AR044628A1 - Derivados de indol con accion inductora de la apoptosis - Google Patents

Derivados de indol con accion inductora de la apoptosis

Info

Publication number
AR044628A1
AR044628A1 ARP040101959A ARP040101959A AR044628A1 AR 044628 A1 AR044628 A1 AR 044628A1 AR P040101959 A ARP040101959 A AR P040101959A AR P040101959 A ARP040101959 A AR P040101959A AR 044628 A1 AR044628 A1 AR 044628A1
Authority
AR
Argentina
Prior art keywords
alkyl
substituted
unsubstituted
alkoxy
carbonyl
Prior art date
Application number
ARP040101959A
Other languages
English (en)
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP03012868A external-priority patent/EP1484329A1/de
Priority claimed from EP04011598A external-priority patent/EP1595878A1/de
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of AR044628A1 publication Critical patent/AR044628A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se aplican como medicamentos para tratar enfermedades tumorales, en particular cuando hay resistencia contra otros medicamentos y cuando hay carcinomas que están formando metástasis. Reivindicación 1: Derivados de indol caracterizados porque tienen la fórmula general (1), en la que: R: representa un heterociclo-(C2-14), sustituido o no sustituido, que contiene uno o varios heteroátomos seleccionados de entre el grupo N, O y S, saturado, no saturado o aromático, unido directamente con el nitrógeno amídico; R1: significa alquil-arilo, no sustituido o sustituido; R2: significa hidrógeno; alquilo-(C1-6), sustituido o no sustituido; R3-R6 significa: hidrógeno; alquilo-(C1-6), no sustituido o sustituido; cicloalquilo-(C3-7), no sustituido o sustituido; amino, monoalquil-(C1-4)-amino, dialquil-(C1-4)-amino; halógeno; alquilo-(C1-4) sustituido por uno o varios átomos de flúor, preferiblemente del grupo trifluorometilo; ciano, ciano-alquilo-(C1-6), de cadena recta o ramificado; alquil-(C1-6)-carbonilo; carboxilo, alcoxi-(C1-4)-carbonilo, carboxi-alquilo-(C1-6) o alcoxi-(C1-6)-carbonilo-alquilo-(C1-6); hidroxi; alcoxi-(C1-6); arilalcoxi-(C1-4), preferiblemente benciloxi; alcoxi-(C1-6)-carbonilamino, alcoxi-(C1- 6)-carbonilamino-alquilo-(C1-6); R7: significa alquil-(C1-6)-carbonilo o alcoxi-(C1-4)-carbonilo; y X, Y: significan oxígeno o azufre, con la reserva de que cuando R representa un grupo 2-, 3-, 4-, 5- o 6- piridilo, sustituido o no sustituido y R1- R6 tiene el significado anteriormente indicado, R7 no representa un resto del alquilo o un grupo ter-butilcarbonilo; sus tautómeros, estereoisómeros, inclusive los diastereoisómeros y enantiómeros, así como sales fisiológicamente compatibles de éstos.
ARP040101959A 2003-06-05 2004-06-04 Derivados de indol con accion inductora de la apoptosis AR044628A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47627703P 2003-06-05 2003-06-05
EP03012868A EP1484329A1 (de) 2003-06-06 2003-06-06 Indolderivate mit Apoptose induzierender Wirkung
EP04011598A EP1595878A1 (de) 2004-05-15 2004-05-15 Indolderivate mit Apoptose induzierender Wirkung

Publications (1)

Publication Number Publication Date
AR044628A1 true AR044628A1 (es) 2005-09-21

Family

ID=33514393

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101959A AR044628A1 (es) 2003-06-05 2004-06-04 Derivados de indol con accion inductora de la apoptosis

Country Status (5)

Country Link
AR (1) AR044628A1 (es)
HK (1) HK1093065A1 (es)
IL (1) IL172130A (es)
NO (1) NO20060045L (es)
TW (1) TWI344462B (es)

Also Published As

Publication number Publication date
TW200504013A (en) 2005-02-01
HK1093065A1 (en) 2007-02-23
TWI344462B (en) 2011-07-01
IL172130A0 (en) 2006-04-10
NO20060045L (no) 2006-03-01
IL172130A (en) 2010-12-30

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