AR048304A1 - Derivados de bencimidazolilo - Google Patents
Derivados de bencimidazoliloInfo
- Publication number
- AR048304A1 AR048304A1 ARP050100706A ARP050100706A AR048304A1 AR 048304 A1 AR048304 A1 AR 048304A1 AR P050100706 A ARP050100706 A AR P050100706A AR P050100706 A ARP050100706 A AR P050100706A AR 048304 A1 AR048304 A1 AR 048304A1
- Authority
- AR
- Argentina
- Prior art keywords
- cr5r6
- group
- independently
- hal
- kor13
- Prior art date
Links
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 229910052717 sulfur Inorganic materials 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 alkylenecycloalkyl Chemical group 0.000 abstract 2
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 abstract 2
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/49—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton
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- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
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- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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Abstract
Derivados de bencimidazolilo y uso de los compuestos de formula (1) para preparar una composicion farmacéutica y a un método de tratamiento que comprende la administracion de dicha composicion farmacéutica a un paciente. Reivindicacion 1: derivados de bencimidazolilo e la formula (1) en donde Ar1 está seleccionado de hidrocarburos aromáticos que contienen 6 a 14 átomos de carbono y residuos heterocíclicos etilénicos insaturados o aromáticos que contienen 3 a 10 átomos de carbono y uno o dos heteroátomos, seleccionados de modo independiente de N, O y S, E es (CR5R6)n, en donde n es 1 o 2; D es (CR5R6)k, en donde k es 0 o 1; R5, R6 están seleccionados, en cada caso de modo independiente entre sí, de H y A; R8, R9, y R10 están seleccionados de modo independiente de un grupo integrado por H, A, cicloalquilo que comprende 3 a 7 átomos de C, Hal, CH2Hal, CH(Hal)2, C(Hal)3, NO2, (CH2)nCN, OHet, N(R11)Het, NR11COR13, NR11COOR13, CONR11R12, COOR13, (CR5R6)kHet, O(CR5R6)kHet, N(R11)(CR5R6)kHet, (CR5R6)kNR11R12, (CR5R6)kOR13, O(CR5R6)kNR11R12, NR11(CR5R6)kNR11R12, O(CR5R6)kR13, NR11(CR5R6)kR13, O(CR5R6)kOR13, NR11(CR5R6)kOR13, (CH2)nNR11R12, (CH2)nO(CH2)kNR11R12, (CH2)nNR11(CH2)kNR11R12, (CH2)nO(CH2)kOR11, (CH2)nNR11(CH2)kOR12, (CH2)nCOOR13, (CH2)nCOR13, (CH2)nCONR11R12, (CH2)nNR11COR13, (CH2)nNR11CONR11R12, (CH2)nNR11SO2A, (CH2)nSO2NR11R12, (CH2)nS(O)uR13, (CH2)nOC(O)R13, (CH2)nCOR13, (CH2)nSR11, CH=N-OA, CH2CH=N-OA, (CH2)nNHOA, (CH2)nCH=N-R11, (CH2)nOC(O) NR11R12, (CH2)nNR11COOR13, (CH2)nN(R11)CH2CH2OR13, (CH2)nN(R11)CH2CH2OCF3, (CH2)nN(R11)C(R13)HCOOR12, (CH2)nN(R11)C(R13)HCOR11, (CH2)nN(R11)CH2CH2N(R12)CH2COOR11, (CH2)n N(R11)CH2CH2 NR11R12, CH=CHCOOR13, CH=CHCH2 NR11R12, CH=CHCH2NR11R12, CH=CHCH2OR13, (CH2)nN(COOR13)COOR14, (CH2)nN(CONH2)COOR13, (CH2)nN(CONH2)CONH2, (CH2)nN(CH2COOR13)COOR14, (CH2)nN(CH2CONH2)COOR13, (CH2)nN(CH2CONH2)CONH2, (CH2)nCHR13COR14, (CH2)nCHR13COOR14, (CH2)nCHR13CH2OR14, (CH2)nOCN y (CH2)nNCO, en donde R11, R12 están seleccionados de modo independiente de un grupo integrado por H, A, (CH2)mAr3 y (CH2)mHet, o en NR11R12; R11 y R12 forman, junto con el átomo de N al que están unidos, un heterociclo de 5, 6 o 7 miembros que opcionalmente contiene 1 o 2 heteroátomos adicionales, seleccionados de N, O y S; R13 , R14 están seleccionados de modo independiente de un grupo integrado por H, Hal, A, (CH2)mAr4 y (CH2)mHet, A está seleccionado del grupo integrado por alquilo, alquenilo, cicloalquilo, alquilencicloalquilo, alcoxi, alcoxialquilo y heterociclilo saturado, con preferencia del grupo integrado por alquilo, alquenilo, cicloalquilo, alquilencicloalquilo, alcoxi y alcoxialquilo; Ar3, Ar4 son, de modo independiente entre sí, residuos hidrocarbonados aromáticos que comprenden 5 a 12 y con preferencia 5 a 10 átomos de C que están opcionalmente sustituidos con uno o varios sustituyentes, seleccionados de un grupo integrado por A, Hal, NO2, CN, OR15, NR15R16, COOR15, CONR15R16, NR15COR16, NR15CONR15R16, NR16SO2A, COR15, SO2NR15R16, S(O)uA y OOCR15, Het es un residuo heterocíclico saturado, insaturado o aromático que está opcionalmente sustituido con uno o varios sustituyentes, seleccionados de un grupo integrado por AQ, Hal, NO2, CN, OR15, NR15R16, COOR15, CONR15R16, NR15COR16, NR15CONR15R16, NR16SO2A, COR15, SO2NR15R16, SW(O)uA y OOCR15; R15, R16 están seleccionados de modo independiente de un grupo integrado por H, AQ y (CH2)mAr6, en donde Ar6 es un hidrocarburo aromático de 5 o 6 miembros que está opcionalmente sustituido con uno o varios sustituyentes seleccionados de un grupo integrado por metilo, etilo, propilo, 2-propilo, ter-butilo, Hal, CN, OH, NH2 y CF3, k, n y m son, de modo independiente entre sí, 0, 1, 2, 3, 4 o 5; Y esta seleccionado de O, S, NR21, C(R22)-NO2, C(R22)-CN y C(CN)2, en donde R21 está seleccionado de modo independiente de los significados dados para R13, R14 y R22 está seleccionado de modo independiente de los significados dados para R11, R12, p es, de modo independiente en cada caso, 0, 1, 2, 3, 4 o 5, q es 0, 1, 2, 3 o 4, con preferencia 0, 1 o 2, u es 0, 1, 2 o 3, con preferencia 0, 1 o 2, y Hal está seleccionado de modo independiente de un grupo integrado por F, Cl, Br e I; sus formas tautoméricas; y sus derivados, sales y solvatos farmacéuticamente aceptables.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04004332 | 2004-02-26 | ||
| EP04004967 | 2004-03-03 |
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| AR048304A1 true AR048304A1 (es) | 2006-04-19 |
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Family Applications (1)
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|---|---|---|---|
| ARP050100706A AR048304A1 (es) | 2004-02-26 | 2005-02-25 | Derivados de bencimidazolilo |
Country Status (7)
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|---|---|
| US (1) | US20070191444A1 (es) |
| EP (1) | EP1718637A2 (es) |
| JP (1) | JP2007523929A (es) |
| AR (1) | AR048304A1 (es) |
| AU (1) | AU2005217042A1 (es) |
| CA (1) | CA2557398A1 (es) |
| WO (1) | WO2005082862A2 (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| ES2383927T3 (es) * | 2007-08-16 | 2012-06-27 | F. Hoffmann-La Roche Ag | Hidantoínas sustituidas |
| SG10202110259QA (en) | 2017-10-05 | 2021-10-28 | Fulcrum Therapeutics Inc | Use of p38 inhibitors to reduce expression of dux4 |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS575785B2 (es) * | 1973-12-18 | 1982-02-01 | ||
| JP2004517080A (ja) * | 2000-11-29 | 2004-06-10 | グラクソ グループ リミテッド | Ｔｉｅ−２および／またはｖｅｇｆｒ−２の阻害剤として有用なベンゾイミダゾール誘導体 |
| TWI236474B (en) * | 2001-04-03 | 2005-07-21 | Telik Inc | Antagonists of MCP-1 function and methods of use thereof |
| CN1705645A (zh) * | 2002-10-24 | 2005-12-07 | 默克专利有限公司 | 作为raf－激酶抑制剂的亚甲基脲衍生物 |
| JP5229853B2 (ja) * | 2003-02-28 | 2013-07-03 | ニッポネックス インコーポレイテッド | 癌その他の疾患の治療に有用な新規な二環尿素誘導体 |
| WO2005054183A2 (en) * | 2003-12-01 | 2005-06-16 | The Scripps Research Institute | Quinolinone based protein kinase inhibitors |
-
2005
- 2005-02-14 US US10/590,798 patent/US20070191444A1/en not_active Abandoned
- 2005-02-14 JP JP2007500097A patent/JP2007523929A/ja active Pending
- 2005-02-14 EP EP05715321A patent/EP1718637A2/en not_active Withdrawn
- 2005-02-14 WO PCT/EP2005/001445 patent/WO2005082862A2/en active Application Filing
- 2005-02-14 AU AU2005217042A patent/AU2005217042A1/en not_active Abandoned
- 2005-02-14 CA CA002557398A patent/CA2557398A1/en not_active Abandoned
- 2005-02-25 AR ARP050100706A patent/AR048304A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1718637A2 (en) | 2006-11-08 |
| WO2005082862A3 (en) | 2005-12-01 |
| AU2005217042A1 (en) | 2005-09-09 |
| WO2005082862A2 (en) | 2005-09-09 |
| JP2007523929A (ja) | 2007-08-23 |
| CA2557398A1 (en) | 2005-09-09 |
| US20070191444A1 (en) | 2007-08-16 |
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