AR044177A1 - Proceso para la preparacion de trans-isomeros de derivados de la difenilazetidinona - Google Patents
Proceso para la preparacion de trans-isomeros de derivados de la difenilazetidinonaInfo
- Publication number
- AR044177A1 AR044177A1 ARP040101537A ARP040101537A AR044177A1 AR 044177 A1 AR044177 A1 AR 044177A1 AR P040101537 A ARP040101537 A AR P040101537A AR P040101537 A ARP040101537 A AR P040101537A AR 044177 A1 AR044177 A1 AR 044177A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- trans
- derivatives
- formula
- lactone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se refiere a los procesos para la preparación de trans-isómeros de derivados de la difenilazetidinona, utilizando una delta-lactona quiral. Asimismo se relaciona con los procesos para la preparación del delta-lactona quiral. Además se refiere a las composiciones farmacéuticas que incluyen los trans-isómeros de los derivados de la difenilazetidinona. Reivindicación 1: Un proceso para preparar transisómeros de la difenilazetidinona de la fórmula (1), como se muestra en los diseños que se acompañan, o una sal de los mismos, en donde R1 y R2 son idénticos o diferentes, y representan al hidrógeno, halógeno o a un grupo alcoxi, y R3 representa al hidrógeno, alquilo o a un grupo protector hidroxi, que comprende la reacción de una delta lactona quiral de la fórmula (2), como se muestra en los diseños que se acompañan, en donde R1 es lo que se ha definido precedentemente, con una difenil imina de la fórmula (3), en donde R2, y R3, son lo que se ha definido precedentemente, ante la presencia de una base fuerte.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN668DE2003 | 2003-05-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR044177A1 true AR044177A1 (es) | 2005-08-24 |
Family
ID=33428285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040101537A AR044177A1 (es) | 2003-05-05 | 2004-05-06 | Proceso para la preparacion de trans-isomeros de derivados de la difenilazetidinona |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1626954A2 (es) |
| CN (1) | CN1805926A (es) |
| AR (1) | AR044177A1 (es) |
| WO (1) | WO2004099132A2 (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0215579D0 (en) | 2002-07-05 | 2002-08-14 | Astrazeneca Ab | Chemical compounds |
| US7871998B2 (en) | 2003-12-23 | 2011-01-18 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity |
| WO2006060808A1 (en) * | 2004-12-03 | 2006-06-08 | Teva Pharmaceutical Industries Ltd. | Ezetimibe polymorphs |
| TW200726746A (en) | 2005-05-06 | 2007-07-16 | Microbia Inc | Processes for production of 4-biphenylylazetidin-2-ones |
| EA200702464A1 (ru) * | 2005-05-11 | 2008-04-28 | Майкробиа, Инк. | Способы получения фенольных 4-бифенилилазетидин-2-онов |
| AU2006249905A1 (en) * | 2005-05-25 | 2006-11-30 | Microbia, Inc. | Processes for production of 4-(biphenylyl)azetidin-2-one phosphonic acids |
| UY29607A1 (es) | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | Compuestos quimicos |
| MY148538A (en) | 2005-06-22 | 2013-04-30 | Astrazeneca Ab | Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
| SA06270191B1 (ar) | 2005-06-22 | 2010-03-29 | استرازينيكا ايه بي | مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم |
| WO2007017705A1 (en) * | 2005-08-09 | 2007-02-15 | Glenmark Pharmaceuticals Limited | Process for the preparation of azetidinones |
| WO2008061238A2 (en) * | 2006-11-16 | 2008-05-22 | Ironwood Pharmaceuticals, Inc. | Processes for production of 4-biphenylyazetidin-2-ones |
| EP2128133A1 (en) | 2008-05-26 | 2009-12-02 | Lek Pharmaceuticals D.D. | Ezetimibe process and composition |
| WO2009147383A1 (en) * | 2008-06-02 | 2009-12-10 | Cipla Limited | Process for the synthesis of arformoterol |
| US9388440B2 (en) | 2009-04-01 | 2016-07-12 | Mylan Laboratories Limited | Enzymatic process for the preparation of (S)-5-(4-fluoro-phenyl)-5-hydroxy-1morpholin-4-yl-pentan-1-one, an intermediate of Ezetimibe and further conversion to Ezetimibe |
| PL231215B1 (pl) | 2011-06-15 | 2019-02-28 | Inst Chemii Organicznej Polskiej Akademii Nauk | Sposób wytwarzania podstawionych azetydynonów oraz związków pośrednich do ich syntezy |
| CN103086938A (zh) * | 2011-10-28 | 2013-05-08 | 沈阳药科大学 | 依泽替米贝的合成方法 |
| CN103121966A (zh) * | 2011-11-17 | 2013-05-29 | 重庆华邦胜凯制药有限公司 | 定向合成(4-氯苯基)-(吡啶-2-基)-甲醇的方法 |
| CN103204795B (zh) * | 2012-01-11 | 2016-12-14 | 重庆华邦胜凯制药有限公司 | 一种手性氮杂环丁酮类化合物的制备方法 |
| PL2864284T3 (pl) | 2012-06-22 | 2017-12-29 | Henkel Ag & Co. Kgaa | Fotolabilne substancje gromadzące substancje zapachowe |
| CN104744331B (zh) * | 2013-12-31 | 2018-05-15 | 浙江九洲药业股份有限公司 | 一种依泽替米贝中间体的合成工艺 |
| CN107176920B (zh) * | 2017-04-19 | 2019-09-20 | 江苏恒盛药业有限公司 | 一种依泽麦布的合成新工艺 |
| CN108586373A (zh) * | 2018-06-22 | 2018-09-28 | 苏州市贝克生物科技有限公司 | 依折麦布中间体的合成方法 |
| CN110818606B (zh) * | 2018-08-08 | 2021-06-29 | 上海博志研新药物技术有限公司 | 依折麦布及其中间体的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631365A (en) * | 1993-09-21 | 1997-05-20 | Schering Corporation | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents |
-
2004
- 2004-05-05 EP EP04731224A patent/EP1626954A2/en not_active Withdrawn
- 2004-05-05 WO PCT/IB2004/001396 patent/WO2004099132A2/en not_active Application Discontinuation
- 2004-05-05 CN CNA2004800162566A patent/CN1805926A/zh active Pending
- 2004-05-06 AR ARP040101537A patent/AR044177A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004099132A3 (en) | 2005-03-24 |
| EP1626954A2 (en) | 2006-02-22 |
| WO2004099132A2 (en) | 2004-11-18 |
| CN1805926A (zh) | 2006-07-19 |
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Legal Events
| Date | Code | Title | Description |
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| FB | Suspension of granting procedure |