AR051071A1 - Antagonismo de la actividad del receptor de interleuquina-21 - Google Patents

Antagonismo de la actividad del receptor de interleuquina-21

Info

Publication number
AR051071A1
AR051071A1 ARP050103287A ARP050103287A AR051071A1 AR 051071 A1 AR051071 A1 AR 051071A1 AR P050103287 A ARP050103287 A AR P050103287A AR P050103287 A ARP050103287 A AR P050103287A AR 051071 A1 AR051071 A1 AR 051071A1
Authority
AR
Argentina
Prior art keywords
activity
antagonists
receptor
fusion protein
interleuquina
Prior art date
Application number
ARP050103287A
Other languages
English (en)
Inventor
Deborah A Young
Mary Collins
Dunussi-Joannopoulos
Marion T Kasaian
Hara Richard Michael O
Matthew Whitters
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR051071A1 publication Critical patent/AR051071A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A01K2217/00—Genetically modified animals
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    • A01K2267/03—Animal model, e.g. for test or diseases
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    • A01K2267/0368—Animal model for inflammation
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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    • G01—MEASURING; TESTING
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    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

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Abstract

Se describen métodos y composiciones para inhibir la actividad de la interleuquina-21 (IL-21)/el receptor de IL-21 (MU-1) usando antagonistas de IL-21 o del receptor IL-21 (ôIL-21Rö o ôMU-1ö). Los antagonistas de IL-21/IL-21R pueden usarse para inducir la supresion inmune in vivo, por ejemplo, para tratar, mejorar o prevenir los trastornos autoinmunes o inflamatorios, incluyendo, por ejemplo, la enfermedad intestinal inflamatoria (IBD), l artritis reumatoide (RA), el rechazo de transplantes/injertos, la psoriasis, el asma, la fibrosis y el lupus eritematoso sistémico (SLE). Reivindicacion 1: Una proteína de fusion caracterizado porque está compuesta por un dominio extracelular de un IL-21R y un fragmento de inmunoglobulina Fc, donde el IL-21R tiene una secuencia de aminoácidos al menos 90% idéntica a la secuencia detallada en SEQ ID N. 2, y donde la proteína de fusion es capaz de unirse a IL-21.
ARP050103287A 2004-08-05 2005-08-05 Antagonismo de la actividad del receptor de interleuquina-21 AR051071A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59908604P 2004-08-05 2004-08-05
US63917604P 2004-12-23 2004-12-23

Publications (1)

Publication Number Publication Date
AR051071A1 true AR051071A1 (es) 2006-12-20

Family

ID=37309615

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103287A AR051071A1 (es) 2004-08-05 2005-08-05 Antagonismo de la actividad del receptor de interleuquina-21

Country Status (16)

Country Link
US (2) US20060039902A1 (es)
EP (1) EP1773394A2 (es)
JP (1) JP2008508885A (es)
KR (1) KR20070057789A (es)
AR (1) AR051071A1 (es)
AU (1) AU2005332996A1 (es)
BR (1) BRPI0514138A (es)
CA (1) CA2574848A1 (es)
CR (1) CR8891A (es)
EC (1) ECSP077226A (es)
IL (1) IL181044A0 (es)
MX (1) MX2007001509A (es)
NO (1) NO20070973L (es)
RU (1) RU2007102287A (es)
TW (1) TW200608995A (es)
WO (1) WO2006135385A2 (es)

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