진을 함유하는 호흡기 질환 치료용 약제학적배합물 |
US20050239778A1 (en) * | 2004-04-22 | 2005-10-27 | Boehringer Ingelheim International Gmbh | Novel medicament combinations for the treatment of respiratory diseases |
US20050272726A1 (en) * | 2004-04-22 | 2005-12-08 | Boehringer Ingelheim International Gmbh | Novel medicaments for the treatment of respiratory diseases |
US7220742B2 (en) * | 2004-05-14 | 2007-05-22 | Boehringer Ingelheim International Gmbh | Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments |
US20050256115A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Aerosol formulation for the inhalation of beta-agonists |
US20050255050A1 (en) * | 2004-05-14 | 2005-11-17 | Boehringer Ingelheim International Gmbh | Powder formulations for inhalation, comprising enantiomerically pure beta agonists |
-
2006
- 2006-10-05 TW TW095137046A patent/TWI389692B/zh active
- 2006-10-05 US US11/543,477 patent/US20070088030A1/en not_active Abandoned
- 2006-10-06 PE PE2006001218A patent/PE20070708A1/es not_active Application Discontinuation
- 2006-10-06 NZ NZ567545A patent/NZ567545A/en unknown
- 2006-10-06 BR BRPI0617278-4A patent/BRPI0617278A2/pt not_active Application Discontinuation
- 2006-10-06 LT LTEP06807028.3T patent/LT1940349T/lt unknown
- 2006-10-06 PL PL06807028T patent/PL1940349T3/pl unknown
- 2006-10-06 AU AU2006301330A patent/AU2006301330B9/en active Active
- 2006-10-06 AR ARP060104405A patent/AR058082A1/es not_active Application Discontinuation
- 2006-10-06 UY UY29844A patent/UY29844A1/es not_active Application Discontinuation
- 2006-10-06 PT PT68070283T patent/PT1940349T/pt unknown
- 2006-10-06 DK DK06807028.3T patent/DK1940349T3/en active
- 2006-10-06 SI SI200632255T patent/SI1940349T1/en unknown
- 2006-10-06 CN CNA2006800377251A patent/CN101282712A/zh active Pending
- 2006-10-06 MY MYPI20081057A patent/MY163503A/en unknown
- 2006-10-06 UA UAA200805249A patent/UA99250C2/ru unknown
- 2006-10-06 ES ES06807028.3T patent/ES2668364T3/es active Active
- 2006-10-06 WO PCT/EP2006/067126 patent/WO2007042468A2/de active Application Filing
- 2006-10-06 CA CA2624786A patent/CA2624786C/en not_active Expired - Fee Related
- 2006-10-06 JP JP2008535001A patent/JP2009511542A/ja active Pending
- 2006-10-06 HU HUE06807028A patent/HUE039186T2/hu unknown
- 2006-10-06 RS RS20180434A patent/RS57085B1/sr unknown
- 2006-10-06 EP EP06807028.3A patent/EP1940349B1/de active Active
- 2006-10-06 EA EA200800927A patent/EA200800927A1/ru unknown
- 2006-10-06 KR KR1020087011009A patent/KR20080059290A/ko not_active Application Discontinuation
-
2008
- 2008-02-11 ZA ZA200801390A patent/ZA200801390B/xx unknown
- 2008-02-14 NO NO20080801A patent/NO343363B1/no unknown
- 2008-03-19 EC EC2008008294A patent/ECSP088294A/es unknown
- 2008-04-08 IL IL190682A patent/IL190682A/en active IP Right Grant
-
2009
- 2009-09-22 US US12/564,477 patent/US20100009984A1/en not_active Abandoned
-
2011
- 2011-04-14 US US13/087,009 patent/US20110190284A1/en not_active Abandoned
-
2018
- 2018-05-07 HR HRP20180713TT patent/HRP20180713T1/hr unknown
- 2018-05-10 CY CY20181100484T patent/CY1120199T1/el unknown
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Legal Events
Date | Code | Title | Description |
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FC | Refusal |