TW200504013A - Indole derivatives having an apoptosis-inducing effect - Google Patents

Indole derivatives having an apoptosis-inducing effect

Info

Publication number
TW200504013A
TW200504013A TW093115555A TW93115555A TW200504013A TW 200504013 A TW200504013 A TW 200504013A TW 093115555 A TW093115555 A TW 093115555A TW 93115555 A TW93115555 A TW 93115555A TW 200504013 A TW200504013 A TW 200504013A
Authority
TW
Taiwan
Prior art keywords
apoptosis
indole derivatives
inducing effect
indole
derivatives
Prior art date
Application number
TW093115555A
Other languages
Chinese (zh)
Other versions
TWI344462B (en
Inventor
Matthias Gerlach
Tilmann Schuster
Peter Emig
Peter Schmidt
Silke Baasner
Eckhard Gunther
Original Assignee
Zentaris Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP03012868A external-priority patent/EP1484329A1/en
Priority claimed from EP04011598A external-priority patent/EP1595878A1/en
Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh
Publication of TW200504013A publication Critical patent/TW200504013A/en
Application granted granted Critical
Publication of TWI344462B publication Critical patent/TWI344462B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

The invention relates to indole, derivatives which are used as drugs for treating tumor diseases, in particular when there is drug resistance against other active compounds and where there is a metastasizing carcinoma.
TW093115555A 2003-06-05 2004-05-31 Indole derivatives having an apoptosis-inducing effect TWI344462B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47627703P 2003-06-05 2003-06-05
EP03012868A EP1484329A1 (en) 2003-06-06 2003-06-06 Indole derivatives with apoptosis inducing activity
EP04011598A EP1595878A1 (en) 2004-05-15 2004-05-15 Indole derivatives with apoptosis inducing activity

Publications (2)

Publication Number Publication Date
TW200504013A true TW200504013A (en) 2005-02-01
TWI344462B TWI344462B (en) 2011-07-01

Family

ID=33514393

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093115555A TWI344462B (en) 2003-06-05 2004-05-31 Indole derivatives having an apoptosis-inducing effect

Country Status (5)

Country Link
AR (1) AR044628A1 (en)
HK (1) HK1093065A1 (en)
IL (1) IL172130A (en)
NO (1) NO20060045L (en)
TW (1) TWI344462B (en)

Also Published As

Publication number Publication date
IL172130A0 (en) 2006-04-10
NO20060045L (en) 2006-03-01
HK1093065A1 (en) 2007-02-23
TWI344462B (en) 2011-07-01
IL172130A (en) 2010-12-30
AR044628A1 (en) 2005-09-21

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees