AR046927A1 - Derivados de morfolina como inhibidores de la recaptacion de norepinefrina - Google Patents

Derivados de morfolina como inhibidores de la recaptacion de norepinefrina

Info

Publication number
AR046927A1
AR046927A1 ARP040104126A ARP040104126A AR046927A1 AR 046927 A1 AR046927 A1 AR 046927A1 AR P040104126 A ARP040104126 A AR P040104126A AR P040104126 A ARP040104126 A AR P040104126A AR 046927 A1 AR046927 A1 AR 046927A1
Authority
AR
Argentina
Prior art keywords
optionally substituted
alkyl
halogen atoms
alkoxy
hydroxy
Prior art date
Application number
ARP040104126A
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English (en)
Original Assignee
Lilly Co Eli
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Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29726235&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR046927(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR046927A1 publication Critical patent/AR046927A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D265/00Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/281,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/301,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/02Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos, métodos de preparacion, intermediarios, composiciones farmacéuticas, usos para el tratamiento de trastornos del sistema nervioso central y/o periférico, y procedimiento para inhibir la recaptacion de norepinefrina en mamíferos. Reivindicacion 1: Un compuesto de formula (1), en la que: X es OH, alcoxi C1-4, NH2 o NH(alquilo C1-4); Rx es H o alquilo C1-4; Ry es H o alquilo C1-4; cada grupo Rz es independientemente H o alquilo C1-4, con la condicion de que no más de 3 grupos Rz pueden ser alquilo C1-4; R1 es alquilo C1-6 (opcionalmente sustituido con 1, 2 o 3 átomos de halogeno y/o con 1 sustituyente seleccionado entre alquiltio C1-4 (opcionalmente sustituido con 1, 2 o 3 átomos de fluor), alcoxi C1-4 (opcionalmente sustituido con 1, 2 o 3 átomos de fluor), cicloalcoxi C3-6, alquilsulfonilo C1-4, ciano, -CO-O(alquilo C1-2), -O-CO-(alquil C1-2) e hidroxi); alquenilo C2-6 (opcionalmente sustituido con 1, 2 o 3 átomos de halogeno); cicloalquilo C3-6 (opcionalmente sustituido con 1, 2 o 3 átomos de halogeno y/o con 1 sustituyentes seleccionado entre alcoxi C1-4 e hidroxi) donde un enlace C-C del resto cicloalquilo está opcionalmente sustituido por un enlace O-C, S-C o C=C; cicloalquilalquilo C4- 7 (opcionalmente sustituido con 1, 2 o 3 átomos de halogeno y/o con 1 sustituyente seleccionado entre alcoxi C1-4 e hidroxi) donde un enlace C-C dentro del resto cicloalquilo está opcionalmente sustituido por un enlace O-C, S-C o C=C; o CH2Ar2; y cada uno de Ar1 y Ar2 es independientemente un anillo fenilo o un anillo heteroarilo de 5 o 6 miembros cada uno de los cuales está opcionalmente sustituido con 1, 2 o 3 sustituyentes (dependiendo del numero de posiciones de sustitucion disponibles) seleccionados independientemente, cada uno, entre alquilo C1-4 (opcionalmente sustituido con 1, 2 o 3 átomos de halogeno), alcoxi C1-4 (opcionalmente sustituido con 1, 2 o 3 átomos de halogeno), alquiltio C1-4 (opcionalmente sustituido con 1, 2 o 3 átomos de halogeno), -CO-O(alquilo C1-4), ciano, -NRR, -CONRR, halo e hidroxi y/o con 1 sustituyente seleccionado entre piridilo, tiofenilo, fenilo, bencilo y fenoxi, cada uno de los cuales está opcionalmente sustituido en el anillo con 1, 2 o 3 sustituyentes seleccionados independientemente cada uno entre halogeno, alquilo C1-4 (opcionalmente sustituido con 1, 2 o 3 átomos de halogeno), alcoxi C1-4 (opcionalmente sustituido con 1, 2 o 3 átomos de halogeno), carboxi, nitro, hidroxi, ciano, - NRR, -CONRR, SO2NRR y SO2R; y cada R es independientemente H o alquilo C1-4; o una sal farmacéuticamente aceptable del mismo.
ARP040104126A 2003-11-10 2004-11-09 Derivados de morfolina como inhibidores de la recaptacion de norepinefrina AR046927A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0326148.4A GB0326148D0 (en) 2003-11-10 2003-11-10 Morpholine derivatives
US53545904P 2004-01-09 2004-01-09

Publications (1)

Publication Number Publication Date
AR046927A1 true AR046927A1 (es) 2006-01-04

Family

ID=29726235

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104126A AR046927A1 (es) 2003-11-10 2004-11-09 Derivados de morfolina como inhibidores de la recaptacion de norepinefrina

Country Status (34)

Country Link
US (1) US7423037B2 (es)
EP (2) EP2223916A1 (es)
JP (1) JP4850068B2 (es)
KR (1) KR100783855B1 (es)
CN (1) CN1878762B (es)
AR (1) AR046927A1 (es)
AT (1) ATE478057T1 (es)
AU (1) AU2004289616B2 (es)
BR (1) BRPI0415273B8 (es)
CA (1) CA2544649C (es)
CR (1) CR8390A (es)
CY (1) CY1110796T1 (es)
DE (1) DE602004028750D1 (es)
DK (1) DK1682523T3 (es)
EA (1) EA009960B1 (es)
EC (1) ECSP066555A (es)
ES (1) ES2348872T3 (es)
GB (1) GB0326148D0 (es)
HK (1) HK1095135A1 (es)
HR (1) HRP20100476T1 (es)
IL (1) IL175365A (es)
MA (1) MA28330A1 (es)
MY (1) MY141048A (es)
NO (1) NO336268B1 (es)
NZ (1) NZ546067A (es)
PE (1) PE20050491A1 (es)
PL (1) PL1682523T3 (es)
PT (1) PT1682523E (es)
SI (1) SI1682523T1 (es)
SV (1) SV2006001934A (es)
TW (1) TWI339658B (es)
UA (1) UA85198C2 (es)
WO (1) WO2005047272A1 (es)
ZA (1) ZA200603680B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070015786A1 (en) * 2003-12-12 2007-01-18 Eli Lily And Company Treatment of hot flashes, impulse control disorders and personality change due to a general medical condition
US8580776B2 (en) * 2007-07-10 2013-11-12 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating neurodegenerating diseases
RU2613633C1 (ru) * 2016-03-09 2017-03-21 федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургская государственная химико-фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФА Минздрава России) Хлорид 4-[(1Е)-1-(6-хлор-4-оксо-4Н-хромен-3-ил)-4-метилпент-1-ен-3-ил]морфолин-4-ия, способ его получения и противотуберкулезная активность

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2645640A (en) 1953-07-14 Phenthiazine derivatives
NL108827C (es) 1956-04-09
GB895309A (en) 1959-11-18 1962-05-02 Res Lab Dr C Janssen Nv Pyrrolidine and piperidine derivatives
US3141823A (en) 1962-09-04 1964-07-21 Res Lab Dr C Janssen N V Method for producing analgesia
US3539573A (en) 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
JPS54130587A (en) 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
IE58370B1 (en) 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8607684D0 (en) 1986-03-27 1986-04-30 Ici America Inc Thiazepine compounds
US4831031A (en) 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5006528A (en) 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
GB8908085D0 (en) 1989-04-11 1989-05-24 Lundbeck & Co As H New therapeutic use
US5238945A (en) 1989-04-11 1993-08-24 H. Lundbeck A/S Method of treating psychoses
US5229382A (en) 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
US5312925A (en) 1992-09-01 1994-05-17 Pfizer Inc. Monohydrate of 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)-ethyl)-6-chloro-1,3-dihydro-2H-indol-2-one-hydrochloride
EG23659A (en) 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
AU9214498A (en) 1997-09-23 1999-04-12 Eli Lilly And Company Treatment of attention-deficit/hyperactivity disorder
CN1255389C (zh) 1998-01-21 2006-05-10 葛兰素集团有限公司 医药活性的吗啉醇
WO2001000214A1 (en) * 1999-06-30 2001-01-04 Merck & Co., Inc. Src kinase inhibitor compounds
PT1459750E (pt) 1999-07-01 2005-08-31 Pharmacia & Upjohn Co Llc (s,s)- reboxetina para tratar a fibromialgia ou outras perturbacoes somatoformes
GB0120461D0 (en) * 2001-08-22 2001-10-17 Astrazeneca Ab Novel compounds
GB0219687D0 (en) * 2002-08-23 2002-10-02 Lilly Co Eli Benzyl morpholine derivatives
JP2004277318A (ja) * 2003-03-14 2004-10-07 Dainippon Pharmaceut Co Ltd 1−(1−置換カルボニル−4−ピペリジニルメチル)ピペリジン誘導体およびそれを含有する医薬組成物
FR2852954B1 (fr) * 2003-03-28 2006-07-14 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
BRPI0415273B1 (pt) 2019-04-30
ES2348872T3 (es) 2010-12-16
JP4850068B2 (ja) 2012-01-11
NO336268B1 (no) 2015-07-06
NZ546067A (en) 2009-04-30
EP1682523A1 (en) 2006-07-26
CY1110796T1 (el) 2015-06-10
US7423037B2 (en) 2008-09-09
CN1878762B (zh) 2010-10-27
PL1682523T3 (pl) 2011-01-31
BRPI0415273B8 (pt) 2021-05-25
EA009960B1 (ru) 2008-04-28
KR100783855B1 (ko) 2007-12-10
MA28330A1 (fr) 2006-12-01
HRP20100476T1 (hr) 2010-10-31
HK1095135A1 (en) 2007-04-27
ATE478057T1 (de) 2010-09-15
EA200600945A1 (ru) 2006-10-27
CA2544649A1 (en) 2005-05-26
BRPI0415273A (pt) 2006-12-19
ZA200603680B (en) 2007-07-25
IL175365A0 (en) 2006-09-05
AU2004289616B2 (en) 2010-08-05
AU2004289616A1 (en) 2005-05-26
ECSP066555A (es) 2006-10-17
UA85198C2 (ru) 2009-01-12
PE20050491A1 (es) 2005-08-24
NO20062700L (no) 2006-08-08
KR20060086408A (ko) 2006-07-31
IL175365A (en) 2011-02-28
PT1682523E (pt) 2010-09-20
GB0326148D0 (en) 2003-12-17
CN1878762A (zh) 2006-12-13
DK1682523T3 (da) 2010-11-15
CA2544649C (en) 2012-08-14
US20070083046A1 (en) 2007-04-12
DE602004028750D1 (de) 2010-09-30
SV2006001934A (es) 2006-02-15
EP2223916A1 (en) 2010-09-01
TWI339658B (en) 2011-04-01
JP2007510720A (ja) 2007-04-26
TW200524885A (en) 2005-08-01
SI1682523T1 (sl) 2010-12-31
CR8390A (es) 2007-12-07
MY141048A (en) 2010-02-25
EP1682523B1 (en) 2010-08-18
WO2005047272A1 (en) 2005-05-26

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