AR045389A1 - Inhibidores del c-kit con estructura de pirazolil-amidil-benzoimidazolilo n-sustituido - Google Patents

Inhibidores del c-kit con estructura de pirazolil-amidil-benzoimidazolilo n-sustituido

Info

Publication number
AR045389A1
AR045389A1 ARP040103010A ARP040103010A AR045389A1 AR 045389 A1 AR045389 A1 AR 045389A1 AR P040103010 A ARP040103010 A AR P040103010A AR P040103010 A ARP040103010 A AR P040103010A AR 045389 A1 AR045389 A1 AR 045389A1
Authority
AR
Argentina
Prior art keywords
alkyl
cyclyl
optionally substituted
heterocyclyl
alkoxy
Prior art date
Application number
ARP040103010A
Other languages
English (en)
Spanish (es)
Original Assignee
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osi Pharm Inc filed Critical Osi Pharm Inc
Publication of AR045389A1 publication Critical patent/AR045389A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP040103010A 2003-08-21 2004-08-20 Inhibidores del c-kit con estructura de pirazolil-amidil-benzoimidazolilo n-sustituido AR045389A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49676603P 2003-08-21 2003-08-21

Publications (1)

Publication Number Publication Date
AR045389A1 true AR045389A1 (es) 2005-10-26

Family

ID=34272512

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040103010A AR045389A1 (es) 2003-08-21 2004-08-20 Inhibidores del c-kit con estructura de pirazolil-amidil-benzoimidazolilo n-sustituido

Country Status (19)

Country Link
EP (1) EP1664032B1 (US07585860-20090908-C00112.png)
JP (1) JP4795237B2 (US07585860-20090908-C00112.png)
KR (1) KR20060115346A (US07585860-20090908-C00112.png)
CN (1) CN1839130A (US07585860-20090908-C00112.png)
AP (1) AP2006003553A0 (US07585860-20090908-C00112.png)
AR (1) AR045389A1 (US07585860-20090908-C00112.png)
AT (1) ATE413395T1 (US07585860-20090908-C00112.png)
AU (1) AU2004268948A1 (US07585860-20090908-C00112.png)
BR (1) BRPI0413785A (US07585860-20090908-C00112.png)
CA (1) CA2536151A1 (US07585860-20090908-C00112.png)
DE (1) DE602004017623D1 (US07585860-20090908-C00112.png)
IL (1) IL173616A0 (US07585860-20090908-C00112.png)
IS (1) IS8320A (US07585860-20090908-C00112.png)
MX (1) MXPA06002017A (US07585860-20090908-C00112.png)
NO (1) NO20060665L (US07585860-20090908-C00112.png)
RU (1) RU2006108791A (US07585860-20090908-C00112.png)
TW (1) TW200524911A (US07585860-20090908-C00112.png)
UA (1) UA84712C2 (US07585860-20090908-C00112.png)
WO (1) WO2005021537A1 (US07585860-20090908-C00112.png)

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JP5583346B2 (ja) * 2006-01-18 2014-09-03 エルジー ハウスホールド アンド ヘルスケア リミテッド ｃ−Ｋｉｔ活性阻害剤、及び、肌美白剤
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JP2012519282A (ja) 2009-02-27 2012-08-23 オーエスアイ・ファーマシューティカルズ，エルエルシー 間葉様腫瘍細胞またはその生成を阻害する薬剤を同定するための方法
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JPWO2012121168A1 (ja) * 2011-03-04 2014-07-17 国立大学法人京都大学 キナーゼ阻害剤
CN103402519B (zh) 2011-04-18 2015-11-25 卫材R&D管理有限公司 肿瘤治疗剂
JP2014519813A (ja) 2011-04-25 2014-08-21 オーエスアイ・ファーマシューティカルズ，エルエルシー 癌薬剤発見、診断、および治療におけるｅｍｔ遺伝子シグネチャーの使用
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AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
JP6423372B2 (ja) 2013-02-28 2018-11-14 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 強力なｒｏｃｋ１およびｒｏｃｋ２阻害剤としてのフェニルピラゾール誘導体
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AR096654A1 (es) * 2013-06-20 2016-01-27 Ab Science Derivados de benzimidazol como inhibidores selectivos de proteína quinasa
IL302218B1 (en) 2014-08-28 2024-06-01 Eisai R&D Man Co Ltd Methods for the production of lanvotinib and its derivatives in a high degree of purity
DK3263106T3 (da) 2015-02-25 2024-01-08 Eisai R&D Man Co Ltd Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat
AU2015384801B2 (en) 2015-03-04 2022-01-06 Eisai R&D Management Co., Ltd. Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer
EP3311841B1 (en) 2015-06-16 2021-07-28 PRISM BioLab Co., Ltd. Anticancer agent
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

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Also Published As

Publication number Publication date
WO2005021537A1 (en) 2005-03-10
NO20060665L (no) 2006-05-16
BRPI0413785A (pt) 2006-11-07
UA84712C2 (en) 2008-11-25
AU2004268948A1 (en) 2005-03-10
MXPA06002017A (es) 2006-05-31
TW200524911A (en) 2005-08-01
KR20060115346A (ko) 2006-11-08
EP1664032A1 (en) 2006-06-07
DE602004017623D1 (de) 2008-12-18
RU2006108791A (ru) 2006-07-27
CN1839130A (zh) 2006-09-27
CA2536151A1 (en) 2005-03-10
EP1664032B1 (en) 2008-11-05
JP4795237B2 (ja) 2011-10-19
JP2007502820A (ja) 2007-02-15
AP2006003553A0 (en) 2006-04-30
IL173616A0 (en) 2006-07-05
ATE413395T1 (de) 2008-11-15
IS8320A (is) 2006-02-21

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