AR056588A1 - Derivados de tropano 3- monosustituido como ligandos de receptores de nociceptina - Google Patents
Derivados de tropano 3- monosustituido como ligandos de receptores de nociceptinaInfo
- Publication number
- AR056588A1 AR056588A1 ARP060104705A ARP060104705A AR056588A1 AR 056588 A1 AR056588 A1 AR 056588A1 AR P060104705 A ARP060104705 A AR P060104705A AR P060104705 A ARP060104705 A AR P060104705A AR 056588 A1 AR056588 A1 AR 056588A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- heterocycloalkyl
- independently selected
- group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Reivindicacion 1: Un compuesto representado por la formula (1) o su sal o solvato farmacéuticamente aceptable, donde R1 es R4-arilo, R4-arilalquilo, R4-heteroarilo, R4-heteroarilalquilo, R4-cicloalquilo, R4-cicloalquilalquilo, R4-heterocicloalquilo o R4-heterocicloalquilalquilo; R2 es R5-arilo, R5-arilalquilo, R5-heteroarilo, R5-heteroarilalquilo, R5-cicloalquilo, R5-cicloalquilalquilo, R5-heterocicloalquilo o R5-heterocicloalquilalquilo; R3 es R6-alquilo, R6-arilo, R6-heteroarilo, R6- cicloalquilo o R6-heterocicloalquilo; X es un enlace, alquileno C1-3, -(CH2)m-N(R7)-(CH2)n-, -(CH2)m-O-(CH2)n-, -(CH2)m-S-(CH2)n-, -C(O)-, -CH(OH)-, -C(O)N(R7)-, -C(O)N(R7)-alquileno o -N(R7)C(O)-; n es 0, 1, 2, 3, 4, 5 o 6; m es 0, 1, 2, 3, 4, 5 o 6; siempre que la suma de m y n sea 0, 1, 2, 3, 4, 5 o 6; cada R4 y R5 es 1 a 3 sustituyentes seleccionados independientemente del grupo formado por H, halo, alquilo, cicloalquilo -CN, -CF3, -(CH2)p-OR8, -N(R10)2 y -(CH2)n-N(R10)2; R6 es 1 a 3 sustituyentes seleccionados independientemente del grupo formado por H, halo, alquilo, cicloalquilo, heterocicloalquilo, heterocicloalquilalquilo, -CN, cianoalquilo, -CF3, -C(O)alquilo, -(CH2)p-OR8, -COOR8, -N(R10)2, -(CH2)n-N(R10)2 y -C(O)N(R10)2; p es 0, 1, 2, 3, 4, 5 o 6; R7 es H o alquilo; R8 y R9 son seleccionados independientemente del grupo formado por H, alquilo, cicloalquilo, haloalquilo, hidroxialquilo, alcoxi, alcoxialquilo, aminoalquilo, alquil-C(O)- y alquil-C(O)-N(R7)-C(O)-; y R10 es seleccionado independientemente del grupo formado por H y alquilo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73170305P | 2005-10-31 | 2005-10-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR056588A1 true AR056588A1 (es) | 2007-10-10 |
Family
ID=37670874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060104705A AR056588A1 (es) | 2005-10-31 | 2006-10-27 | Derivados de tropano 3- monosustituido como ligandos de receptores de nociceptina |
Country Status (20)
Country | Link |
---|---|
US (2) | US7479494B2 (es) |
EP (1) | EP1951721B1 (es) |
JP (1) | JP2009513664A (es) |
KR (1) | KR20080064175A (es) |
CN (1) | CN101351465A (es) |
AR (1) | AR056588A1 (es) |
AT (1) | ATE490252T1 (es) |
AU (1) | AU2006309085A1 (es) |
BR (1) | BRPI0618137A2 (es) |
CA (1) | CA2627546A1 (es) |
DE (1) | DE602006018645D1 (es) |
EC (1) | ECSP088410A (es) |
IL (1) | IL191049A0 (es) |
NO (1) | NO20082443L (es) |
PE (1) | PE20071159A1 (es) |
RU (1) | RU2008121743A (es) |
SG (1) | SG166811A1 (es) |
TW (1) | TW200800189A (es) |
WO (1) | WO2007053435A1 (es) |
ZA (1) | ZA200803718B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20090018972A (ko) | 2006-05-19 | 2009-02-24 | 아보트 러보러터리즈 | Cns 활성 융합된 비사이클로헤테로사이클 치환된 아자비사이클릭 알칸 유도체 |
EP2086958B1 (en) * | 2007-08-31 | 2015-01-14 | Purdue Pharma LP | Substituted-quinoxaline-type-piperidine compounds and the uses thereof |
JP2011528365A (ja) * | 2008-07-16 | 2011-11-17 | シェーリング コーポレイション | Gpr119モジュレーターとしての二環式ヘテロ環誘導体およびそれらの使用方法 |
EP2324013B3 (en) | 2008-07-21 | 2014-10-22 | Purdue Pharma LP | Substituted-quinoxaline-type bridged-piperidine compounds and the uses thereof |
JP5421368B2 (ja) * | 2008-08-01 | 2014-02-19 | パーデュー、ファーマ、リミテッド、パートナーシップ | テトラヒドロピリジニルおよびジヒドロピロリル化合物およびそれらの使用 |
WO2012009263A1 (en) * | 2010-07-12 | 2012-01-19 | Temple University-Of The Commonwealth System Of Higher Education | Cocaine analogs and methods of preparation and uses thereof |
WO2015182724A1 (ja) | 2014-05-28 | 2015-12-03 | トーアエイヨー株式会社 | 置換トロパン誘導体 |
US11131530B2 (en) | 2018-01-29 | 2021-09-28 | Lawrence Livermore National Security, Llc | Opto-thermal laser detonator |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1265057B1 (it) * | 1993-08-05 | 1996-10-28 | Dompe Spa | Tropil 7-azaindolil-3-carbossiamidi |
US6451816B1 (en) * | 1997-06-20 | 2002-09-17 | Klinge Pharma Gmbh | Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression |
DE19624668A1 (de) | 1996-06-20 | 1998-02-19 | Klinge Co Chem Pharm Fab | Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden |
NZ335422A (en) | 1996-11-26 | 2000-10-27 | Zeneca Ltd | 8-azabicyclo[3.2.1]octane-, 8-azabicyclo [3.2.1] oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives for use in insecticides |
US7485650B2 (en) * | 1998-07-27 | 2009-02-03 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
US20040067950A1 (en) * | 1998-07-27 | 2004-04-08 | Schering-Plough Corporation | High affinity ligands for nociceptin receptor ORL-1 |
ID29137A (id) * | 1998-07-27 | 2001-08-02 | Schering Corp | Ligan-ligan afinitas tinggi untuk reseptor nosiseptin orl-1 |
US6262066B1 (en) * | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
AR037211A1 (es) * | 2001-11-07 | 2004-10-27 | Schering Corp | Derivados de heteroarilo como ligandos superiores para el receptor de nociceptina orl-1 |
AR037364A1 (es) * | 2001-11-16 | 2004-11-03 | Schering Corp | Azetidinil diaminas utiles como ligandos del receptor de nociceptina orl-1 |
-
2006
- 2006-10-26 PE PE2006001305A patent/PE20071159A1/es not_active Application Discontinuation
- 2006-10-27 WO PCT/US2006/041925 patent/WO2007053435A1/en active Application Filing
- 2006-10-27 CA CA002627546A patent/CA2627546A1/en not_active Abandoned
- 2006-10-27 DE DE602006018645T patent/DE602006018645D1/de active Active
- 2006-10-27 CN CNA2006800499526A patent/CN101351465A/zh active Pending
- 2006-10-27 BR BRPI0618137-6A patent/BRPI0618137A2/pt not_active IP Right Cessation
- 2006-10-27 EP EP06826822A patent/EP1951721B1/en active Active
- 2006-10-27 AR ARP060104705A patent/AR056588A1/es not_active Application Discontinuation
- 2006-10-27 KR KR1020087012155A patent/KR20080064175A/ko not_active Application Discontinuation
- 2006-10-27 JP JP2008537972A patent/JP2009513664A/ja not_active Withdrawn
- 2006-10-27 SG SG201008032-3A patent/SG166811A1/en unknown
- 2006-10-27 TW TW095139885A patent/TW200800189A/zh unknown
- 2006-10-27 RU RU2008121743/04A patent/RU2008121743A/ru not_active Application Discontinuation
- 2006-10-27 AT AT06826822T patent/ATE490252T1/de not_active IP Right Cessation
- 2006-10-27 AU AU2006309085A patent/AU2006309085A1/en not_active Abandoned
- 2006-10-30 US US11/589,388 patent/US7479494B2/en active Active
-
2008
- 2008-04-27 IL IL191049A patent/IL191049A0/en unknown
- 2008-04-29 ZA ZA200803718A patent/ZA200803718B/xx unknown
- 2008-04-29 EC EC2008008410A patent/ECSP088410A/es unknown
- 2008-05-30 NO NO20082443A patent/NO20082443L/no not_active Application Discontinuation
- 2008-12-18 US US12/338,384 patent/US7910603B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
TW200800189A (en) | 2008-01-01 |
IL191049A0 (en) | 2008-12-29 |
BRPI0618137A2 (pt) | 2011-08-16 |
PE20071159A1 (es) | 2007-11-30 |
US20070249604A1 (en) | 2007-10-25 |
SG166811A1 (en) | 2010-12-29 |
AU2006309085A1 (en) | 2007-05-10 |
NO20082443L (no) | 2008-07-30 |
US20090105248A1 (en) | 2009-04-23 |
DE602006018645D1 (de) | 2011-01-13 |
RU2008121743A (ru) | 2009-12-10 |
CN101351465A (zh) | 2009-01-21 |
ZA200803718B (en) | 2009-03-25 |
JP2009513664A (ja) | 2009-04-02 |
KR20080064175A (ko) | 2008-07-08 |
WO2007053435A1 (en) | 2007-05-10 |
ECSP088410A (es) | 2008-05-30 |
CA2627546A1 (en) | 2007-05-10 |
EP1951721A1 (en) | 2008-08-06 |
US7910603B2 (en) | 2011-03-22 |
US7479494B2 (en) | 2009-01-20 |
EP1951721B1 (en) | 2010-12-01 |
ATE490252T1 (de) | 2010-12-15 |
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