AR051302A1 - Un procedimiento para preparar saquinavir utilizando un intermediario - Google Patents

Un procedimiento para preparar saquinavir utilizando un intermediario

Info

Publication number
AR051302A1
AR051302A1 ARP050104036A ARP050104036A AR051302A1 AR 051302 A1 AR051302 A1 AR 051302A1 AR P050104036 A ARP050104036 A AR P050104036A AR P050104036 A ARP050104036 A AR P050104036A AR 051302 A1 AR051302 A1 AR 051302A1
Authority
AR
Argentina
Prior art keywords
formula
saquinavir
intermediary
prepare
procedure
Prior art date
Application number
ARP050104036A
Other languages
English (en)
Inventor
Reddy Bandi Parthasaradhi
Reddy Kura Rathnakar
Reddy Rapolu Raji
Kumar Dandamudi Satish
Original Assignee
Hetero Drugs Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hetero Drugs Ltd filed Critical Hetero Drugs Ltd
Publication of AR051302A1 publication Critical patent/AR051302A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Reivindicacion 1: Un procedimiento para preparar saquinavir de la formula (1) o una sal farmacéuticamente aceptable del mismo caracterizado porque comprende. A) hacer reaccionar N2-(2-quinolinilcarbonil)-L-asparagina de la formula (2) con cloruro de pivaloilo de formula (3) en presencia de una base orgánica para obtener un anhídrido mixto de formula (4); b) hacer reaccionar el anhídrido mixto de formula (4) con [3S, 4aS, 8aS]-2-(3(s)-amino-2-( R )-hidroxi-4-fenilbutil -N-(1,1- dimetiletil)decahidro-3-isoquinolina carboxa-mida de formula (5) para obtener saquinavir de la formula (1) y opcionalmente convertir saquinavir en sus sales ácidas de adicion farmacéuticamente aceptables. Reivindicacion 13: Compuesto de formula (4).
ARP050104036A 2005-06-16 2005-09-26 Un procedimiento para preparar saquinavir utilizando un intermediario AR051302A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2005/000204 WO2006134612A1 (en) 2005-06-16 2005-06-16 A process for the preparation of saquinavir using novel intermediate

Publications (1)

Publication Number Publication Date
AR051302A1 true AR051302A1 (es) 2007-01-03

Family

ID=37531996

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050104036A AR051302A1 (es) 2005-06-16 2005-09-26 Un procedimiento para preparar saquinavir utilizando un intermediario

Country Status (2)

Country Link
AR (1) AR051302A1 (es)
WO (1) WO2006134612A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2398773A2 (en) * 2009-02-17 2011-12-28 Hetero Research Foundation Novel polymorphs of saquinavir
CN102260243B (zh) * 2011-06-09 2013-08-14 沈阳亿灵医药科技有限公司 沙奎那韦琥珀酸半酯盐及其制剂
CN111013309B (zh) * 2019-12-17 2022-01-14 南通市天时化工有限公司 特戊酰氯生产过程中尾气的净化与物料回收的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927913D0 (en) * 1989-12-11 1990-02-14 Hoffmann La Roche Amino acid derivatives

Also Published As

Publication number Publication date
WO2006134612A1 (en) 2006-12-21

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