AR056024A1 - Derivados de acido 3- oxo-indazol-escuarico - Google Patents
Derivados de acido 3- oxo-indazol-escuaricoInfo
- Publication number
- AR056024A1 AR056024A1 ARP060103477A ARP060103477A AR056024A1 AR 056024 A1 AR056024 A1 AR 056024A1 AR P060103477 A ARP060103477 A AR P060103477A AR P060103477 A ARP060103477 A AR P060103477A AR 056024 A1 AR056024 A1 AR 056024A1
- Authority
- AR
- Argentina
- Prior art keywords
- hal
- so2nh2
- nhso2a
- cooa
- conh2
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de ácido escuárico de la formula (1), en donde: R1 es H, A, Hal, CN, NO2, C(=O)A, CHO, CH(OH)A, NH2, NH(C=O)A, COOH, COOA, SO2NH2, CONH2, CONA2, (CH2)mAr o Het; R2 es OH, OA, Hal, CF3, SO2NH2, NHAc o NHSO2A; R2', R2'' son en cada caso, de modo independiente entre sí, H o Hal; Ac es acetilo; Ar es fenilo no sustituido o mono-, di- o trisustituido con Hal, A, OH, OA, NH2, NO2, CN, COOH, COOA, CONH2, NHCOA, NHCONH2, NHSO2A, SO2NH2 y/o S(O)mA; Het es furilo, tienilo, pirrolilo, imidazolilo, piridilo, pirimidinilo, pirazolilo, tiazolilo o indolilo no sustituido o mono-, di- o trisustituido con A, Hal, OH y/u OA; A es alquilo no ramificado o ramificado C1-10, en donde 1-7 átomos de H pueden estar reemplazados por F; X está ausente, es CH2, CHA, CA2 o una formula (2); m es 0, 1 o 2; n es 1, 2, 3 o 4; así como sus derivados, tautomeros, sales, solvatos y estereoisomeros de utilidad farmacéutica, incluyendo sus mezclas en todas las proporciones. Son inhibidores de las quinasas CHK1, CHK2 y SGK y se pueden utilizar, por ejemplo, para el tratamiento de enfermedades y dolencias tales como cáncer, diabetes, obesidad, síndrome metabolico (dislipidemia), hipertonía sistémica y pulmonar, enfermedades cardiocirculatorias y nefropatías, en general con cualquier tipo de fibrosis y procesos inflamatorios.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102005037499A DE102005037499A1 (de) | 2005-08-09 | 2005-08-09 | Pyrazolderivate |
Publications (1)
Publication Number | Publication Date |
---|---|
AR056024A1 true AR056024A1 (es) | 2007-09-12 |
Family
ID=37004918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060103477A AR056024A1 (es) | 2005-08-09 | 2006-08-09 | Derivados de acido 3- oxo-indazol-escuarico |
Country Status (9)
Country | Link |
---|---|
US (1) | US7662827B2 (es) |
EP (1) | EP1912998B1 (es) |
JP (1) | JP2009504582A (es) |
AR (1) | AR056024A1 (es) |
AU (1) | AU2006278862B2 (es) |
CA (1) | CA2618524C (es) |
DE (1) | DE102005037499A1 (es) |
ES (1) | ES2406737T3 (es) |
WO (1) | WO2007017083A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2623221T3 (es) | 2005-05-20 | 2017-07-10 | Methylgene Inc | Inhibidores de la señalización del receptor de VEGF y del receptor de HGF |
WO2007053343A2 (en) * | 2005-10-28 | 2007-05-10 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
US20080255155A1 (en) * | 2006-10-18 | 2008-10-16 | Stephane Raeppel | Kinase inhibitors and uses thereof |
WO2008115890A2 (en) * | 2007-03-19 | 2008-09-25 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors |
EP2276346B1 (en) * | 2008-04-30 | 2016-11-23 | National Health Research Institutes | Fused bicyclic pyrimidine compounds as aurora kinase inhibitors |
GB0818033D0 (en) | 2008-10-02 | 2008-11-05 | Respivert Ltd | Novel compound |
WO2010038086A2 (en) | 2008-10-02 | 2010-04-08 | Respivert Limited | Novel compounds |
CN102333770B (zh) | 2008-12-11 | 2015-01-28 | 瑞斯比维特有限公司 | P38map激酶抑制剂 |
GB0905955D0 (en) | 2009-04-06 | 2009-05-20 | Respivert Ltd | Novel compounds |
US8334315B2 (en) | 2009-05-07 | 2012-12-18 | Gruenenthal Gmbh | Substituted aromatic carboxamide and urea derivatives as vanilloid receptor ligands |
GB201005589D0 (en) | 2010-04-01 | 2010-05-19 | Respivert Ltd | Novel compounds |
CN103570723B (zh) * | 2012-07-27 | 2016-07-13 | 广西梧州制药(集团)股份有限公司 | 吡唑并嘧啶衍生物及其制备方法和在药物制备中的用途 |
CA2998647A1 (en) * | 2014-10-03 | 2016-04-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders |
CN106432240B (zh) * | 2016-09-21 | 2018-11-09 | 四川大学 | 含腺嘌呤结构的芳香族二胺及其制备方法和含腺嘌呤结构的聚酰亚胺及其制备方法 |
EP3774797A1 (en) | 2018-04-05 | 2021-02-17 | Merck Patent GmbH | Heteroaryl compounds as type ii irak inhibitors and uses hereof |
EP3906026A4 (en) | 2018-12-31 | 2022-10-19 | Biomea Fusion, LLC | IRREVERSIBLE MENIN-MLL INTERACTION INHIBITORS |
EP3906029A4 (en) | 2018-12-31 | 2022-09-21 | Biomea Fusion, LLC | INHIBITORS OF MENIN-MLL INTERACTION |
AU2022331496A1 (en) | 2021-08-20 | 2024-02-29 | Biomea Fusion, Inc. | Crystalline form of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(1-oxo -2-propen-1-yl)amino]-1-piperidinyl]methyl]-2-pyridinecarboxamide, an irreversible menin-mll inhibitor for the treatment of cancer |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999023091A1 (en) * | 1997-11-03 | 1999-05-14 | Boehringer Ingelheim Pharmaceuticals, Inc. | Aromatic heterocyclic compounds as anti-inflammatory agents |
ATE300299T1 (de) * | 1997-12-22 | 2005-08-15 | Bayer Pharmaceuticals Corp | Inhibierung der raf-kinase durch substituierte heterocyclische harnstoffverbindungen |
ES2155817T3 (es) | 1997-12-22 | 2007-06-16 | Bayer Pharmaceuticals Corp. | Inhibicion de la actividad de la quinasa p38 utilizando ureas heterociclicas sustituidas con arilo y heteroarilo. |
PL341356A1 (en) | 1997-12-22 | 2001-04-09 | Bayer Ag | Raf kinase inhibition employing aryl- and heteroaryl-substituted heterocyclic ureas |
EP1041982B1 (en) * | 1997-12-22 | 2011-10-19 | Bayer HealthCare LLC | INHIBITION OF p38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS |
KR100709497B1 (ko) * | 1999-03-12 | 2007-04-20 | 베링거 인겔하임 파마슈티칼즈, 인코포레이티드 | 소염제로서 유용한 화합물 및 이의 제조방법 |
DE60228103D1 (de) | 2001-10-02 | 2008-09-18 | Smithkline Beecham Corp | Chemische verbindungen |
WO2003032989A1 (en) * | 2001-10-18 | 2003-04-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors |
UA80171C2 (en) * | 2002-12-19 | 2007-08-27 | Pfizer Prod Inc | Pyrrolopyrimidine derivatives |
CA2516624C (en) * | 2003-02-28 | 2013-05-14 | Bayer Pharmaceuticals Corporation | 2-oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatory disorders |
US20070010529A1 (en) * | 2003-05-19 | 2007-01-11 | Kanji Takahashi | Nitrogenous heterocyclic compounds and medical use thereof |
DE10352979A1 (de) * | 2003-11-13 | 2005-06-09 | Merck Patent Gmbh | Pyridopyrimidinone |
UY28931A1 (es) * | 2004-06-03 | 2005-12-30 | Bayer Pharmaceuticals Corp | Derivados de pirrolotriazina utiles para tratar trastornos hiper-proliferativos y enfermedades asociadas con angiogenesis |
GB0423554D0 (en) * | 2004-10-22 | 2004-11-24 | Cancer Rec Tech Ltd | Therapeutic compounds |
FR2878849B1 (fr) | 2004-12-06 | 2008-09-12 | Aventis Pharma Sa | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
EA012613B1 (ru) * | 2004-12-06 | 2009-10-30 | Авентис Фарма С.А. | Замещённые индолы, содержащие их композиции, способ получения и применение |
GB0500435D0 (en) * | 2005-01-10 | 2005-02-16 | Novartis Ag | Organic compounds |
-
2005
- 2005-08-09 DE DE102005037499A patent/DE102005037499A1/de not_active Withdrawn
-
2006
- 2006-07-24 US US12/063,020 patent/US7662827B2/en not_active Expired - Fee Related
- 2006-07-24 JP JP2008525422A patent/JP2009504582A/ja active Pending
- 2006-07-24 CA CA2618524A patent/CA2618524C/en not_active Expired - Fee Related
- 2006-07-24 AU AU2006278862A patent/AU2006278862B2/en not_active Ceased
- 2006-07-24 ES ES06776357T patent/ES2406737T3/es active Active
- 2006-07-24 WO PCT/EP2006/007245 patent/WO2007017083A1/de active Application Filing
- 2006-07-24 EP EP06776357A patent/EP1912998B1/de not_active Not-in-force
- 2006-08-09 AR ARP060103477A patent/AR056024A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US20080207647A1 (en) | 2008-08-28 |
JP2009504582A (ja) | 2009-02-05 |
AU2006278862B2 (en) | 2011-11-17 |
AU2006278862A1 (en) | 2007-02-15 |
EP1912998A1 (de) | 2008-04-23 |
CA2618524C (en) | 2014-05-13 |
CA2618524A1 (en) | 2007-02-15 |
ES2406737T3 (es) | 2013-06-07 |
EP1912998B1 (de) | 2013-03-06 |
US7662827B2 (en) | 2010-02-16 |
WO2007017083A1 (de) | 2007-02-15 |
DE102005037499A1 (de) | 2007-02-15 |
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