AR043154A1 - Derivados sustituidos con nitrogeno de hexahidro-pirazino[1,2-a] pirimidin-4,7-diona, procedimientos para su preparacion y su uso como medicamentos - Google Patents

Derivados sustituidos con nitrogeno de hexahidro-pirazino[1,2-a] pirimidin-4,7-diona, procedimientos para su preparacion y su uso como medicamentos

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Publication number
AR043154A1
AR043154A1 ARP040100426A ARP040100426A AR043154A1 AR 043154 A1 AR043154 A1 AR 043154A1 AR P040100426 A ARP040100426 A AR P040100426A AR P040100426 A ARP040100426 A AR P040100426A AR 043154 A1 AR043154 A1 AR 043154A1
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AR
Argentina
Prior art keywords
alkyl
aryl
alkylene
coo
cycloalkyl
Prior art date
Application number
ARP040100426A
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English (en)
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Aventis Pharma Gmbh
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Publication date
Priority claimed from DE10305885A external-priority patent/DE10305885A1/de
Priority claimed from DE10349671A external-priority patent/DE10349671A1/de
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of AR043154A1 publication Critical patent/AR043154A1/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente se refiere a derivados sustituidos de hexahidro-pirazino [1,2-a]pirimidin-4,7-diona, así como a sus sales de tolerancia fisiológica y derivados de funcionalidad fisiológica. Compuestos adecuados como anoréxicos, para el tratamiento de la adiposidad. Reivindicación 1: Compuestos de la fórmula (1) en la que significan: A: un anillo mono- bi- o espirocíclico de 3 a 12 miembros, que puede contener uno o varios heteroátomos del grupo N, O, y S, y el anillo de 3 a 12 miembros puede presentar otros sustituyentes como F, Cl, Br, NO2, CF3, OCF3, CN, alquilo C1-6, arilo, CON(R11)(R12), N(R13)(R14), OH, O-alquilo C1-6, S-alquilo C1-6, N(R15)CO-alquilo C1-6 o COO-alquilo C1-6; R11, R12, R13, R14, R15, independientemente entre sí, H, alquilo C1-6, heterociclo; n 0,1; m 0,1,2,3,4,5,6; R1 R8, alquilen C1-6-R8, alquenilen C2-6-R9, (SO2)-R8, (SO2)-alquilen C1-6-R8, (SO2)-alquenilen C2-6-R9, (C=O)-R8,(C=O)-alquilen C1-6-R8, (C=O)NH-R8, (C=O)-alquenilen C2-6-R9, (C=O)-NH-alquilen C1-6-R8, (C=O)-NH-alquenilen C2-6-R9, COO-R8, COO-alquilen C1-6-R8, COO-alquenilen C2-6-R9, alquinilen-R9, (alquil C1-4)-heterociclo, en donde los grupos alquileno pueden estar sustituidos con F; R8, R9 independientemente entre sí H, F, Cl, Br, I, OH, CF3, arilo, heterociclo, cicloalquilo C3-8, pudiendo los ciclos o grupos cíclicos estar mono- o hasta trisustituidos con F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O-alquilo C1-6, alquilo C1-6. NH2, CON(R11)(R12), N(R13)(R14), SO2-CH3, COOH, COO-alquilo C1-6, CONH2; R2 NH2, NO2, N(R13)(R14), NH-SO2-CH3, NH-SO2-R12, NR11-SO2-R12, N(CO)R11, un heterociclo que contiene N, en donde el heterociclo está ligado a través de un átomo de N, NHCONR11, N(alquil C1-6)N+(alquil C1-4)3; R3, R4, R5 independientemente entre sí H, F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O-alquilo C1-6, O-alcoxi C1-4-alquilo C1-4, S-alquilo C1-6, alquilo C1-6, alquenilo C2-6, cicloalquilo C3-8, O-cicloalquilo C3-8, cicloalquenilo C3-8, O-cicloalquenilo C3-8, alquinilo C2-6, arilo, O-aril-alquilen C1-8-arilo, O-alquilen C1-8-arilo, S-arilo, N(alquil C1-6)2, SO2-CH3, COOH, COO-alquilo C1-6, CO-N(alquilo C1-6)2; R6 H, F, Cl, Br, I, OH, CF3, NO2, CN, OCF3, O-alquilo C1-6, O-alcoxi C1-4-alquilo C1-4, S-alquilo C1-6, alquilo C1-6, alquenilo C2-6, cicloalquilo C3-8, O-cicloalquilo C3-8, cicloalquenilo C3-8, O-cicloalquenilo C3-8, alquinilo C2-6, alquilen C0-8-arilo, O-alquilen C0-8-arilo, S-arilo, N(alquilo C1-6)2, SO2-CH3, COOH, COO-alquilo C1-6, CO-N(alquilo C1-6)2; así como sus sales de tolerancia fisiológica.
ARP040100426A 2003-02-13 2004-02-11 Derivados sustituidos con nitrogeno de hexahidro-pirazino[1,2-a] pirimidin-4,7-diona, procedimientos para su preparacion y su uso como medicamentos AR043154A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10305885A DE10305885A1 (de) 2003-02-13 2003-02-13 Substituierte Hexahydro-pyrazino(1,2-a)pyrimidin-4,7-dionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE10349671A DE10349671A1 (de) 2003-10-24 2003-10-24 Stickstoff substituierte Hexahydro-pyrazino(1,2-a)pyrimidin-4,7-dionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
AR043154A1 true AR043154A1 (es) 2005-07-20

Family

ID=32870333

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040100426A AR043154A1 (es) 2003-02-13 2004-02-11 Derivados sustituidos con nitrogeno de hexahidro-pirazino[1,2-a] pirimidin-4,7-diona, procedimientos para su preparacion y su uso como medicamentos

Country Status (20)

Country Link
EP (1) EP1597259B1 (es)
JP (1) JP2006517551A (es)
KR (1) KR20050100686A (es)
AR (1) AR043154A1 (es)
AT (1) ATE393769T1 (es)
AU (1) AU2004212043A1 (es)
BR (1) BRPI0407387A (es)
CA (1) CA2514791A1 (es)
CO (1) CO5690596A2 (es)
DE (1) DE502004007000D1 (es)
HR (1) HRP20050711A2 (es)
MA (1) MA27734A1 (es)
MX (1) MXPA05008288A (es)
NO (1) NO20054208L (es)
PE (1) PE20040949A1 (es)
PL (1) PL377660A1 (es)
RS (1) RS20050572A (es)
RU (1) RU2005128499A (es)
TW (1) TW200510417A (es)
WO (1) WO2004072077A1 (es)

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US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
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US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683702B1 (de) 2011-03-08 2014-12-24 Sanofi Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8846666B2 (en) 2011-03-08 2014-09-30 Sanofi Oxathiazine derivatives which are substituted with benzyl or heteromethylene groups, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
US8809325B2 (en) 2011-03-08 2014-08-19 Sanofi Benzyl-oxathiazine derivatives substituted with adamantane and noradamantane, medicaments containing said compounds and use thereof
US8871758B2 (en) 2011-03-08 2014-10-28 Sanofi Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
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Publication number Publication date
AU2004212043A1 (en) 2004-08-26
EP1597259A1 (de) 2005-11-23
PL377660A1 (pl) 2006-02-06
PE20040949A1 (es) 2005-01-12
WO2004072077A1 (de) 2004-08-26
KR20050100686A (ko) 2005-10-19
CA2514791A1 (en) 2004-08-26
MA27734A1 (fr) 2006-02-01
CO5690596A2 (es) 2006-10-31
ATE393769T1 (de) 2008-05-15
RU2005128499A (ru) 2006-01-27
MXPA05008288A (es) 2006-03-21
BRPI0407387A (pt) 2006-02-07
NO20054208L (no) 2005-09-09
EP1597259B1 (de) 2008-04-30
JP2006517551A (ja) 2006-07-27
HRP20050711A2 (en) 2006-09-30
TW200510417A (en) 2005-03-16
DE502004007000D1 (de) 2008-06-12
RS20050572A (en) 2007-09-21

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