AR043110A1 - Sal de heparina de bajo peso molecular con trietanolamina util como agente terapeutico-antitrombotico de administracion topica, procedimientos para preparar dichas sales, proceso para la eliminacion de la higroscopicidad de la sal de heparina, composiciones farmaceuticas para uso topico en terapia a - Google Patents
Sal de heparina de bajo peso molecular con trietanolamina util como agente terapeutico-antitrombotico de administracion topica, procedimientos para preparar dichas sales, proceso para la eliminacion de la higroscopicidad de la sal de heparina, composiciones farmaceuticas para uso topico en terapia aInfo
- Publication number
- AR043110A1 AR043110A1 ARP040100347A ARP040100347A AR043110A1 AR 043110 A1 AR043110 A1 AR 043110A1 AR P040100347 A ARP040100347 A AR P040100347A AR P040100347 A ARP040100347 A AR P040100347A AR 043110 A1 AR043110 A1 AR 043110A1
- Authority
- AR
- Argentina
- Prior art keywords
- salt
- triethanolamine
- useful
- low molecular
- therapeutic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
Abstract
Sal de heparina de bajo peso molecular con trietanolamina útil como agente terapéutico-antitrombótico de administración tópica, que comprende al menos 60% de su masa total con un peso molecular inferior a 8000 Da y un peso molecular promedio comprendido entre 4000 y 6000 Da, presentando además dicha sal un contenido de azufre orgánico de entre 6,1 y 7,5 % en peso (teórico 6,8 % en peso) y un contenido de trietanolamina de entre 42,6 y 52,1 % en peso (teórico 47,4 % en peso). Se describen además procedimientos para preparar dichas sales, proceso para la eliminación de la higroscopicidad de la sal de heparina, composiciones farmacéuticas para uso tópico en terapia antitrombótica y usos en dichas terapias.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP040100347A AR043110A1 (es) | 2004-02-04 | 2004-02-04 | Sal de heparina de bajo peso molecular con trietanolamina util como agente terapeutico-antitrombotico de administracion topica, procedimientos para preparar dichas sales, proceso para la eliminacion de la higroscopicidad de la sal de heparina, composiciones farmaceuticas para uso topico en terapia a |
US11/024,082 US20050234015A1 (en) | 2004-02-04 | 2004-12-28 | Low molecular weight heparin salt with triethanolamine useful as therapeutic-antitrombotic agent of local delivery, procedures for preparing them, process for elimination of hygroscopicity of heparin salt, pharmaceutical compositions for local use in antithrombotic therapy and uses therein |
JP2004379644A JP4607575B2 (ja) | 2004-02-04 | 2004-12-28 | 局所的送達の治療用抗血栓剤として有用なトリエタノールアミンを伴う低分子量ヘパリン塩、それらの調製方法、ヘパリン塩の吸湿性を除去するためのプロセス、抗血栓療法における局所的使用のための薬学組成物及びそれにおける使用 |
CA2491398A CA2491398C (en) | 2004-02-04 | 2005-01-04 | Processes for preparing triethanolamine salts of low molecular weight heparin and their use in topical creams for antithrombotic therapy |
AT05250081T ATE415424T1 (de) | 2004-02-04 | 2005-01-10 | Salz von heparin mit niedrigem molekulargewicht mit triethanolamin |
DE602005011189T DE602005011189D1 (de) | 2004-02-04 | 2005-01-10 | Salz von Heparin mit niedrigem Molekulargewicht mit Triethanolamin |
EP05250081A EP1561760B1 (en) | 2004-02-04 | 2005-01-10 | Low molecular weight heparin salt with triethanolamine |
CNB2005100091529A CN100564397C (zh) | 2004-02-04 | 2005-02-04 | 用作局部给药的抗血栓形成治疗剂的低分子量肝素三乙醇胺盐其制法和用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ARP040100347A AR043110A1 (es) | 2004-02-04 | 2004-02-04 | Sal de heparina de bajo peso molecular con trietanolamina util como agente terapeutico-antitrombotico de administracion topica, procedimientos para preparar dichas sales, proceso para la eliminacion de la higroscopicidad de la sal de heparina, composiciones farmaceuticas para uso topico en terapia a |
Publications (1)
Publication Number | Publication Date |
---|---|
AR043110A1 true AR043110A1 (es) | 2005-07-20 |
Family
ID=34658432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040100347A AR043110A1 (es) | 2004-02-04 | 2004-02-04 | Sal de heparina de bajo peso molecular con trietanolamina util como agente terapeutico-antitrombotico de administracion topica, procedimientos para preparar dichas sales, proceso para la eliminacion de la higroscopicidad de la sal de heparina, composiciones farmaceuticas para uso topico en terapia a |
Country Status (8)
Country | Link |
---|---|
US (1) | US20050234015A1 (es) |
EP (1) | EP1561760B1 (es) |
JP (1) | JP4607575B2 (es) |
CN (1) | CN100564397C (es) |
AR (1) | AR043110A1 (es) |
AT (1) | ATE415424T1 (es) |
CA (1) | CA2491398C (es) |
DE (1) | DE602005011189D1 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101735336B (zh) * | 2009-11-06 | 2012-07-18 | 深圳海王药业有限公司 | 低聚岩藻糖化糖胺聚糖及其制备方法 |
CN101724086B (zh) * | 2009-11-25 | 2012-09-26 | 深圳海王药业有限公司 | 低聚凤梨参糖胺聚糖及其制备方法 |
KR101794877B1 (ko) * | 2010-09-14 | 2017-11-07 | 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 | 고순도 헤파린 및 그 제조방법 |
CN102746421B (zh) * | 2012-05-23 | 2014-03-12 | 杭州龙扬生物科技有限公司 | 粗品肝素钠的除杂工艺 |
RU2539380C1 (ru) * | 2014-01-14 | 2015-01-20 | Александр Ливиевич Ураков | Отбеливатель кровоподтеков |
CN104188902B (zh) * | 2014-08-25 | 2017-03-29 | 深圳市天道医药有限公司 | 一种高稳定性达肝素钠注射液的生产工艺 |
CN104479047B (zh) * | 2014-12-20 | 2016-08-17 | 山东绅联生物科技有限公司 | 一种中品肝素钠的提取方法 |
RU2573382C1 (ru) * | 2015-01-16 | 2016-01-20 | Александр Ливиевич Ураков | Средство для внутрикожного отбеливания синяка |
RU2639283C1 (ru) * | 2016-12-12 | 2017-12-20 | Общество с ограниченной ответственностью "Институт термологии" | Способ обесцвечивания синяка под глазом |
RU2639485C1 (ru) * | 2017-01-23 | 2017-12-21 | Общество с ограниченной ответственностью "Институт термологии" | Средство для прижизненного отбеливания кожи в области синяков под глазами |
CN111019014A (zh) * | 2019-11-22 | 2020-04-17 | 苏州二叶制药有限公司 | 一种那曲肝素钙的制备工艺 |
CN114773530B (zh) * | 2022-03-29 | 2023-05-12 | 河南驼人医疗器械研究院有限公司 | 一种具有抗凝血功能的聚合物乳液及其制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3020220A1 (de) * | 1980-05-28 | 1981-12-03 | Theodor Prof. Dr. 4400 Münster Eckert | Organische salze des heparin, der heparinoide, ihre herstellung und sie enthaltende arzneimittel |
DE3331009A1 (de) * | 1983-08-27 | 1985-03-14 | Basf Ag, 6700 Ludwigshafen | Verfahren zur erhoehung der enteralen resorbierbarkeit von heparin bzw. heparinoiden sowie das so erhaeltliche heparin- bzw. heparinoidpraeparat |
FR2584728B1 (fr) * | 1985-07-12 | 1987-11-20 | Choay Sa | Procede de sulfatation de glycosaminoglycanes et de leurs fragments |
AR243204A1 (es) * | 1986-11-21 | 1993-07-30 | Ajorca Sa | Un metodo para la depolimerizacion quimica de polisacaridos. |
DE3744119A1 (de) * | 1987-12-24 | 1989-07-06 | Basf Ag | Verwendung von polysulfatierten heparinen |
GB8826448D0 (en) * | 1988-11-11 | 1988-12-14 | Thrombosis Res Inst | Improvements in/relating to organic compounds |
US6458383B2 (en) * | 1999-08-17 | 2002-10-01 | Lipocine, Inc. | Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin |
DE10141106A1 (de) * | 2001-08-22 | 2003-03-13 | Aventis Pharma Gmbh | Verwendung von Heparinoid-Derivaten zur Behandlung und Diagnose von mit Heparinoiden behandelbaren Erkrankungen |
US20040072796A1 (en) * | 2002-04-18 | 2004-04-15 | Embury Stephen H. | Method and composition for preventing pain in sickle cell patients |
-
2004
- 2004-02-04 AR ARP040100347A patent/AR043110A1/es active IP Right Grant
- 2004-12-28 JP JP2004379644A patent/JP4607575B2/ja active Active
- 2004-12-28 US US11/024,082 patent/US20050234015A1/en not_active Abandoned
-
2005
- 2005-01-04 CA CA2491398A patent/CA2491398C/en active Active
- 2005-01-10 DE DE602005011189T patent/DE602005011189D1/de active Active
- 2005-01-10 AT AT05250081T patent/ATE415424T1/de not_active IP Right Cessation
- 2005-01-10 EP EP05250081A patent/EP1561760B1/en active Active
- 2005-02-04 CN CNB2005100091529A patent/CN100564397C/zh not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1561760B1 (en) | 2008-11-26 |
JP4607575B2 (ja) | 2011-01-05 |
ATE415424T1 (de) | 2008-12-15 |
DE602005011189D1 (de) | 2009-01-08 |
CN1651470A (zh) | 2005-08-10 |
EP1561760A2 (en) | 2005-08-10 |
CA2491398A1 (en) | 2005-08-04 |
CA2491398C (en) | 2011-04-12 |
JP2005220347A (ja) | 2005-08-18 |
EP1561760A3 (en) | 2007-03-28 |
CN100564397C (zh) | 2009-12-02 |
US20050234015A1 (en) | 2005-10-20 |
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