AR055482A1 - Inmunogeno anti veneno contra el veneno de la arana violinista - Google Patents
Inmunogeno anti veneno contra el veneno de la arana violinistaInfo
- Publication number
- AR055482A1 AR055482A1 ARP050103622A ARP050103622A AR055482A1 AR 055482 A1 AR055482 A1 AR 055482A1 AR P050103622 A ARP050103622 A AR P050103622A AR P050103622 A ARP050103622 A AR P050103622A AR 055482 A1 AR055482 A1 AR 055482A1
- Authority
- AR
- Argentina
- Prior art keywords
- sphingomyelinase
- arana
- loxosceles
- fragments
- boneti
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43513—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae
- C07K14/43518—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from arachnidae from spiders
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Insects & Arthropods (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La presente comprende el aislamiento, caracterizacion y expresion de los fragmentos de DNA codificantes de las esfingomielinasas D de 3 especies de arana del género Loxosceles: L.boneti, L. reclusa y L. laeta. También comprende la produccion por medios recombinantes de las esfingomielinasas D activas y su uso como inmunogeno para la produccion en vertebrados de anticuerpos neutralizantes del veneno correspondiente y de los fragmentos F(ab')2 respectivos. También se incluye el uso de las esfingomielinasas D recombinantes como parte de una matriz antigénica util en la inmunopurificacion de anticuerpos y sus fragmentos o como parte de algun dispositivo diagnostico para corroborar en clínica que el agente causal del estado de envenenamiento de un paciente sea una arana del género Loxosceles. reivindicacion 1: Una proteína aislada del veneno de la arana Loxosceles boneti, que presenta una actividad de esfingomielinasa y produce dermonecrosis en un mamífero inoculado con ella, caracterizada por que tiene la secuencia aminoácida SEQ: ID. N°: 11.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MXPA04008435A MXPA04008435A (es) | 2004-08-31 | 2004-08-31 | Inmunogeno y anti-veneno contra el veneno de la arana violinista. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055482A1 true AR055482A1 (es) | 2007-08-22 |
Family
ID=36000447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103622A AR055482A1 (es) | 2004-08-31 | 2005-08-30 | Inmunogeno anti veneno contra el veneno de la arana violinista |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8287860B2 (es) |
| AR (1) | AR055482A1 (es) |
| AU (1) | AU2005280742B2 (es) |
| BR (1) | BRPI0514809A (es) |
| MX (2) | MXPA04008435A (es) |
| WO (1) | WO2006025718A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04008435A (es) * | 2004-08-31 | 2006-03-02 | Univ Mexico Nacional Autonoma | Inmunogeno y anti-veneno contra el veneno de la arana violinista. |
| MX367136B (es) | 2012-10-18 | 2019-08-06 | Inosan Biopharma S A Star | Proceso para purificar fragmentos de anticuerpos polivalentes derivados de plasma hiperinmune. |
| IT202000023809A1 (it) * | 2020-10-09 | 2022-04-09 | Craniomed Group S R L | Anatossine e anticorpi per l’uso nella prevenzione e nel trattamento della malattia da coronavirus. |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196193A (en) | 1989-10-31 | 1993-03-23 | Ophidian Pharmaceuticals, Inc. | Antivenoms and methods for making antivenoms |
| MXPA99011191A (es) | 1999-12-03 | 2005-04-04 | Univ Mexico Nacional Autonoma | Inmunogeno, anti-veneno y vacuna contra el venenode la arana viuda negra. |
| MXPA04008435A (es) * | 2004-08-31 | 2006-03-02 | Univ Mexico Nacional Autonoma | Inmunogeno y anti-veneno contra el veneno de la arana violinista. |
-
2004
- 2004-08-31 MX MXPA04008435A patent/MXPA04008435A/es active IP Right Grant
-
2005
- 2005-08-29 BR BRPI0514809-0A patent/BRPI0514809A/pt not_active Application Discontinuation
- 2005-08-29 WO PCT/MX2005/000071 patent/WO2006025718A2/es active Application Filing
- 2005-08-29 AU AU2005280742A patent/AU2005280742B2/en not_active Ceased
- 2005-08-29 MX MX2011012895A patent/MX344494B/es unknown
- 2005-08-29 US US11/574,488 patent/US8287860B2/en active Active
- 2005-08-30 AR ARP050103622A patent/AR055482A1/es not_active Application Discontinuation
-
2012
- 2012-09-11 US US13/610,516 patent/US8541551B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006025718A3 (es) | 2006-11-02 |
| US8541551B2 (en) | 2013-09-24 |
| AU2005280742A1 (en) | 2006-03-09 |
| US20110177078A1 (en) | 2011-07-21 |
| US20130071399A1 (en) | 2013-03-21 |
| MX344494B (es) | 2016-12-19 |
| AU2005280742B2 (en) | 2013-01-17 |
| US8287860B2 (en) | 2012-10-16 |
| BRPI0514809A (pt) | 2008-06-24 |
| WO2006025718A2 (es) | 2006-03-09 |
| MXPA04008435A (es) | 2006-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |