AR046153A1 - Agonistas kappa - Google Patents
Agonistas kappaInfo
- Publication number
- AR046153A1 AR046153A1 ARP040102408A ARP040102408A AR046153A1 AR 046153 A1 AR046153 A1 AR 046153A1 AR P040102408 A ARP040102408 A AR P040102408A AR P040102408 A ARP040102408 A AR P040102408A AR 046153 A1 AR046153 A1 AR 046153A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- mono
- hal
- cycloalkyl
- so3r
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
Los compuestos de la fórmula (1), en donde significan: A es un sistema de anillos mono o bicíclico aromático o no aromático carba- o heterocíclico insustituido o mono o polisustituido con R1; R1 es H, Hal, NO2, NHR, NRR, OR, CO-R, SO3R, SO2R, SR, CF3, OCF3, SCF3, alquilo C1-8, cicloalquilo C3-14; R2 es H, Hal, NO2, NHR, NRR, OR, CO-R, SO3R, SO2R, SR, CF3, OCF3, SCF3, alquilo C1-8, cicloalquilo C3-14; R3 es alquilo C1-8; X es CO, CS, SO2; Y es un enlace simple, O, NH, CH2; R es H o un grupo alquilo C1-8, cicloalquilo C3-14, arilo C6-10 o aralquilo C7-14, que puede estar mono o polisustituido con R5 y cuya cadena C de alquilo puede estar interrumpida por -O-; Hal es F, Cl, Br o I; m es 0, 1, 2, 3 ó 4; y n es 0, 1, 2 ó 3; así como sus derivados, solvatos y estereoisómeros de utilidad farmacéutica, excluyendo sus mezclas en todas las proporciones, son apropiados como para el tratamiento del síndrome de intestino irritable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10331723A DE10331723A1 (de) | 2003-07-11 | 2003-07-11 | Kappa-Agonisten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR046153A1 true AR046153A1 (es) | 2005-11-30 |
Family
ID=34071646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102408A AR046153A1 (es) | 2003-07-11 | 2004-07-08 | Agonistas kappa |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20060178426A1 (es) |
| EP (1) | EP1644327A1 (es) |
| JP (1) | JP2007506677A (es) |
| KR (1) | KR20060030895A (es) |
| CN (1) | CN1819994A (es) |
| AR (1) | AR046153A1 (es) |
| AU (1) | AU2004256892A1 (es) |
| BR (1) | BRPI0412451A (es) |
| CA (1) | CA2531817A1 (es) |
| DE (1) | DE10331723A1 (es) |
| MX (1) | MXPA06000366A (es) |
| RU (1) | RU2006104024A (es) |
| WO (1) | WO2005007626A1 (es) |
| ZA (1) | ZA200601228B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2393885T7 (es) | 2007-06-04 | 2014-01-30 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| US20100221329A1 (en) | 2008-12-03 | 2010-09-02 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase c agonists and methods of use |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| JP6251038B2 (ja) | 2011-03-01 | 2017-12-20 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃアゴニストの調製方法 |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| US10011637B2 (en) | 2013-06-05 | 2018-07-03 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
| JP6577943B2 (ja) * | 2013-06-28 | 2019-09-18 | ネクター セラピューティクス | κオピオイド作動薬及びその使用 |
| WO2015042071A1 (en) * | 2013-09-19 | 2015-03-26 | Allergan, Inc. | Diphenyl urea derivatives as formyl peptide receptor modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4034785A1 (de) * | 1990-11-02 | 1992-05-07 | Merck Patent Gmbh | 1-(2-arylethyl)-pyrrolidine |
| US6303611B1 (en) * | 1996-03-08 | 2001-10-16 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US6133307A (en) * | 1997-04-30 | 2000-10-17 | Warner-Lambert Company | Certain benzofuranyl-N-[pyrrolidin-1-YL]-N-methyl-acetamide derivatives useful as opioid agonists |
| DE19849650A1 (de) * | 1998-10-29 | 2000-05-04 | Merck Patent Gmbh | Kappa-Opiatagonisten für die Behandlung des Irritable Bowel Syndroms (IBS) |
-
2003
- 2003-07-11 DE DE10331723A patent/DE10331723A1/de not_active Withdrawn
-
2004
- 2004-06-18 MX MXPA06000366A patent/MXPA06000366A/es not_active Application Discontinuation
- 2004-06-18 AU AU2004256892A patent/AU2004256892A1/en not_active Abandoned
- 2004-06-18 RU RU2006104024/04A patent/RU2006104024A/ru not_active Application Discontinuation
- 2004-06-18 CA CA002531817A patent/CA2531817A1/en not_active Abandoned
- 2004-06-18 EP EP04740074A patent/EP1644327A1/de not_active Withdrawn
- 2004-06-18 US US10/563,975 patent/US20060178426A1/en not_active Abandoned
- 2004-06-18 JP JP2006519787A patent/JP2007506677A/ja active Pending
- 2004-06-18 BR BRPI0412451-0A patent/BRPI0412451A/pt not_active Application Discontinuation
- 2004-06-18 WO PCT/EP2004/006630 patent/WO2005007626A1/de not_active Application Discontinuation
- 2004-06-18 CN CNA2004800197796A patent/CN1819994A/zh active Pending
- 2004-06-18 KR KR1020067000254A patent/KR20060030895A/ko not_active Application Discontinuation
- 2004-07-08 AR ARP040102408A patent/AR046153A1/es unknown
-
2006
- 2006-02-10 ZA ZA200601228A patent/ZA200601228B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0412451A (pt) | 2006-09-19 |
| CN1819994A (zh) | 2006-08-16 |
| RU2006104024A (ru) | 2006-07-27 |
| ZA200601228B (en) | 2007-05-30 |
| CA2531817A1 (en) | 2005-01-27 |
| KR20060030895A (ko) | 2006-04-11 |
| EP1644327A1 (de) | 2006-04-12 |
| JP2007506677A (ja) | 2007-03-22 |
| WO2005007626A1 (de) | 2005-01-27 |
| AU2004256892A1 (en) | 2005-01-27 |
| US20060178426A1 (en) | 2006-08-10 |
| MXPA06000366A (es) | 2006-03-28 |
| DE10331723A1 (de) | 2005-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR046153A1 (es) | Agonistas kappa | |
| AR054035A1 (es) | Derivados benzodioxano y benzodioxolano y uso de los mismos | |
| AR034475A1 (es) | Derivados de androstano antiinflamatorios | |
| AR056864A1 (es) | Derivados de (heteroariloxibencil)benceno sustituidos con glucopiranosilo, medicamentos que contienen estos compuestos, su uso y procedimiento para su fabricacion | |
| AR017311A1 (es) | Compuestos heteroaromaticos, procedimiento para su preparacion, su uso para la preparacion de medicamentos | |
| ECSP034865A (es) | Resolución óptica de (1-benzilo-4-metilopiperidina-3-il)-metilamina y su uso para la preparación de derivados de pirrolo 2,3-pirimidina como inhibidores de proteina quinasas | |
| AR057082A1 (es) | Derivados de ciclohexilaminisoquinolona | |
| NO20092050L (no) | Nye sulfonamidderivater som bradykininantagonister | |
| AR055592A1 (es) | Derivados de 2-amino-5-cicloalquil-hidantoina como moduladores y/o inhibidores de la beta-secretasa(bace) | |
| AR060268A1 (es) | Tiazolil - dihidro - indazoles | |
| AR035816A1 (es) | Compuestos derivados de dihidro-benzo[b][1,4]diazepin-2-ona, su uso, un proceso para prepararlos y medicamentos que los contienen. | |
| AR063015A1 (es) | Derivados de quinazolinona 5-sustituida y composiciones que los comprenden y metodos para utilizarlos en el tratamiento del cancer | |
| AR042956A1 (es) | Inhibidores de girasa y usos de los mismos | |
| CO5630005A2 (es) | Triazolopirimidinas sustituidas, procedimientos para su obtencion y el uso de las mismas para combatir hongos, asi como productos que las contienen | |
| AR048974A1 (es) | Derivados sustituidos del dioxido de oxazol-benzoisotiazol y composiciones farmaceuticas. | |
| DK130584D0 (da) | N-(2-nitrophenyl)-4-amino-pyrimidin-derivater samt deres fremstilling og anvendelse som mikrobicider | |
| CO5690582A2 (es) | Derivados de n-tiazol-2-il-benzamida | |
| AR042362A1 (es) | Derivados de 3h-quinazolin-4-ona, proceso de obtencion y composiciones farmaceuticas que los contienen | |
| AR060267A1 (es) | Tiazolil- dihidro -ciclopentapirazoles | |
| AR054529A1 (es) | Derivados de benzazepina como moduladores del receptor de 5-hidroxi-triptamina 6 | |
| AR020165A1 (es) | Derivados de pirimidinas sustituidas, su procedimiento de preparacion, composiciones farmaceuticas que las contienen y el uso de los mismos para la preparacion de medicamentos | |
| AR039601A1 (es) | Derivados de nitrosodifenilamina y composiciones farmaceuticas que los comprenden como medicamentos que se pueden utilizar en el tratamiento de patologias que se caracterizan por estres oxidativo | |
| AR070264A1 (es) | Derivados de oxazepinopirimidona heteroarilamida sustituidos | |
| NO20050612L (no) | Pyrrolidinderivater som oksytocinantagonister | |
| SE8107387L (sv) | Nya fenylalkylaminer, framstellning derav och anvendning som lekemedel |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |