AR056005A1 - Cianopirrol - sulfonamidas moduladores del receptor de progesterona y usos de los mismos - Google Patents
Cianopirrol - sulfonamidas moduladores del receptor de progesterona y usos de los mismosInfo
- Publication number
- AR056005A1 AR056005A1 ARP060103257A ARP060103257A AR056005A1 AR 056005 A1 AR056005 A1 AR 056005A1 AR P060103257 A ARP060103257 A AR P060103257A AR P060103257 A ARP060103257 A AR P060103257A AR 056005 A1 AR056005 A1 AR 056005A1
- Authority
- AR
- Argentina
- Prior art keywords
- substituted
- alkyl
- aryl
- alkenyl
- alkynyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Los compuestos de la presente son utiles para la contracepcion y terapia de reemplazo hormonal. Reivindicacion 1: Un compuesto que tiene la estructura de la formula (1), o su sal aceptable para uso farmacéutico donde: R1 se selecciona del grupo que consiste en: H, CN, SO2-alquilo C1-6, SO2-cicloalquilo C3-8, SO2-alquilo C1-6 sustituido, SO2-arilo, SO2-arilo sustituido, SO2-heteroarilo, SO2-heterociclo, SO2-alquenilo C3-6, SO2-alquinilo C3-6, SO2-alquenilo C3-6 sustituido, SO2-alquinilo C3-6 sustituido, C(O)-alquilo C1-6, C(O)-cicloalquilo C3-8, C(O)-alquilo C1-6 sustituido, C(O)-arilo, C(O)-arilo sustituido, C(O)-heteroarilo, C(O)-heterociclo, C(O)-alquenilo C3-6, C(O)-alquinilo C3-6, C(O)-alquenilo C3-6 sustituido, C(O)-alquinilo C3-6 sustituido, C(O)O-alquilo C1-6, C(O)O-cicloalquilo C3-8, C(O)O-alquilo C1-6 sustituido, C(O)O-arilo, C(O)O-arilo sustituido, C(O)O-heteroarilo, C(O)O-heterociclo, C(O)O-alquenilo C3-6, C(O)O-alquinilo C3-6, C(O)O-alquenilo C3-6 sustituido, C(O)O- alquinilo C3-6 sustituido, C(O)NH-alquilo C1-6, C(O)NH-cicloalquilo C3-8, C(O)N-di-ciclolquilo C3-8, C(O)N-di-alquilo C1-6, C(O)N-di-alquilo C1-6 disustituido, C(O)NH-alquilo C1-6 sustituido, C(O)NH-arilo, C(O)N-di-arilo, C(O)NH-arilo sustituido, C(O)N-diarilo, C(O)NH-heteroarilo, C(O)NH-heterociclo, C(O)N-diheteroarilo, C(O)N-diheterociclo, C(O)NH-alquenilo C3-6, C(O)NH-alquinilo C3-6, C(O)NH-alquenilo C3-6 sustituido y C(O)NH-alquinilo C3-6 sustituido; o R1 es un grupo de union a una segunda estructura de formula (1) para formar un dímero de formula (1), dicho grupo de union se selecciona del grupo que consiste en C(O)- y S(O)2-; R2 se selecciona del grupo que consiste en H, alquilo C1-6, alquilo C1-6 sustituido, cicloalquilo C3- 6, SO2-alquilo y SO2-alquilo sustituido; con la condicion de que por lo menos uno de R1 o R2 contengan un grupo que tiene un enlace SO2- al N o R1 es un grupo de union S(O)2-; o R1 y R2 se unen para formar -(C(R8)a(R9)b)c-SO2-(C(R8)d(R9)e)f-; R8 y R9 son, independientemente, H, halogeno, o alquilo C1-6; a y b son, independientemente, 0 a 2, con la condicion de que a + b = 2; d y e son, independientemente, 0 a 2, con la condicion de que a + b = 2; c y f son, independientemente, 0 a 5, con la condicion de que uno de c o f sea mayor que 0; R3,. R4, R5 y R6 se seleccionan independientemente del grupo que consiste en H, halogeno, CN, alquilo C1-6, alquilo C1-6 sustituido, (CHmXn)zCHpXq, cicloalquilo C3-6, O-alquilo C1-6, O-alquilo C1-6 sustituido, O-(CHmXn)zCHpXq, arilo, heteroarilo, heterociclo, arilo sustituido, heteroarilo sustituido, heterociclo sustituido; X es halogeno; m y n son independientemente, 0 a 2, con la condicion de que m + n = 2; p y q son, independientemente, 0 a 3, con la condicion de que p + q = 3; y z es 0 a 10; R7 se selecciona del grupo que consiste en H, alquilo C1-6, C(O)O-alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alquilo C1-6 sustituido, cicloalquilo C3-6 y cicloalquilo C3-6 sustituido.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70400905P | 2005-07-29 | 2005-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR056005A1 true AR056005A1 (es) | 2007-09-12 |
Family
ID=37309001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060103257A AR056005A1 (es) | 2005-07-29 | 2006-07-27 | Cianopirrol - sulfonamidas moduladores del receptor de progesterona y usos de los mismos |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7291643B2 (es) |
| EP (1) | EP1910285A1 (es) |
| JP (1) | JP5185114B2 (es) |
| KR (1) | KR20080031915A (es) |
| CN (1) | CN101233104A (es) |
| AR (1) | AR056005A1 (es) |
| AU (1) | AU2006275833B2 (es) |
| BR (1) | BRPI0614412A2 (es) |
| CA (1) | CA2612977A1 (es) |
| CR (1) | CR9627A (es) |
| EC (1) | ECSP088147A (es) |
| GT (1) | GT200600336A (es) |
| HN (1) | HN2008000135A (es) |
| IL (1) | IL188314A (es) |
| MX (1) | MX2008001338A (es) |
| NO (1) | NO20076683L (es) |
| PE (1) | PE20070404A1 (es) |
| RU (1) | RU2007148077A (es) |
| SA (1) | SA06270246B1 (es) |
| TW (1) | TW200734302A (es) |
| UA (1) | UA92500C2 (es) |
| WO (1) | WO2007016212A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20070341A1 (es) * | 2005-07-29 | 2007-04-13 | Wyeth Corp | Derivados de pirrol como moduladores del receptor de progesterona |
| PE20070182A1 (es) * | 2005-07-29 | 2007-03-06 | Wyeth Corp | Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona |
| TW200848019A (en) | 2007-03-06 | 2008-12-16 | Wyeth Corp | Aryl sulfonamides useful for modulation of the progesterone receptor |
| TW200848021A (en) * | 2007-03-06 | 2008-12-16 | Wyeth Corp | Sulfonylated heterocycles useful for modulation of the progesterone receptor |
| WO2009082478A1 (en) * | 2007-12-20 | 2009-07-02 | Duramed Pharmaceuticals, Inc. | Dosage regimens and pharmaceutical compositions and packages for emergency contraception |
| JP6293770B2 (ja) | 2012-11-05 | 2018-03-14 | ナント ホールディングス アイピー，エルエルシー | ヘッジホッグシグナル伝達経路阻害剤としての環状スルホンアミド含有誘導体 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680413A (en) * | 1986-01-17 | 1987-07-14 | Nippon Soda Co., Ltd. | Process for the production of 3-phenyl-4-cyanopyrroles |
| US5310938A (en) * | 1987-07-29 | 1994-05-10 | American Cyanamid Company | Substituted arylpyrrole compounds |
| EP0339342A1 (de) * | 1988-04-23 | 1989-11-02 | Bayer Ag | N-Substituierte N-Amino-pyrrole |
| GB8903592D0 (en) * | 1989-02-16 | 1989-04-05 | Boots Co Plc | Therapeutic agents |
| DE4036645A1 (de) | 1990-11-16 | 1992-05-21 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, deren enthaltende mittel und deren verwendung |
| JP2699024B2 (ja) | 1990-11-22 | 1998-01-19 | 富士写真フイルム株式会社 | 新規な色素形成カプラーおよび該カプラーを含有するハロゲン化銀カラー写真感光材料 |
| US5187168A (en) * | 1991-10-24 | 1993-02-16 | American Home Products Corporation | Substituted quinazolines as angiotensin II antagonists |
| US5236925A (en) * | 1991-10-24 | 1993-08-17 | American Home Products Corporation | Fused pyrimidines as angiotensin II antagonists |
| AU5891494A (en) | 1993-01-29 | 1994-08-15 | Nippon Soda Co., Ltd. | Heterocyclic derivative |
| CA2223918C (en) * | 1995-06-07 | 2006-01-10 | Nippon Shinyaku Co., Ltd. | Pyrrole derivatives and medicinal composition |
| US6013421A (en) * | 1996-07-19 | 2000-01-11 | Fuji Photo Film Co., Ltd. | Silver halide photographic light-sensitive material and image-forming method |
| US20010007867A1 (en) * | 1999-12-13 | 2001-07-12 | Yuhpyng L. Chen | Substituted 6,5-hetero-bicyclic derivatives |
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| DE60210755T2 (de) * | 2001-03-09 | 2006-11-16 | Pfizer Products Inc., Groton | Triazolopyridine als entzündungshemmende mittel |
| AP2002002460A0 (en) * | 2001-03-09 | 2002-06-30 | Pfizer Prod Inc | Novel benzimidazole anti-inflammatory compounds. |
| ES2247271T3 (es) * | 2001-04-04 | 2006-03-01 | Pfizer Products Inc. | Nuevos benzotriazoles como compuestos antiinflamatorios. |
| AU2003276201A1 (en) | 2002-11-11 | 2004-06-03 | Bayer Healthcare Ag | Phenyl or heteroaryl amino alkane derivatives as ip receptor antagonist |
| JP4584908B2 (ja) | 2003-02-12 | 2010-11-24 | ロレアル | 皮膚または皮膚付属物の色素沈着を刺激するための１５−ヒドロキシプロスタグランジンデヒドロゲナーゼの阻害剤の使用 |
| WO2005105739A2 (en) * | 2004-04-27 | 2005-11-10 | Wyeth | Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same |
| GT200500183A (es) | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos | |
| GT200500185A (es) * | 2004-08-09 | 2006-04-10 | Moduladores del receptor de progesterona que comprenden derivados de pirrol-oxindol y sus usos |
-
2006
- 2006-07-26 PE PE2006000915A patent/PE20070404A1/es not_active Application Discontinuation
- 2006-07-27 US US11/494,226 patent/US7291643B2/en not_active Expired - Fee Related
- 2006-07-27 BR BRPI0614412A patent/BRPI0614412A2/pt not_active IP Right Cessation
- 2006-07-27 CA CA002612977A patent/CA2612977A1/en not_active Abandoned
- 2006-07-27 TW TW095127519A patent/TW200734302A/zh unknown
- 2006-07-27 CN CNA2006800277588A patent/CN101233104A/zh active Pending
- 2006-07-27 UA UAA200801075A patent/UA92500C2/ru unknown
- 2006-07-27 AU AU2006275833A patent/AU2006275833B2/en not_active Ceased
- 2006-07-27 KR KR1020087002371A patent/KR20080031915A/ko not_active Application Discontinuation
- 2006-07-27 EP EP06774705A patent/EP1910285A1/en not_active Withdrawn
- 2006-07-27 GT GT200600336A patent/GT200600336A/es unknown
- 2006-07-27 JP JP2008524136A patent/JP5185114B2/ja not_active Expired - Fee Related
- 2006-07-27 AR ARP060103257A patent/AR056005A1/es not_active Application Discontinuation
- 2006-07-27 WO PCT/US2006/029125 patent/WO2007016212A1/en active Application Filing
- 2006-07-27 RU RU2007148077/04A patent/RU2007148077A/ru not_active Application Discontinuation
- 2006-07-27 MX MX2008001338A patent/MX2008001338A/es active IP Right Grant
- 2006-07-29 SA SA06270246A patent/SA06270246B1/ar unknown
-
2007
- 2007-12-20 CR CR9627A patent/CR9627A/es not_active Application Discontinuation
- 2007-12-20 IL IL188314A patent/IL188314A/en not_active IP Right Cessation
- 2007-12-28 NO NO20076683A patent/NO20076683L/no not_active Application Discontinuation
-
2008
- 2008-01-28 HN HN2008000135A patent/HN2008000135A/es unknown
- 2008-01-28 EC EC2008008147A patent/ECSP088147A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2007148077A (ru) | 2009-09-10 |
| IL188314A0 (en) | 2008-04-13 |
| MX2008001338A (es) | 2008-03-25 |
| PE20070404A1 (es) | 2007-05-10 |
| BRPI0614412A2 (pt) | 2016-11-22 |
| JP2009502947A (ja) | 2009-01-29 |
| EP1910285A1 (en) | 2008-04-16 |
| JP5185114B2 (ja) | 2013-04-17 |
| TW200734302A (en) | 2007-09-16 |
| HN2008000135A (es) | 2010-08-19 |
| US20070027126A1 (en) | 2007-02-01 |
| US7291643B2 (en) | 2007-11-06 |
| SA06270246B1 (ar) | 2010-11-22 |
| CA2612977A1 (en) | 2007-02-08 |
| WO2007016212A1 (en) | 2007-02-08 |
| CR9627A (es) | 2008-03-06 |
| NO20076683L (no) | 2008-02-04 |
| GT200600336A (es) | 2007-05-28 |
| AU2006275833B2 (en) | 2012-04-26 |
| IL188314A (en) | 2012-09-24 |
| AU2006275833A1 (en) | 2007-02-08 |
| UA92500C2 (ru) | 2010-11-10 |
| ECSP088147A (es) | 2008-02-20 |
| CN101233104A (zh) | 2008-07-30 |
| KR20080031915A (ko) | 2008-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |